Regulator of Vps4 activity in the MVB pathway protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of Vps4 activity in the MVB pathway, putative

Species:

Leishmania mexicana

UniProt:

E9AY20_LEIMU

TriTrypDb:

LmxM.26.0380

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY20

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.324
CLV_NRD_NRD_1	45	47	PF00675	0.286
CLV_PCSK_KEX2_1	45	47	PF00082	0.297
CLV_PCSK_SKI1_1	142	146	PF00082	0.307
CLV_PCSK_SKI1_1	2	6	PF00082	0.629
CLV_PCSK_SKI1_1	24	28	PF00082	0.332
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DOC_CKS1_1	175	180	PF01111	0.443
DOC_CKS1_1	239	244	PF01111	0.507
DOC_PP2B_LxvP_1	245	248	PF13499	0.519
DOC_USP7_MATH_1	120	124	PF00917	0.524
DOC_USP7_MATH_1	215	219	PF00917	0.557
DOC_USP7_UBL2_3	101	105	PF12436	0.441
DOC_USP7_UBL2_3	2	6	PF12436	0.524
DOC_WW_Pin1_4	174	179	PF00397	0.443
DOC_WW_Pin1_4	238	243	PF00397	0.525
LIG_14-3-3_CanoR_1	24	32	PF00244	0.553
LIG_14-3-3_CanoR_1	45	49	PF00244	0.473
LIG_APCC_ABBA_1	80	85	PF00400	0.457
LIG_BRCT_BRCA1_1	10	14	PF00533	0.591
LIG_Clathr_ClatBox_1	51	55	PF01394	0.560
LIG_eIF4E_1	77	83	PF01652	0.524
LIG_FHA_1	120	126	PF00498	0.460
LIG_FHA_1	25	31	PF00498	0.536
LIG_LIR_Apic_2	243	249	PF02991	0.535
LIG_LIR_Gen_1	152	161	PF02991	0.481
LIG_LIR_Gen_1	75	84	PF02991	0.480
LIG_LIR_Nem_3	11	17	PF02991	0.554
LIG_LIR_Nem_3	75	80	PF02991	0.480
LIG_LIR_Nem_3	81	86	PF02991	0.454
LIG_Pex14_2	145	149	PF04695	0.485
LIG_PTB_Apo_2	157	164	PF02174	0.481
LIG_SH2_CRK	176	180	PF00017	0.560
LIG_SH2_NCK_1	176	180	PF00017	0.560
LIG_SH2_NCK_1	254	258	PF00017	0.571
LIG_SH2_PTP2	246	249	PF00017	0.592
LIG_SH2_SRC	246	249	PF00017	0.592
LIG_SH2_STAT5	176	179	PF00017	0.560
LIG_SH2_STAT5	186	189	PF00017	0.457
LIG_SH2_STAT5	246	249	PF00017	0.592
LIG_SH3_3	236	242	PF00018	0.660
LIG_SUMO_SIM_par_1	50	55	PF11976	0.560
LIG_TYR_ITIM	252	257	PF00017	0.386
LIG_UBA3_1	51	56	PF00899	0.457
MOD_CK1_1	238	244	PF00069	0.564
MOD_CK1_1	40	46	PF00069	0.536
MOD_CK2_1	131	137	PF00069	0.538
MOD_CK2_1	156	162	PF00069	0.516
MOD_CK2_1	44	50	PF00069	0.473
MOD_GlcNHglycan	10	13	PF01048	0.617
MOD_GlcNHglycan	110	113	PF01048	0.354
MOD_GlcNHglycan	127	130	PF01048	0.243
MOD_GlcNHglycan	212	215	PF01048	0.533
MOD_GlcNHglycan	217	220	PF01048	0.531
MOD_GlcNHglycan	223	227	PF01048	0.578
MOD_GlcNHglycan	242	245	PF01048	0.578
MOD_GlcNHglycan	58	61	PF01048	0.281
MOD_GSK3_1	40	47	PF00069	0.455
MOD_NEK2_1	125	130	PF00069	0.485
MOD_NEK2_1	144	149	PF00069	0.366
MOD_NEK2_1	156	161	PF00069	0.454
MOD_NEK2_1	194	199	PF00069	0.625
MOD_NEK2_1	210	215	PF00069	0.470
MOD_NEK2_1	25	30	PF00069	0.475
MOD_NEK2_1	37	42	PF00069	0.526
MOD_NEK2_1	5	10	PF00069	0.681
MOD_PIKK_1	40	46	PF00454	0.536
MOD_PKA_2	235	241	PF00069	0.448
MOD_PKA_2	44	50	PF00069	0.473
MOD_Plk_1	154	160	PF00069	0.449
MOD_Plk_1	161	167	PF00069	0.437
MOD_Plk_4	120	126	PF00069	0.457
MOD_Plk_4	78	84	PF00069	0.485
MOD_ProDKin_1	174	180	PF00069	0.443
MOD_ProDKin_1	238	244	PF00069	0.520
MOD_SUMO_rev_2	110	120	PF00179	0.524
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.466
TRG_ENDOCYTIC_2	254	257	PF00928	0.622
TRG_ENDOCYTIC_2	77	80	PF00928	0.534
TRG_ER_diArg_1	61	64	PF00400	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR2	Leptomonas seymouri	83%	100%
A0A0S4IPS2	Bodo saltans	46%	100%
A0A1X0P8G8	Trypanosomatidae	57%	100%
A0A3Q8IDL4	Leishmania donovani	94%	100%
A0A422N7B4	Trypanosoma rangeli	58%	99%
A4HEP4	Leishmania braziliensis	87%	100%
A4I1X4	Leishmania infantum	94%	100%
D0A1V0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
P53843	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	90%
P53990	Homo sapiens	31%	73%
Q3ZBV1	Bos taurus	30%	73%
Q4Q9F3	Leishmania major	93%	100%
Q54I39	Dictyostelium discoideum	29%	72%
Q568Z6	Rattus norvegicus	31%	73%
Q5R6G8	Pongo abelii	30%	73%
Q9CX00	Mus musculus	31%	74%
V5DIL5	Trypanosoma cruzi	59%	100%