IU_nuc_hydro domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inosine-uridine preferring nucleoside hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9AY16_LEIMU

TriTrypDb:

LmxM.26.0340

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9AY16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY16

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0006152	purine nucleoside catabolic process	6	1
GO:0009056	catabolic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009164	nucleoside catabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	8
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	8
GO:0008477	purine nucleosidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.327
CLV_NRD_NRD_1	76	78	PF00675	0.576
CLV_PCSK_KEX2_1	76	78	PF00082	0.517
CLV_PCSK_SKI1_1	21	25	PF00082	0.225
CLV_PCSK_SKI1_1	217	221	PF00082	0.473
CLV_PCSK_SKI1_1	319	323	PF00082	0.464
DEG_Nend_UBRbox_2	1	3	PF02207	0.552
DOC_ANK_TNKS_1	76	83	PF00023	0.250
DOC_MAPK_DCC_7	217	226	PF00069	0.273
DOC_MAPK_DCC_7	49	59	PF00069	0.332
DOC_MAPK_gen_1	18	28	PF00069	0.450
DOC_MAPK_MEF2A_6	167	175	PF00069	0.273
DOC_MAPK_MEF2A_6	76	83	PF00069	0.273
DOC_PP1_RVXF_1	22	29	PF00149	0.218
DOC_PP4_FxxP_1	132	135	PF00568	0.316
DOC_USP7_MATH_1	141	145	PF00917	0.302
DOC_USP7_MATH_1	165	169	PF00917	0.365
DOC_USP7_MATH_1	237	241	PF00917	0.238
DOC_USP7_MATH_1	277	281	PF00917	0.269
DOC_USP7_MATH_1	289	293	PF00917	0.241
DOC_WW_Pin1_4	60	65	PF00397	0.286
LIG_14-3-3_CanoR_1	142	146	PF00244	0.215
LIG_14-3-3_CanoR_1	217	222	PF00244	0.273
LIG_14-3-3_CanoR_1	267	272	PF00244	0.305
LIG_14-3-3_CanoR_1	319	325	PF00244	0.362
LIG_BRCT_BRCA1_1	128	132	PF00533	0.276
LIG_BRCT_BRCA1_1	143	147	PF00533	0.259
LIG_Clathr_ClatBox_1	221	225	PF01394	0.302
LIG_Clathr_ClatBox_1	333	337	PF01394	0.307
LIG_FHA_1	114	120	PF00498	0.326
LIG_FHA_1	268	274	PF00498	0.315
LIG_FHA_1	48	54	PF00498	0.369
LIG_LIR_Apic_2	129	135	PF02991	0.296
LIG_LIR_Gen_1	144	152	PF02991	0.312
LIG_LIR_Gen_1	232	242	PF02991	0.302
LIG_LIR_Gen_1	287	297	PF02991	0.355
LIG_LIR_Gen_1	327	336	PF02991	0.338
LIG_LIR_Nem_3	144	150	PF02991	0.312
LIG_LIR_Nem_3	232	238	PF02991	0.302
LIG_LIR_Nem_3	287	293	PF02991	0.355
LIG_LIR_Nem_3	327	333	PF02991	0.259
LIG_PCNA_PIPBox_1	1	10	PF02747	0.587
LIG_PCNA_yPIPBox_3	66	77	PF02747	0.328
LIG_Pex14_2	28	32	PF04695	0.300
LIG_SH2_CRK	235	239	PF00017	0.236
LIG_SH2_CRK	290	294	PF00017	0.273
LIG_SH2_GRB2like	260	263	PF00017	0.201
LIG_SH2_NCK_1	290	294	PF00017	0.331
LIG_SH2_SRC	260	263	PF00017	0.201
LIG_SH2_STAP1	115	119	PF00017	0.325
LIG_SH2_STAP1	235	239	PF00017	0.286
LIG_SH2_STAP1	278	282	PF00017	0.398
LIG_SH2_STAT3	72	75	PF00017	0.318
LIG_SH2_STAT5	115	118	PF00017	0.371
LIG_SH2_STAT5	188	191	PF00017	0.388
LIG_SH2_STAT5	209	212	PF00017	0.253
LIG_SH2_STAT5	290	293	PF00017	0.302
LIG_SH2_STAT5	31	34	PF00017	0.354
LIG_SH2_STAT5	72	75	PF00017	0.352
LIG_SH3_3	11	17	PF00018	0.491
LIG_SH3_3	236	242	PF00018	0.286
LIG_SH3_3	49	55	PF00018	0.292
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.353
LIG_SUMO_SIM_par_1	222	227	PF11976	0.327
LIG_SUMO_SIM_par_1	50	56	PF11976	0.297
LIG_SUMO_SIM_par_1	82	87	PF11976	0.272
MOD_CK1_1	124	130	PF00069	0.352
MOD_CK1_1	240	246	PF00069	0.271
MOD_CK1_1	248	254	PF00069	0.229
MOD_CK1_1	265	271	PF00069	0.273
MOD_GlcNHglycan	107	110	PF01048	0.599
MOD_GlcNHglycan	313	316	PF01048	0.466
MOD_GSK3_1	121	128	PF00069	0.351
MOD_GSK3_1	224	231	PF00069	0.291
MOD_GSK3_1	237	244	PF00069	0.194
MOD_GSK3_1	262	269	PF00069	0.288
MOD_GSK3_1	284	291	PF00069	0.277
MOD_GSK3_1	302	309	PF00069	0.228
MOD_GSK3_1	43	50	PF00069	0.391
MOD_GSK3_1	53	60	PF00069	0.270
MOD_LATS_1	215	221	PF00433	0.273
MOD_N-GLC_1	302	307	PF02516	0.473
MOD_NEK2_1	43	48	PF00069	0.411
MOD_NEK2_2	141	146	PF00069	0.302
MOD_NEK2_2	325	330	PF00069	0.228
MOD_PIKK_1	313	319	PF00454	0.174
MOD_PKA_2	141	147	PF00069	0.215
MOD_PKA_2	266	272	PF00069	0.305
MOD_PKA_2	284	290	PF00069	0.277
MOD_Plk_1	224	230	PF00069	0.267
MOD_Plk_4	217	223	PF00069	0.351
MOD_Plk_4	325	331	PF00069	0.229
MOD_Plk_4	53	59	PF00069	0.287
MOD_ProDKin_1	60	66	PF00069	0.287
MOD_SUMO_for_1	194	197	PF00179	0.273
TRG_DiLeu_BaEn_2	154	160	PF01217	0.273
TRG_ENDOCYTIC_2	235	238	PF00928	0.236
TRG_ENDOCYTIC_2	260	263	PF00928	0.337
TRG_ENDOCYTIC_2	290	293	PF00928	0.273
TRG_ENDOCYTIC_2	31	34	PF00928	0.360
TRG_ER_diArg_1	295	298	PF00400	0.273
TRG_NLS_MonoExtN_4	15	22	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P506	Leptomonas seymouri	54%	99%
A0A0S4JP56	Bodo saltans	23%	78%
A0A3Q8INW1	Leishmania donovani	92%	100%
A4I1X0	Leishmania infantum	92%	100%
Q4Q9F7	Leishmania major	91%	100%
V5BZE1	Trypanosoma cruzi	25%	81%