Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY36_LEIMU

TriTrypDb:

LmxM.26.0570

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.528
CLV_Separin_Metazoa	140	144	PF03568	0.443
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DOC_CKS1_1	38	43	PF01111	0.624
DOC_CKS1_1	84	89	PF01111	0.482
DOC_PP4_FxxP_1	38	41	PF00568	0.556
DOC_USP7_MATH_1	105	109	PF00917	0.377
DOC_USP7_MATH_1	63	67	PF00917	0.661
DOC_WW_Pin1_4	37	42	PF00397	0.599
DOC_WW_Pin1_4	83	88	PF00397	0.455
LIG_Actin_WH2_2	129	145	PF00022	0.249
LIG_BIR_III_4	2	6	PF00653	0.541
LIG_FHA_1	120	126	PF00498	0.552
LIG_FHA_1	137	143	PF00498	0.316
LIG_FHA_1	20	26	PF00498	0.314
LIG_FHA_2	4	10	PF00498	0.393
LIG_FHA_2	42	48	PF00498	0.528
LIG_LIR_Gen_1	135	145	PF02991	0.415
LIG_LIR_Gen_1	9	20	PF02991	0.343
LIG_LIR_Nem_3	135	141	PF02991	0.391
LIG_LIR_Nem_3	9	15	PF02991	0.340
LIG_SH2_GRB2like	11	14	PF00017	0.351
LIG_SH2_STAP1	138	142	PF00017	0.518
LIG_SH2_STAT3	11	14	PF00017	0.336
LIG_SH2_STAT5	11	14	PF00017	0.336
LIG_SH2_STAT5	138	141	PF00017	0.496
LIG_SH2_STAT5	75	78	PF00017	0.447
LIG_SH2_STAT5	89	92	PF00017	0.282
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.395
LIG_TYR_ITIM	136	141	PF00017	0.367
LIG_UBA3_1	109	118	PF00899	0.369
MOD_CK1_1	108	114	PF00069	0.384
MOD_CK1_1	66	72	PF00069	0.543
MOD_CK2_1	3	9	PF00069	0.411
MOD_GlcNHglycan	51	54	PF01048	0.689
MOD_GlcNHglycan	70	73	PF01048	0.412
MOD_GSK3_1	108	115	PF00069	0.370
MOD_GSK3_1	132	139	PF00069	0.445
MOD_GSK3_1	37	44	PF00069	0.481
MOD_N-GLC_1	66	71	PF02516	0.552
MOD_NEK2_1	112	117	PF00069	0.428
MOD_PIKK_1	19	25	PF00454	0.323
MOD_Plk_1	66	72	PF00069	0.479
MOD_Plk_4	105	111	PF00069	0.427
MOD_Plk_4	124	130	PF00069	0.454
MOD_Plk_4	132	138	PF00069	0.417
MOD_Plk_4	30	36	PF00069	0.407
MOD_Plk_4	85	91	PF00069	0.480
MOD_ProDKin_1	37	43	PF00069	0.610
MOD_ProDKin_1	83	89	PF00069	0.452
TRG_ENDOCYTIC_2	138	141	PF00928	0.409
TRG_NES_CRM1_1	14	28	PF08389	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P5	Leptomonas seymouri	78%	97%
A0A0S4JUR6	Bodo saltans	40%	100%
A0A1X0NSG3	Trypanosomatidae	56%	100%
A0A3Q8IC22	Leishmania donovani	98%	100%
A0A422N5D6	Trypanosoma rangeli	63%	100%
A4HER2	Leishmania braziliensis	93%	100%
A4I1Y9	Leishmania infantum	98%	100%
C9ZS26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
Q4Q9D7	Leishmania major	96%	100%
V5BQ40	Trypanosoma cruzi	61%	100%