Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AY05_LEIMU

TriTrypDb:

LmxM.26.0230

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.592
CLV_C14_Caspase3-7	39	43	PF00656	0.440
CLV_NRD_NRD_1	135	137	PF00675	0.651
CLV_NRD_NRD_1	365	367	PF00675	0.607
CLV_NRD_NRD_1	57	59	PF00675	0.569
CLV_PCSK_KEX2_1	365	367	PF00082	0.617
CLV_PCSK_KEX2_1	57	59	PF00082	0.569
CLV_PCSK_SKI1_1	198	202	PF00082	0.706
CLV_PCSK_SKI1_1	360	364	PF00082	0.514
CLV_PCSK_SKI1_1	79	83	PF00082	0.468
DEG_APCC_DBOX_1	85	93	PF00400	0.555
DEG_Nend_UBRbox_2	1	3	PF02207	0.733
DOC_CKS1_1	325	330	PF01111	0.672
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	210	213	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	319	325	PF00134	0.794
DOC_PP1_RVXF_1	196	203	PF00149	0.412
DOC_PP1_RVXF_1	88	95	PF00149	0.590
DOC_PP2B_LxvP_1	210	213	PF13499	0.576
DOC_PP4_FxxP_1	258	261	PF00568	0.563
DOC_PP4_FxxP_1	94	97	PF00568	0.579
DOC_USP7_MATH_1	120	124	PF00917	0.544
DOC_USP7_MATH_1	163	167	PF00917	0.584
DOC_USP7_MATH_1	173	177	PF00917	0.639
DOC_USP7_MATH_1	48	52	PF00917	0.586
DOC_WW_Pin1_4	112	117	PF00397	0.458
DOC_WW_Pin1_4	171	176	PF00397	0.771
DOC_WW_Pin1_4	257	262	PF00397	0.562
DOC_WW_Pin1_4	324	329	PF00397	0.691
DOC_WW_Pin1_4	337	342	PF00397	0.648
DOC_WW_Pin1_4	93	98	PF00397	0.571
LIG_14-3-3_CanoR_1	177	187	PF00244	0.502
LIG_14-3-3_CanoR_1	195	201	PF00244	0.383
LIG_14-3-3_CanoR_1	310	316	PF00244	0.546
LIG_14-3-3_CanoR_1	86	90	PF00244	0.495
LIG_Actin_WH2_2	145	161	PF00022	0.602
LIG_Actin_WH2_2	344	362	PF00022	0.416
LIG_BRCT_BRCA1_1	198	202	PF00533	0.414
LIG_Clathr_ClatBox_1	247	251	PF01394	0.623
LIG_EVH1_2	98	102	PF00568	0.451
LIG_FHA_1	1	7	PF00498	0.680
LIG_FHA_1	107	113	PF00498	0.607
LIG_FHA_1	263	269	PF00498	0.526
LIG_FHA_1	28	34	PF00498	0.670
LIG_FHA_1	61	67	PF00498	0.542
LIG_FHA_2	310	316	PF00498	0.516
LIG_FHA_2	350	356	PF00498	0.698
LIG_FHA_2	80	86	PF00498	0.535
LIG_LIR_Apic_2	257	261	PF02991	0.485
LIG_LIR_Gen_1	13	23	PF02991	0.355
LIG_LIR_Gen_1	184	193	PF02991	0.695
LIG_LIR_Gen_1	207	216	PF02991	0.439
LIG_LIR_Gen_1	352	359	PF02991	0.687
LIG_LIR_Nem_3	13	19	PF02991	0.549
LIG_LIR_Nem_3	184	190	PF02991	0.703
LIG_LIR_Nem_3	207	211	PF02991	0.445
LIG_LIR_Nem_3	285	291	PF02991	0.637
LIG_LIR_Nem_3	318	324	PF02991	0.772
LIG_LIR_Nem_3	352	356	PF02991	0.693
LIG_SH2_CRK	197	201	PF00017	0.635
LIG_SH2_CRK	208	212	PF00017	0.461
LIG_SH2_CRK	288	292	PF00017	0.536
LIG_SH2_NCK_1	208	212	PF00017	0.432
LIG_SH2_STAP1	187	191	PF00017	0.702
LIG_SH2_STAP1	23	27	PF00017	0.544
LIG_SH2_STAP1	353	357	PF00017	0.691
LIG_SH2_STAT3	23	26	PF00017	0.551
LIG_SH2_STAT5	283	286	PF00017	0.600
LIG_SH3_3	108	114	PF00018	0.648
LIG_SH3_3	265	271	PF00018	0.525
LIG_SH3_3	284	290	PF00018	0.522
LIG_SH3_3	319	325	PF00018	0.718
LIG_SH3_3	94	100	PF00018	0.604
LIG_SUMO_SIM_par_1	263	270	PF11976	0.547
LIG_TRAF2_1	352	355	PF00917	0.695
LIG_TRAF2_1	82	85	PF00917	0.661
LIG_TRFH_1	208	212	PF08558	0.646
MOD_CDC14_SPxK_1	174	177	PF00782	0.514
MOD_CDK_SPxK_1	171	177	PF00069	0.512
MOD_CK1_1	123	129	PF00069	0.577
MOD_CK1_1	176	182	PF00069	0.660
MOD_CK1_1	257	263	PF00069	0.497
MOD_CK1_1	282	288	PF00069	0.606
MOD_CK1_1	346	352	PF00069	0.631
MOD_CK2_1	349	355	PF00069	0.706
MOD_CK2_1	48	54	PF00069	0.556
MOD_CK2_1	79	85	PF00069	0.545
MOD_GlcNHglycan	122	126	PF01048	0.678
MOD_GlcNHglycan	181	184	PF01048	0.703
MOD_GlcNHglycan	262	265	PF01048	0.617
MOD_GlcNHglycan	50	53	PF01048	0.569
MOD_GSK3_1	173	180	PF00069	0.746
MOD_GSK3_1	311	318	PF00069	0.720
MOD_GSK3_1	333	340	PF00069	0.780
MOD_GSK3_1	44	51	PF00069	0.430
MOD_LATS_1	296	302	PF00433	0.408
MOD_LATS_1	77	83	PF00433	0.394
MOD_NEK2_1	106	111	PF00069	0.746
MOD_NEK2_1	33	38	PF00069	0.504
MOD_OFUCOSY	34	40	PF10250	0.599
MOD_PIKK_1	33	39	PF00454	0.494
MOD_PIKK_1	346	352	PF00454	0.719
MOD_PIKK_1	79	85	PF00454	0.582
MOD_PK_1	339	345	PF00069	0.494
MOD_PKA_1	298	304	PF00069	0.444
MOD_PKA_2	120	126	PF00069	0.493
MOD_PKA_2	176	182	PF00069	0.536
MOD_PKA_2	309	315	PF00069	0.523
MOD_PKA_2	85	91	PF00069	0.552
MOD_PKB_1	337	345	PF00069	0.716
MOD_Plk_1	12	18	PF00069	0.553
MOD_Plk_1	206	212	PF00069	0.536
MOD_Plk_1	276	282	PF00069	0.456
MOD_Plk_1	84	90	PF00069	0.553
MOD_Plk_4	148	154	PF00069	0.676
MOD_Plk_4	206	212	PF00069	0.439
MOD_Plk_4	262	268	PF00069	0.660
MOD_Plk_4	279	285	PF00069	0.488
MOD_Plk_4	343	349	PF00069	0.751
MOD_ProDKin_1	112	118	PF00069	0.462
MOD_ProDKin_1	171	177	PF00069	0.772
MOD_ProDKin_1	257	263	PF00069	0.562
MOD_ProDKin_1	324	330	PF00069	0.693
MOD_ProDKin_1	337	343	PF00069	0.644
MOD_ProDKin_1	93	99	PF00069	0.578
MOD_SUMO_rev_2	354	362	PF00179	0.682
TRG_DiLeu_BaEn_4	354	360	PF01217	0.683
TRG_DiLeu_BaEn_4	84	90	PF01217	0.649
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.549
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.534
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.664
TRG_ENDOCYTIC_2	187	190	PF00928	0.702
TRG_ENDOCYTIC_2	197	200	PF00928	0.526
TRG_ENDOCYTIC_2	208	211	PF00928	0.468
TRG_ENDOCYTIC_2	288	291	PF00928	0.543
TRG_ENDOCYTIC_2	353	356	PF00928	0.697
TRG_ER_diArg_1	364	366	PF00400	0.618
TRG_ER_diArg_1	56	58	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P503	Leptomonas seymouri	37%	94%
A0A3Q8IDK6	Leishmania donovani	81%	99%
A4HEN2	Leishmania braziliensis	69%	100%
A4I1W0	Leishmania infantum	81%	99%
Q4Q9G8	Leishmania major	81%	100%