Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY26_LEIMU

TriTrypDb:

LmxM.26.0440

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

E9AY26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.451
CLV_NRD_NRD_1	27	29	PF00675	0.467
CLV_PCSK_KEX2_1	16	18	PF00082	0.451
CLV_PCSK_KEX2_1	27	29	PF00082	0.467
CLV_PCSK_SKI1_1	254	258	PF00082	0.644
DOC_PP4_FxxP_1	190	193	PF00568	0.661
DOC_USP7_MATH_1	144	148	PF00917	0.703
DOC_USP7_MATH_1	155	159	PF00917	0.640
DOC_USP7_MATH_1	64	68	PF00917	0.691
DOC_WW_Pin1_4	100	105	PF00397	0.704
DOC_WW_Pin1_4	189	194	PF00397	0.697
DOC_WW_Pin1_4	201	206	PF00397	0.747
DOC_WW_Pin1_4	211	216	PF00397	0.644
LIG_14-3-3_CanoR_1	16	24	PF00244	0.602
LIG_14-3-3_CanoR_1	27	32	PF00244	0.680
LIG_14-3-3_CanoR_1	92	102	PF00244	0.671
LIG_BRCT_BRCA1_1	45	49	PF00533	0.712
LIG_BRCT_BRCA1_1	96	100	PF00533	0.700
LIG_deltaCOP1_diTrp_1	302	311	PF00928	0.434
LIG_FHA_1	19	25	PF00498	0.735
LIG_FHA_1	323	329	PF00498	0.298
LIG_FHA_2	122	128	PF00498	0.665
LIG_FHA_2	158	164	PF00498	0.665
LIG_FHA_2	56	62	PF00498	0.689
LIG_FHA_2	71	77	PF00498	0.606
LIG_LIR_Gen_1	230	239	PF02991	0.275
LIG_LIR_Gen_1	309	318	PF02991	0.326
LIG_LIR_Nem_3	230	235	PF02991	0.275
LIG_LIR_Nem_3	301	307	PF02991	0.378
LIG_PCNA_PIPBox_1	182	191	PF02747	0.614
LIG_Pex14_1	228	232	PF04695	0.275
LIG_SH2_CRK	223	227	PF00017	0.507
LIG_SH2_CRK	250	254	PF00017	0.439
LIG_SH2_STAT5	142	145	PF00017	0.587
LIG_SH2_STAT5	246	249	PF00017	0.433
LIG_SH2_STAT5	293	296	PF00017	0.413
LIG_SH3_3	2	8	PF00018	0.642
LIG_SH3_3	294	300	PF00018	0.377
LIG_SH3_3	38	44	PF00018	0.706
LIG_SH3_3	98	104	PF00018	0.535
LIG_SUMO_SIM_par_1	293	298	PF11976	0.371
LIG_TRAF2_1	124	127	PF00917	0.680
LIG_TRAF2_1	318	321	PF00917	0.359
LIG_TRFH_1	100	104	PF08558	0.570
LIG_TYR_ITIM	221	226	PF00017	0.610
MOD_CDK_SPK_2	189	194	PF00069	0.536
MOD_CDK_SPK_2	211	216	PF00069	0.530
MOD_CK1_1	158	164	PF00069	0.693
MOD_CK1_1	172	178	PF00069	0.723
MOD_CK1_1	36	42	PF00069	0.656
MOD_CK1_1	47	53	PF00069	0.688
MOD_CK2_1	111	117	PF00069	0.608
MOD_CK2_1	121	127	PF00069	0.615
MOD_CK2_1	157	163	PF00069	0.763
MOD_CK2_1	211	217	PF00069	0.522
MOD_CK2_1	262	268	PF00069	0.336
MOD_CK2_1	70	76	PF00069	0.612
MOD_GlcNHglycan	113	116	PF01048	0.462
MOD_GlcNHglycan	146	149	PF01048	0.466
MOD_GlcNHglycan	159	163	PF01048	0.450
MOD_GlcNHglycan	171	174	PF01048	0.514
MOD_GlcNHglycan	311	314	PF01048	0.619
MOD_GlcNHglycan	66	69	PF01048	0.527
MOD_GSK3_1	165	172	PF00069	0.765
MOD_GSK3_1	322	329	PF00069	0.463
MOD_GSK3_1	43	50	PF00069	0.672
MOD_LATS_1	25	31	PF00433	0.653
MOD_NEK2_1	138	143	PF00069	0.599
MOD_NEK2_1	227	232	PF00069	0.302
MOD_NEK2_1	237	242	PF00069	0.202
MOD_NEK2_1	33	38	PF00069	0.627
MOD_NEK2_1	49	54	PF00069	0.731
MOD_NEK2_1	94	99	PF00069	0.736
MOD_NEK2_2	249	254	PF00069	0.381
MOD_NEK2_2	87	92	PF00069	0.570
MOD_PIKK_1	206	212	PF00454	0.732
MOD_PIKK_1	33	39	PF00454	0.766
MOD_PK_1	27	33	PF00069	0.684
MOD_PKA_1	16	22	PF00069	0.568
MOD_PKA_1	27	33	PF00069	0.731
MOD_PKA_2	144	150	PF00069	0.574
MOD_PKA_2	16	22	PF00069	0.568
MOD_PKA_2	27	33	PF00069	0.731
MOD_PKA_2	94	100	PF00069	0.650
MOD_Plk_1	138	144	PF00069	0.545
MOD_Plk_4	173	179	PF00069	0.633
MOD_Plk_4	285	291	PF00069	0.475
MOD_Plk_4	44	50	PF00069	0.754
MOD_ProDKin_1	100	106	PF00069	0.704
MOD_ProDKin_1	189	195	PF00069	0.699
MOD_ProDKin_1	201	207	PF00069	0.747
MOD_ProDKin_1	211	217	PF00069	0.637
MOD_SUMO_for_1	193	196	PF00179	0.584
TRG_ENDOCYTIC_2	223	226	PF00928	0.585
TRG_ENDOCYTIC_2	250	253	PF00928	0.433
TRG_ER_diArg_1	15	17	PF00400	0.658
TRG_ER_diArg_1	26	28	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P498	Leptomonas seymouri	49%	100%
A0A0S4KLN6	Bodo saltans	29%	100%
A0A1X0NSG9	Trypanosomatidae	36%	100%
A0A3R7MX83	Trypanosoma rangeli	34%	100%
A0A3S7WZN6	Leishmania donovani	82%	100%
A4HEQ0	Leishmania braziliensis	61%	100%
A4I1Y0	Leishmania infantum	82%	100%
C9ZS39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q9E7	Leishmania major	86%	100%
V5B9G1	Trypanosoma cruzi	36%	100%