AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised conserved protein (DUF2305), putative

Species:

Leishmania mexicana

UniProt:

E9AY04_LEIMU

TriTrypDb:

LmxM.26.0220

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	12
GO:0016020	membrane	2	8
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AY04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY04

Function

Biological processes
Term	Name	Level	Count
GO:0019915	lipid storage	3	12
GO:0051179	localization	1	12
GO:0051235	maintenance of location	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016298	lipase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.302
CLV_NRD_NRD_1	43	45	PF00675	0.392
CLV_NRD_NRD_1	49	51	PF00675	0.243
CLV_PCSK_KEX2_1	43	45	PF00082	0.380
CLV_PCSK_SKI1_1	199	203	PF00082	0.479
CLV_PCSK_SKI1_1	239	243	PF00082	0.446
CLV_PCSK_SKI1_1	255	259	PF00082	0.374
CLV_PCSK_SKI1_1	50	54	PF00082	0.212
DEG_APCC_DBOX_1	254	262	PF00400	0.263
DOC_CYCLIN_RxL_1	196	206	PF00134	0.268
DOC_MAPK_gen_1	50	56	PF00069	0.401
DOC_PP1_RVXF_1	169	175	PF00149	0.365
DOC_PP1_RVXF_1	49	56	PF00149	0.461
DOC_PP4_FxxP_1	65	68	PF00568	0.441
DOC_USP7_MATH_1	131	135	PF00917	0.480
DOC_USP7_MATH_1	158	162	PF00917	0.538
DOC_USP7_MATH_1	86	90	PF00917	0.462
DOC_WW_Pin1_4	163	168	PF00397	0.417
LIG_14-3-3_CanoR_1	146	150	PF00244	0.464
LIG_14-3-3_CanoR_1	171	175	PF00244	0.531
LIG_14-3-3_CanoR_1	281	287	PF00244	0.244
LIG_14-3-3_CanoR_1	44	54	PF00244	0.560
LIG_14-3-3_CanoR_1	97	102	PF00244	0.520
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_deltaCOP1_diTrp_1	264	271	PF00928	0.230
LIG_eIF4E_1	196	202	PF01652	0.292
LIG_FHA_1	207	213	PF00498	0.194
LIG_FHA_1	226	232	PF00498	0.249
LIG_FHA_1	270	276	PF00498	0.138
LIG_FHA_2	112	118	PF00498	0.465
LIG_FHA_2	202	208	PF00498	0.302
LIG_LIR_Gen_1	230	240	PF02991	0.278
LIG_LIR_Gen_1	25	33	PF02991	0.501
LIG_LIR_Gen_1	75	86	PF02991	0.425
LIG_LIR_Nem_3	236	241	PF02991	0.218
LIG_LIR_Nem_3	25	30	PF02991	0.495
LIG_LIR_Nem_3	264	269	PF02991	0.278
LIG_LIR_Nem_3	75	81	PF02991	0.425
LIG_NRBOX	197	203	PF00104	0.336
LIG_PTB_Apo_2	226	233	PF02174	0.279
LIG_PTB_Phospho_1	226	232	PF10480	0.315
LIG_SH2_CRK	147	151	PF00017	0.463
LIG_SH2_STAT5	260	263	PF00017	0.224
LIG_SH2_STAT5	32	35	PF00017	0.512
LIG_SH3_3	51	57	PF00018	0.439
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.419
LIG_SUMO_SIM_par_1	199	204	PF11976	0.284
LIG_TRAF2_1	34	37	PF00917	0.647
LIG_TRFH_1	154	158	PF08558	0.479
LIG_UBA3_1	190	197	PF00899	0.314
MOD_CK1_1	173	179	PF00069	0.338
MOD_CK1_1	206	212	PF00069	0.188
MOD_CK1_1	3	9	PF00069	0.608
MOD_CK2_1	201	207	PF00069	0.302
MOD_CK2_1	267	273	PF00069	0.263
MOD_CK2_1	31	37	PF00069	0.579
MOD_CK2_1	86	92	PF00069	0.497
MOD_Cter_Amidation	41	44	PF01082	0.480
MOD_GlcNHglycan	282	285	PF01048	0.483
MOD_GSK3_1	107	114	PF00069	0.516
MOD_GSK3_1	170	177	PF00069	0.493
MOD_GSK3_1	32	39	PF00069	0.634
MOD_N-GLC_1	299	304	PF02516	0.549
MOD_NEK2_1	111	116	PF00069	0.482
MOD_NEK2_1	174	179	PF00069	0.314
MOD_NEK2_1	201	206	PF00069	0.242
MOD_NEK2_1	214	219	PF00069	0.268
MOD_NEK2_1	227	232	PF00069	0.290
MOD_NEK2_1	23	28	PF00069	0.554
MOD_NEK2_1	72	77	PF00069	0.482
MOD_PKA_2	145	151	PF00069	0.523
MOD_PKA_2	170	176	PF00069	0.343
MOD_PKA_2	280	286	PF00069	0.244
MOD_Plk_4	107	113	PF00069	0.495
MOD_Plk_4	145	151	PF00069	0.382
MOD_Plk_4	170	176	PF00069	0.501
MOD_Plk_4	227	233	PF00069	0.327
MOD_Plk_4	3	9	PF00069	0.592
MOD_ProDKin_1	163	169	PF00069	0.417
TRG_DiLeu_BaEn_1	237	242	PF01217	0.315
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.302
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.285
TRG_ENDOCYTIC_2	147	150	PF00928	0.515
TRG_ENDOCYTIC_2	232	235	PF00928	0.337
TRG_ENDOCYTIC_2	66	69	PF00928	0.412
TRG_ER_diArg_1	43	45	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP9	Leptomonas seymouri	68%	100%
A0A0S4IN66	Bodo saltans	37%	100%
A0A1X0NSK1	Trypanosomatidae	45%	100%
A0A3S7WZH7	Leishmania donovani	91%	100%
A0A422NVG9	Trypanosoma rangeli	43%	100%
A4HEN1	Leishmania braziliensis	77%	100%
A4I1V9	Leishmania infantum	91%	100%
C9ZS60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
Q4Q9G9	Leishmania major	90%	100%
Q5F477	Gallus gallus	26%	97%
Q5HZX7	Rattus norvegicus	23%	97%
Q5R7E8	Pongo abelii	25%	97%
Q8BVA5	Mus musculus	24%	96%
Q9H6V9	Homo sapiens	25%	97%
Q9W0H3	Drosophila melanogaster	25%	100%
V5BUL9	Trypanosoma cruzi	44%	100%