Mitochondrial fission process protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY35_LEIMU

TriTrypDb:

LmxM.26.0560

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.800
CLV_C14_Caspase3-7	12	16	PF00656	0.786
CLV_C14_Caspase3-7	420	424	PF00656	0.767
CLV_C14_Caspase3-7	536	540	PF00656	0.708
CLV_NRD_NRD_1	147	149	PF00675	0.451
CLV_NRD_NRD_1	237	239	PF00675	0.697
CLV_NRD_NRD_1	611	613	PF00675	0.400
CLV_PCSK_KEX2_1	147	149	PF00082	0.451
CLV_PCSK_KEX2_1	175	177	PF00082	0.688
CLV_PCSK_KEX2_1	237	239	PF00082	0.697
CLV_PCSK_KEX2_1	611	613	PF00082	0.400
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.688
CLV_PCSK_SKI1_1	168	172	PF00082	0.594
CLV_PCSK_SKI1_1	612	616	PF00082	0.412
CLV_PCSK_SKI1_1	684	688	PF00082	0.409
CLV_Separin_Metazoa	314	318	PF03568	0.740
DEG_APCC_DBOX_1	139	147	PF00400	0.649
DEG_APCC_DBOX_1	220	228	PF00400	0.541
DEG_APCC_DBOX_1	610	618	PF00400	0.582
DEG_SPOP_SBC_1	351	355	PF00917	0.821
DOC_CKS1_1	332	337	PF01111	0.815
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.546
DOC_MAPK_gen_1	237	243	PF00069	0.526
DOC_MAPK_gen_1	611	619	PF00069	0.577
DOC_MAPK_MEF2A_6	280	289	PF00069	0.346
DOC_PP2B_LxvP_1	211	214	PF13499	0.558
DOC_PP2B_LxvP_1	228	231	PF13499	0.325
DOC_PP2B_LxvP_1	289	292	PF13499	0.411
DOC_PP2B_LxvP_1	587	590	PF13499	0.649
DOC_PP4_FxxP_1	397	400	PF00568	0.784
DOC_PP4_FxxP_1	634	637	PF00568	0.604
DOC_USP7_MATH_1	162	166	PF00917	0.389
DOC_USP7_MATH_1	338	342	PF00917	0.827
DOC_USP7_MATH_1	351	355	PF00917	0.705
DOC_USP7_MATH_1	378	382	PF00917	0.831
DOC_USP7_MATH_1	434	438	PF00917	0.714
DOC_USP7_MATH_1	48	52	PF00917	0.738
DOC_USP7_MATH_1	511	515	PF00917	0.807
DOC_USP7_MATH_1	646	650	PF00917	0.636
DOC_USP7_MATH_1	90	94	PF00917	0.734
DOC_USP7_UBL2_3	689	693	PF12436	0.669
DOC_WW_Pin1_4	114	119	PF00397	0.727
DOC_WW_Pin1_4	331	336	PF00397	0.753
DOC_WW_Pin1_4	344	349	PF00397	0.739
DOC_WW_Pin1_4	408	413	PF00397	0.767
DOC_WW_Pin1_4	423	428	PF00397	0.803
DOC_WW_Pin1_4	484	489	PF00397	0.845
DOC_WW_Pin1_4	500	505	PF00397	0.742
DOC_WW_Pin1_4	509	514	PF00397	0.756
LIG_14-3-3_CanoR_1	116	126	PF00244	0.683
LIG_14-3-3_CanoR_1	140	144	PF00244	0.653
LIG_14-3-3_CanoR_1	168	174	PF00244	0.593
LIG_14-3-3_CanoR_1	221	225	PF00244	0.469
LIG_14-3-3_CanoR_1	306	315	PF00244	0.704
LIG_14-3-3_CanoR_1	416	425	PF00244	0.784
LIG_14-3-3_CanoR_1	440	448	PF00244	0.784
LIG_14-3-3_CanoR_1	533	538	PF00244	0.723
LIG_14-3-3_CanoR_1	568	574	PF00244	0.554
LIG_14-3-3_CanoR_1	611	617	PF00244	0.614
LIG_APCC_ABBA_1	26	31	PF00400	0.756
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_BIR_III_2	345	349	PF00653	0.690
LIG_BRCT_BRCA1_1	122	126	PF00533	0.697
LIG_BRCT_BRCA1_1	73	77	PF00533	0.628
LIG_BRCT_BRCA1_1	90	94	PF00533	0.780
LIG_CtBP_PxDLS_1	590	594	PF00389	0.639
LIG_deltaCOP1_diTrp_1	273	278	PF00928	0.515
LIG_FHA_1	311	317	PF00498	0.734
LIG_FHA_1	420	426	PF00498	0.799
LIG_FHA_1	442	448	PF00498	0.799
LIG_LIR_Apic_2	632	637	PF02991	0.587
LIG_LIR_Gen_1	123	131	PF02991	0.685
LIG_LIR_Gen_1	208	217	PF02991	0.561
LIG_LIR_Gen_1	51	62	PF02991	0.810
LIG_LIR_Gen_1	670	680	PF02991	0.622
LIG_LIR_Gen_1	98	108	PF02991	0.722
LIG_LIR_Nem_3	123	129	PF02991	0.644
LIG_LIR_Nem_3	208	213	PF02991	0.504
LIG_LIR_Nem_3	51	57	PF02991	0.809
LIG_LIR_Nem_3	670	675	PF02991	0.643
LIG_LIR_Nem_3	98	104	PF02991	0.732
LIG_Pex14_2	173	177	PF04695	0.555
LIG_Pex14_2	290	294	PF04695	0.411
LIG_SH2_CRK	101	105	PF00017	0.784
LIG_SH2_CRK	54	58	PF00017	0.809
LIG_SH2_CRK	682	686	PF00017	0.575
LIG_SH2_GRB2like	131	134	PF00017	0.674
LIG_SH2_GRB2like	210	213	PF00017	0.518
LIG_SH2_GRB2like	84	87	PF00017	0.736
LIG_SH2_NCK_1	101	105	PF00017	0.739
LIG_SH2_NCK_1	54	58	PF00017	0.736
LIG_SH2_PTP2	642	645	PF00017	0.575
LIG_SH2_SRC	210	213	PF00017	0.518
LIG_SH2_SRC	38	41	PF00017	0.836
LIG_SH2_SRC	96	99	PF00017	0.594
LIG_SH2_STAP1	101	105	PF00017	0.739
LIG_SH2_STAP1	131	135	PF00017	0.674
LIG_SH2_STAP1	682	686	PF00017	0.608
LIG_SH2_STAT5	135	138	PF00017	0.697
LIG_SH2_STAT5	152	155	PF00017	0.260
LIG_SH2_STAT5	210	213	PF00017	0.573
LIG_SH2_STAT5	331	334	PF00017	0.696
LIG_SH2_STAT5	61	64	PF00017	0.803
LIG_SH2_STAT5	642	645	PF00017	0.575
LIG_SH3_1	280	286	PF00018	0.346
LIG_SH3_3	201	207	PF00018	0.424
LIG_SH3_3	280	286	PF00018	0.346
LIG_SH3_3	329	335	PF00018	0.822
LIG_SH3_3	409	415	PF00018	0.728
LIG_SH3_3	424	430	PF00018	0.850
LIG_SH3_3	516	522	PF00018	0.766
LIG_SH3_3	571	577	PF00018	0.545
LIG_SH3_3	688	694	PF00018	0.512
LIG_SUMO_SIM_anti_2	572	578	PF11976	0.583
LIG_SUMO_SIM_anti_2	648	656	PF11976	0.488
LIG_SUMO_SIM_par_1	15	25	PF11976	0.811
LIG_SUMO_SIM_par_1	481	487	PF11976	0.790
LIG_SUMO_SIM_par_1	533	541	PF11976	0.717
LIG_SUMO_SIM_par_1	552	558	PF11976	0.448
LIG_SUMO_SIM_par_1	572	578	PF11976	0.555
LIG_TRAF2_1	30	33	PF00917	0.732
LIG_TYR_ITIM	52	57	PF00017	0.810
LIG_TYR_ITIM	680	685	PF00017	0.562
LIG_UBA3_1	293	300	PF00899	0.436
LIG_WRC_WIRS_1	631	636	PF05994	0.621
MOD_CDC14_SPxK_1	336	339	PF00782	0.732
MOD_CDK_SPK_2	486	491	PF00069	0.771
MOD_CDK_SPxK_1	333	339	PF00069	0.728
MOD_CDK_SPxxK_3	484	491	PF00069	0.773
MOD_CDK_SPxxK_3	513	520	PF00069	0.781
MOD_CK1_1	117	123	PF00069	0.715
MOD_CK1_1	138	144	PF00069	0.597
MOD_CK1_1	195	201	PF00069	0.470
MOD_CK1_1	205	211	PF00069	0.563
MOD_CK1_1	223	229	PF00069	0.393
MOD_CK1_1	24	30	PF00069	0.772
MOD_CK1_1	360	366	PF00069	0.781
MOD_CK1_1	372	378	PF00069	0.688
MOD_CK1_1	381	387	PF00069	0.747
MOD_CK1_1	42	48	PF00069	0.802
MOD_CK1_1	426	432	PF00069	0.812
MOD_CK1_1	441	447	PF00069	0.681
MOD_CK1_1	482	488	PF00069	0.797
MOD_CK1_1	526	532	PF00069	0.614
MOD_CK1_1	55	61	PF00069	0.665
MOD_CK1_1	65	71	PF00069	0.736
MOD_CK1_1	82	88	PF00069	0.607
MOD_CK2_1	223	229	PF00069	0.454
MOD_CK2_1	27	33	PF00069	0.732
MOD_CMANNOS	275	278	PF00535	0.716
MOD_GlcNHglycan	159	162	PF01048	0.411
MOD_GlcNHglycan	179	182	PF01048	0.735
MOD_GlcNHglycan	194	197	PF01048	0.654
MOD_GlcNHglycan	207	210	PF01048	0.623
MOD_GlcNHglycan	254	257	PF01048	0.767
MOD_GlcNHglycan	268	271	PF01048	0.667
MOD_GlcNHglycan	308	311	PF01048	0.547
MOD_GlcNHglycan	354	357	PF01048	0.590
MOD_GlcNHglycan	359	362	PF01048	0.605
MOD_GlcNHglycan	376	379	PF01048	0.482
MOD_GlcNHglycan	383	386	PF01048	0.561
MOD_GlcNHglycan	577	580	PF01048	0.409
MOD_GlcNHglycan	67	70	PF01048	0.590
MOD_GSK3_1	100	107	PF00069	0.649
MOD_GSK3_1	110	117	PF00069	0.676
MOD_GSK3_1	121	128	PF00069	0.683
MOD_GSK3_1	135	142	PF00069	0.652
MOD_GSK3_1	153	160	PF00069	0.276
MOD_GSK3_1	195	202	PF00069	0.490
MOD_GSK3_1	274	281	PF00069	0.550
MOD_GSK3_1	306	313	PF00069	0.700
MOD_GSK3_1	327	334	PF00069	0.741
MOD_GSK3_1	368	375	PF00069	0.834
MOD_GSK3_1	38	45	PF00069	0.724
MOD_GSK3_1	383	390	PF00069	0.675
MOD_GSK3_1	419	426	PF00069	0.779
MOD_GSK3_1	434	441	PF00069	0.842
MOD_GSK3_1	478	485	PF00069	0.823
MOD_GSK3_1	48	55	PF00069	0.737
MOD_GSK3_1	509	516	PF00069	0.839
MOD_GSK3_1	533	540	PF00069	0.734
MOD_GSK3_1	60	67	PF00069	0.696
MOD_GSK3_1	71	78	PF00069	0.667
MOD_GSK3_1	88	95	PF00069	0.698
MOD_GSK3_1	9	16	PF00069	0.751
MOD_LATS_1	304	310	PF00433	0.686
MOD_LATS_1	438	444	PF00433	0.806
MOD_N-GLC_1	13	18	PF02516	0.535
MOD_N-GLC_1	310	315	PF02516	0.591
MOD_N-GLC_1	357	362	PF02516	0.535
MOD_NEK2_1	122	127	PF00069	0.666
MOD_NEK2_1	13	18	PF00069	0.725
MOD_NEK2_1	139	144	PF00069	0.649
MOD_NEK2_1	153	158	PF00069	0.434
MOD_NEK2_1	169	174	PF00069	0.539
MOD_NEK2_1	177	182	PF00069	0.422
MOD_NEK2_1	184	189	PF00069	0.394
MOD_NEK2_1	352	357	PF00069	0.770
MOD_NEK2_1	52	57	PF00069	0.731
MOD_NEK2_1	667	672	PF00069	0.597
MOD_NEK2_1	77	82	PF00069	0.637
MOD_NEK2_2	135	140	PF00069	0.622
MOD_PIKK_1	39	45	PF00454	0.829
MOD_PIKK_1	442	448	PF00454	0.782
MOD_PIKK_1	695	701	PF00454	0.618
MOD_PK_1	533	539	PF00069	0.733
MOD_PKA_2	139	145	PF00069	0.651
MOD_PKA_2	220	226	PF00069	0.470
MOD_PKA_2	338	344	PF00069	0.771
MOD_PKA_2	372	378	PF00069	0.788
MOD_PKA_2	381	387	PF00069	0.717
MOD_PKA_2	441	447	PF00069	0.858
MOD_PKA_2	65	71	PF00069	0.773
MOD_PKB_1	440	448	PF00069	0.790
MOD_Plk_1	13	19	PF00069	0.733
MOD_Plk_1	21	27	PF00069	0.715
MOD_Plk_1	52	58	PF00069	0.752
MOD_Plk_1	538	544	PF00069	0.640
MOD_Plk_1	647	653	PF00069	0.497
MOD_Plk_1	99	105	PF00069	0.740
MOD_Plk_4	100	106	PF00069	0.727
MOD_Plk_4	110	116	PF00069	0.640
MOD_Plk_4	125	131	PF00069	0.681
MOD_Plk_4	223	229	PF00069	0.486
MOD_Plk_4	24	30	PF00069	0.792
MOD_Plk_4	327	333	PF00069	0.751
MOD_Plk_4	338	344	PF00069	0.773
MOD_Plk_4	479	485	PF00069	0.779
MOD_Plk_4	569	575	PF00069	0.549
MOD_Plk_4	603	609	PF00069	0.605
MOD_Plk_4	612	618	PF00069	0.648
MOD_Plk_4	657	663	PF00069	0.459
MOD_Plk_4	79	85	PF00069	0.698
MOD_ProDKin_1	114	120	PF00069	0.724
MOD_ProDKin_1	331	337	PF00069	0.750
MOD_ProDKin_1	344	350	PF00069	0.736
MOD_ProDKin_1	408	414	PF00069	0.766
MOD_ProDKin_1	423	429	PF00069	0.803
MOD_ProDKin_1	484	490	PF00069	0.843
MOD_ProDKin_1	500	506	PF00069	0.743
MOD_ProDKin_1	509	515	PF00069	0.756
MOD_SUMO_rev_2	462	470	PF00179	0.624
MOD_SUMO_rev_2	494	500	PF00179	0.700
TRG_DiLeu_BaLyEn_6	681	686	PF01217	0.604
TRG_ENDOCYTIC_2	101	104	PF00928	0.690
TRG_ENDOCYTIC_2	105	108	PF00928	0.675
TRG_ENDOCYTIC_2	152	155	PF00928	0.353
TRG_ENDOCYTIC_2	210	213	PF00928	0.500
TRG_ENDOCYTIC_2	54	57	PF00928	0.810
TRG_ENDOCYTIC_2	642	645	PF00928	0.546
TRG_ENDOCYTIC_2	682	685	PF00928	0.569
TRG_ER_diArg_1	146	148	PF00400	0.682
TRG_ER_diArg_1	236	238	PF00400	0.491
TRG_ER_diArg_1	316	319	PF00400	0.816
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A2	Leptomonas seymouri	49%	99%
A0A3S7WZN2	Leishmania donovani	92%	100%
A4HER1	Leishmania braziliensis	73%	100%
A4I1Y8	Leishmania infantum	92%	100%
Q4Q9D8	Leishmania major	90%	100%