Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY33_LEIMU

TriTrypDb:

LmxM.26.0540

Length:

1152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.484
CLV_C14_Caspase3-7	26	30	PF00656	0.508
CLV_C14_Caspase3-7	299	303	PF00656	0.619
CLV_C14_Caspase3-7	50	54	PF00656	0.483
CLV_C14_Caspase3-7	541	545	PF00656	0.610
CLV_C14_Caspase3-7	636	640	PF00656	0.464
CLV_C14_Caspase3-7	680	684	PF00656	0.583
CLV_C14_Caspase3-7	701	705	PF00656	0.553
CLV_NRD_NRD_1	1016	1018	PF00675	0.626
CLV_NRD_NRD_1	1105	1107	PF00675	0.478
CLV_NRD_NRD_1	237	239	PF00675	0.524
CLV_NRD_NRD_1	249	251	PF00675	0.509
CLV_NRD_NRD_1	502	504	PF00675	0.702
CLV_NRD_NRD_1	580	582	PF00675	0.470
CLV_NRD_NRD_1	898	900	PF00675	0.472
CLV_NRD_NRD_1	959	961	PF00675	0.627
CLV_PCSK_FUR_1	235	239	PF00082	0.542
CLV_PCSK_FUR_1	499	503	PF00082	0.663
CLV_PCSK_KEX2_1	1016	1018	PF00082	0.594
CLV_PCSK_KEX2_1	1105	1107	PF00082	0.478
CLV_PCSK_KEX2_1	237	239	PF00082	0.524
CLV_PCSK_KEX2_1	249	251	PF00082	0.517
CLV_PCSK_KEX2_1	499	501	PF00082	0.755
CLV_PCSK_KEX2_1	502	504	PF00082	0.691
CLV_PCSK_KEX2_1	580	582	PF00082	0.470
CLV_PCSK_KEX2_1	897	899	PF00082	0.466
CLV_PCSK_KEX2_1	959	961	PF00082	0.594
CLV_PCSK_SKI1_1	1105	1109	PF00082	0.474
CLV_PCSK_SKI1_1	237	241	PF00082	0.484
CLV_PCSK_SKI1_1	271	275	PF00082	0.690
CLV_PCSK_SKI1_1	28	32	PF00082	0.547
CLV_PCSK_SKI1_1	338	342	PF00082	0.597
CLV_PCSK_SKI1_1	348	352	PF00082	0.642
CLV_PCSK_SKI1_1	427	431	PF00082	0.560
CLV_Separin_Metazoa	1102	1106	PF03568	0.472
DEG_APCC_DBOX_1	236	244	PF00400	0.522
DEG_APCC_DBOX_1	270	278	PF00400	0.537
DEG_MDM2_SWIB_1	981	988	PF02201	0.500
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DEG_SCF_FBW7_1	1041	1048	PF00400	0.643
DEG_SPOP_SBC_1	698	702	PF00917	0.514
DOC_CYCLIN_RxL_1	235	246	PF00134	0.497
DOC_CYCLIN_RxL_1	470	483	PF00134	0.595
DOC_CYCLIN_yClb5_NLxxxL_5	686	695	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	815	821	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	847	853	PF00134	0.385
DOC_MAPK_gen_1	166	174	PF00069	0.492
DOC_MAPK_gen_1	235	243	PF00069	0.480
DOC_MAPK_MEF2A_6	221	230	PF00069	0.479
DOC_MAPK_MEF2A_6	614	623	PF00069	0.440
DOC_MAPK_MEF2A_6	807	815	PF00069	0.432
DOC_PP1_RVXF_1	359	365	PF00149	0.461
DOC_PP1_RVXF_1	425	431	PF00149	0.556
DOC_PP1_RVXF_1	912	919	PF00149	0.522
DOC_PP2B_LxvP_1	1038	1041	PF13499	0.690
DOC_PP2B_LxvP_1	457	460	PF13499	0.603
DOC_PP4_FxxP_1	663	666	PF00568	0.545
DOC_USP7_MATH_1	1008	1012	PF00917	0.542
DOC_USP7_MATH_1	1045	1049	PF00917	0.591
DOC_USP7_MATH_1	1067	1071	PF00917	0.726
DOC_USP7_MATH_1	1088	1092	PF00917	0.648
DOC_USP7_MATH_1	16	20	PF00917	0.619
DOC_USP7_MATH_1	186	190	PF00917	0.552
DOC_USP7_MATH_1	245	249	PF00917	0.522
DOC_USP7_MATH_1	296	300	PF00917	0.517
DOC_USP7_MATH_1	438	442	PF00917	0.741
DOC_USP7_MATH_1	57	61	PF00917	0.544
DOC_USP7_MATH_1	633	637	PF00917	0.519
DOC_USP7_MATH_1	664	668	PF00917	0.548
DOC_USP7_MATH_1	698	702	PF00917	0.514
DOC_USP7_MATH_1	799	803	PF00917	0.598
DOC_USP7_MATH_1	944	948	PF00917	0.456
DOC_WW_Pin1_4	1003	1008	PF00397	0.480
DOC_WW_Pin1_4	1041	1046	PF00397	0.681
DOC_WW_Pin1_4	1065	1070	PF00397	0.663
DOC_WW_Pin1_4	132	137	PF00397	0.565
DOC_WW_Pin1_4	480	485	PF00397	0.486
DOC_WW_Pin1_4	510	515	PF00397	0.468
DOC_WW_Pin1_4	594	599	PF00397	0.708
DOC_WW_Pin1_4	6	11	PF00397	0.476
DOC_WW_Pin1_4	614	619	PF00397	0.470
DOC_WW_Pin1_4	640	645	PF00397	0.582
DOC_WW_Pin1_4	678	683	PF00397	0.600
DOC_WW_Pin1_4	793	798	PF00397	0.604
DOC_WW_Pin1_4	958	963	PF00397	0.563
LIG_14-3-3_CanoR_1	1046	1050	PF00244	0.524
LIG_14-3-3_CanoR_1	1073	1077	PF00244	0.513
LIG_14-3-3_CanoR_1	150	160	PF00244	0.491
LIG_14-3-3_CanoR_1	166	175	PF00244	0.531
LIG_14-3-3_CanoR_1	255	259	PF00244	0.521
LIG_14-3-3_CanoR_1	263	272	PF00244	0.516
LIG_14-3-3_CanoR_1	338	347	PF00244	0.647
LIG_14-3-3_CanoR_1	376	385	PF00244	0.499
LIG_14-3-3_CanoR_1	469	474	PF00244	0.449
LIG_14-3-3_CanoR_1	503	512	PF00244	0.574
LIG_14-3-3_CanoR_1	580	589	PF00244	0.660
LIG_14-3-3_CanoR_1	706	716	PF00244	0.476
LIG_Actin_WH2_2	13	30	PF00022	0.543
LIG_Actin_WH2_2	875	892	PF00022	0.422
LIG_Actin_WH2_2	912	929	PF00022	0.429
LIG_BRCT_BRCA1_1	260	264	PF00533	0.543
LIG_BRCT_BRCA1_1	761	765	PF00533	0.543
LIG_Clathr_ClatBox_1	812	816	PF01394	0.428
LIG_deltaCOP1_diTrp_1	466	473	PF00928	0.583
LIG_EVH1_2	460	464	PF00568	0.511
LIG_FHA_1	1	7	PF00498	0.612
LIG_FHA_1	129	135	PF00498	0.522
LIG_FHA_1	223	229	PF00498	0.465
LIG_FHA_1	306	312	PF00498	0.580
LIG_FHA_1	419	425	PF00498	0.629
LIG_FHA_1	481	487	PF00498	0.570
LIG_FHA_1	692	698	PF00498	0.557
LIG_FHA_1	708	714	PF00498	0.486
LIG_FHA_1	72	78	PF00498	0.569
LIG_FHA_1	910	916	PF00498	0.451
LIG_FHA_2	1094	1100	PF00498	0.583
LIG_FHA_2	470	476	PF00498	0.423
LIG_FHA_2	966	972	PF00498	0.512
LIG_Integrin_RGD_1	905	907	PF01839	0.444
LIG_LIR_Apic_2	1003	1007	PF02991	0.547
LIG_LIR_Apic_2	662	666	PF02991	0.551
LIG_LIR_Gen_1	1093	1103	PF02991	0.496
LIG_LIR_Gen_1	314	322	PF02991	0.554
LIG_LIR_Nem_3	1093	1098	PF02991	0.514
LIG_LIR_Nem_3	1099	1104	PF02991	0.461
LIG_LIR_Nem_3	206	210	PF02991	0.558
LIG_LIR_Nem_3	314	318	PF02991	0.614
LIG_LIR_Nem_3	356	362	PF02991	0.703
LIG_LIR_Nem_3	693	699	PF02991	0.520
LIG_LIR_Nem_3	971	976	PF02991	0.453
LIG_LIR_Nem_3	982	988	PF02991	0.478
LIG_NRBOX	346	352	PF00104	0.559
LIG_NRBOX	859	865	PF00104	0.523
LIG_PCNA_yPIPBox_3	338	351	PF02747	0.574
LIG_Pex14_2	464	468	PF04695	0.508
LIG_Pex14_2	981	985	PF04695	0.428
LIG_Rb_pABgroove_1	975	983	PF01858	0.437
LIG_SH2_CRK	1004	1008	PF00017	0.474
LIG_SH2_NCK_1	1095	1099	PF00017	0.466
LIG_SH2_PTP2	696	699	PF00017	0.486
LIG_SH2_STAP1	404	408	PF00017	0.452
LIG_SH2_STAP1	420	424	PF00017	0.474
LIG_SH2_STAT5	1004	1007	PF00017	0.479
LIG_SH2_STAT5	1095	1098	PF00017	0.467
LIG_SH2_STAT5	207	210	PF00017	0.559
LIG_SH2_STAT5	315	318	PF00017	0.551
LIG_SH2_STAT5	385	388	PF00017	0.602
LIG_SH2_STAT5	420	423	PF00017	0.469
LIG_SH2_STAT5	566	569	PF00017	0.512
LIG_SH2_STAT5	696	699	PF00017	0.450
LIG_SH3_3	1063	1069	PF00018	0.612
LIG_SH3_3	1077	1083	PF00018	0.522
LIG_SH3_3	130	136	PF00018	0.567
LIG_SH3_3	227	233	PF00018	0.558
LIG_SH3_3	441	447	PF00018	0.591
LIG_SH3_3	455	461	PF00018	0.459
LIG_SH3_3	612	618	PF00018	0.381
LIG_SH3_3	641	647	PF00018	0.523
LIG_SH3_3	710	716	PF00018	0.522
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.471
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.560
LIG_SUMO_SIM_par_1	2	7	PF11976	0.609
LIG_SUMO_SIM_par_1	597	603	PF11976	0.594
LIG_SUMO_SIM_par_1	811	816	PF11976	0.443
LIG_TRAF2_1	189	192	PF00917	0.464
LIG_TRAF2_1	801	804	PF00917	0.585
LIG_TRFH_1	726	730	PF08558	0.554
LIG_TYR_ITSM	692	699	PF00017	0.528
LIG_UBA3_1	812	820	PF00899	0.508
LIG_Vh1_VBS_1	1089	1107	PF01044	0.405
LIG_WRC_WIRS_1	394	399	PF05994	0.402
MOD_CDC14_SPxK_1	513	516	PF00782	0.491
MOD_CDK_SPK_2	1041	1046	PF00069	0.574
MOD_CDK_SPxK_1	510	516	PF00069	0.471
MOD_CDK_SPxxK_3	1003	1010	PF00069	0.484
MOD_CK1_1	1075	1081	PF00069	0.614
MOD_CK1_1	1091	1097	PF00069	0.502
MOD_CK1_1	145	151	PF00069	0.555
MOD_CK1_1	154	160	PF00069	0.564
MOD_CK1_1	19	25	PF00069	0.560
MOD_CK1_1	222	228	PF00069	0.522
MOD_CK1_1	314	320	PF00069	0.591
MOD_CK1_1	377	383	PF00069	0.375
MOD_CK1_1	38	44	PF00069	0.435
MOD_CK1_1	396	402	PF00069	0.527
MOD_CK1_1	531	537	PF00069	0.558
MOD_CK1_1	594	600	PF00069	0.614
MOD_CK1_1	721	727	PF00069	0.569
MOD_CK1_1	734	740	PF00069	0.570
MOD_CK1_1	963	969	PF00069	0.520
MOD_CK2_1	1093	1099	PF00069	0.597
MOD_CK2_1	186	192	PF00069	0.591
MOD_CK2_1	44	50	PF00069	0.600
MOD_CK2_1	469	475	PF00069	0.420
MOD_CK2_1	799	805	PF00069	0.610
MOD_CK2_1	965	971	PF00069	0.522
MOD_CMANNOS	970	973	PF00535	0.543
MOD_Cter_Amidation	497	500	PF01082	0.601
MOD_DYRK1A_RPxSP_1	614	618	PF00069	0.440
MOD_GlcNHglycan	1059	1062	PF01048	0.735
MOD_GlcNHglycan	1069	1072	PF01048	0.554
MOD_GlcNHglycan	1113	1116	PF01048	0.565
MOD_GlcNHglycan	1127	1130	PF01048	0.461
MOD_GlcNHglycan	160	163	PF01048	0.601
MOD_GlcNHglycan	168	171	PF01048	0.550
MOD_GlcNHglycan	188	191	PF01048	0.507
MOD_GlcNHglycan	196	199	PF01048	0.517
MOD_GlcNHglycan	21	24	PF01048	0.546
MOD_GlcNHglycan	294	297	PF01048	0.550
MOD_GlcNHglycan	298	301	PF01048	0.530
MOD_GlcNHglycan	305	308	PF01048	0.502
MOD_GlcNHglycan	324	327	PF01048	0.657
MOD_GlcNHglycan	37	40	PF01048	0.497
MOD_GlcNHglycan	434	438	PF01048	0.532
MOD_GlcNHglycan	488	491	PF01048	0.636
MOD_GlcNHglycan	493	496	PF01048	0.607
MOD_GlcNHglycan	550	553	PF01048	0.645
MOD_GlcNHglycan	582	585	PF01048	0.598
MOD_GlcNHglycan	593	596	PF01048	0.559
MOD_GlcNHglycan	602	605	PF01048	0.521
MOD_GlcNHglycan	635	638	PF01048	0.511
MOD_GlcNHglycan	676	679	PF01048	0.569
MOD_GlcNHglycan	69	72	PF01048	0.564
MOD_GlcNHglycan	701	704	PF01048	0.570
MOD_GlcNHglycan	732	736	PF01048	0.632
MOD_GlcNHglycan	761	764	PF01048	0.562
MOD_GlcNHglycan	797	800	PF01048	0.619
MOD_GlcNHglycan	824	827	PF01048	0.552
MOD_GlcNHglycan	885	888	PF01048	0.407
MOD_GlcNHglycan	891	894	PF01048	0.409
MOD_GlcNHglycan	939	942	PF01048	0.639
MOD_GlcNHglycan	962	965	PF01048	0.592
MOD_GSK3_1	100	107	PF00069	0.591
MOD_GSK3_1	1041	1048	PF00069	0.612
MOD_GSK3_1	1053	1060	PF00069	0.651
MOD_GSK3_1	1067	1074	PF00069	0.584
MOD_GSK3_1	1090	1097	PF00069	0.529
MOD_GSK3_1	1107	1114	PF00069	0.371
MOD_GSK3_1	128	135	PF00069	0.510
MOD_GSK3_1	139	146	PF00069	0.552
MOD_GSK3_1	151	158	PF00069	0.537
MOD_GSK3_1	166	173	PF00069	0.530
MOD_GSK3_1	19	26	PF00069	0.565
MOD_GSK3_1	254	261	PF00069	0.584
MOD_GSK3_1	292	299	PF00069	0.532
MOD_GSK3_1	34	41	PF00069	0.447
MOD_GSK3_1	414	421	PF00069	0.671
MOD_GSK3_1	428	435	PF00069	0.529
MOD_GSK3_1	438	445	PF00069	0.640
MOD_GSK3_1	482	489	PF00069	0.583
MOD_GSK3_1	544	551	PF00069	0.472
MOD_GSK3_1	590	597	PF00069	0.637
MOD_GSK3_1	610	617	PF00069	0.545
MOD_GSK3_1	624	631	PF00069	0.403
MOD_GSK3_1	651	658	PF00069	0.478
MOD_GSK3_1	67	74	PF00069	0.470
MOD_GSK3_1	674	681	PF00069	0.520
MOD_GSK3_1	685	692	PF00069	0.528
MOD_GSK3_1	714	721	PF00069	0.538
MOD_GSK3_1	750	757	PF00069	0.533
MOD_GSK3_1	784	791	PF00069	0.608
MOD_GSK3_1	795	802	PF00069	0.539
MOD_GSK3_1	958	965	PF00069	0.605
MOD_N-GLC_1	689	694	PF02516	0.582
MOD_N-GLC_1	937	942	PF02516	0.513
MOD_N-GLC_2	194	196	PF02516	0.536
MOD_N-GLC_2	731	733	PF02516	0.499
MOD_NEK2_1	284	289	PF00069	0.621
MOD_NEK2_1	311	316	PF00069	0.583
MOD_NEK2_1	428	433	PF00069	0.578
MOD_NEK2_1	622	627	PF00069	0.424
MOD_NEK2_1	650	655	PF00069	0.481
MOD_NEK2_1	69	74	PF00069	0.568
MOD_NEK2_1	691	696	PF00069	0.554
MOD_NEK2_1	754	759	PF00069	0.654
MOD_NEK2_1	792	797	PF00069	0.511
MOD_NEK2_1	889	894	PF00069	0.448
MOD_NEK2_2	258	263	PF00069	0.537
MOD_PIKK_1	1107	1113	PF00454	0.381
MOD_PIKK_1	522	528	PF00454	0.467
MOD_PK_1	505	511	PF00069	0.574
MOD_PKA_1	580	586	PF00069	0.401
MOD_PKA_2	1045	1051	PF00069	0.576
MOD_PKA_2	1072	1078	PF00069	0.516
MOD_PKA_2	112	118	PF00069	0.499
MOD_PKA_2	243	249	PF00069	0.514
MOD_PKA_2	254	260	PF00069	0.443
MOD_PKA_2	311	317	PF00069	0.548
MOD_PKA_2	468	474	PF00069	0.413
MOD_PKA_2	504	510	PF00069	0.594
MOD_PKA_2	580	586	PF00069	0.569
MOD_PKA_2	889	895	PF00069	0.451
MOD_PKA_2	90	96	PF00069	0.440
MOD_PKB_1	164	172	PF00069	0.491
MOD_PKB_1	503	511	PF00069	0.594
MOD_Plk_1	28	34	PF00069	0.582
MOD_Plk_1	937	943	PF00069	0.536
MOD_Plk_4	1115	1121	PF00069	0.392
MOD_Plk_4	155	161	PF00069	0.551
MOD_Plk_4	28	34	PF00069	0.672
MOD_Plk_4	284	290	PF00069	0.633
MOD_Plk_4	305	311	PF00069	0.597
MOD_Plk_4	393	399	PF00069	0.502
MOD_Plk_4	414	420	PF00069	0.608
MOD_Plk_4	469	475	PF00069	0.418
MOD_Plk_4	505	511	PF00069	0.574
MOD_Plk_4	545	551	PF00069	0.484
MOD_Plk_4	651	657	PF00069	0.528
MOD_Plk_4	681	687	PF00069	0.621
MOD_Plk_4	691	697	PF00069	0.456
MOD_Plk_4	714	720	PF00069	0.534
MOD_Plk_4	721	727	PF00069	0.506
MOD_ProDKin_1	1003	1009	PF00069	0.478
MOD_ProDKin_1	1041	1047	PF00069	0.681
MOD_ProDKin_1	1065	1071	PF00069	0.662
MOD_ProDKin_1	132	138	PF00069	0.562
MOD_ProDKin_1	480	486	PF00069	0.491
MOD_ProDKin_1	510	516	PF00069	0.471
MOD_ProDKin_1	594	600	PF00069	0.704
MOD_ProDKin_1	6	12	PF00069	0.478
MOD_ProDKin_1	614	620	PF00069	0.463
MOD_ProDKin_1	640	646	PF00069	0.573
MOD_ProDKin_1	678	684	PF00069	0.601
MOD_ProDKin_1	793	799	PF00069	0.600
MOD_ProDKin_1	958	964	PF00069	0.561
TRG_DiLeu_BaEn_1	388	393	PF01217	0.453
TRG_DiLeu_BaEn_1	971	976	PF01217	0.469
TRG_DiLeu_BaEn_4	803	809	PF01217	0.576
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.548
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.642
TRG_DiLeu_BaLyEn_6	646	651	PF01217	0.481
TRG_ENDOCYTIC_2	1095	1098	PF00928	0.505
TRG_ENDOCYTIC_2	1101	1104	PF00928	0.458
TRG_ENDOCYTIC_2	207	210	PF00928	0.559
TRG_ENDOCYTIC_2	315	318	PF00928	0.551
TRG_ENDOCYTIC_2	696	699	PF00928	0.458
TRG_ER_diArg_1	1104	1106	PF00400	0.468
TRG_ER_diArg_1	235	238	PF00400	0.571
TRG_ER_diArg_1	343	346	PF00400	0.506
TRG_ER_diArg_1	360	363	PF00400	0.487
TRG_ER_diArg_1	499	502	PF00400	0.754
TRG_ER_diArg_1	669	672	PF00400	0.465
TRG_ER_diArg_1	89	92	PF00400	0.549
TRG_ER_diArg_1	897	899	PF00400	0.469
TRG_NES_CRM1_1	1099	1111	PF08389	0.538
TRG_NES_CRM1_1	124	138	PF08389	0.566
TRG_NLS_Bipartite_1	237	256	PF00514	0.559
TRG_NLS_MonoExtC_3	104	109	PF00514	0.420
TRG_NLS_MonoExtN_4	249	256	PF00514	0.671
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP0	Leptomonas seymouri	34%	98%
A0A3S7WZP9	Leishmania donovani	87%	100%
A4HEQ9	Leishmania braziliensis	70%	100%
A4I1Y6	Leishmania infantum	87%	100%
Q4Q9E0	Leishmania major	86%	100%