Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY32_LEIMU

TriTrypDb:

LmxM.26.0500

Length:

473

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	16
GO:0042995	cell projection	2	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0110165	cellular anatomical entity	1	16
GO:0120025	plasma membrane bounded cell projection	3	16
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AY32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.265
CLV_NRD_NRD_1	48	50	PF00675	0.395
CLV_PCSK_KEX2_1	162	164	PF00082	0.338
CLV_PCSK_KEX2_1	247	249	PF00082	0.490
CLV_PCSK_KEX2_1	433	435	PF00082	0.566
CLV_PCSK_KEX2_1	48	50	PF00082	0.354
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.342
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.281
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.380
CLV_PCSK_PC7_1	429	435	PF00082	0.379
CLV_PCSK_SKI1_1	244	248	PF00082	0.415
CLV_PCSK_SKI1_1	330	334	PF00082	0.512
CLV_PCSK_SKI1_1	442	446	PF00082	0.639
DEG_APCC_DBOX_1	329	337	PF00400	0.281
DOC_ANK_TNKS_1	169	176	PF00023	0.281
DOC_CYCLIN_RxL_1	159	168	PF00134	0.369
DOC_MAPK_gen_1	241	251	PF00069	0.347
DOC_MIT_MIM_1	275	284	PF04212	0.313
DOC_PP1_SILK_1	208	213	PF00149	0.302
DOC_WW_Pin1_4	10	15	PF00397	0.633
DOC_WW_Pin1_4	100	105	PF00397	0.415
DOC_WW_Pin1_4	73	78	PF00397	0.600
LIG_14-3-3_CanoR_1	150	156	PF00244	0.415
LIG_14-3-3_CanoR_1	185	189	PF00244	0.348
LIG_14-3-3_CanoR_1	212	218	PF00244	0.516
LIG_14-3-3_CanoR_1	248	252	PF00244	0.524
LIG_14-3-3_CanoR_1	280	285	PF00244	0.238
LIG_14-3-3_CanoR_1	350	355	PF00244	0.359
LIG_14-3-3_CanoR_1	7	14	PF00244	0.745
LIG_Actin_WH2_2	347	364	PF00022	0.453
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	345	349	PF00533	0.153
LIG_DLG_GKlike_1	153	161	PF00625	0.341
LIG_EH1_1	348	356	PF00400	0.203
LIG_FHA_1	14	20	PF00498	0.750
LIG_FHA_1	229	235	PF00498	0.399
LIG_FHA_1	320	326	PF00498	0.478
LIG_FHA_1	386	392	PF00498	0.468
LIG_FHA_2	240	246	PF00498	0.482
LIG_FHA_2	271	277	PF00498	0.337
LIG_LIR_Gen_1	35	43	PF02991	0.674
LIG_LIR_Nem_3	106	112	PF02991	0.452
LIG_LIR_Nem_3	35	39	PF02991	0.575
LIG_NRBOX	434	440	PF00104	0.377
LIG_PCNA_yPIPBox_3	413	421	PF02747	0.416
LIG_PCNA_yPIPBox_3	429	439	PF02747	0.288
LIG_SH2_NCK_1	112	116	PF00017	0.339
LIG_SH2_STAT3	456	459	PF00017	0.619
LIG_SH2_STAT5	188	191	PF00017	0.332
LIG_SH2_STAT5	227	230	PF00017	0.447
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.258
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.247
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.308
LIG_SUMO_SIM_par_1	231	238	PF11976	0.347
LIG_SUMO_SIM_par_1	304	309	PF11976	0.354
LIG_SUMO_SIM_par_1	387	393	PF11976	0.294
LIG_SUMO_SIM_par_1	416	422	PF11976	0.323
LIG_TRAF2_1	273	276	PF00917	0.377
LIG_TYR_ITIM	110	115	PF00017	0.362
MOD_CK1_1	10	16	PF00069	0.596
MOD_CK1_1	103	109	PF00069	0.447
MOD_CK1_1	156	162	PF00069	0.377
MOD_CK1_1	32	38	PF00069	0.454
MOD_CK1_1	353	359	PF00069	0.442
MOD_CK2_1	192	198	PF00069	0.314
MOD_CK2_1	199	205	PF00069	0.319
MOD_CK2_1	239	245	PF00069	0.472
MOD_CK2_1	270	276	PF00069	0.245
MOD_CK2_1	306	312	PF00069	0.410
MOD_CK2_1	328	334	PF00069	0.362
MOD_CK2_1	357	363	PF00069	0.283
MOD_CK2_1	95	101	PF00069	0.422
MOD_GlcNHglycan	1	4	PF01048	0.770
MOD_GlcNHglycan	143	146	PF01048	0.411
MOD_GlcNHglycan	201	204	PF01048	0.343
MOD_GlcNHglycan	308	311	PF01048	0.287
MOD_GlcNHglycan	345	348	PF01048	0.426
MOD_GlcNHglycan	9	12	PF01048	0.625
MOD_GSK3_1	151	158	PF00069	0.345
MOD_GSK3_1	184	191	PF00069	0.318
MOD_GSK3_1	3	10	PF00069	0.510
MOD_GSK3_1	319	326	PF00069	0.407
MOD_GSK3_1	337	344	PF00069	0.357
MOD_GSK3_1	350	357	PF00069	0.425
MOD_GSK3_1	419	426	PF00069	0.438
MOD_GSK3_1	73	80	PF00069	0.541
MOD_GSK3_1	95	102	PF00069	0.398
MOD_N-GLC_1	127	132	PF02516	0.350
MOD_N-GLC_1	270	275	PF02516	0.304
MOD_N-GLC_1	299	304	PF02516	0.377
MOD_N-GLC_1	364	369	PF02516	0.303
MOD_NEK2_1	151	156	PF00069	0.353
MOD_NEK2_1	192	197	PF00069	0.284
MOD_NEK2_1	211	216	PF00069	0.510
MOD_NEK2_1	306	311	PF00069	0.335
MOD_NEK2_1	336	341	PF00069	0.302
MOD_NEK2_1	343	348	PF00069	0.338
MOD_NEK2_1	354	359	PF00069	0.376
MOD_PIKK_1	29	35	PF00454	0.685
MOD_PIKK_1	319	325	PF00454	0.460
MOD_PIKK_1	402	408	PF00454	0.288
MOD_PKA_1	247	253	PF00069	0.483
MOD_PKA_2	184	190	PF00069	0.396
MOD_PKA_2	211	217	PF00069	0.332
MOD_PKA_2	247	253	PF00069	0.483
MOD_PKA_2	6	12	PF00069	0.532
MOD_PKA_2	71	77	PF00069	0.466
MOD_Plk_1	192	198	PF00069	0.241
MOD_Plk_1	270	276	PF00069	0.273
MOD_Plk_1	299	305	PF00069	0.363
MOD_Plk_1	319	325	PF00069	0.446
MOD_Plk_4	184	190	PF00069	0.361
MOD_Plk_4	213	219	PF00069	0.493
MOD_Plk_4	350	356	PF00069	0.359
MOD_ProDKin_1	10	16	PF00069	0.633
MOD_ProDKin_1	100	106	PF00069	0.412
MOD_ProDKin_1	73	79	PF00069	0.593
TRG_DiLeu_BaEn_1	174	179	PF01217	0.187
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.446
TRG_ENDOCYTIC_2	112	115	PF00928	0.371
TRG_ER_diArg_1	48	50	PF00400	0.406
TRG_NES_CRM1_1	205	219	PF08389	0.222
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	75%	100%
A0A0N1PD72	Leptomonas seymouri	27%	100%
A0A0S4IIC5	Bodo saltans	26%	67%
A0A0S4IT30	Bodo saltans	24%	71%
A0A0S4JDM4	Bodo saltans	27%	70%
A0A0S4JHR1	Bodo saltans	24%	76%
A0A0S4JL85	Bodo saltans	24%	100%
A0A0S4JPV3	Bodo saltans	39%	98%
A0A1X0NTY3	Trypanosomatidae	52%	100%
A0A1X0P364	Trypanosomatidae	21%	100%
A0A3Q8IDE6	Leishmania donovani	26%	100%
A0A3R7L7Y9	Trypanosoma rangeli	54%	100%
A0A3R7P015	Trypanosoma rangeli	25%	100%
A0A3S5H5G2	Leishmania donovani	29%	100%
A0A3S5H6F0	Leishmania donovani	24%	100%
A0A3S7WXH1	Leishmania donovani	24%	100%
A0A3S7WZL6	Leishmania donovani	92%	100%
A0A422NBD9	Trypanosoma rangeli	25%	69%
A4H461	Leishmania braziliensis	29%	100%
A4HCM9	Leishmania braziliensis	27%	100%
A4HEQ6	Leishmania braziliensis	79%	100%
A4HFQ6	Leishmania braziliensis	26%	100%
A4HHW0	Leishmania braziliensis	30%	100%
A4HSD0	Leishmania infantum	29%	100%
A4HU75	Leishmania infantum	24%	100%
A4I053	Leishmania infantum	25%	100%
A4I1Y5	Leishmania infantum	92%	100%
A4I2T1	Leishmania infantum	26%	100%
A7Z026	Bos taurus	28%	68%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADA9	Leishmania major	27%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O75864	Homo sapiens	27%	68%
P10775	Sus scrofa	28%	100%
P13489	Homo sapiens	25%	100%
P41391	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P46060	Homo sapiens	25%	81%
P46061	Mus musculus	25%	80%
Q4Q9E1	Leishmania major	90%	100%
Q4QBG0	Leishmania major	24%	100%
Q4QJI8	Leishmania major	28%	100%
Q8HZP9	Pan troglodytes	25%	100%
Q9VIW3	Drosophila melanogaster	23%	79%
V5BC30	Trypanosoma cruzi	23%	68%
V5BC66	Trypanosoma cruzi	27%	72%
V5BJF0	Trypanosoma cruzi	24%	96%
V5BPZ7	Trypanosoma cruzi	54%	100%