TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AY19_LEIMU

TriTrypDb:

LmxM.26.0370

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AY19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY19

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044784	metaphase/anaphase transition of cell cycle	4	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0045840	positive regulation of mitotic nuclear division	7	1
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	1
GO:0045931	positive regulation of mitotic cell cycle	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051301	cell division	2	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051785	positive regulation of nuclear division	7	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901970	positive regulation of mitotic sister chromatid separation	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901989	positive regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	1
GO:1903047	mitotic cell cycle process	3	1
GO:1905818	regulation of chromosome separation	5	1
GO:1905820	positive regulation of chromosome separation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.453
CLV_NRD_NRD_1	240	242	PF00675	0.454
CLV_NRD_NRD_1	557	559	PF00675	0.402
CLV_NRD_NRD_1	80	82	PF00675	0.406
CLV_PCSK_FUR_1	240	244	PF00082	0.438
CLV_PCSK_KEX2_1	240	242	PF00082	0.538
CLV_PCSK_KEX2_1	557	559	PF00082	0.402
CLV_PCSK_KEX2_1	80	82	PF00082	0.406
CLV_PCSK_KEX2_1	800	802	PF00082	0.388
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.530
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.388
CLV_PCSK_SKI1_1	107	111	PF00082	0.388
CLV_PCSK_SKI1_1	175	179	PF00082	0.429
CLV_PCSK_SKI1_1	792	796	PF00082	0.312
CLV_PCSK_SKI1_1	797	801	PF00082	0.312
DEG_Nend_UBRbox_1	1	4	PF02207	0.594
DEG_SPOP_SBC_1	532	536	PF00917	0.586
DOC_CKS1_1	483	488	PF01111	0.550
DOC_CKS1_1	674	679	PF01111	0.340
DOC_CYCLIN_RxL_1	172	184	PF00134	0.556
DOC_CYCLIN_RxL_1	599	608	PF00134	0.430
DOC_CYCLIN_RxL_1	789	798	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.465
DOC_MAPK_gen_1	172	181	PF00069	0.465
DOC_MAPK_gen_1	265	275	PF00069	0.351
DOC_MAPK_gen_1	557	566	PF00069	0.430
DOC_MAPK_HePTP_8	343	355	PF00069	0.444
DOC_MAPK_HePTP_8	554	566	PF00069	0.466
DOC_MAPK_MEF2A_6	268	277	PF00069	0.366
DOC_MAPK_MEF2A_6	346	355	PF00069	0.438
DOC_MAPK_MEF2A_6	557	566	PF00069	0.586
DOC_PP1_RVXF_1	447	454	PF00149	0.421
DOC_PP1_RVXF_1	600	607	PF00149	0.426
DOC_PP2B_LxvP_1	769	772	PF13499	0.388
DOC_PP2B_LxvP_1	837	840	PF13499	0.435
DOC_USP7_MATH_1	328	332	PF00917	0.471
DOC_USP7_MATH_1	496	500	PF00917	0.667
DOC_USP7_MATH_1	575	579	PF00917	0.511
DOC_USP7_MATH_1	64	68	PF00917	0.469
DOC_USP7_MATH_1	659	663	PF00917	0.314
DOC_USP7_MATH_1	812	816	PF00917	0.502
DOC_WW_Pin1_4	299	304	PF00397	0.757
DOC_WW_Pin1_4	482	487	PF00397	0.675
DOC_WW_Pin1_4	489	494	PF00397	0.651
DOC_WW_Pin1_4	501	506	PF00397	0.543
DOC_WW_Pin1_4	673	678	PF00397	0.291
LIG_14-3-3_CanoR_1	15	25	PF00244	0.383
LIG_14-3-3_CanoR_1	2	11	PF00244	0.570
LIG_14-3-3_CanoR_1	219	227	PF00244	0.419
LIG_14-3-3_CanoR_1	455	463	PF00244	0.507
LIG_14-3-3_CanoR_1	476	483	PF00244	0.711
LIG_14-3-3_CanoR_1	49	53	PF00244	0.494
LIG_14-3-3_CanoR_1	624	633	PF00244	0.446
LIG_14-3-3_CanoR_1	648	654	PF00244	0.443
LIG_14-3-3_CanoR_1	692	700	PF00244	0.340
LIG_14-3-3_CanoR_1	792	797	PF00244	0.302
LIG_14-3-3_CanoR_1	80	86	PF00244	0.413
LIG_14-3-3_CanoR_1	89	95	PF00244	0.417
LIG_BIR_III_2	224	228	PF00653	0.383
LIG_eIF4E_1	681	687	PF01652	0.312
LIG_FHA_1	338	344	PF00498	0.562
LIG_FHA_1	371	377	PF00498	0.423
LIG_FHA_1	5	11	PF00498	0.519
LIG_FHA_1	568	574	PF00498	0.415
LIG_FHA_1	58	64	PF00498	0.394
LIG_FHA_1	584	590	PF00498	0.652
LIG_FHA_1	662	668	PF00498	0.325
LIG_FHA_1	699	705	PF00498	0.332
LIG_FHA_1	768	774	PF00498	0.261
LIG_FHA_1	844	850	PF00498	0.462
LIG_FHA_2	141	147	PF00498	0.369
LIG_FHA_2	219	225	PF00498	0.472
LIG_FHA_2	287	293	PF00498	0.466
LIG_FHA_2	502	508	PF00498	0.685
LIG_FHA_2	793	799	PF00498	0.312
LIG_FHA_2	823	829	PF00498	0.425
LIG_GBD_Chelix_1	689	697	PF00786	0.388
LIG_LIR_Apic_2	828	833	PF02991	0.390
LIG_LIR_Gen_1	146	155	PF02991	0.427
LIG_LIR_Gen_1	421	432	PF02991	0.490
LIG_LIR_Gen_1	756	765	PF02991	0.316
LIG_LIR_Gen_1	784	794	PF02991	0.340
LIG_LIR_Gen_1	831	840	PF02991	0.458
LIG_LIR_Nem_3	146	152	PF02991	0.417
LIG_LIR_Nem_3	421	427	PF02991	0.500
LIG_LIR_Nem_3	450	456	PF02991	0.476
LIG_LIR_Nem_3	756	760	PF02991	0.316
LIG_LIR_Nem_3	784	789	PF02991	0.388
LIG_LIR_Nem_3	831	837	PF02991	0.472
LIG_PDZ_Class_3	848	853	PF00595	0.560
LIG_REV1ctd_RIR_1	451	459	PF16727	0.400
LIG_SH2_CRK	683	687	PF00017	0.388
LIG_SH2_CRK	744	748	PF00017	0.402
LIG_SH2_CRK	757	761	PF00017	0.242
LIG_SH2_NCK_1	802	806	PF00017	0.312
LIG_SH2_NCK_1	830	834	PF00017	0.455
LIG_SH2_SRC	244	247	PF00017	0.465
LIG_SH2_SRC	42	45	PF00017	0.461
LIG_SH2_SRC	612	615	PF00017	0.455
LIG_SH2_SRC	681	684	PF00017	0.388
LIG_SH2_SRC	750	753	PF00017	0.388
LIG_SH2_SRC	802	805	PF00017	0.312
LIG_SH2_SRC	99	102	PF00017	0.327
LIG_SH2_STAP1	244	248	PF00017	0.498
LIG_SH2_STAP1	424	428	PF00017	0.385
LIG_SH2_STAP1	612	616	PF00017	0.451
LIG_SH2_STAP1	750	754	PF00017	0.312
LIG_SH2_STAP1	802	806	PF00017	0.312
LIG_SH2_STAP1	99	103	PF00017	0.340
LIG_SH2_STAT3	643	646	PF00017	0.388
LIG_SH2_STAT5	204	207	PF00017	0.465
LIG_SH2_STAT5	42	45	PF00017	0.443
LIG_SH2_STAT5	424	427	PF00017	0.438
LIG_SH2_STAT5	644	647	PF00017	0.312
LIG_SH3_3	480	486	PF00018	0.714
LIG_SH3_3	488	494	PF00018	0.766
LIG_SH3_3	508	514	PF00018	0.590
LIG_SH3_3	762	768	PF00018	0.293
LIG_SH3_3	846	852	PF00018	0.622
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.451
LIG_SUMO_SIM_par_1	562	567	PF11976	0.279
LIG_SUMO_SIM_par_1	845	851	PF11976	0.480
LIG_TRAF2_1	143	146	PF00917	0.395
LIG_TRAF2_1	840	843	PF00917	0.485
LIG_TRAF2_1	848	851	PF00917	0.569
LIG_TYR_ITIM	832	837	PF00017	0.473
MOD_CDK_SPK_2	501	506	PF00069	0.603
MOD_CDK_SPxK_1	299	305	PF00069	0.640
MOD_CK1_1	19	25	PF00069	0.357
MOD_CK1_1	331	337	PF00069	0.457
MOD_CK1_1	395	401	PF00069	0.604
MOD_CK1_1	484	490	PF00069	0.735
MOD_CK1_1	501	507	PF00069	0.725
MOD_CK1_1	515	521	PF00069	0.575
MOD_CK1_1	567	573	PF00069	0.470
MOD_CK1_1	585	591	PF00069	0.515
MOD_CK1_1	778	784	PF00069	0.221
MOD_CK1_1	815	821	PF00069	0.562
MOD_CK2_1	140	146	PF00069	0.332
MOD_CK2_1	286	292	PF00069	0.423
MOD_CK2_1	456	462	PF00069	0.451
MOD_CK2_1	476	482	PF00069	0.464
MOD_CK2_1	501	507	PF00069	0.698
MOD_CK2_1	515	521	PF00069	0.604
MOD_CK2_1	624	630	PF00069	0.537
MOD_CK2_1	649	655	PF00069	0.243
MOD_CK2_1	659	665	PF00069	0.311
MOD_CK2_1	792	798	PF00069	0.312
MOD_GlcNHglycan	107	110	PF01048	0.312
MOD_GlcNHglycan	326	329	PF01048	0.501
MOD_GlcNHglycan	385	388	PF01048	0.715
MOD_GlcNHglycan	517	521	PF01048	0.713
MOD_GlcNHglycan	577	580	PF01048	0.446
MOD_GlcNHglycan	60	63	PF01048	0.425
MOD_GlcNHglycan	783	786	PF01048	0.340
MOD_GlcNHglycan	816	820	PF01048	0.463
MOD_GSK3_1	101	108	PF00069	0.376
MOD_GSK3_1	164	171	PF00069	0.368
MOD_GSK3_1	299	306	PF00069	0.634
MOD_GSK3_1	324	331	PF00069	0.479
MOD_GSK3_1	337	344	PF00069	0.370
MOD_GSK3_1	47	54	PF00069	0.396
MOD_GSK3_1	481	488	PF00069	0.655
MOD_GSK3_1	496	503	PF00069	0.717
MOD_GSK3_1	512	519	PF00069	0.650
MOD_GSK3_1	581	588	PF00069	0.596
MOD_GSK3_1	620	627	PF00069	0.470
MOD_GSK3_1	669	676	PF00069	0.291
MOD_GSK3_1	774	781	PF00069	0.327
MOD_N-GLC_1	383	388	PF02516	0.471
MOD_N-GLC_1	501	506	PF02516	0.676
MOD_NEK2_1	140	145	PF00069	0.345
MOD_NEK2_1	232	237	PF00069	0.386
MOD_NEK2_1	285	290	PF00069	0.488
MOD_NEK2_1	314	319	PF00069	0.444
MOD_NEK2_1	370	375	PF00069	0.534
MOD_NEK2_1	377	382	PF00069	0.588
MOD_NEK2_1	410	415	PF00069	0.520
MOD_NEK2_1	48	53	PF00069	0.548
MOD_NEK2_1	533	538	PF00069	0.680
MOD_NEK2_1	564	569	PF00069	0.469
MOD_NEK2_1	820	825	PF00069	0.481
MOD_NEK2_2	469	474	PF00069	0.374
MOD_PIKK_1	437	443	PF00454	0.482
MOD_PIKK_1	496	502	PF00454	0.684
MOD_PIKK_1	524	530	PF00454	0.548
MOD_PIKK_1	573	579	PF00454	0.494
MOD_PK_1	341	347	PF00069	0.431
MOD_PK_1	512	518	PF00069	0.597
MOD_PKA_2	218	224	PF00069	0.434
MOD_PKA_2	377	383	PF00069	0.582
MOD_PKA_2	4	10	PF00069	0.521
MOD_PKA_2	437	443	PF00069	0.584
MOD_PKA_2	48	54	PF00069	0.495
MOD_PKA_2	691	697	PF00069	0.340
MOD_PKA_2	88	94	PF00069	0.358
MOD_PKB_1	474	482	PF00069	0.513
MOD_Plk_1	341	347	PF00069	0.431
MOD_Plk_1	64	70	PF00069	0.387
MOD_Plk_1	775	781	PF00069	0.207
MOD_Plk_1	842	848	PF00069	0.518
MOD_Plk_4	191	197	PF00069	0.374
MOD_Plk_4	206	212	PF00069	0.401
MOD_Plk_4	38	44	PF00069	0.389
MOD_Plk_4	81	87	PF00069	0.371
MOD_ProDKin_1	299	305	PF00069	0.748
MOD_ProDKin_1	482	488	PF00069	0.674
MOD_ProDKin_1	489	495	PF00069	0.653
MOD_ProDKin_1	501	507	PF00069	0.543
MOD_ProDKin_1	673	679	PF00069	0.291
MOD_SUMO_for_1	523	526	PF00179	0.679
MOD_SUMO_rev_2	167	177	PF00179	0.383
MOD_SUMO_rev_2	507	514	PF00179	0.616
TRG_DiLeu_BaEn_1	206	211	PF01217	0.431
TRG_DiLeu_BaEn_4	720	726	PF01217	0.591
TRG_DiLeu_LyEn_5	720	725	PF01217	0.514
TRG_ENDOCYTIC_2	424	427	PF00928	0.423
TRG_ENDOCYTIC_2	683	686	PF00928	0.388
TRG_ENDOCYTIC_2	744	747	PF00928	0.312
TRG_ENDOCYTIC_2	757	760	PF00928	0.312
TRG_ENDOCYTIC_2	834	837	PF00928	0.485
TRG_ER_diArg_1	169	172	PF00400	0.425
TRG_ER_diArg_1	239	241	PF00400	0.436
TRG_ER_diArg_1	473	476	PF00400	0.420
TRG_ER_diArg_1	556	558	PF00400	0.391
TRG_ER_diArg_1	79	81	PF00400	0.432
TRG_NLS_MonoExtC_3	240	246	PF00514	0.441
TRG_NLS_MonoExtN_4	172	179	PF00514	0.396
TRG_NLS_MonoExtN_4	240	245	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P507	Leptomonas seymouri	50%	100%
A0A3Q8IDI5	Leishmania donovani	90%	100%
A4HEP3	Leishmania braziliensis	73%	100%
A4I1X3	Leishmania infantum	90%	100%
Q4Q9F4	Leishmania major	90%	100%