Mini-chromosome maintenance complex-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mini-chromosome maintenance complex-binding protein

Species:

Leishmania mexicana

UniProt:

E9AXZ6_LEIMU

TriTrypDb:

LmxM.26.0150

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AXZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.390
CLV_C14_Caspase3-7	452	456	PF00656	0.322
CLV_C14_Caspase3-7	496	500	PF00656	0.390
CLV_C14_Caspase3-7	89	93	PF00656	0.674
CLV_NRD_NRD_1	133	135	PF00675	0.302
CLV_NRD_NRD_1	157	159	PF00675	0.451
CLV_NRD_NRD_1	560	562	PF00675	0.435
CLV_PCSK_KEX2_1	135	137	PF00082	0.302
CLV_PCSK_KEX2_1	560	562	PF00082	0.326
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.302
CLV_PCSK_SKI1_1	520	524	PF00082	0.440
CLV_Separin_Metazoa	370	374	PF03568	0.326
DEG_APCC_DBOX_1	494	502	PF00400	0.337
DEG_SCF_FBW7_1	268	275	PF00400	0.295
DEG_SPOP_SBC_1	147	151	PF00917	0.326
DOC_CKS1_1	282	287	PF01111	0.391
DOC_CYCLIN_RxL_1	259	271	PF00134	0.390
DOC_CYCLIN_RxL_1	517	526	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.337
DOC_PP2B_LxvP_1	440	443	PF13499	0.385
DOC_PP2B_LxvP_1	504	507	PF13499	0.231
DOC_PP4_FxxP_1	189	192	PF00568	0.415
DOC_USP7_MATH_1	148	152	PF00917	0.387
DOC_USP7_MATH_1	190	194	PF00917	0.374
DOC_USP7_MATH_1	272	276	PF00917	0.417
DOC_WW_Pin1_4	268	273	PF00397	0.362
DOC_WW_Pin1_4	281	286	PF00397	0.308
DOC_WW_Pin1_4	287	292	PF00397	0.257
DOC_WW_Pin1_4	31	36	PF00397	0.508
DOC_WW_Pin1_4	341	346	PF00397	0.325
DOC_WW_Pin1_4	378	383	PF00397	0.321
DOC_WW_Pin1_4	470	475	PF00397	0.400
DOC_WW_Pin1_4	505	510	PF00397	0.317
DOC_WW_Pin1_4	591	596	PF00397	0.507
LIG_14-3-3_CanoR_1	162	171	PF00244	0.375
LIG_14-3-3_CanoR_1	465	471	PF00244	0.341
LIG_14-3-3_CanoR_1	583	588	PF00244	0.340
LIG_BIR_II_1	1	5	PF00653	0.337
LIG_BRCT_BRCA1_1	185	189	PF00533	0.402
LIG_deltaCOP1_diTrp_1	415	423	PF00928	0.390
LIG_DLG_GKlike_1	583	590	PF00625	0.357
LIG_EH_1	216	220	PF12763	0.390
LIG_FHA_1	203	209	PF00498	0.297
LIG_FHA_1	282	288	PF00498	0.405
LIG_FHA_1	295	301	PF00498	0.324
LIG_FHA_1	302	308	PF00498	0.343
LIG_FHA_1	366	372	PF00498	0.446
LIG_FHA_1	391	397	PF00498	0.317
LIG_FHA_1	437	443	PF00498	0.321
LIG_FHA_1	446	452	PF00498	0.346
LIG_FHA_1	484	490	PF00498	0.402
LIG_FHA_2	150	156	PF00498	0.417
LIG_FHA_2	162	168	PF00498	0.341
LIG_FHA_2	306	312	PF00498	0.415
LIG_FHA_2	38	44	PF00498	0.555
LIG_FHA_2	511	517	PF00498	0.326
LIG_IRF3_LxIS_1	338	343	PF10401	0.390
LIG_LIR_Apic_2	103	108	PF02991	0.289
LIG_LIR_Apic_2	186	192	PF02991	0.393
LIG_LIR_Gen_1	244	254	PF02991	0.346
LIG_LIR_Gen_1	314	324	PF02991	0.280
LIG_LIR_Gen_1	420	431	PF02991	0.315
LIG_LIR_Gen_1	434	444	PF02991	0.268
LIG_LIR_Nem_3	226	230	PF02991	0.272
LIG_LIR_Nem_3	244	249	PF02991	0.303
LIG_LIR_Nem_3	269	273	PF02991	0.321
LIG_LIR_Nem_3	314	320	PF02991	0.280
LIG_LIR_Nem_3	420	426	PF02991	0.402
LIG_LIR_Nem_3	434	440	PF02991	0.314
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.409
LIG_PTB_Apo_2	538	545	PF02174	0.272
LIG_SH2_CRK	270	274	PF00017	0.415
LIG_SH2_NCK_1	270	274	PF00017	0.422
LIG_SH2_PTP2	105	108	PF00017	0.302
LIG_SH2_SRC	105	108	PF00017	0.281
LIG_SH2_SRC	497	500	PF00017	0.415
LIG_SH2_STAT3	228	231	PF00017	0.415
LIG_SH2_STAT3	435	438	PF00017	0.302
LIG_SH2_STAT5	105	108	PF00017	0.281
LIG_SH2_STAT5	27	30	PF00017	0.499
LIG_SH2_STAT5	270	273	PF00017	0.372
LIG_SH2_STAT5	302	305	PF00017	0.336
LIG_SH2_STAT5	31	34	PF00017	0.500
LIG_SH2_STAT5	317	320	PF00017	0.208
LIG_SH2_STAT5	390	393	PF00017	0.390
LIG_SH2_STAT5	497	500	PF00017	0.280
LIG_SH2_STAT6	229	233	PF00017	0.311
LIG_SH3_3	41	47	PF00018	0.497
LIG_SUMO_SIM_par_1	337	344	PF11976	0.415
LIG_SUMO_SIM_par_1	441	448	PF11976	0.317
LIG_TRAF2_1	151	154	PF00917	0.326
LIG_TRAF2_1	479	482	PF00917	0.326
LIG_TYR_ITIM	268	273	PF00017	0.390
LIG_UBA3_1	422	428	PF00899	0.354
MOD_CDK_SPK_2	378	383	PF00069	0.321
MOD_CDK_SPxxK_3	31	38	PF00069	0.497
MOD_CDK_SPxxK_3	470	477	PF00069	0.326
MOD_CK1_1	122	128	PF00069	0.247
MOD_CK1_1	15	21	PF00069	0.514
MOD_CK1_1	178	184	PF00069	0.459
MOD_CK1_1	290	296	PF00069	0.391
MOD_CK1_1	410	416	PF00069	0.341
MOD_CK2_1	147	153	PF00069	0.350
MOD_CK2_1	161	167	PF00069	0.241
MOD_CK2_1	17	23	PF00069	0.539
MOD_CK2_1	410	416	PF00069	0.368
MOD_Cter_Amidation	558	561	PF01082	0.326
MOD_GlcNHglycan	124	127	PF01048	0.372
MOD_GlcNHglycan	17	20	PF01048	0.480
MOD_GlcNHglycan	180	183	PF01048	0.339
MOD_GlcNHglycan	249	252	PF01048	0.415
MOD_GlcNHglycan	329	332	PF01048	0.358
MOD_GlcNHglycan	351	355	PF01048	0.352
MOD_GlcNHglycan	490	493	PF01048	0.417
MOD_GlcNHglycan	84	87	PF01048	0.575
MOD_GSK3_1	13	20	PF00069	0.497
MOD_GSK3_1	142	149	PF00069	0.330
MOD_GSK3_1	161	168	PF00069	0.388
MOD_GSK3_1	171	178	PF00069	0.302
MOD_GSK3_1	268	275	PF00069	0.336
MOD_GSK3_1	290	297	PF00069	0.451
MOD_GSK3_1	301	308	PF00069	0.324
MOD_GSK3_1	466	473	PF00069	0.341
MOD_GSK3_1	512	519	PF00069	0.353
MOD_GSK3_1	550	557	PF00069	0.317
MOD_GSK3_1	585	592	PF00069	0.566
MOD_N-GLC_1	252	257	PF02516	0.390
MOD_N-GLC_1	399	404	PF02516	0.268
MOD_N-GLC_1	540	545	PF02516	0.272
MOD_NEK2_1	14	19	PF00069	0.566
MOD_NEK2_1	266	271	PF00069	0.466
MOD_NEK2_1	303	308	PF00069	0.324
MOD_NEK2_1	340	345	PF00069	0.415
MOD_NEK2_1	466	471	PF00069	0.386
MOD_NEK2_1	50	55	PF00069	0.513
MOD_NEK2_1	523	528	PF00069	0.325
MOD_NEK2_1	550	555	PF00069	0.333
MOD_NEK2_1	74	79	PF00069	0.473
MOD_NEK2_1	81	86	PF00069	0.509
MOD_PIKK_1	172	178	PF00454	0.175
MOD_PIKK_1	45	51	PF00454	0.519
MOD_PKA_2	122	128	PF00069	0.326
MOD_PKA_2	161	167	PF00069	0.316
MOD_PKA_2	247	253	PF00069	0.356
MOD_PKA_2	37	43	PF00069	0.551
MOD_PKA_2	516	522	PF00069	0.411
MOD_PKB_1	581	589	PF00069	0.326
MOD_Plk_1	444	450	PF00069	0.321
MOD_Plk_1	510	516	PF00069	0.338
MOD_Plk_1	540	546	PF00069	0.272
MOD_Plk_2-3	407	413	PF00069	0.151
MOD_Plk_4	100	106	PF00069	0.309
MOD_Plk_4	585	591	PF00069	0.527
MOD_ProDKin_1	268	274	PF00069	0.362
MOD_ProDKin_1	281	287	PF00069	0.308
MOD_ProDKin_1	31	37	PF00069	0.504
MOD_ProDKin_1	341	347	PF00069	0.325
MOD_ProDKin_1	378	384	PF00069	0.321
MOD_ProDKin_1	470	476	PF00069	0.400
MOD_ProDKin_1	505	511	PF00069	0.317
MOD_ProDKin_1	591	597	PF00069	0.504
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.415
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.326
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.422
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.415
TRG_ENDOCYTIC_2	230	233	PF00928	0.311
TRG_ENDOCYTIC_2	270	273	PF00928	0.415
TRG_ENDOCYTIC_2	317	320	PF00928	0.272
TRG_ENDOCYTIC_2	419	422	PF00928	0.411
TRG_ENDOCYTIC_2	437	440	PF00928	0.273
TRG_ER_diArg_1	133	136	PF00400	0.306
TRG_ER_diArg_1	576	579	PF00400	0.402
TRG_NES_CRM1_1	441	455	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX8	Leptomonas seymouri	53%	95%
A0A0S4IND2	Bodo saltans	29%	100%
A0A0S4ISE5	Bodo saltans	29%	100%
A0A1X0NSJ6	Trypanosomatidae	35%	99%
A0A3Q8ICQ6	Leishmania donovani	91%	100%
A0A422NVG0	Trypanosoma rangeli	38%	100%
A4HEM0	Leishmania braziliensis	75%	100%
A4I1V2	Leishmania infantum	91%	100%
A5PJM5	Bos taurus	21%	93%
B1H268	Rattus norvegicus	24%	93%
C9ZS69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
Q4Q9H7	Leishmania major	93%	100%
Q501D5	Arabidopsis thaliana	25%	100%
Q5ZJV4	Gallus gallus	23%	94%
Q803A6	Danio rerio	25%	95%
Q8R3C0	Mus musculus	23%	93%
Q9BTE3	Homo sapiens	22%	93%
Q9VM60	Drosophila melanogaster	24%	99%
V5BZF8	Trypanosoma cruzi	37%	100%