Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AY22_LEIMU

TriTrypDb:

LmxM.26.0400

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AY22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	376	378	PF00675	0.412
CLV_NRD_NRD_1	383	385	PF00675	0.428
CLV_NRD_NRD_1	545	547	PF00675	0.510
CLV_PCSK_KEX2_1	375	377	PF00082	0.441
CLV_PCSK_KEX2_1	383	385	PF00082	0.425
CLV_PCSK_KEX2_1	522	524	PF00082	0.317
CLV_PCSK_KEX2_1	545	547	PF00082	0.475
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.299
CLV_PCSK_SKI1_1	286	290	PF00082	0.391
CLV_PCSK_SKI1_1	383	387	PF00082	0.562
CLV_PCSK_SKI1_1	94	98	PF00082	0.306
DEG_APCC_DBOX_1	382	390	PF00400	0.575
DEG_COP1_1	330	339	PF00400	0.493
DEG_SPOP_SBC_1	247	251	PF00917	0.651
DOC_CYCLIN_RxL_1	283	293	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	61	64	PF00134	0.571
DOC_MAPK_gen_1	253	261	PF00069	0.523
DOC_PP2B_LxvP_1	144	147	PF13499	0.533
DOC_PP2B_LxvP_1	15	18	PF13499	0.566
DOC_PP2B_LxvP_1	231	234	PF13499	0.505
DOC_PP2B_LxvP_1	61	64	PF13499	0.571
DOC_USP7_MATH_1	122	126	PF00917	0.598
DOC_USP7_MATH_1	235	239	PF00917	0.595
DOC_USP7_MATH_1	247	251	PF00917	0.701
DOC_USP7_MATH_1	268	272	PF00917	0.569
DOC_USP7_MATH_1	316	320	PF00917	0.757
DOC_USP7_MATH_1	4	8	PF00917	0.457
DOC_USP7_MATH_1	401	405	PF00917	0.555
DOC_USP7_MATH_1	558	562	PF00917	0.321
DOC_WW_Pin1_4	101	106	PF00397	0.696
DOC_WW_Pin1_4	109	114	PF00397	0.671
DOC_WW_Pin1_4	116	121	PF00397	0.619
DOC_WW_Pin1_4	206	211	PF00397	0.815
DOC_WW_Pin1_4	322	327	PF00397	0.553
DOC_WW_Pin1_4	80	85	PF00397	0.497
LIG_14-3-3_CanoR_1	286	294	PF00244	0.425
LIG_14-3-3_CanoR_1	315	321	PF00244	0.790
LIG_14-3-3_CanoR_1	329	339	PF00244	0.431
LIG_14-3-3_CanoR_1	539	545	PF00244	0.502
LIG_14-3-3_CanoR_1	88	92	PF00244	0.491
LIG_14-3-3_CanoR_1	98	105	PF00244	0.657
LIG_Actin_WH2_2	10	25	PF00022	0.346
LIG_Actin_WH2_2	84	100	PF00022	0.509
LIG_Clathr_ClatBox_1	342	346	PF01394	0.478
LIG_FHA_1	200	206	PF00498	0.736
LIG_FHA_1	234	240	PF00498	0.529
LIG_FHA_1	315	321	PF00498	0.792
LIG_FHA_1	514	520	PF00498	0.517
LIG_FHA_1	522	528	PF00498	0.517
LIG_FHA_1	67	73	PF00498	0.582
LIG_FHA_2	348	354	PF00498	0.434
LIG_FHA_2	42	48	PF00498	0.550
LIG_FHA_2	476	482	PF00498	0.517
LIG_FHA_2	524	530	PF00498	0.555
LIG_FHA_2	551	557	PF00498	0.625
LIG_Integrin_isoDGR_2	363	365	PF01839	0.300
LIG_Integrin_RGD_1	536	538	PF01839	0.355
LIG_LIR_Apic_2	483	488	PF02991	0.521
LIG_LIR_Gen_1	356	366	PF02991	0.473
LIG_LIR_Gen_1	404	413	PF02991	0.555
LIG_LIR_Gen_1	446	455	PF02991	0.538
LIG_LIR_Gen_1	476	482	PF02991	0.555
LIG_LIR_Nem_3	356	361	PF02991	0.377
LIG_LIR_Nem_3	441	447	PF02991	0.542
LIG_LIR_Nem_3	556	562	PF02991	0.539
LIG_LIR_Nem_3	69	74	PF02991	0.334
LIG_LYPXL_yS_3	559	562	PF13949	0.601
LIG_MAD2	227	235	PF02301	0.375
LIG_PDZ_Class_3	561	566	PF00595	0.502
LIG_Pex14_1	32	36	PF04695	0.473
LIG_Pex14_2	381	385	PF04695	0.412
LIG_REV1ctd_RIR_1	34	41	PF16727	0.476
LIG_SH2_SRC	445	448	PF00017	0.555
LIG_SH2_STAP1	131	135	PF00017	0.335
LIG_SH2_STAP1	163	167	PF00017	0.472
LIG_SH2_STAT5	260	263	PF00017	0.438
LIG_SH2_STAT5	372	375	PF00017	0.504
LIG_SH2_STAT5	406	409	PF00017	0.547
LIG_SH2_STAT5	477	480	PF00017	0.555
LIG_SH2_STAT5	498	501	PF00017	0.555
LIG_SH2_STAT5	85	88	PF00017	0.278
LIG_SH3_2	147	152	PF14604	0.445
LIG_SH3_3	144	150	PF00018	0.371
LIG_SH3_3	183	189	PF00018	0.482
LIG_SH3_3	334	340	PF00018	0.464
LIG_SH3_3	426	432	PF00018	0.555
LIG_SH3_3	488	494	PF00018	0.555
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.565
LIG_SUMO_SIM_anti_2	503	508	PF11976	0.517
LIG_SUMO_SIM_par_1	470	476	PF11976	0.520
LIG_TRAF2_1	351	354	PF00917	0.505
LIG_TRAF2_1	63	66	PF00917	0.309
LIG_WRC_WIRS_1	531	536	PF05994	0.606
MOD_CDK_SPxK_1	101	107	PF00069	0.597
MOD_CDK_SPxxK_3	322	329	PF00069	0.523
MOD_CK1_1	159	165	PF00069	0.590
MOD_CK1_1	209	215	PF00069	0.776
MOD_CK1_1	246	252	PF00069	0.630
MOD_CK1_1	290	296	PF00069	0.517
MOD_CK1_1	311	317	PF00069	0.600
MOD_CK1_1	473	479	PF00069	0.544
MOD_CK2_1	347	353	PF00069	0.468
MOD_CK2_1	41	47	PF00069	0.538
MOD_CK2_1	475	481	PF00069	0.532
MOD_CK2_1	523	529	PF00069	0.555
MOD_CK2_1	550	556	PF00069	0.628
MOD_GlcNHglycan	116	119	PF01048	0.803
MOD_GlcNHglycan	180	183	PF01048	0.661
MOD_GlcNHglycan	245	248	PF01048	0.575
MOD_GlcNHglycan	250	253	PF01048	0.682
MOD_GlcNHglycan	309	313	PF01048	0.558
MOD_GlcNHglycan	462	465	PF01048	0.299
MOD_GSK3_1	114	121	PF00069	0.744
MOD_GSK3_1	153	160	PF00069	0.689
MOD_GSK3_1	205	212	PF00069	0.746
MOD_GSK3_1	241	248	PF00069	0.631
MOD_GSK3_1	288	295	PF00069	0.504
MOD_GSK3_1	310	317	PF00069	0.748
MOD_GSK3_1	318	325	PF00069	0.671
MOD_GSK3_1	521	528	PF00069	0.547
MOD_GSK3_1	546	553	PF00069	0.610
MOD_GSK3_1	97	104	PF00069	0.553
MOD_NEK2_1	129	134	PF00069	0.496
MOD_NEK2_1	161	166	PF00069	0.545
MOD_NEK2_1	205	210	PF00069	0.733
MOD_NEK2_1	22	27	PF00069	0.583
MOD_NEK2_1	287	292	PF00069	0.432
MOD_NEK2_1	327	332	PF00069	0.353
MOD_NEK2_1	470	475	PF00069	0.513
MOD_NEK2_1	480	485	PF00069	0.509
MOD_NEK2_1	540	545	PF00069	0.555
MOD_NEK2_1	97	102	PF00069	0.522
MOD_PIKK_1	314	320	PF00454	0.650
MOD_PIKK_1	546	552	PF00454	0.543
MOD_PKA_2	314	320	PF00069	0.787
MOD_PKA_2	401	407	PF00069	0.555
MOD_PKA_2	538	544	PF00069	0.502
MOD_PKA_2	550	556	PF00069	0.504
MOD_PKA_2	87	93	PF00069	0.495
MOD_PKA_2	97	103	PF00069	0.622
MOD_Plk_1	353	359	PF00069	0.466
MOD_Plk_1	480	486	PF00069	0.545
MOD_Plk_4	163	169	PF00069	0.562
MOD_Plk_4	235	241	PF00069	0.516
MOD_Plk_4	401	407	PF00069	0.555
MOD_Plk_4	475	481	PF00069	0.509
MOD_ProDKin_1	101	107	PF00069	0.700
MOD_ProDKin_1	109	115	PF00069	0.673
MOD_ProDKin_1	116	122	PF00069	0.619
MOD_ProDKin_1	206	212	PF00069	0.814
MOD_ProDKin_1	322	328	PF00069	0.540
MOD_ProDKin_1	80	86	PF00069	0.500
TRG_DiLeu_BaEn_1	92	97	PF01217	0.502
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.481
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.498
TRG_ENDOCYTIC_2	406	409	PF00928	0.517
TRG_ENDOCYTIC_2	447	450	PF00928	0.553
TRG_ENDOCYTIC_2	477	480	PF00928	0.555
TRG_ENDOCYTIC_2	559	562	PF00928	0.601
TRG_ER_diArg_1	269	272	PF00400	0.495
TRG_ER_diArg_1	375	377	PF00400	0.401
TRG_ER_diArg_1	383	385	PF00400	0.341
TRG_ER_diArg_1	409	412	PF00400	0.517
TRG_ER_diArg_1	544	546	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB74	Leptomonas seymouri	51%	100%
A0A1X0NTZ1	Trypanosomatidae	35%	100%
A0A3Q8IGV6	Leishmania donovani	87%	100%
A4HEP6	Leishmania braziliensis	72%	100%
A4I1X6	Leishmania infantum	88%	100%
Q4Q9F1	Leishmania major	84%	99%