LeishMANIAdb
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NAD-dependent protein deacetylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NAD-dependent protein deacetylase
Gene product:
Silent information regulator 2 related protein 1
Species:
Leishmania mexicana
UniProt:
E9AY03_LEIMU
TriTrypDb:
LmxM.26.0210
Length:
373

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: ipemberton@photeomix.com
Publication title: The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design
Publication 1st author(s): Ronin
Publication Identifier(s): 29543820
Host organism: -1
Interaction detection method(s): x-ray crystallography
Interaction type: direct interaction
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: A0A6L0XH39
ID(s) interactor B: P04637
Taxid interactor A: Leishmania infantum
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AY03
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY03

PDB structure(s): 5ol0_A , 5ol0_B

Function

Biological processes
Term Name Level Count
GO:0001775 cell activation 2 1
GO:0002274 myeloid leukocyte activation 3 1
GO:0002376 immune system process 1 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009605 response to external stimulus 2 1
GO:0009607 response to biotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0042113 B cell activation 4 1
GO:0042116 macrophage activation 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043207 response to external biotic stimulus 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0045321 leukocyte activation 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046649 lymphocyte activation 3 1
GO:0050896 response to stimulus 1 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0051707 response to other organism 2 1
GO:0051716 cellular response to stimulus 2 1
GO:0052167 modulation by symbiont of host innate immune response 7 1
GO:0052173 response to defenses of other organism 3 1
GO:0052200 response to host defenses 4 1
GO:0052553 modulation by symbiont of host immune response 6 1
GO:0052572 response to host immune response 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0075136 response to host 3 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004407 histone deacetylase activity 4 9
GO:0005488 binding 1 10
GO:0008270 zinc ion binding 6 8
GO:0016740 transferase activity 2 10
GO:0016787 hydrolase activity 2 9
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 9
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 9
GO:0017136 NAD-dependent histone deacetylase activity 5 9
GO:0019213 deacetylase activity 3 9
GO:0033558 protein lysine deacetylase activity 3 9
GO:0034979 NAD-dependent protein deacetylase activity 4 9
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0046914 transition metal ion binding 5 8
GO:0051287 NAD binding 4 10
GO:0070403 NAD+ binding 4 10
GO:0097159 organic cyclic compound binding 2 10
GO:0140096 catalytic activity, acting on a protein 2 9
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003950 NAD+ ADP-ribosyltransferase activity 5 1
GO:0016757 glycosyltransferase activity 3 4
GO:0016763 pentosyltransferase activity 4 1
GO:0042903 tubulin deacetylase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 308 312 PF00656 0.561
CLV_NRD_NRD_1 32 34 PF00675 0.457
CLV_PCSK_KEX2_1 32 34 PF00082 0.457
CLV_PCSK_KEX2_1 354 356 PF00082 0.497
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.484
CLV_PCSK_SKI1_1 32 36 PF00082 0.444
CLV_PCSK_SKI1_1 327 331 PF00082 0.380
DEG_APCC_DBOX_1 31 39 PF00400 0.435
DEG_SPOP_SBC_1 304 308 PF00917 0.686
DOC_CKS1_1 101 106 PF01111 0.358
DOC_MAPK_FxFP_2 250 253 PF00069 0.387
DOC_MAPK_gen_1 242 250 PF00069 0.470
DOC_MAPK_gen_1 27 36 PF00069 0.451
DOC_MAPK_HePTP_8 26 38 PF00069 0.448
DOC_MAPK_MEF2A_6 233 240 PF00069 0.378
DOC_MAPK_MEF2A_6 29 38 PF00069 0.501
DOC_PP1_RVXF_1 325 332 PF00149 0.398
DOC_PP4_FxxP_1 250 253 PF00568 0.387
DOC_PP4_FxxP_1 51 54 PF00568 0.413
DOC_USP7_MATH_1 143 147 PF00917 0.448
DOC_USP7_MATH_1 279 283 PF00917 0.714
DOC_USP7_MATH_1 304 308 PF00917 0.728
DOC_USP7_MATH_1 40 44 PF00917 0.523
DOC_WW_Pin1_4 1 6 PF00397 0.709
DOC_WW_Pin1_4 100 105 PF00397 0.445
DOC_WW_Pin1_4 133 138 PF00397 0.510
DOC_WW_Pin1_4 154 159 PF00397 0.486
DOC_WW_Pin1_4 275 280 PF00397 0.741
DOC_WW_Pin1_4 293 298 PF00397 0.777
DOC_WW_Pin1_4 50 55 PF00397 0.416
LIG_14-3-3_CanoR_1 120 129 PF00244 0.483
LIG_14-3-3_CanoR_1 175 183 PF00244 0.536
LIG_14-3-3_CanoR_1 293 297 PF00244 0.673
LIG_14-3-3_CanoR_1 355 363 PF00244 0.517
LIG_FHA_1 121 127 PF00498 0.465
LIG_FHA_1 210 216 PF00498 0.432
LIG_FHA_2 257 263 PF00498 0.555
LIG_HP1_1 236 240 PF01393 0.417
LIG_Integrin_RGD_1 332 334 PF01839 0.520
LIG_LIR_Apic_2 50 54 PF02991 0.414
LIG_LIR_Gen_1 196 207 PF02991 0.483
LIG_LIR_Gen_1 56 67 PF02991 0.453
LIG_LIR_Nem_3 196 202 PF02991 0.483
LIG_LIR_Nem_3 310 316 PF02991 0.538
LIG_LIR_Nem_3 344 348 PF02991 0.450
LIG_LIR_Nem_3 56 62 PF02991 0.453
LIG_LIR_Nem_3 84 89 PF02991 0.446
LIG_Pex14_1 96 100 PF04695 0.465
LIG_RPA_C_Fungi 237 249 PF08784 0.453
LIG_SH2_CRK 59 63 PF00017 0.302
LIG_SH2_GRB2like 59 62 PF00017 0.289
LIG_SH2_SRC 165 168 PF00017 0.460
LIG_SH2_SRC 261 264 PF00017 0.364
LIG_SH2_STAP1 261 265 PF00017 0.366
LIG_SH2_STAT5 165 168 PF00017 0.409
LIG_SH2_STAT5 25 28 PF00017 0.367
LIG_SH2_STAT5 345 348 PF00017 0.445
LIG_SH3_3 2 8 PF00018 0.658
LIG_SH3_3 250 256 PF00018 0.526
LIG_SUMO_SIM_anti_2 210 215 PF11976 0.322
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.327
LIG_SUMO_SIM_par_1 210 218 PF11976 0.419
LIG_TRAF2_1 297 300 PF00917 0.723
LIG_TRAF2_1 8 11 PF00917 0.621
LIG_TRFH_1 224 228 PF08558 0.420
MOD_CDK_SPK_2 1 6 PF00069 0.666
MOD_CDK_SPK_2 293 298 PF00069 0.573
MOD_CK1_1 174 180 PF00069 0.443
MOD_CK1_1 271 277 PF00069 0.719
MOD_CK1_1 305 311 PF00069 0.601
MOD_CK1_1 53 59 PF00069 0.302
MOD_CK2_1 293 299 PF00069 0.748
MOD_DYRK1A_RPxSP_1 293 297 PF00069 0.497
MOD_GlcNHglycan 169 172 PF01048 0.460
MOD_GlcNHglycan 279 282 PF01048 0.729
MOD_GSK3_1 167 174 PF00069 0.460
MOD_GSK3_1 269 276 PF00069 0.683
MOD_GSK3_1 302 309 PF00069 0.616
MOD_GSK3_1 68 75 PF00069 0.327
MOD_NEK2_1 169 174 PF00069 0.383
MOD_NEK2_2 256 261 PF00069 0.594
MOD_PIKK_1 120 126 PF00454 0.319
MOD_PIKK_1 271 277 PF00454 0.760
MOD_PKA_2 174 180 PF00069 0.443
MOD_PKA_2 292 298 PF00069 0.674
MOD_PKA_2 356 362 PF00069 0.523
MOD_Plk_1 209 215 PF00069 0.169
MOD_Plk_4 209 215 PF00069 0.268
MOD_Plk_4 256 262 PF00069 0.420
MOD_ProDKin_1 1 7 PF00069 0.697
MOD_ProDKin_1 100 106 PF00069 0.291
MOD_ProDKin_1 133 139 PF00069 0.383
MOD_ProDKin_1 154 160 PF00069 0.348
MOD_ProDKin_1 275 281 PF00069 0.741
MOD_ProDKin_1 293 299 PF00069 0.779
MOD_ProDKin_1 50 56 PF00069 0.250
MOD_SUMO_for_1 297 300 PF00179 0.509
TRG_DiLeu_BaLyEn_6 107 112 PF01217 0.354
TRG_DiLeu_BaLyEn_6 114 119 PF01217 0.278
TRG_ENDOCYTIC_2 345 348 PF00928 0.445
TRG_ENDOCYTIC_2 59 62 PF00928 0.302
TRG_ER_diArg_1 31 33 PF00400 0.457
TRG_ER_diArg_1 355 358 PF00400 0.589
TRG_Pf-PMV_PEXEL_1 110 114 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVQ5 Leptomonas seymouri 69% 98%
A0A1X0NT02 Trypanosomatidae 57% 100%
A0A3Q8IDH7 Leishmania donovani 92% 100%
A0A422NVE3 Trypanosoma rangeli 55% 100%
A0A6L0XH39 Leishmania infantum 93% 100%
A8NWP2 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 28% 100%
B0RM75 Xanthomonas campestris pv. campestris (strain B100) 28% 100%
B2RZ55 Rattus norvegicus 26% 93%
C8V3W5 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 37% 76%
C9ZS62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E1BRE2 Gallus gallus 28% 100%
E2RDZ6 Canis lupus familiaris 31% 100%
E9AIR9 Leishmania braziliensis 78% 100%
F7DKV7 Xenopus tropicalis 31% 100%
F7EZ75 Macaca mulatta 30% 100%
O94640 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 79%
P06700 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 66%
P0CS88 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 38% 100%
P53685 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 74%
P53686 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P53687 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 83%
Q0P595 Bos taurus 26% 93%
Q25337 Leishmania major 91% 100%
Q3ZBQ0 Bos taurus 30% 100%
Q4UZX0 Xanthomonas campestris pv. campestris (strain 8004) 28% 100%
Q54QE6 Dictyostelium discoideum 46% 73%
Q57V41 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 50% 100%
Q5A1W9 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 77%
Q5AW69 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 52% 100%
Q5HZN8 Xenopus laevis 30% 100%
Q5R6G3 Pongo abelii 30% 100%
Q68F47 Xenopus laevis 30% 100%
Q68FX9 Rattus norvegicus 29% 100%
Q6FWI7 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 36% 73%
Q757M7 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 37% 67%
Q89EA6 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 29% 100%
Q8BKJ9 Mus musculus 26% 93%
Q8K2C6 Mus musculus 29% 100%
Q8PDM9 Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) 28% 100%
Q8PQK3 Xanthomonas axonopodis pv. citri (strain 306) 30% 100%
Q9NRC8 Homo sapiens 25% 93%
Q9NXA8 Homo sapiens 30% 100%
V5BZF3 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS