DUF2085 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXZ3_LEIMU

TriTrypDb:

LmxM.26.0075 , LmxM.26.0115

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AXZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004175	endopeptidase activity	4	3
GO:0004252	serine-type endopeptidase activity	5	3
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	4
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.475
CLV_NRD_NRD_1	213	215	PF00675	0.708
CLV_NRD_NRD_1	220	222	PF00675	0.703
CLV_PCSK_KEX2_1	155	157	PF00082	0.415
CLV_PCSK_KEX2_1	183	185	PF00082	0.430
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.429
CLV_PCSK_PC7_1	179	185	PF00082	0.524
CLV_PCSK_SKI1_1	221	225	PF00082	0.710
CLV_PCSK_SKI1_1	47	51	PF00082	0.610
CLV_PCSK_SKI1_1	85	89	PF00082	0.682
CLV_PCSK_SKI1_1	94	98	PF00082	0.412
DOC_MAPK_gen_1	183	191	PF00069	0.609
DOC_USP7_MATH_1	115	119	PF00917	0.719
DOC_WW_Pin1_4	121	126	PF00397	0.660
DOC_WW_Pin1_4	174	179	PF00397	0.693
LIG_14-3-3_CanoR_1	94	101	PF00244	0.169
LIG_Actin_WH2_2	139	157	PF00022	0.708
LIG_BRCT_BRCA1_1	206	210	PF00533	0.373
LIG_BRCT_BRCA1_1	53	57	PF00533	0.466
LIG_eIF4E_1	100	106	PF01652	0.365
LIG_eIF4E_1	139	145	PF01652	0.706
LIG_eIF4E_1	175	181	PF01652	0.700
LIG_FHA_1	139	145	PF00498	0.645
LIG_FHA_1	19	25	PF00498	0.350
LIG_FHA_1	69	75	PF00498	0.466
LIG_FHA_1	86	92	PF00498	0.434
LIG_FHA_2	169	175	PF00498	0.640
LIG_FHA_2	211	217	PF00498	0.403
LIG_LIR_Apic_2	173	178	PF02991	0.595
LIG_LIR_Gen_1	107	117	PF02991	0.289
LIG_LIR_Gen_1	203	211	PF02991	0.365
LIG_LIR_Gen_1	3	12	PF02991	0.555
LIG_LIR_Nem_3	107	112	PF02991	0.289
LIG_LIR_Nem_3	149	153	PF02991	0.719
LIG_LIR_Nem_3	171	175	PF02991	0.645
LIG_LIR_Nem_3	203	209	PF02991	0.393
LIG_LIR_Nem_3	21	26	PF02991	0.206
LIG_LIR_Nem_3	3	7	PF02991	0.668
LIG_MLH1_MIPbox_1	207	211	PF16413	0.404
LIG_Pex14_2	109	113	PF04695	0.286
LIG_PTB_Apo_2	190	197	PF02174	0.447
LIG_REV1ctd_RIR_1	208	219	PF16727	0.626
LIG_SH2_CRK	139	143	PF00017	0.703
LIG_SH2_CRK	206	210	PF00017	0.365
LIG_SH2_NCK_1	4	8	PF00017	0.576
LIG_SH2_PTP2	175	178	PF00017	0.607
LIG_SH2_SRC	4	7	PF00017	0.577
LIG_SH2_STAP1	172	176	PF00017	0.603
LIG_SH2_STAP1	206	210	PF00017	0.365
LIG_SH2_STAP1	4	8	PF00017	0.581
LIG_SH2_STAT5	100	103	PF00017	0.402
LIG_SH2_STAT5	111	114	PF00017	0.271
LIG_SH2_STAT5	150	153	PF00017	0.623
LIG_SH2_STAT5	166	169	PF00017	0.599
LIG_SH2_STAT5	175	178	PF00017	0.616
LIG_SH2_STAT5	66	69	PF00017	0.414
LIG_SH3_3	80	86	PF00018	0.476
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.648
LIG_SUMO_SIM_par_1	34	41	PF11976	0.434
LIG_SxIP_EBH_1	144	156	PF03271	0.536
LIG_TYR_ITIM	204	209	PF00017	0.416
LIG_WRC_WIRS_1	106	111	PF05994	0.271
LIG_WW_3	227	231	PF00397	0.455
MOD_CDK_SPK_2	174	179	PF00069	0.631
MOD_CK2_1	168	174	PF00069	0.553
MOD_GSK3_1	115	122	PF00069	0.531
MOD_GSK3_1	14	21	PF00069	0.330
MOD_GSK3_1	200	207	PF00069	0.352
MOD_N-GLC_1	128	133	PF02516	0.683
MOD_N-GLC_1	68	73	PF02516	0.600
MOD_NEK2_1	105	110	PF00069	0.286
MOD_NEK2_1	146	151	PF00069	0.415
MOD_NEK2_1	204	209	PF00069	0.309
MOD_NEK2_1	210	215	PF00069	0.541
MOD_NEK2_1	25	30	PF00069	0.569
MOD_NEK2_1	37	42	PF00069	0.498
MOD_NEK2_1	51	56	PF00069	0.537
MOD_NEK2_1	65	70	PF00069	0.440
MOD_PKA_2	146	152	PF00069	0.440
MOD_PKA_2	38	44	PF00069	0.637
MOD_Plk_1	18	24	PF00069	0.393
MOD_Plk_1	215	221	PF00069	0.574
MOD_Plk_4	140	146	PF00069	0.530
MOD_Plk_4	18	24	PF00069	0.273
MOD_Plk_4	205	211	PF00069	0.271
MOD_Plk_4	7	13	PF00069	0.298
MOD_ProDKin_1	121	127	PF00069	0.589
MOD_ProDKin_1	174	180	PF00069	0.636
TRG_ENDOCYTIC_2	139	142	PF00928	0.665
TRG_ENDOCYTIC_2	206	209	PF00928	0.365
TRG_ENDOCYTIC_2	4	7	PF00928	0.467
TRG_ER_diArg_1	183	185	PF00400	0.651
TRG_ER_diArg_1	211	214	PF00400	0.539
TRG_NES_CRM1_1	6	19	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z5	Leptomonas seymouri	77%	99%
A0A0S4INS6	Bodo saltans	44%	100%
A0A1X0NU17	Trypanosomatidae	58%	100%
A0A3Q8IDK2	Leishmania donovani	96%	100%
A0A422N342	Trypanosoma rangeli	60%	100%
A4HEL7	Leishmania braziliensis	87%	100%
A4I1V0	Leishmania infantum	97%	100%
C9ZS72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
Q4Q9H9	Leishmania major	95%	100%
Q4Q9I2	Leishmania major	96%	100%
V5B9I6	Trypanosoma cruzi	59%	100%