LeishMANIAdb
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Leucine-rich repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AY32_LEIMU
TriTrypDb:
LmxM.26.0500
Length:
473

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
TermNameLevelCount
GO:0005929 cilium 4 16
GO:0016020 membrane 2 1
GO:0042995 cell projection 2 16
GO:0043226 organelle 2 16
GO:0043227 membrane-bounded organelle 3 16
GO:0110165 cellular anatomical entity 1 16
GO:0120025 plasma membrane bounded cell projection 3 16
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Expansion

Sequence features

E9AY32
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY32

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 82 86 PF00656 0.265
CLV_NRD_NRD_1 48 50 PF00675 0.395
CLV_PCSK_KEX2_1 162 164 PF00082 0.338
CLV_PCSK_KEX2_1 247 249 PF00082 0.490
CLV_PCSK_KEX2_1 433 435 PF00082 0.566
CLV_PCSK_KEX2_1 48 50 PF00082 0.354
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.342
CLV_PCSK_PC1ET2_1 247 249 PF00082 0.281
CLV_PCSK_PC1ET2_1 433 435 PF00082 0.380
CLV_PCSK_PC7_1 429 435 PF00082 0.379
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HUH0 Leptomonas seymouri 75% 100%
A0A0N1PD72 Leptomonas seymouri 27% 100%
A0A0S4IIC5 Bodo saltans 26% 67%
A0A0S4IT30 Bodo saltans 24% 71%
A0A0S4JDM4 Bodo saltans 27% 70%
A0A0S4JHR1 Bodo saltans 24% 76%
A0A0S4JL85 Bodo saltans 24% 100%
A0A0S4JPV3 Bodo saltans 39% 98%
A0A1X0NTY3 Trypanosomatidae 52% 100%
A0A1X0P364 Trypanosomatidae 21% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS