Nuclear lim interactor-interacting factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear lim interactor-interacting factor-like protein

Species:

Leishmania mexicana

UniProt:

E9AXZ7_LEIMU

TriTrypDb:

LmxM.26.0160

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXZ7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0016791	phosphatase activity	5	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.421
CLV_NRD_NRD_1	225	227	PF00675	0.393
CLV_NRD_NRD_1	69	71	PF00675	0.575
CLV_NRD_NRD_1	81	83	PF00675	0.345
CLV_PCSK_KEX2_1	168	170	PF00082	0.421
CLV_PCSK_KEX2_1	225	227	PF00082	0.393
CLV_PCSK_KEX2_1	69	71	PF00082	0.616
CLV_PCSK_PC7_1	164	170	PF00082	0.421
CLV_PCSK_SKI1_1	138	142	PF00082	0.467
CLV_PCSK_SKI1_1	257	261	PF00082	0.326
CLV_PCSK_SKI1_1	99	103	PF00082	0.491
DEG_APCC_DBOX_1	98	106	PF00400	0.257
DEG_SPOP_SBC_1	57	61	PF00917	0.693
DOC_CDC14_PxL_1	260	268	PF14671	0.355
DOC_CYCLIN_yCln2_LP_2	101	104	PF00134	0.485
DOC_MAPK_DCC_7	99	107	PF00069	0.536
DOC_MAPK_gen_1	168	175	PF00069	0.290
DOC_MAPK_gen_1	222	230	PF00069	0.268
DOC_MAPK_gen_1	255	263	PF00069	0.251
DOC_MAPK_MEF2A_6	112	119	PF00069	0.278
DOC_MAPK_MEF2A_6	255	263	PF00069	0.290
DOC_MAPK_MEF2A_6	99	107	PF00069	0.465
DOC_MAPK_NFAT4_5	112	120	PF00069	0.309
DOC_PP2B_LxvP_1	101	104	PF13499	0.411
DOC_PP2B_LxvP_1	140	143	PF13499	0.305
DOC_PP2B_LxvP_1	261	264	PF13499	0.251
DOC_SPAK_OSR1_1	169	173	PF12202	0.393
DOC_USP7_MATH_1	106	110	PF00917	0.498
DOC_WW_Pin1_4	230	235	PF00397	0.294
DOC_WW_Pin1_4	38	43	PF00397	0.714
DOC_WW_Pin1_4	81	86	PF00397	0.450
LIG_14-3-3_CanoR_1	25	33	PF00244	0.656
LIG_Actin_WH2_2	210	227	PF00022	0.393
LIG_APCC_ABBA_1	199	204	PF00400	0.308
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	166	170	PF00533	0.393
LIG_eIF4E_1	136	142	PF01652	0.437
LIG_EVH1_1	102	106	PF00568	0.398
LIG_EVH1_2	103	107	PF00568	0.429
LIG_FHA_1	112	118	PF00498	0.283
LIG_FHA_1	146	152	PF00498	0.294
LIG_FHA_1	190	196	PF00498	0.355
LIG_FHA_1	59	65	PF00498	0.685
LIG_FHA_2	205	211	PF00498	0.393
LIG_FHA_2	6	12	PF00498	0.597
LIG_FHA_2	74	80	PF00498	0.545
LIG_LIR_Gen_1	133	143	PF02991	0.413
LIG_LIR_Gen_1	160	170	PF02991	0.305
LIG_LIR_Gen_1	258	266	PF02991	0.362
LIG_LIR_Gen_1	273	284	PF02991	0.326
LIG_LIR_Nem_3	133	139	PF02991	0.403
LIG_LIR_Nem_3	152	158	PF02991	0.124
LIG_LIR_Nem_3	160	165	PF02991	0.276
LIG_LIR_Nem_3	167	173	PF02991	0.246
LIG_LIR_Nem_3	258	263	PF02991	0.362
LIG_LIR_Nem_3	273	279	PF02991	0.336
LIG_MAD2	226	234	PF02301	0.290
LIG_MYND_1	100	104	PF01753	0.463
LIG_PCNA_TLS_4	156	163	PF02747	0.290
LIG_PDZ_Class_3	285	290	PF00595	0.469
LIG_REV1ctd_RIR_1	13	21	PF16727	0.611
LIG_SH2_CRK	136	140	PF00017	0.320
LIG_SH2_STAP1	136	140	PF00017	0.342
LIG_SH2_STAP1	149	153	PF00017	0.342
LIG_SH2_STAT3	237	240	PF00017	0.308
LIG_SH2_STAT5	149	152	PF00017	0.299
LIG_SH2_STAT5	158	161	PF00017	0.287
LIG_SH2_STAT5	182	185	PF00017	0.308
LIG_SH2_STAT5	213	216	PF00017	0.294
LIG_SH3_3	97	103	PF00018	0.479
LIG_SH3_4	6	13	PF00018	0.622
LIG_SUMO_SIM_anti_2	137	145	PF11976	0.251
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.526
LIG_SUMO_SIM_par_1	113	118	PF11976	0.306
LIG_SUMO_SIM_par_1	137	145	PF11976	0.391
LIG_SUMO_SIM_par_1	226	231	PF11976	0.311
LIG_TRAF2_1	8	11	PF00917	0.621
LIG_TRFH_1	260	264	PF08558	0.393
LIG_TYR_ITIM	134	139	PF00017	0.393
LIG_WRPW_2	155	158	PF00400	0.308
LIG_WW_2	103	106	PF00397	0.415
MOD_CK1_1	274	280	PF00069	0.329
MOD_CK1_1	34	40	PF00069	0.669
MOD_CK2_1	5	11	PF00069	0.579
MOD_GlcNHglycan	2	5	PF01048	0.756
MOD_GlcNHglycan	27	30	PF01048	0.737
MOD_GSK3_1	119	126	PF00069	0.297
MOD_GSK3_1	141	148	PF00069	0.324
MOD_GSK3_1	34	41	PF00069	0.575
MOD_N-GLC_1	38	43	PF02516	0.590
MOD_N-GLC_1	70	75	PF02516	0.552
MOD_N-GLC_1	86	91	PF02516	0.404
MOD_NEK2_1	123	128	PF00069	0.304
MOD_NEK2_1	175	180	PF00069	0.308
MOD_NEK2_1	23	28	PF00069	0.532
MOD_NEK2_1	271	276	PF00069	0.409
MOD_NEK2_2	149	154	PF00069	0.347
MOD_PIKK_1	189	195	PF00454	0.222
MOD_PIKK_1	31	37	PF00454	0.716
MOD_PIKK_1	45	51	PF00454	0.415
MOD_PIKK_1	6	12	PF00454	0.561
MOD_PKA_2	24	30	PF00069	0.669
MOD_Plk_1	119	125	PF00069	0.308
MOD_Plk_1	209	215	PF00069	0.316
MOD_Plk_2-3	204	210	PF00069	0.393
MOD_Plk_4	111	117	PF00069	0.344
MOD_Plk_4	119	125	PF00069	0.307
MOD_Plk_4	246	252	PF00069	0.335
MOD_Plk_4	271	277	PF00069	0.332
MOD_ProDKin_1	230	236	PF00069	0.294
MOD_ProDKin_1	38	44	PF00069	0.708
MOD_ProDKin_1	81	87	PF00069	0.443
MOD_SUMO_rev_2	144	148	PF00179	0.251
TRG_AP2beta_CARGO_1	160	169	PF09066	0.290
TRG_DiLeu_BaEn_1	258	263	PF01217	0.297
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.375
TRG_DiLeu_LyEn_5	97	102	PF01217	0.372
TRG_ENDOCYTIC_2	136	139	PF00928	0.327
TRG_ENDOCYTIC_2	276	279	PF00928	0.344
TRG_ER_diArg_1	168	170	PF00400	0.424
TRG_ER_diArg_1	224	226	PF00400	0.393
TRG_NES_CRM1_1	219	231	PF08389	0.144
TRG_NES_CRM1_1	44	58	PF08389	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD7	Leptomonas seymouri	72%	100%
A0A0N1PG96	Leptomonas seymouri	53%	82%
A0A0S4IJH3	Bodo saltans	42%	100%
A0A0S4IMS1	Bodo saltans	52%	86%
A0A0S4JIG1	Bodo saltans	42%	79%
A0A0S4JKZ9	Bodo saltans	28%	66%
A0A1X0NYI7	Trypanosomatidae	50%	72%
A0A3Q8IDG4	Leishmania donovani	51%	79%
A0A3R7NSE5	Trypanosoma rangeli	28%	100%
A0A3S7WZH2	Leishmania donovani	95%	100%
A0A422P4K3	Trypanosoma rangeli	46%	71%
A4HD85	Leishmania braziliensis	25%	75%
A4HEA5	Leishmania braziliensis	50%	79%
A4HEM1	Leishmania braziliensis	87%	100%
A4I1Q1	Leishmania infantum	51%	79%
A4I1V3	Leishmania infantum	96%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	69%
E9AEA2	Leishmania major	28%	100%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	79%
O14595	Homo sapiens	38%	100%
P58466	Mus musculus	43%	100%
Q07949	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	73%
Q20432	Caenorhabditis elegans	39%	100%
Q4Q9H6	Leishmania major	95%	100%
Q4Q9N6	Leishmania major	51%	80%
Q61C05	Caenorhabditis briggsae	39%	100%
Q8BX07	Mus musculus	41%	100%
Q9GZU7	Homo sapiens	43%	100%
Q9PTJ6	Gallus gallus	39%	100%
V5BSW0	Trypanosoma cruzi	29%	100%