ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY08_LEIMU

TriTrypDb:

LmxM.26.0260

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.559
CLV_C14_Caspase3-7	426	430	PF00656	0.469
CLV_C14_Caspase3-7	69	73	PF00656	0.606
CLV_NRD_NRD_1	142	144	PF00675	0.609
CLV_NRD_NRD_1	172	174	PF00675	0.585
CLV_NRD_NRD_1	345	347	PF00675	0.407
CLV_NRD_NRD_1	38	40	PF00675	0.620
CLV_NRD_NRD_1	402	404	PF00675	0.524
CLV_NRD_NRD_1	414	416	PF00675	0.538
CLV_NRD_NRD_1	487	489	PF00675	0.485
CLV_NRD_NRD_1	528	530	PF00675	0.438
CLV_PCSK_FUR_1	400	404	PF00082	0.556
CLV_PCSK_KEX2_1	135	137	PF00082	0.668
CLV_PCSK_KEX2_1	144	146	PF00082	0.593
CLV_PCSK_KEX2_1	171	173	PF00082	0.604
CLV_PCSK_KEX2_1	38	40	PF00082	0.644
CLV_PCSK_KEX2_1	402	404	PF00082	0.507
CLV_PCSK_KEX2_1	414	416	PF00082	0.450
CLV_PCSK_KEX2_1	487	489	PF00082	0.485
CLV_PCSK_KEX2_1	528	530	PF00082	0.438
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.732
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.712
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.604
CLV_PCSK_SKI1_1	174	178	PF00082	0.610
CLV_PCSK_SKI1_1	229	233	PF00082	0.436
CLV_PCSK_SKI1_1	264	268	PF00082	0.582
CLV_PCSK_SKI1_1	271	275	PF00082	0.440
CLV_PCSK_SKI1_1	325	329	PF00082	0.479
CLV_PCSK_SKI1_1	39	43	PF00082	0.579
CLV_PCSK_SKI1_1	403	407	PF00082	0.574
CLV_PCSK_SKI1_1	468	472	PF00082	0.509
DEG_APCC_DBOX_1	228	236	PF00400	0.428
DEG_APCC_DBOX_1	256	264	PF00400	0.555
DEG_APCC_DBOX_1	401	409	PF00400	0.545
DEG_Nend_UBRbox_3	1	3	PF02207	0.317
DOC_ANK_TNKS_1	67	74	PF00023	0.506
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.510
DOC_MAPK_gen_1	143	152	PF00069	0.602
DOC_MAPK_gen_1	262	269	PF00069	0.519
DOC_MAPK_MEF2A_6	145	154	PF00069	0.623
DOC_MAPK_MEF2A_6	19	26	PF00069	0.359
DOC_PP1_RVXF_1	227	234	PF00149	0.464
DOC_PP2B_LxvP_1	123	126	PF13499	0.655
DOC_PP2B_LxvP_1	369	372	PF13499	0.483
DOC_PP2B_PxIxI_1	19	25	PF00149	0.365
DOC_PP4_FxxP_1	183	186	PF00568	0.526
DOC_SPAK_OSR1_1	51	55	PF12202	0.529
DOC_USP7_MATH_1	217	221	PF00917	0.566
DOC_USP7_MATH_1	421	425	PF00917	0.664
DOC_USP7_MATH_1	491	495	PF00917	0.567
DOC_USP7_MATH_1	535	539	PF00917	0.646
DOC_USP7_MATH_1	98	102	PF00917	0.570
DOC_WW_Pin1_4	222	227	PF00397	0.457
DOC_WW_Pin1_4	392	397	PF00397	0.544
DOC_WW_Pin1_4	456	461	PF00397	0.498
LIG_14-3-3_CanoR_1	120	124	PF00244	0.562
LIG_14-3-3_CanoR_1	181	186	PF00244	0.533
LIG_14-3-3_CanoR_1	282	288	PF00244	0.607
LIG_14-3-3_CanoR_1	403	409	PF00244	0.502
LIG_14-3-3_CanoR_1	414	419	PF00244	0.562
LIG_14-3-3_CanoR_1	422	431	PF00244	0.502
LIG_14-3-3_CanoR_1	46	55	PF00244	0.582
LIG_14-3-3_CanoR_1	576	585	PF00244	0.556
LIG_APCC_ABBA_1	155	160	PF00400	0.672
LIG_APCC_ABBA_1	52	57	PF00400	0.586
LIG_APCC_ABBAyCdc20_2	51	57	PF00400	0.594
LIG_BIR_III_4	216	220	PF00653	0.580
LIG_BRCT_BRCA1_1	437	441	PF00533	0.431
LIG_BRCT_BRCA1_1	48	52	PF00533	0.460
LIG_CaM_IQ_9	563	578	PF13499	0.301
LIG_CtBP_PxDLS_1	591	595	PF00389	0.483
LIG_eIF4E_1	102	108	PF01652	0.610
LIG_eIF4E_1	434	440	PF01652	0.489
LIG_FHA_1	119	125	PF00498	0.599
LIG_FHA_1	19	25	PF00498	0.269
LIG_FHA_1	282	288	PF00498	0.603
LIG_FHA_1	73	79	PF00498	0.585
LIG_FHA_2	211	217	PF00498	0.545
LIG_FHA_2	40	46	PF00498	0.528
LIG_FHA_2	405	411	PF00498	0.587
LIG_FHA_2	471	477	PF00498	0.533
LIG_FHA_2	568	574	PF00498	0.561
LIG_GBD_Chelix_1	99	107	PF00786	0.483
LIG_LIR_Gen_1	225	235	PF02991	0.440
LIG_LIR_Gen_1	240	251	PF02991	0.465
LIG_LIR_Gen_1	557	568	PF02991	0.511
LIG_LIR_Gen_1	57	67	PF02991	0.479
LIG_LIR_Nem_3	178	183	PF02991	0.625
LIG_LIR_Nem_3	216	221	PF02991	0.456
LIG_LIR_Nem_3	225	230	PF02991	0.419
LIG_LIR_Nem_3	240	246	PF02991	0.457
LIG_LIR_Nem_3	310	316	PF02991	0.520
LIG_LIR_Nem_3	49	55	PF02991	0.504
LIG_LIR_Nem_3	557	563	PF02991	0.530
LIG_LIR_Nem_3	93	99	PF02991	0.595
LIG_MYND_1	153	157	PF01753	0.381
LIG_MYND_1	493	497	PF01753	0.566
LIG_NRBOX	102	108	PF00104	0.416
LIG_NRBOX	231	237	PF00104	0.478
LIG_NRBOX	481	487	PF00104	0.473
LIG_NRBOX	81	87	PF00104	0.567
LIG_PCNA_PIPBox_1	428	437	PF02747	0.464
LIG_PCNA_yPIPBox_3	422	435	PF02747	0.542
LIG_Pex14_2	466	470	PF04695	0.383
LIG_SH2_CRK	218	222	PF00017	0.564
LIG_SH2_CRK	227	231	PF00017	0.535
LIG_SH2_NCK_1	55	59	PF00017	0.465
LIG_SH2_NCK_1	578	582	PF00017	0.544
LIG_SH2_PTP2	208	211	PF00017	0.511
LIG_SH2_SRC	55	58	PF00017	0.398
LIG_SH2_STAP1	227	231	PF00017	0.533
LIG_SH2_STAP1	247	251	PF00017	0.574
LIG_SH2_STAP1	291	295	PF00017	0.623
LIG_SH2_STAP1	55	59	PF00017	0.510
LIG_SH2_STAT5	102	105	PF00017	0.589
LIG_SH2_STAT5	208	211	PF00017	0.511
LIG_SH2_STAT5	314	317	PF00017	0.565
LIG_SH2_STAT5	384	387	PF00017	0.484
LIG_SH2_STAT5	434	437	PF00017	0.487
LIG_SH2_STAT5	484	487	PF00017	0.530
LIG_SH2_STAT5	523	526	PF00017	0.415
LIG_SH2_STAT5	578	581	PF00017	0.550
LIG_SH3_1	487	493	PF00018	0.600
LIG_SH3_3	147	153	PF00018	0.549
LIG_SH3_3	487	493	PF00018	0.558
LIG_SH3_3	496	502	PF00018	0.352
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.571
LIG_SUMO_SIM_par_1	20	25	PF11976	0.274
LIG_SUMO_SIM_par_1	592	601	PF11976	0.496
LIG_TRAF2_1	137	140	PF00917	0.746
LIG_TRAF2_1	273	276	PF00917	0.553
LIG_TRAF2_1	42	45	PF00917	0.537
LIG_TRFH_1	583	587	PF08558	0.368
LIG_UBA3_1	182	188	PF00899	0.628
LIG_WRC_WIRS_1	23	28	PF05994	0.508
MOD_CDK_SPxxK_3	222	229	PF00069	0.447
MOD_CK1_1	118	124	PF00069	0.594
MOD_CK1_1	25	31	PF00069	0.455
MOD_CK1_1	424	430	PF00069	0.637
MOD_CK2_1	113	119	PF00069	0.679
MOD_CK2_1	25	31	PF00069	0.468
MOD_CK2_1	39	45	PF00069	0.466
MOD_CK2_1	470	476	PF00069	0.452
MOD_CK2_1	566	572	PF00069	0.540
MOD_Cter_Amidation	400	403	PF01082	0.313
MOD_GlcNHglycan	243	246	PF01048	0.573
MOD_GlcNHglycan	293	296	PF01048	0.524
MOD_GlcNHglycan	321	324	PF01048	0.540
MOD_GlcNHglycan	423	426	PF01048	0.710
MOD_GlcNHglycan	48	51	PF01048	0.603
MOD_GSK3_1	115	122	PF00069	0.581
MOD_GSK3_1	18	25	PF00069	0.269
MOD_GSK3_1	413	420	PF00069	0.634
MOD_GSK3_1	423	430	PF00069	0.649
MOD_GSK3_1	466	473	PF00069	0.445
MOD_GSK3_1	572	579	PF00069	0.580
MOD_N-GLC_1	238	243	PF02516	0.397
MOD_NEK2_1	274	279	PF00069	0.455
MOD_NEK2_1	435	440	PF00069	0.491
MOD_NEK2_1	466	471	PF00069	0.438
MOD_NEK2_1	508	513	PF00069	0.464
MOD_NEK2_1	566	571	PF00069	0.436
MOD_NEK2_1	78	83	PF00069	0.543
MOD_NEK2_2	217	222	PF00069	0.570
MOD_NEK2_2	549	554	PF00069	0.451
MOD_OFUCOSY	598	604	PF10250	0.335
MOD_PIKK_1	424	430	PF00454	0.652
MOD_PIKK_1	44	50	PF00454	0.625
MOD_PKA_1	414	420	PF00069	0.655
MOD_PKA_2	119	125	PF00069	0.568
MOD_PKA_2	18	24	PF00069	0.267
MOD_PKA_2	281	287	PF00069	0.479
MOD_PKA_2	413	419	PF00069	0.621
MOD_PKA_2	421	427	PF00069	0.590
MOD_Plk_1	118	124	PF00069	0.670
MOD_Plk_1	238	244	PF00069	0.584
MOD_Plk_1	274	280	PF00069	0.536
MOD_Plk_1	572	578	PF00069	0.348
MOD_Plk_4	119	125	PF00069	0.592
MOD_Plk_4	160	166	PF00069	0.680
MOD_Plk_4	18	24	PF00069	0.267
MOD_Plk_4	238	244	PF00069	0.584
MOD_Plk_4	283	289	PF00069	0.625
MOD_Plk_4	404	410	PF00069	0.498
MOD_Plk_4	430	436	PF00069	0.409
MOD_Plk_4	451	457	PF00069	0.444
MOD_Plk_4	491	497	PF00069	0.568
MOD_Plk_4	549	555	PF00069	0.395
MOD_Plk_4	98	104	PF00069	0.509
MOD_ProDKin_1	222	228	PF00069	0.448
MOD_ProDKin_1	392	398	PF00069	0.536
MOD_ProDKin_1	456	462	PF00069	0.497
TRG_DiLeu_BaEn_1	119	124	PF01217	0.672
TRG_DiLeu_BaEn_1	451	456	PF01217	0.506
TRG_DiLeu_BaEn_3	476	482	PF01217	0.557
TRG_DiLeu_BaEn_4	477	483	PF01217	0.554
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.388
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.571
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.396
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.562
TRG_ENDOCYTIC_2	180	183	PF00928	0.656
TRG_ENDOCYTIC_2	208	211	PF00928	0.435
TRG_ENDOCYTIC_2	218	221	PF00928	0.522
TRG_ENDOCYTIC_2	227	230	PF00928	0.449
TRG_ENDOCYTIC_2	505	508	PF00928	0.517
TRG_ER_diArg_1	400	403	PF00400	0.538
TRG_ER_diArg_1	486	488	PF00400	0.482
TRG_ER_diArg_1	528	530	PF00400	0.524
TRG_NLS_MonoCore_2	170	175	PF00514	0.571
TRG_NLS_MonoExtC_3	170	175	PF00514	0.588
TRG_NLS_MonoExtN_4	170	175	PF00514	0.571
TRG_NLS_MonoExtN_4	400	407	PF00514	0.571
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	528	533	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P504	Leptomonas seymouri	67%	88%
A0A0S4IN30	Bodo saltans	26%	67%
A0A1X0NT69	Trypanosomatidae	35%	79%
A0A3Q8IGU6	Leishmania donovani	91%	100%
A0A3S5IS00	Trypanosoma rangeli	34%	85%
A4HEN5	Leishmania braziliensis	83%	100%
A4I1W3	Leishmania infantum	91%	100%
C9ZS57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
Q4Q9G5	Leishmania major	91%	100%
V5BZE7	Trypanosoma cruzi	34%	86%