DNA polymerase sigma-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase sigma-like protein

Species:

Leishmania mexicana

UniProt:

E9AY31_LEIMU

TriTrypDb:

LmxM.26.0490

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0031499	TRAMP complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AY31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY31

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0031123	RNA 3'-end processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043631	RNA polyadenylation	6	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071076	RNA 3' uridylation	8	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	12
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0050265	RNA uridylyltransferase activity	4	12
GO:0070566	adenylyltransferase activity	5	12
GO:0070569	uridylyltransferase activity	5	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.612
CLV_MEL_PAP_1	334	340	PF00089	0.563
CLV_NRD_NRD_1	235	237	PF00675	0.515
CLV_NRD_NRD_1	364	366	PF00675	0.439
CLV_NRD_NRD_1	446	448	PF00675	0.523
CLV_NRD_NRD_1	454	456	PF00675	0.493
CLV_NRD_NRD_1	55	57	PF00675	0.724
CLV_NRD_NRD_1	76	78	PF00675	0.713
CLV_PCSK_FUR_1	53	57	PF00082	0.781
CLV_PCSK_KEX2_1	364	366	PF00082	0.362
CLV_PCSK_KEX2_1	454	456	PF00082	0.497
CLV_PCSK_KEX2_1	53	55	PF00082	0.699
CLV_PCSK_KEX2_1	76	78	PF00082	0.659
CLV_PCSK_PC7_1	450	456	PF00082	0.533
CLV_PCSK_SKI1_1	119	123	PF00082	0.553
CLV_PCSK_SKI1_1	218	222	PF00082	0.540
CLV_PCSK_SKI1_1	398	402	PF00082	0.492
CLV_PCSK_SKI1_1	79	83	PF00082	0.491
DOC_CYCLIN_yCln2_LP_2	111	114	PF00134	0.693
DOC_MAPK_gen_1	258	266	PF00069	0.438
DOC_MAPK_gen_1	364	370	PF00069	0.438
DOC_MAPK_gen_1	454	462	PF00069	0.301
DOC_MAPK_MEF2A_6	158	165	PF00069	0.500
DOC_MAPK_MEF2A_6	260	268	PF00069	0.448
DOC_PP2B_LxvP_1	111	114	PF13499	0.693
DOC_PP2B_LxvP_1	173	176	PF13499	0.394
DOC_PP4_FxxP_1	285	288	PF00568	0.351
DOC_PP4_FxxP_1	376	379	PF00568	0.449
DOC_PP4_FxxP_1	6	9	PF00568	0.594
DOC_USP7_MATH_1	211	215	PF00917	0.587
DOC_USP7_MATH_1	81	85	PF00917	0.776
DOC_USP7_MATH_1	88	92	PF00917	0.712
DOC_USP7_UBL2_3	374	378	PF12436	0.432
DOC_WW_Pin1_4	133	138	PF00397	0.426
DOC_WW_Pin1_4	424	429	PF00397	0.571
DOC_WW_Pin1_4	91	96	PF00397	0.685
LIG_14-3-3_CanoR_1	153	157	PF00244	0.473
LIG_14-3-3_CanoR_1	21	27	PF00244	0.617
LIG_14-3-3_CanoR_1	234	244	PF00244	0.431
LIG_14-3-3_CanoR_1	413	419	PF00244	0.484
LIG_14-3-3_CanoR_1	76	86	PF00244	0.783
LIG_BRCT_BRCA1_1	237	241	PF00533	0.443
LIG_BRCT_BRCA1_1	414	418	PF00533	0.511
LIG_BRCT_BRCA1_1	93	97	PF00533	0.682
LIG_EH1_1	319	327	PF00400	0.358
LIG_FHA_1	103	109	PF00498	0.625
LIG_FHA_1	169	175	PF00498	0.434
LIG_FHA_1	210	216	PF00498	0.495
LIG_FHA_1	403	409	PF00498	0.432
LIG_FHA_1	80	86	PF00498	0.752
LIG_FHA_2	136	142	PF00498	0.460
LIG_FHA_2	157	163	PF00498	0.352
LIG_FHA_2	357	363	PF00498	0.375
LIG_LIR_Apic_2	283	288	PF02991	0.271
LIG_LIR_Apic_2	375	379	PF02991	0.475
LIG_LIR_Gen_1	238	248	PF02991	0.444
LIG_LIR_Gen_1	31	42	PF02991	0.497
LIG_LIR_Nem_3	238	244	PF02991	0.402
LIG_LIR_Nem_3	31	37	PF02991	0.493
LIG_LIR_Nem_3	360	366	PF02991	0.439
LIG_LIR_Nem_3	415	421	PF02991	0.422
LIG_NRBOX	127	133	PF00104	0.481
LIG_PCNA_yPIPBox_3	337	350	PF02747	0.459
LIG_SH2_CRK	166	170	PF00017	0.451
LIG_SH2_CRK	34	38	PF00017	0.497
LIG_SH2_STAT3	329	332	PF00017	0.426
LIG_SH2_STAT5	133	136	PF00017	0.507
LIG_SH2_STAT5	280	283	PF00017	0.490
LIG_SH2_STAT5	329	332	PF00017	0.477
LIG_SH2_STAT5	385	388	PF00017	0.300
LIG_SH2_STAT5	438	441	PF00017	0.545
LIG_SH2_STAT5	474	477	PF00017	0.424
LIG_SH3_3	386	392	PF00018	0.418
LIG_SH3_3	93	99	PF00018	0.547
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.368
LIG_SUMO_SIM_par_1	203	209	PF11976	0.472
LIG_TRFH_1	133	137	PF08558	0.500
LIG_UBA3_1	296	301	PF00899	0.357
MOD_CK1_1	136	142	PF00069	0.454
MOD_CK1_1	168	174	PF00069	0.351
MOD_CK1_1	194	200	PF00069	0.523
MOD_CK1_1	209	215	PF00069	0.502
MOD_CK1_1	216	222	PF00069	0.473
MOD_CK1_1	223	229	PF00069	0.325
MOD_CK1_1	35	41	PF00069	0.759
MOD_CK1_1	427	433	PF00069	0.507
MOD_CK1_1	57	63	PF00069	0.762
MOD_CK1_1	91	97	PF00069	0.628
MOD_GlcNHglycan	186	189	PF01048	0.520
MOD_GlcNHglycan	193	196	PF01048	0.465
MOD_GlcNHglycan	208	211	PF01048	0.580
MOD_GlcNHglycan	271	275	PF01048	0.461
MOD_GlcNHglycan	338	341	PF01048	0.540
MOD_GlcNHglycan	414	417	PF01048	0.525
MOD_GlcNHglycan	443	446	PF01048	0.310
MOD_GlcNHglycan	59	63	PF01048	0.748
MOD_GlcNHglycan	72	75	PF01048	0.706
MOD_GlcNHglycan	90	93	PF01048	0.724
MOD_GSK3_1	152	159	PF00069	0.463
MOD_GSK3_1	194	201	PF00069	0.489
MOD_GSK3_1	209	216	PF00069	0.449
MOD_GSK3_1	266	273	PF00069	0.476
MOD_GSK3_1	28	35	PF00069	0.684
MOD_GSK3_1	316	323	PF00069	0.363
MOD_GSK3_1	398	405	PF00069	0.410
MOD_GSK3_1	54	61	PF00069	0.774
MOD_GSK3_1	77	84	PF00069	0.731
MOD_GSK3_1	91	98	PF00069	0.544
MOD_N-GLC_1	198	203	PF02516	0.431
MOD_N-GLC_1	424	429	PF02516	0.550
MOD_N-GLC_2	305	307	PF02516	0.490
MOD_NEK2_1	156	161	PF00069	0.269
MOD_NEK2_1	220	225	PF00069	0.402
MOD_NEK2_1	235	240	PF00069	0.453
MOD_NEK2_1	270	275	PF00069	0.432
MOD_NEK2_1	342	347	PF00069	0.468
MOD_NEK2_1	402	407	PF00069	0.392
MOD_PIKK_1	213	219	PF00454	0.390
MOD_PIKK_1	235	241	PF00454	0.532
MOD_PIKK_1	430	436	PF00454	0.517
MOD_PKA_1	54	60	PF00069	0.798
MOD_PKA_2	152	158	PF00069	0.514
MOD_PKA_2	235	241	PF00069	0.428
MOD_PKA_2	336	342	PF00069	0.508
MOD_PKA_2	412	418	PF00069	0.486
MOD_PKA_2	54	60	PF00069	0.798
MOD_PKB_1	77	85	PF00069	0.706
MOD_Plk_1	266	272	PF00069	0.379
MOD_Plk_4	107	113	PF00069	0.646
MOD_Plk_4	398	404	PF00069	0.390
MOD_Plk_4	414	420	PF00069	0.368
MOD_Plk_4	81	87	PF00069	0.760
MOD_ProDKin_1	133	139	PF00069	0.436
MOD_ProDKin_1	424	430	PF00069	0.566
MOD_ProDKin_1	91	97	PF00069	0.688
MOD_SUMO_rev_2	262	266	PF00179	0.543
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.429
TRG_ENDOCYTIC_2	166	169	PF00928	0.454
TRG_ENDOCYTIC_2	34	37	PF00928	0.499
TRG_ER_diArg_1	334	337	PF00400	0.561
TRG_ER_diArg_1	363	365	PF00400	0.398
TRG_ER_diArg_1	53	56	PF00400	0.750
TRG_ER_diArg_1	76	79	PF00400	0.711
TRG_NES_CRM1_1	164	179	PF08389	0.484
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD64	Leptomonas seymouri	62%	85%
A0A0S4IQ72	Bodo saltans	28%	87%
A0A1X0NU61	Trypanosomatidae	36%	100%
A0A3Q8IDQ5	Leishmania donovani	88%	80%
A0A3S5IS02	Trypanosoma rangeli	38%	100%
A4HEQ5	Leishmania braziliensis	71%	100%
A4I1Y4	Leishmania infantum	88%	80%
C9ZS34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
Q4Q9E2	Leishmania major	87%	100%
V5B9F7	Trypanosoma cruzi	37%	100%