ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY10_LEIMU

TriTrypDb:

LmxM.26.0280

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AY10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.496
CLV_NRD_NRD_1	48	50	PF00675	0.382
CLV_NRD_NRD_1	98	100	PF00675	0.553
CLV_PCSK_KEX2_1	140	142	PF00082	0.514
CLV_PCSK_KEX2_1	48	50	PF00082	0.366
CLV_PCSK_KEX2_1	98	100	PF00082	0.417
CLV_PCSK_SKI1_1	119	123	PF00082	0.499
CLV_PCSK_SKI1_1	184	188	PF00082	0.521
DEG_APCC_DBOX_1	139	147	PF00400	0.534
DEG_APCC_DBOX_1	98	106	PF00400	0.265
DOC_USP7_MATH_1	82	86	PF00917	0.418
LIG_14-3-3_CanoR_1	133	139	PF00244	0.491
LIG_14-3-3_CanoR_1	4	8	PF00244	0.603
LIG_BIR_III_2	158	162	PF00653	0.515
LIG_FHA_1	113	119	PF00498	0.468
LIG_FHA_1	166	172	PF00498	0.467
LIG_FHA_1	186	192	PF00498	0.542
LIG_FHA_1	38	44	PF00498	0.543
LIG_FHA_1	71	77	PF00498	0.407
LIG_FHA_2	106	112	PF00498	0.487
LIG_LIR_Gen_1	39	46	PF02991	0.406
LIG_LIR_Nem_3	39	45	PF02991	0.387
LIG_SH2_STAT5	169	172	PF00017	0.468
LIG_SH2_STAT5	194	197	PF00017	0.573
LIG_TRAF2_1	148	151	PF00917	0.559
LIG_UBA3_1	86	91	PF00899	0.433
MOD_CK1_1	52	58	PF00069	0.252
MOD_CK1_1	6	12	PF00069	0.403
MOD_GlcNHglycan	51	54	PF01048	0.270
MOD_GSK3_1	170	177	PF00069	0.530
MOD_N-GLC_1	37	42	PF02516	0.510
MOD_NEK2_1	105	110	PF00069	0.422
MOD_NEK2_1	170	175	PF00069	0.501
MOD_NEK2_1	186	191	PF00069	0.510
MOD_NEK2_1	37	42	PF00069	0.546
MOD_NEK2_1	70	75	PF00069	0.377
MOD_NEK2_2	82	87	PF00069	0.500
MOD_NMyristoyl	1	7	PF02799	0.522
MOD_PKA_2	3	9	PF00069	0.617
MOD_Plk_1	37	43	PF00069	0.528
MOD_Plk_4	134	140	PF00069	0.492
MOD_Plk_4	165	171	PF00069	0.524
MOD_Plk_4	37	43	PF00069	0.511
MOD_Plk_4	76	82	PF00069	0.461
MOD_SUMO_for_1	178	181	PF00179	0.488
MOD_SUMO_rev_2	6	11	PF00179	0.563
TRG_AP2beta_CARGO_1	39	49	PF09066	0.372
TRG_DiLeu_BaEn_1	151	156	PF01217	0.510
TRG_ER_diArg_1	139	141	PF00400	0.495
TRG_ER_diArg_1	48	50	PF00400	0.382
TRG_ER_diArg_1	97	99	PF00400	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J3	Leptomonas seymouri	73%	100%
A0A0S4IJA5	Bodo saltans	24%	78%
A0A1X0NST0	Trypanosomatidae	36%	100%
A0A3S7WZL3	Leishmania donovani	93%	98%
A0A422NVH2	Trypanosoma rangeli	39%	100%
A4I1W5	Leishmania infantum	93%	98%
C9ZS55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AIS0	Leishmania braziliensis	82%	100%
Q4Q9G3	Leishmania major	91%	100%
V5DR87	Trypanosoma cruzi	39%	100%