Putative 60S ribosomal protein L7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7, putative

Species:

Leishmania mexicana

UniProt:

E9AXZ9_LEIMU

TriTrypDb:

LmxM.26.0180

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	17
GO:0022625	cytosolic large ribosomal subunit	5	17
GO:0032991	protein-containing complex	1	17
GO:0044391	ribosomal subunit	3	17
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AXZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXZ9

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	17
GO:0000470	maturation of LSU-rRNA	9	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006364	rRNA processing	8	17
GO:0006396	RNA processing	6	17
GO:0006725	cellular aromatic compound metabolic process	3	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016070	RNA metabolic process	5	17
GO:0016072	rRNA metabolic process	7	17
GO:0034470	ncRNA processing	7	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034660	ncRNA metabolic process	6	17
GO:0043170	macromolecule metabolic process	3	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0046483	heterocycle metabolic process	3	17
GO:0071704	organic substance metabolic process	2	17
GO:0090304	nucleic acid metabolic process	4	17
GO:1901360	organic cyclic compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.211
CLV_NRD_NRD_1	147	149	PF00675	0.355
CLV_NRD_NRD_1	266	268	PF00675	0.470
CLV_NRD_NRD_1	80	82	PF00675	0.513
CLV_NRD_NRD_1	96	98	PF00675	0.391
CLV_PCSK_FUR_1	263	267	PF00082	0.483
CLV_PCSK_KEX2_1	114	116	PF00082	0.325
CLV_PCSK_KEX2_1	198	200	PF00082	0.411
CLV_PCSK_KEX2_1	265	267	PF00082	0.483
CLV_PCSK_KEX2_1	62	64	PF00082	0.343
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.411
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.483
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.343
CLV_PCSK_SKI1_1	109	113	PF00082	0.413
CLV_PCSK_SKI1_1	148	152	PF00082	0.343
CLV_PCSK_SKI1_1	157	161	PF00082	0.343
CLV_PCSK_SKI1_1	2	6	PF00082	0.421
CLV_PCSK_SKI1_1	63	67	PF00082	0.343
CLV_PCSK_SKI1_1	82	86	PF00082	0.343
DEG_APCC_DBOX_1	147	155	PF00400	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.423
DOC_ANK_TNKS_1	266	273	PF00023	0.486
DOC_MAPK_DCC_7	2	11	PF00069	0.424
DOC_MAPK_FxFP_2	5	8	PF00069	0.421
DOC_MAPK_gen_1	146	156	PF00069	0.343
DOC_MAPK_gen_1	198	204	PF00069	0.406
DOC_PP2B_LxvP_1	255	258	PF13499	0.417
DOC_PP4_FxxP_1	5	8	PF00568	0.421
DOC_USP7_MATH_1	10	14	PF00917	0.439
DOC_USP7_MATH_1	40	44	PF00917	0.749
DOC_USP7_UBL2_3	142	146	PF12436	0.355
DOC_USP7_UBL2_3	85	89	PF12436	0.386
DOC_WW_Pin1_4	16	21	PF00397	0.470
DOC_WW_Pin1_4	24	29	PF00397	0.493
LIG_14-3-3_CanoR_1	115	125	PF00244	0.392
LIG_14-3-3_CanoR_1	14	18	PF00244	0.462
LIG_14-3-3_CanoR_1	208	217	PF00244	0.512
LIG_Actin_WH2_2	160	178	PF00022	0.343
LIG_FHA_1	160	166	PF00498	0.343
LIG_FHA_1	39	45	PF00498	0.742
LIG_FHA_1	89	95	PF00498	0.428
LIG_LIR_Gen_1	162	171	PF02991	0.343
LIG_LIR_Nem_3	179	184	PF02991	0.426
LIG_LYPXL_yS_3	186	189	PF13949	0.384
LIG_PCNA_yPIPBox_3	142	154	PF02747	0.345
LIG_PCNA_yPIPBox_3	166	175	PF02747	0.355
LIG_Pex14_2	160	164	PF04695	0.343
LIG_Pex14_2	3	7	PF04695	0.421
LIG_PTB_Apo_2	158	165	PF02174	0.343
LIG_PTB_Apo_2	231	238	PF02174	0.383
LIG_PTB_Phospho_1	231	237	PF10480	0.376
LIG_Rb_LxCxE_1	225	238	PF01857	0.451
LIG_RPA_C_Fungi	76	88	PF08784	0.407
LIG_SH2_CRK	184	188	PF00017	0.377
LIG_SH2_NCK_1	221	225	PF00017	0.590
LIG_SH2_SRC	124	127	PF00017	0.369
LIG_SH2_STAP1	99	103	PF00017	0.343
LIG_SH2_STAT5	124	127	PF00017	0.355
LIG_SH2_STAT5	181	184	PF00017	0.366
LIG_SH2_STAT5	201	204	PF00017	0.234
LIG_SH2_STAT5	237	240	PF00017	0.436
LIG_SH2_STAT5	93	96	PF00017	0.472
LIG_SH3_3	49	55	PF00018	0.611
LIG_SUMO_SIM_par_1	130	135	PF11976	0.256
LIG_SUMO_SIM_par_1	7	13	PF11976	0.428
LIG_TRFH_1	253	257	PF08558	0.415
MOD_CK1_1	13	19	PF00069	0.464
MOD_CK1_1	188	194	PF00069	0.390
MOD_GlcNHglycan	22	25	PF01048	0.491
MOD_GlcNHglycan	58	61	PF01048	0.332
MOD_GSK3_1	20	27	PF00069	0.490
MOD_GSK3_1	34	41	PF00069	0.504
MOD_GSK3_1	9	16	PF00069	0.446
MOD_N-GLC_1	24	29	PF02516	0.502
MOD_N-GLC_1	46	51	PF02516	0.684
MOD_NEK2_1	88	93	PF00069	0.377
MOD_NEK2_1	9	14	PF00069	0.437
MOD_NEK2_2	40	45	PF00069	0.568
MOD_PKA_1	34	40	PF00069	0.491
MOD_PKA_1	97	103	PF00069	0.483
MOD_PKA_2	13	19	PF00069	0.459
MOD_PKA_2	277	283	PF00069	0.421
MOD_PKB_1	95	103	PF00069	0.483
MOD_Plk_4	159	165	PF00069	0.343
MOD_Plk_4	277	283	PF00069	0.421
MOD_Plk_4	40	46	PF00069	0.716
MOD_ProDKin_1	16	22	PF00069	0.473
MOD_ProDKin_1	24	30	PF00069	0.495
MOD_SUMO_rev_2	102	111	PF00179	0.345
TRG_ENDOCYTIC_2	186	189	PF00928	0.384
TRG_ENDOCYTIC_2	201	204	PF00928	0.403
TRG_ER_diArg_1	113	115	PF00400	0.193
TRG_ER_diArg_1	154	157	PF00400	0.343
TRG_ER_diArg_1	94	97	PF00400	0.506
TRG_NLS_MonoExtN_4	263	269	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU7	Leptomonas seymouri	92%	100%
A0A0S4IU62	Bodo saltans	82%	100%
A0A0S4JDH9	Bodo saltans	24%	83%
A0A1D8PDL6	Candida albicans (strain SC5314 / ATCC MYA-2876)	42%	100%
A0A1X0NSK2	Trypanosomatidae	86%	100%
A0A3Q8INU3	Leishmania donovani	98%	100%
A0A3R7M5J8	Trypanosoma rangeli	77%	100%
A0A3S7WZH9	Leishmania donovani	98%	100%
A0A422NVF3	Trypanosoma rangeli	85%	100%
A0BD73	Paramecium tetraurelia	43%	100%
A0CEY2	Paramecium tetraurelia	42%	100%
A4HEM2	Leishmania braziliensis	96%	100%
A4HEM3	Leishmania braziliensis	92%	100%
A4I1V4	Leishmania infantum	95%	100%
C9ZS66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
C9ZS67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9AHB0	Leishmania infantum	98%	100%
E9AXZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O01802	Caenorhabditis elegans	47%	100%
O60143	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P05426	Rattus norvegicus	48%	100%
P05737	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P0DJ13	Tetrahymena thermophila	40%	100%
P11874	Dictyostelium discoideum	45%	100%
P14148	Mus musculus	49%	100%
P17937	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P18124	Homo sapiens	48%	100%
P25457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P32100	Drosophila melanogaster	48%	100%
P60039	Arabidopsis thaliana	44%	100%
P60040	Arabidopsis thaliana	45%	100%
Q12213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q4Q9H4	Leishmania major	98%	100%
Q4R506	Macaca fascicularis	48%	100%
Q58DT1	Bos taurus	49%	100%
Q5R9R4	Pongo abelii	49%	100%
Q5RAH8	Pongo abelii	29%	100%
Q5ZJ56	Gallus gallus	50%	100%
Q6BTA4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	43%	100%
Q6C603	Yarrowia lipolytica (strain CLIB 122 / E 150)	45%	100%
Q6DKI1	Homo sapiens	29%	100%
Q6FSN6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	43%	100%
Q755A7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	100%
Q7SBD5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q8SS93	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q9D8M4	Mus musculus	29%	100%
Q9LHP1	Arabidopsis thaliana	45%	100%
Q9SAI5	Arabidopsis thaliana	34%	100%
V5DR72	Trypanosoma cruzi	84%	100%