Putative spliced leader RNA PSE-promoter transcription factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliced leader RNA PSE-promoter transcription factor, putative

Species:

Leishmania mexicana

UniProt:

E9AY38_LEIMU

TriTrypDb:

LmxM.26.0590

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.601
CLV_NRD_NRD_1	125	127	PF00675	0.680
CLV_NRD_NRD_1	2	4	PF00675	0.605
CLV_NRD_NRD_1	28	30	PF00675	0.587
CLV_NRD_NRD_1	292	294	PF00675	0.487
CLV_NRD_NRD_1	310	312	PF00675	0.333
CLV_NRD_NRD_1	434	436	PF00675	0.579
CLV_NRD_NRD_1	468	470	PF00675	0.581
CLV_NRD_NRD_1	534	536	PF00675	0.575
CLV_NRD_NRD_1	545	547	PF00675	0.497
CLV_NRD_NRD_1	61	63	PF00675	0.526
CLV_PCSK_FUR_1	26	30	PF00082	0.586
CLV_PCSK_FUR_1	58	62	PF00082	0.587
CLV_PCSK_KEX2_1	124	126	PF00082	0.634
CLV_PCSK_KEX2_1	2	4	PF00082	0.603
CLV_PCSK_KEX2_1	28	30	PF00082	0.588
CLV_PCSK_KEX2_1	292	294	PF00082	0.379
CLV_PCSK_KEX2_1	310	312	PF00082	0.500
CLV_PCSK_KEX2_1	43	45	PF00082	0.563
CLV_PCSK_KEX2_1	434	436	PF00082	0.581
CLV_PCSK_KEX2_1	467	469	PF00082	0.613
CLV_PCSK_KEX2_1	534	536	PF00082	0.575
CLV_PCSK_KEX2_1	545	547	PF00082	0.497
CLV_PCSK_KEX2_1	57	59	PF00082	0.425
CLV_PCSK_KEX2_1	60	62	PF00082	0.397
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.654
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.609
CLV_PCSK_PC7_1	24	30	PF00082	0.589
CLV_PCSK_PC7_1	464	470	PF00082	0.655
CLV_PCSK_SKI1_1	224	228	PF00082	0.510
CLV_PCSK_SKI1_1	315	319	PF00082	0.447
CLV_PCSK_SKI1_1	343	347	PF00082	0.496
DEG_APCC_DBOX_1	223	231	PF00400	0.499
DEG_APCC_DBOX_1	323	331	PF00400	0.482
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DEG_SCF_FBW7_1	412	419	PF00400	0.595
DOC_CDC14_PxL_1	232	240	PF14671	0.532
DOC_CKS1_1	170	175	PF01111	0.444
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.656
DOC_MAPK_DCC_7	43	51	PF00069	0.625
DOC_MAPK_gen_1	26	34	PF00069	0.578
DOC_MAPK_gen_1	532	540	PF00069	0.601
DOC_MAPK_gen_1	661	671	PF00069	0.697
DOC_MAPK_JIP1_4	26	32	PF00069	0.581
DOC_MAPK_MEF2A_6	258	265	PF00069	0.457
DOC_PP2B_LxvP_1	207	210	PF13499	0.603
DOC_PP2B_LxvP_1	30	33	PF13499	0.577
DOC_PP2B_LxvP_1	418	421	PF13499	0.763
DOC_PP2B_LxvP_1	499	502	PF13499	0.526
DOC_PP2B_LxvP_1	611	614	PF13499	0.647
DOC_USP7_MATH_1	158	162	PF00917	0.708
DOC_USP7_MATH_1	177	181	PF00917	0.611
DOC_USP7_MATH_1	356	360	PF00917	0.446
DOC_USP7_MATH_1	396	400	PF00917	0.565
DOC_USP7_MATH_1	410	414	PF00917	0.636
DOC_USP7_MATH_1	460	464	PF00917	0.707
DOC_USP7_MATH_1	507	511	PF00917	0.501
DOC_USP7_MATH_1	527	531	PF00917	0.294
DOC_WW_Pin1_4	100	105	PF00397	0.471
DOC_WW_Pin1_4	148	153	PF00397	0.753
DOC_WW_Pin1_4	159	164	PF00397	0.594
DOC_WW_Pin1_4	169	174	PF00397	0.579
DOC_WW_Pin1_4	202	207	PF00397	0.456
DOC_WW_Pin1_4	412	417	PF00397	0.626
DOC_WW_Pin1_4	509	514	PF00397	0.509
DOC_WW_Pin1_4	533	538	PF00397	0.582
DOC_WW_Pin1_4	612	617	PF00397	0.703
LIG_14-3-3_CanoR_1	124	129	PF00244	0.507
LIG_14-3-3_CanoR_1	2	6	PF00244	0.627
LIG_14-3-3_CanoR_1	608	614	PF00244	0.668
LIG_14-3-3_CanoR_1	661	671	PF00244	0.718
LIG_APCC_ABBA_1	328	333	PF00400	0.449
LIG_BRCT_BRCA1_1	165	169	PF00533	0.677
LIG_BRCT_BRCA1_1	18	22	PF00533	0.719
LIG_CaM_IQ_9	296	312	PF13499	0.528
LIG_CaM_NSCaTE_8	314	321	PF13499	0.445
LIG_FHA_1	248	254	PF00498	0.518
LIG_FHA_1	413	419	PF00498	0.740
LIG_FHA_1	479	485	PF00498	0.602
LIG_FHA_1	639	645	PF00498	0.721
LIG_FHA_1	91	97	PF00498	0.577
LIG_FHA_2	104	110	PF00498	0.573
LIG_FHA_2	356	362	PF00498	0.572
LIG_FHA_2	445	451	PF00498	0.522
LIG_FHA_2	619	625	PF00498	0.703
LIG_FHA_2	663	669	PF00498	0.708
LIG_Integrin_RGD_1	218	220	PF01839	0.532
LIG_LIR_Gen_1	196	207	PF02991	0.527
LIG_LIR_Nem_3	19	25	PF02991	0.666
LIG_LIR_Nem_3	196	202	PF02991	0.453
LIG_LIR_Nem_3	229	235	PF02991	0.460
LIG_LIR_Nem_3	494	499	PF02991	0.626
LIG_LIR_Nem_3	553	559	PF02991	0.553
LIG_LIR_Nem_3	562	568	PF02991	0.503
LIG_LIR_Nem_3	82	87	PF02991	0.566
LIG_LYPXL_yS_3	235	238	PF13949	0.454
LIG_MLH1_MIPbox_1	18	22	PF16413	0.719
LIG_MYND_1	416	420	PF01753	0.475
LIG_NRBOX	109	115	PF00104	0.541
LIG_PCNA_PIPBox_1	599	608	PF02747	0.432
LIG_PDZ_Class_2	666	671	PF00595	0.637
LIG_Pex14_1	341	345	PF04695	0.515
LIG_Pex14_2	345	349	PF04695	0.494
LIG_PTB_Apo_2	44	51	PF02174	0.594
LIG_SH2_CRK	556	560	PF00017	0.583
LIG_SH2_CRK	84	88	PF00017	0.479
LIG_SH2_NCK_1	117	121	PF00017	0.494
LIG_SH2_NCK_1	165	169	PF00017	0.677
LIG_SH2_STAP1	165	169	PF00017	0.677
LIG_SH2_STAT3	525	528	PF00017	0.616
LIG_SH2_STAT5	21	24	PF00017	0.728
LIG_SH2_STAT5	570	573	PF00017	0.430
LIG_SH2_STAT5	580	583	PF00017	0.463
LIG_SH2_STAT5	606	609	PF00017	0.426
LIG_SH3_3	30	36	PF00018	0.599
LIG_SH3_3	414	420	PF00018	0.681
LIG_SH3_3	652	658	PF00018	0.803
LIG_Sin3_3	519	526	PF02671	0.559
LIG_SUMO_SIM_par_1	103	109	PF11976	0.379
LIG_SUMO_SIM_par_1	225	231	PF11976	0.525
LIG_SUMO_SIM_par_1	536	541	PF11976	0.483
LIG_SUMO_SIM_par_1	546	553	PF11976	0.528
LIG_TRAF2_1	448	451	PF00917	0.632
LIG_TRAF2_1	665	668	PF00917	0.706
LIG_WRC_WIRS_1	342	347	PF05994	0.506
MOD_CDK_SPK_2	148	153	PF00069	0.736
MOD_CK1_1	180	186	PF00069	0.700
MOD_CK1_1	612	618	PF00069	0.715
MOD_CK1_1	631	637	PF00069	0.705
MOD_CK1_1	95	101	PF00069	0.454
MOD_CK2_1	138	144	PF00069	0.813
MOD_CK2_1	188	194	PF00069	0.580
MOD_CK2_1	444	450	PF00069	0.537
MOD_CK2_1	612	618	PF00069	0.700
MOD_CK2_1	662	668	PF00069	0.655
MOD_GlcNHglycan	120	123	PF01048	0.495
MOD_GlcNHglycan	182	185	PF01048	0.659
MOD_GlcNHglycan	232	235	PF01048	0.545
MOD_GlcNHglycan	319	322	PF01048	0.439
MOD_GlcNHglycan	357	361	PF01048	0.456
MOD_GlcNHglycan	412	415	PF01048	0.719
MOD_GlcNHglycan	473	477	PF01048	0.582
MOD_GlcNHglycan	591	594	PF01048	0.576
MOD_GlcNHglycan	611	614	PF01048	0.400
MOD_GlcNHglycan	633	636	PF01048	0.651
MOD_GSK3_1	138	145	PF00069	0.745
MOD_GSK3_1	159	166	PF00069	0.633
MOD_GSK3_1	176	183	PF00069	0.555
MOD_GSK3_1	412	419	PF00069	0.666
MOD_GSK3_1	555	562	PF00069	0.653
MOD_GSK3_1	612	619	PF00069	0.646
MOD_GSK3_1	620	627	PF00069	0.693
MOD_NEK2_1	1	6	PF00069	0.692
MOD_NEK2_1	222	227	PF00069	0.431
MOD_NEK2_1	228	233	PF00069	0.433
MOD_NEK2_1	247	252	PF00069	0.276
MOD_NEK2_1	355	360	PF00069	0.565
MOD_NEK2_1	373	378	PF00069	0.323
MOD_NEK2_1	472	477	PF00069	0.581
MOD_NEK2_1	508	513	PF00069	0.537
MOD_NEK2_1	559	564	PF00069	0.423
MOD_NEK2_1	7	12	PF00069	0.690
MOD_PIKK_1	373	379	PF00454	0.430
MOD_PIKK_1	478	484	PF00454	0.613
MOD_PIKK_1	559	565	PF00454	0.572
MOD_PIKK_1	618	624	PF00454	0.521
MOD_PIKK_1	90	96	PF00454	0.576
MOD_PK_1	124	130	PF00069	0.416
MOD_PK_1	76	82	PF00069	0.585
MOD_PKA_1	124	130	PF00069	0.537
MOD_PKA_2	1	7	PF00069	0.634
MOD_PKA_2	124	130	PF00069	0.668
MOD_Plk_1	228	234	PF00069	0.498
MOD_Plk_1	425	431	PF00069	0.551
MOD_Plk_1	485	491	PF00069	0.659
MOD_Plk_1	568	574	PF00069	0.438
MOD_Plk_1	595	601	PF00069	0.485
MOD_Plk_1	76	82	PF00069	0.476
MOD_Plk_2-3	188	194	PF00069	0.657
MOD_Plk_4	109	115	PF00069	0.542
MOD_Plk_4	586	592	PF00069	0.479
MOD_Plk_4	92	98	PF00069	0.329
MOD_ProDKin_1	100	106	PF00069	0.466
MOD_ProDKin_1	148	154	PF00069	0.751
MOD_ProDKin_1	159	165	PF00069	0.590
MOD_ProDKin_1	169	175	PF00069	0.579
MOD_ProDKin_1	202	208	PF00069	0.462
MOD_ProDKin_1	412	418	PF00069	0.630
MOD_ProDKin_1	509	515	PF00069	0.502
MOD_ProDKin_1	533	539	PF00069	0.585
MOD_ProDKin_1	612	618	PF00069	0.711
MOD_SUMO_for_1	663	666	PF00179	0.692
TRG_DiLeu_BaEn_1	249	254	PF01217	0.421
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.415
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.510
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.566
TRG_ENDOCYTIC_2	235	238	PF00928	0.434
TRG_ENDOCYTIC_2	371	374	PF00928	0.495
TRG_ENDOCYTIC_2	496	499	PF00928	0.609
TRG_ENDOCYTIC_2	556	559	PF00928	0.570
TRG_ENDOCYTIC_2	565	568	PF00928	0.481
TRG_ENDOCYTIC_2	606	609	PF00928	0.490
TRG_ENDOCYTIC_2	84	87	PF00928	0.523
TRG_ER_diArg_1	1	3	PF00400	0.616
TRG_ER_diArg_1	123	126	PF00400	0.656
TRG_ER_diArg_1	236	239	PF00400	0.407
TRG_ER_diArg_1	25	28	PF00400	0.603
TRG_ER_diArg_1	287	290	PF00400	0.546
TRG_ER_diArg_1	310	312	PF00400	0.481
TRG_ER_diArg_1	365	368	PF00400	0.574
TRG_ER_diArg_1	382	385	PF00400	0.389
TRG_ER_diArg_1	434	436	PF00400	0.575
TRG_ER_diArg_1	467	469	PF00400	0.680
TRG_ER_diArg_1	533	535	PF00400	0.575
TRG_ER_diArg_1	544	546	PF00400	0.507
TRG_ER_diArg_1	58	61	PF00400	0.518
TRG_ER_diArg_1	658	661	PF00400	0.783
TRG_NES_CRM1_1	280	294	PF08389	0.508
TRG_NLS_Bipartite_1	43	61	PF00514	0.610
TRG_NLS_MonoExtC_3	56	61	PF00514	0.593
TRG_NLS_MonoExtN_4	54	61	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A3	Leptomonas seymouri	64%	99%
A0A0S4JUQ3	Bodo saltans	36%	100%
A0A1X0NT43	Trypanosomatidae	46%	100%
A0A3Q8ICN9	Leishmania donovani	92%	95%
A0A422N5D7	Trypanosoma rangeli	48%	100%
A4HER4	Leishmania braziliensis	79%	100%
A4I1Z1	Leishmania infantum	92%	95%
C9ZS25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q9D5	Leishmania major	93%	100%
V5BPZ1	Trypanosoma cruzi	48%	100%