Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY39_LEIMU

TriTrypDb:

LmxM.26.0600

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY39

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0019905	syntaxin binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.292
CLV_MEL_PAP_1	134	140	PF00089	0.292
CLV_NRD_NRD_1	113	115	PF00675	0.373
CLV_NRD_NRD_1	152	154	PF00675	0.334
CLV_NRD_NRD_1	172	174	PF00675	0.145
CLV_NRD_NRD_1	220	222	PF00675	0.296
CLV_NRD_NRD_1	262	264	PF00675	0.201
CLV_NRD_NRD_1	92	94	PF00675	0.306
CLV_PCSK_KEX2_1	115	117	PF00082	0.308
CLV_PCSK_KEX2_1	151	153	PF00082	0.394
CLV_PCSK_KEX2_1	220	222	PF00082	0.281
CLV_PCSK_KEX2_1	262	264	PF00082	0.475
CLV_PCSK_KEX2_1	304	306	PF00082	0.289
CLV_PCSK_KEX2_1	76	78	PF00082	0.388
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.277
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.369
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.284
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.413
CLV_PCSK_SKI1_1	230	234	PF00082	0.373
CLV_PCSK_SKI1_1	291	295	PF00082	0.284
CLV_PCSK_SKI1_1	328	332	PF00082	0.530
CLV_PCSK_SKI1_1	34	38	PF00082	0.509
CLV_PCSK_SKI1_1	93	97	PF00082	0.466
DOC_MAPK_gen_1	220	228	PF00069	0.167
DOC_USP7_MATH_1	129	133	PF00917	0.292
DOC_USP7_MATH_1	14	18	PF00917	0.698
DOC_USP7_MATH_1	2	6	PF00917	0.644
DOC_WW_Pin1_4	19	24	PF00397	0.619
LIG_14-3-3_CanoR_1	137	145	PF00244	0.395
LIG_14-3-3_CanoR_1	191	199	PF00244	0.217
LIG_14-3-3_CanoR_1	223	227	PF00244	0.333
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_FHA_1	204	210	PF00498	0.257
LIG_FHA_2	271	277	PF00498	0.395
LIG_LIR_Gen_1	178	188	PF02991	0.415
LIG_LIR_Gen_1	192	202	PF02991	0.396
LIG_LIR_Nem_3	178	184	PF02991	0.305
LIG_LIR_Nem_3	192	198	PF02991	0.314
LIG_LIR_Nem_3	241	247	PF02991	0.305
LIG_Pex14_2	177	181	PF04695	0.362
LIG_SH2_SRC	202	205	PF00017	0.441
LIG_SH2_STAP1	240	244	PF00017	0.328
LIG_SH2_STAT3	104	107	PF00017	0.292
LIG_SH2_STAT3	240	243	PF00017	0.303
LIG_SH2_STAT5	104	107	PF00017	0.337
LIG_SH3_3	248	254	PF00018	0.376
LIG_TRAF2_1	201	204	PF00917	0.413
LIG_TRAF2_1	9	12	PF00917	0.574
LIG_TRAF2_1	97	100	PF00917	0.369
MOD_CK2_1	270	276	PF00069	0.411
MOD_CK2_1	6	12	PF00069	0.662
MOD_GlcNHglycan	4	7	PF01048	0.643
MOD_GSK3_1	2	9	PF00069	0.634
MOD_GSK3_1	222	229	PF00069	0.385
MOD_GSK3_1	66	73	PF00069	0.243
MOD_N-GLC_1	19	24	PF02516	0.570
MOD_NEK2_1	1	6	PF00069	0.647
MOD_NEK2_1	109	114	PF00069	0.331
MOD_NEK2_1	247	252	PF00069	0.315
MOD_NEK2_1	28	33	PF00069	0.583
MOD_NEK2_1	84	89	PF00069	0.167
MOD_PIKK_1	136	142	PF00454	0.235
MOD_PKA_1	173	179	PF00069	0.423
MOD_PKA_2	136	142	PF00069	0.388
MOD_PKA_2	190	196	PF00069	0.180
MOD_PKA_2	222	228	PF00069	0.441
MOD_PKA_2	270	276	PF00069	0.370
MOD_PKB_1	153	161	PF00069	0.292
MOD_Plk_2-3	222	228	PF00069	0.362
MOD_Plk_4	141	147	PF00069	0.351
MOD_Plk_4	247	253	PF00069	0.282
MOD_ProDKin_1	19	25	PF00069	0.615
MOD_SUMO_for_1	252	255	PF00179	0.371
MOD_SUMO_for_1	303	306	PF00179	0.303
MOD_SUMO_rev_2	157	166	PF00179	0.262
TRG_DiLeu_BaEn_1	194	199	PF01217	0.292
TRG_ENDOCYTIC_2	195	198	PF00928	0.378
TRG_ER_diArg_1	219	221	PF00400	0.323
TRG_NES_CRM1_1	70	82	PF08389	0.337
TRG_NLS_Bipartite_1	65	79	PF00514	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W3	Leptomonas seymouri	65%	99%
A0A0S4JT11	Bodo saltans	30%	90%
A0A1X0NSF2	Trypanosomatidae	35%	93%
A0A3Q8IFN3	Leishmania donovani	92%	100%
A0A3R7M749	Trypanosoma rangeli	36%	91%
A4HER5	Leishmania braziliensis	81%	100%
A4I1Z2	Leishmania infantum	92%	100%
C9ZS22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
Q4Q9D4	Leishmania major	92%	100%
V5BZC0	Trypanosoma cruzi	34%	91%