LeishMANIAdb
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Cysteine-rich DPF motif domain-containing protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Cysteine-rich DPF motif domain-containing protein 1
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AY23_LEIMU
TriTrypDb:
LmxM.26.0410
Length:
100

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY23
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY23

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 32 34 PF00082 0.426
CLV_PCSK_KEX2_1 46 48 PF00082 0.462
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.421
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.412
CLV_PCSK_SKI1_1 16 20 PF00082 0.504
LIG_FHA_1 39 45 PF00498 0.530
LIG_LIR_Nem_3 78 83 PF02991 0.486
LIG_NRP_CendR_1 99 100 PF00754 0.639
LIG_Pex14_1 79 83 PF04695 0.401
LIG_SH2_SRC 42 45 PF00017 0.522
LIG_SH2_STAT5 30 33 PF00017 0.511
LIG_SH2_STAT5 80 83 PF00017 0.372
LIG_UBA3_1 1 7 PF00899 0.435
MOD_N-GLC_1 3 8 PF02516 0.575
MOD_PK_1 47 53 PF00069 0.525
MOD_Plk_4 47 53 PF00069 0.502
MOD_SUMO_rev_2 13 21 PF00179 0.516
TRG_ENDOCYTIC_2 83 86 PF00928 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK67 Leptomonas seymouri 67% 100%
A0A3S7WZQ3 Leishmania donovani 85% 100%
A4HEP7 Leishmania braziliensis 88% 100%
A4I1X7 Leishmania infantum 85% 100%
C9ZS42 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
Q4Q9F0 Leishmania major 87% 100%
V5BQ50 Trypanosoma cruzi 43% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS