ApaG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF525), putative

Species:

Leishmania mexicana

UniProt:

E9AY37_LEIMU

TriTrypDb:

LmxM.26.0580

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0009295	nucleoid	2	1
GO:0042645	mitochondrial nucleoid	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY37

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0070987	error-free translesion synthesis	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.471
CLV_C14_Caspase3-7	284	288	PF00656	0.538
CLV_NRD_NRD_1	102	104	PF00675	0.465
CLV_NRD_NRD_1	182	184	PF00675	0.538
CLV_NRD_NRD_1	292	294	PF00675	0.689
CLV_NRD_NRD_1	302	304	PF00675	0.603
CLV_NRD_NRD_1	331	333	PF00675	0.413
CLV_NRD_NRD_1	84	86	PF00675	0.411
CLV_PCSK_KEX2_1	102	104	PF00082	0.465
CLV_PCSK_KEX2_1	181	183	PF00082	0.543
CLV_PCSK_KEX2_1	331	333	PF00082	0.413
CLV_PCSK_KEX2_1	431	433	PF00082	0.369
CLV_PCSK_KEX2_1	84	86	PF00082	0.411
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.369
CLV_PCSK_PC7_1	178	184	PF00082	0.538
CLV_PCSK_SKI1_1	293	297	PF00082	0.671
CLV_PCSK_SKI1_1	529	533	PF00082	0.509
CLV_PCSK_SKI1_1	9	13	PF00082	0.393
DOC_CKS1_1	127	132	PF01111	0.477
DOC_MAPK_gen_1	315	323	PF00069	0.362
DOC_MAPK_MEF2A_6	489	496	PF00069	0.304
DOC_PP4_FxxP_1	206	209	PF00568	0.521
DOC_PP4_FxxP_1	59	62	PF00568	0.397
DOC_SPAK_OSR1_1	205	209	PF12202	0.527
DOC_USP7_MATH_1	109	113	PF00917	0.520
DOC_USP7_MATH_1	118	122	PF00917	0.626
DOC_USP7_MATH_1	210	214	PF00917	0.570
DOC_USP7_MATH_1	217	221	PF00917	0.447
DOC_USP7_MATH_1	246	250	PF00917	0.580
DOC_USP7_MATH_1	363	367	PF00917	0.619
DOC_USP7_MATH_1	372	376	PF00917	0.774
DOC_USP7_MATH_1	469	473	PF00917	0.304
DOC_USP7_MATH_1	74	78	PF00917	0.468
DOC_USP7_UBL2_3	17	21	PF12436	0.364
DOC_WW_Pin1_4	126	131	PF00397	0.581
DOC_WW_Pin1_4	358	363	PF00397	0.741
DOC_WW_Pin1_4	381	386	PF00397	0.608
DOC_WW_Pin1_4	549	554	PF00397	0.590
LIG_14-3-3_CanoR_1	514	518	PF00244	0.403
LIG_14-3-3_CanoR_1	75	83	PF00244	0.403
LIG_Actin_WH2_2	48	63	PF00022	0.385
LIG_Actin_WH2_2	76	92	PF00022	0.480
LIG_APCC_ABBA_1	494	499	PF00400	0.388
LIG_BRCT_BRCA1_1	471	475	PF00533	0.304
LIG_BRCT_BRCA1_1	76	80	PF00533	0.408
LIG_Clathr_ClatBox_1	442	446	PF01394	0.304
LIG_CtBP_PxDLS_1	196	200	PF00389	0.532
LIG_EVH1_2	202	206	PF00568	0.530
LIG_FHA_1	153	159	PF00498	0.588
LIG_FHA_1	226	232	PF00498	0.401
LIG_FHA_1	333	339	PF00498	0.470
LIG_FHA_1	348	354	PF00498	0.410
LIG_FHA_1	381	387	PF00498	0.610
LIG_FHA_1	514	520	PF00498	0.481
LIG_FHA_1	55	61	PF00498	0.379
LIG_FHA_1	569	575	PF00498	0.529
LIG_FHA_2	320	326	PF00498	0.421
LIG_FHA_2	550	556	PF00498	0.579
LIG_Integrin_isoDGR_2	576	578	PF01839	0.538
LIG_Integrin_RGD_1	406	408	PF01839	0.462
LIG_LIR_Apic_2	19	25	PF02991	0.426
LIG_LIR_Apic_2	57	62	PF02991	0.390
LIG_LIR_Gen_1	27	37	PF02991	0.368
LIG_LIR_Gen_1	77	86	PF02991	0.455
LIG_LIR_LC3C_4	439	444	PF02991	0.304
LIG_LIR_Nem_3	200	204	PF02991	0.468
LIG_LIR_Nem_3	220	225	PF02991	0.408
LIG_LIR_Nem_3	27	33	PF02991	0.363
LIG_LIR_Nem_3	49	54	PF02991	0.373
LIG_LIR_Nem_3	6	11	PF02991	0.383
LIG_LIR_Nem_3	77	83	PF02991	0.454
LIG_MYND_1	465	469	PF01753	0.304
LIG_PTB_Apo_2	41	48	PF02174	0.459
LIG_PTB_Phospho_1	41	47	PF10480	0.457
LIG_SH2_CRK	8	12	PF00017	0.380
LIG_SH2_NCK_1	22	26	PF00017	0.418
LIG_SH2_PTP2	418	421	PF00017	0.304
LIG_SH2_SRC	22	25	PF00017	0.422
LIG_SH2_SRC	418	421	PF00017	0.304
LIG_SH2_STAT3	247	250	PF00017	0.492
LIG_SH2_STAT5	214	217	PF00017	0.497
LIG_SH2_STAT5	352	355	PF00017	0.470
LIG_SH2_STAT5	418	421	PF00017	0.340
LIG_SH3_3	124	130	PF00018	0.480
LIG_SH3_3	155	161	PF00018	0.632
LIG_SH3_3	190	196	PF00018	0.516
LIG_SH3_3	206	212	PF00018	0.515
LIG_SH3_3	359	365	PF00018	0.502
LIG_SUMO_SIM_par_1	213	221	PF11976	0.593
LIG_SUMO_SIM_par_1	228	235	PF11976	0.326
LIG_SUMO_SIM_par_1	319	325	PF11976	0.326
LIG_SUMO_SIM_par_1	341	347	PF11976	0.390
LIG_SUMO_SIM_par_1	441	446	PF11976	0.304
LIG_SUMO_SIM_par_1	515	521	PF11976	0.464
LIG_TRAF2_1	148	151	PF00917	0.554
LIG_TRAF2_1	322	325	PF00917	0.431
LIG_TRAF2_1	531	534	PF00917	0.521
LIG_TYR_ITIM	416	421	PF00017	0.304
MOD_CDK_SPxK_1	381	387	PF00069	0.610
MOD_CK1_1	112	118	PF00069	0.569
MOD_CK1_1	121	127	PF00069	0.619
MOD_CK1_1	134	140	PF00069	0.572
MOD_CK1_1	146	152	PF00069	0.718
MOD_CK1_1	235	241	PF00069	0.471
MOD_CK1_1	355	361	PF00069	0.584
MOD_CK1_1	379	385	PF00069	0.720
MOD_CK1_1	400	406	PF00069	0.656
MOD_CK1_1	477	483	PF00069	0.304
MOD_CK1_1	539	545	PF00069	0.544
MOD_CK1_1	73	79	PF00069	0.429
MOD_CK2_1	319	325	PF00069	0.426
MOD_CK2_1	363	369	PF00069	0.688
MOD_CK2_1	479	485	PF00069	0.304
MOD_Cter_Amidation	14	17	PF01082	0.340
MOD_Cter_Amidation	301	304	PF01082	0.513
MOD_GlcNHglycan	110	114	PF01048	0.689
MOD_GlcNHglycan	120	123	PF01048	0.593
MOD_GlcNHglycan	136	139	PF01048	0.630
MOD_GlcNHglycan	234	237	PF01048	0.427
MOD_GlcNHglycan	271	274	PF01048	0.557
MOD_GlcNHglycan	365	368	PF01048	0.590
MOD_GlcNHglycan	397	400	PF01048	0.696
MOD_GlcNHglycan	476	479	PF01048	0.304
MOD_GlcNHglycan	481	484	PF01048	0.308
MOD_GlcNHglycan	5	8	PF01048	0.387
MOD_GlcNHglycan	520	523	PF01048	0.615
MOD_GlcNHglycan	541	545	PF01048	0.676
MOD_GlcNHglycan	547	550	PF01048	0.798
MOD_GlcNHglycan	565	568	PF01048	0.563
MOD_GlcNHglycan	72	75	PF01048	0.420
MOD_GlcNHglycan	76	79	PF01048	0.405
MOD_GSK3_1	109	116	PF00069	0.483
MOD_GSK3_1	134	141	PF00069	0.631
MOD_GSK3_1	149	156	PF00069	0.589
MOD_GSK3_1	334	341	PF00069	0.602
MOD_GSK3_1	352	359	PF00069	0.415
MOD_GSK3_1	372	379	PF00069	0.578
MOD_GSK3_1	513	520	PF00069	0.449
MOD_GSK3_1	536	543	PF00069	0.553
MOD_GSK3_1	545	552	PF00069	0.559
MOD_GSK3_1	69	76	PF00069	0.616
MOD_N-GLC_1	185	190	PF02516	0.585
MOD_N-GLC_1	197	202	PF02516	0.488
MOD_NEK2_1	232	237	PF00069	0.421
MOD_NEK2_1	380	385	PF00069	0.613
MOD_NEK2_1	488	493	PF00069	0.405
MOD_NEK2_1	525	530	PF00069	0.557
MOD_NEK2_1	89	94	PF00069	0.584
MOD_PIKK_1	146	152	PF00454	0.609
MOD_PIKK_1	246	252	PF00454	0.489
MOD_PKA_1	16	22	PF00069	0.362
MOD_PKA_2	170	176	PF00069	0.523
MOD_PKA_2	177	183	PF00069	0.539
MOD_PKA_2	488	494	PF00069	0.304
MOD_PKA_2	513	519	PF00069	0.417
MOD_PKA_2	539	545	PF00069	0.540
MOD_PKA_2	577	583	PF00069	0.656
MOD_PKA_2	60	66	PF00069	0.417
MOD_PKA_2	74	80	PF00069	0.404
MOD_PKB_1	538	546	PF00069	0.606
MOD_Plk_1	197	203	PF00069	0.434
MOD_Plk_4	170	176	PF00069	0.523
MOD_Plk_4	210	216	PF00069	0.574
MOD_Plk_4	235	241	PF00069	0.471
MOD_ProDKin_1	126	132	PF00069	0.579
MOD_ProDKin_1	358	364	PF00069	0.745
MOD_ProDKin_1	381	387	PF00069	0.610
MOD_ProDKin_1	549	555	PF00069	0.591
MOD_SUMO_for_1	531	534	PF00179	0.500
MOD_SUMO_rev_2	408	412	PF00179	0.308
TRG_DiLeu_BaEn_1	165	170	PF01217	0.521
TRG_DiLeu_BaEn_1	211	216	PF01217	0.507
TRG_DiLeu_BaEn_1	325	330	PF01217	0.484
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.526
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.304
TRG_ENDOCYTIC_2	418	421	PF00928	0.298
TRG_ENDOCYTIC_2	8	11	PF00928	0.382
TRG_ER_diArg_1	101	103	PF00400	0.464
TRG_ER_diArg_1	181	183	PF00400	0.543
TRG_ER_diArg_1	330	332	PF00400	0.421
TRG_ER_diArg_1	421	424	PF00400	0.304
TRG_ER_diArg_1	83	85	PF00400	0.415
TRG_ER_diArg_1	96	99	PF00400	0.473
TRG_ER_diLys_1	583	588	PF00400	0.697
TRG_NES_CRM1_1	27	41	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I464	Leptomonas seymouri	60%	99%
A0A3Q8IGW6	Leishmania donovani	88%	100%
A4HER3	Leishmania braziliensis	80%	99%
A4I1Z0	Leishmania infantum	89%	100%
Q4Q9D6	Leishmania major	87%	98%