Mediator of RNA polymerase II transcription subunit 16

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AXZ0_LEIMU

TriTrypDb:

LmxM.26.0058

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.413
CLV_NRD_NRD_1	225	227	PF00675	0.369
CLV_NRD_NRD_1	82	84	PF00675	0.278
CLV_PCSK_KEX2_1	227	229	PF00082	0.407
CLV_PCSK_KEX2_1	82	84	PF00082	0.278
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.452
CLV_PCSK_SKI1_1	123	127	PF00082	0.396
CLV_PCSK_SKI1_1	70	74	PF00082	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.534
DEG_ODPH_VHL_1	245	257	PF01847	0.355
DOC_CKS1_1	136	141	PF01111	0.413
DOC_MAPK_MEF2A_6	250	257	PF00069	0.387
DOC_PP1_RVXF_1	175	182	PF00149	0.441
DOC_PP2B_LxvP_1	47	50	PF13499	0.475
DOC_PP4_FxxP_1	136	139	PF00568	0.410
DOC_USP7_MATH_1	105	109	PF00917	0.337
DOC_USP7_MATH_1	116	120	PF00917	0.437
DOC_USP7_MATH_1	197	201	PF00917	0.590
DOC_USP7_MATH_1	57	61	PF00917	0.243
DOC_WW_Pin1_4	135	140	PF00397	0.334
DOC_WW_Pin1_4	199	204	PF00397	0.518
LIG_14-3-3_CanoR_1	53	57	PF00244	0.416
LIG_14-3-3_CanoR_1	70	75	PF00244	0.549
LIG_FHA_1	102	108	PF00498	0.416
LIG_FHA_1	136	142	PF00498	0.346
LIG_FHA_1	234	240	PF00498	0.352
LIG_FHA_1	89	95	PF00498	0.363
LIG_FHA_2	207	213	PF00498	0.481
LIG_FHA_2	41	47	PF00498	0.451
LIG_GBD_Chelix_1	253	261	PF00786	0.401
LIG_LIR_Apic_2	81	87	PF02991	0.551
LIG_LIR_LC3C_4	124	128	PF02991	0.330
LIG_LIR_Nem_3	150	156	PF02991	0.578
LIG_LIR_Nem_3	212	218	PF02991	0.465
LIG_NRBOX	57	63	PF00104	0.427
LIG_PCNA_yPIPBox_3	226	238	PF02747	0.270
LIG_PDZ_Wminus1_1	267	269	PF00595	0.405
LIG_SH2_CRK	90	94	PF00017	0.423
LIG_SH2_STAP1	90	94	PF00017	0.421
LIG_SH2_STAT5	90	93	PF00017	0.352
LIG_SH3_3	159	165	PF00018	0.580
LIG_SH3_3	241	247	PF00018	0.460
LIG_SUMO_SIM_par_1	76	81	PF11976	0.313
LIG_TYR_ITIM	88	93	PF00017	0.427
MOD_CK2_1	20	26	PF00069	0.436
MOD_CK2_1	206	212	PF00069	0.483
MOD_CK2_1	40	46	PF00069	0.293
MOD_GlcNHglycan	118	121	PF01048	0.425
MOD_GlcNHglycan	123	126	PF01048	0.420
MOD_GlcNHglycan	199	202	PF01048	0.592
MOD_GlcNHglycan	209	212	PF01048	0.486
MOD_GlcNHglycan	22	25	PF01048	0.500
MOD_GlcNHglycan	257	260	PF01048	0.457
MOD_GSK3_1	101	108	PF00069	0.406
MOD_GSK3_1	15	22	PF00069	0.392
MOD_GSK3_1	195	202	PF00069	0.674
MOD_GSK3_1	203	210	PF00069	0.501
MOD_GSK3_1	257	264	PF00069	0.417
MOD_NEK2_1	156	161	PF00069	0.448
MOD_NEK2_1	257	262	PF00069	0.383
MOD_NEK2_1	40	45	PF00069	0.261
MOD_NEK2_1	64	69	PF00069	0.398
MOD_NEK2_1	88	93	PF00069	0.359
MOD_PIKK_1	105	111	PF00454	0.420
MOD_PKA_2	52	58	PF00069	0.399
MOD_Plk_4	148	154	PF00069	0.453
MOD_Plk_4	203	209	PF00069	0.668
MOD_Plk_4	233	239	PF00069	0.350
MOD_Plk_4	261	267	PF00069	0.584
MOD_Plk_4	57	63	PF00069	0.296
MOD_Plk_4	88	94	PF00069	0.500
MOD_ProDKin_1	135	141	PF00069	0.339
MOD_ProDKin_1	199	205	PF00069	0.516
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.477
TRG_ENDOCYTIC_2	90	93	PF00928	0.356
TRG_ER_diArg_1	82	84	PF00400	0.278
TRG_NES_CRM1_1	229	243	PF08389	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y9	Leptomonas seymouri	34%	95%
A0A3Q8IDH0	Leishmania donovani	83%	100%
E9ACT2	Leishmania major	84%	100%
E9AHA7	Leishmania infantum	83%	100%
E9AIR8	Leishmania braziliensis	65%	100%