Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY27_LEIMU

TriTrypDb:

LmxM.26.0450

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 3
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AY27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.430
CLV_NRD_NRD_1	107	109	PF00675	0.397
CLV_NRD_NRD_1	285	287	PF00675	0.448
CLV_NRD_NRD_1	93	95	PF00675	0.618
CLV_PCSK_KEX2_1	107	109	PF00082	0.367
CLV_PCSK_KEX2_1	93	95	PF00082	0.648
CLV_PCSK_SKI1_1	12	16	PF00082	0.311
CLV_PCSK_SKI1_1	152	156	PF00082	0.489
CLV_PCSK_SKI1_1	286	290	PF00082	0.490
CLV_PCSK_SKI1_1	446	450	PF00082	0.488
DEG_APCC_DBOX_1	11	19	PF00400	0.311
DEG_APCC_DBOX_1	137	145	PF00400	0.523
DEG_APCC_DBOX_1	285	293	PF00400	0.450
DOC_CKS1_1	257	262	PF01111	0.568
DOC_CKS1_1	347	352	PF01111	0.429
DOC_CKS1_1	59	64	PF01111	0.560
DOC_MAPK_HePTP_8	9	21	PF00069	0.505
DOC_MAPK_MEF2A_6	12	21	PF00069	0.407
DOC_MAPK_MEF2A_6	234	243	PF00069	0.385
DOC_MAPK_MEF2A_6	74	83	PF00069	0.392
DOC_MAPK_NFAT4_5	12	20	PF00069	0.306
DOC_MAPK_RevD_3	78	94	PF00069	0.403
DOC_PP1_RVXF_1	118	124	PF00149	0.319
DOC_PP4_FxxP_1	123	126	PF00568	0.493
DOC_PP4_FxxP_1	155	158	PF00568	0.452
DOC_PP4_FxxP_1	347	350	PF00568	0.469
DOC_USP7_MATH_1	137	141	PF00917	0.613
DOC_USP7_MATH_1	249	253	PF00917	0.439
DOC_USP7_MATH_1	438	442	PF00917	0.543
DOC_USP7_MATH_2	317	323	PF00917	0.472
DOC_WW_Pin1_4	256	261	PF00397	0.626
DOC_WW_Pin1_4	346	351	PF00397	0.428
DOC_WW_Pin1_4	434	439	PF00397	0.556
DOC_WW_Pin1_4	58	63	PF00397	0.554
LIG_14-3-3_CanoR_1	120	124	PF00244	0.609
LIG_14-3-3_CanoR_1	138	142	PF00244	0.516
LIG_14-3-3_CanoR_1	280	289	PF00244	0.459
LIG_14-3-3_CanoR_1	382	389	PF00244	0.617
LIG_14-3-3_CanoR_1	56	60	PF00244	0.542
LIG_Actin_WH2_2	137	154	PF00022	0.462
LIG_BRCT_BRCA1_1	385	389	PF00533	0.396
LIG_BRCT_BRCA1_1	426	430	PF00533	0.484
LIG_BRCT_BRCA1_2	385	391	PF00533	0.384
LIG_FHA_1	160	166	PF00498	0.338
LIG_FHA_1	277	283	PF00498	0.380
LIG_FHA_1	338	344	PF00498	0.502
LIG_FHA_2	131	137	PF00498	0.614
LIG_FHA_2	183	189	PF00498	0.596
LIG_LIR_Apic_2	122	126	PF02991	0.459
LIG_LIR_Apic_2	255	260	PF02991	0.442
LIG_LIR_Gen_1	162	172	PF02991	0.443
LIG_LIR_Nem_3	162	167	PF02991	0.398
LIG_LIR_Nem_3	399	405	PF02991	0.547
LIG_MYND_1	126	130	PF01753	0.453
LIG_NRP_CendR_1	450	451	PF00754	0.478
LIG_Rb_pABgroove_1	424	432	PF01858	0.352
LIG_SH2_CRK	214	218	PF00017	0.370
LIG_SH2_CRK	370	374	PF00017	0.574
LIG_SH2_NCK_1	214	218	PF00017	0.249
LIG_SH2_PTP2	164	167	PF00017	0.235
LIG_SH2_STAP1	214	218	PF00017	0.370
LIG_SH2_STAP1	300	304	PF00017	0.516
LIG_SH2_STAP1	444	448	PF00017	0.467
LIG_SH2_STAT3	296	299	PF00017	0.397
LIG_SH2_STAT5	164	167	PF00017	0.291
LIG_SH2_STAT5	184	187	PF00017	0.484
LIG_SH2_STAT5	209	212	PF00017	0.499
LIG_SH2_STAT5	273	276	PF00017	0.399
LIG_SH2_STAT5	281	284	PF00017	0.353
LIG_SH2_STAT5	297	300	PF00017	0.446
LIG_SH2_STAT5	8	11	PF00017	0.516
LIG_SH3_3	168	174	PF00018	0.480
LIG_SH3_3	56	62	PF00018	0.521
LIG_SUMO_SIM_anti_2	237	243	PF11976	0.448
LIG_SUMO_SIM_par_1	239	245	PF11976	0.445
LIG_SUMO_SIM_par_1	79	85	PF11976	0.436
LIG_TRAF2_1	186	189	PF00917	0.536
LIG_TRAF2_1	317	320	PF00917	0.464
LIG_TYR_ITSM	160	167	PF00017	0.448
LIG_WRC_WIRS_1	395	400	PF05994	0.534
MOD_CDK_SPK_2	256	261	PF00069	0.493
MOD_CK1_1	252	258	PF00069	0.623
MOD_CK1_1	338	344	PF00069	0.427
MOD_CK1_1	380	386	PF00069	0.683
MOD_CK1_1	396	402	PF00069	0.592
MOD_CK1_1	58	64	PF00069	0.518
MOD_CK1_1	66	72	PF00069	0.504
MOD_CK1_1	89	95	PF00069	0.591
MOD_CK2_1	137	143	PF00069	0.487
MOD_CK2_1	182	188	PF00069	0.565
MOD_GlcNHglycan	356	359	PF01048	0.646
MOD_GlcNHglycan	398	401	PF01048	0.491
MOD_GlcNHglycan	409	412	PF01048	0.538
MOD_GSK3_1	252	259	PF00069	0.458
MOD_GSK3_1	335	342	PF00069	0.519
MOD_GSK3_1	394	401	PF00069	0.676
MOD_GSK3_1	434	441	PF00069	0.560
MOD_GSK3_1	54	61	PF00069	0.541
MOD_GSK3_1	63	70	PF00069	0.482
MOD_N-GLC_1	159	164	PF02516	0.407
MOD_N-GLC_1	182	187	PF02516	0.629
MOD_N-GLC_1	327	332	PF02516	0.652
MOD_N-GLC_1	338	343	PF02516	0.494
MOD_N-GLC_1	351	356	PF02516	0.638
MOD_N-GLC_1	417	422	PF02516	0.674
MOD_NEK2_1	182	187	PF00069	0.630
MOD_NEK2_1	337	342	PF00069	0.629
MOD_NEK2_1	398	403	PF00069	0.601
MOD_NEK2_1	67	72	PF00069	0.404
MOD_NEK2_2	249	254	PF00069	0.528
MOD_NEK2_2	281	286	PF00069	0.450
MOD_PIKK_1	201	207	PF00454	0.467
MOD_PK_1	94	100	PF00069	0.487
MOD_PKA_2	119	125	PF00069	0.554
MOD_PKA_2	137	143	PF00069	0.603
MOD_PKA_2	48	54	PF00069	0.650
MOD_PKA_2	55	61	PF00069	0.533
MOD_Plk_1	159	165	PF00069	0.393
MOD_Plk_1	182	188	PF00069	0.632
MOD_Plk_1	201	207	PF00069	0.495
MOD_Plk_1	338	344	PF00069	0.674
MOD_Plk_1	380	386	PF00069	0.524
MOD_Plk_4	319	325	PF00069	0.601
MOD_Plk_4	55	61	PF00069	0.550
MOD_Plk_4	86	92	PF00069	0.527
MOD_ProDKin_1	256	262	PF00069	0.628
MOD_ProDKin_1	346	352	PF00069	0.428
MOD_ProDKin_1	434	440	PF00069	0.556
MOD_ProDKin_1	58	64	PF00069	0.559
TRG_ENDOCYTIC_2	164	167	PF00928	0.512
TRG_ENDOCYTIC_2	214	217	PF00928	0.386
TRG_ENDOCYTIC_2	370	373	PF00928	0.528
TRG_ENDOCYTIC_2	405	408	PF00928	0.501
TRG_ER_diArg_1	106	108	PF00400	0.492
TRG_ER_diArg_1	449	451	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P2	Leptomonas seymouri	37%	97%
A0A1X0NSG2	Trypanosomatidae	21%	100%
A0A3Q8ICS7	Leishmania donovani	88%	100%
A0A3R7NPG1	Trypanosoma rangeli	25%	100%
A4HEQ1	Leishmania braziliensis	69%	100%
A4I1Y1	Leishmania infantum	88%	100%
C9ZS38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4Q9E6	Leishmania major	86%	100%