Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXY9_LEIMU

TriTrypDb:

LmxM.26.0055

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.624
CLV_NRD_NRD_1	120	122	PF00675	0.568
CLV_NRD_NRD_1	187	189	PF00675	0.703
CLV_NRD_NRD_1	242	244	PF00675	0.818
CLV_NRD_NRD_1	43	45	PF00675	0.637
CLV_NRD_NRD_1	80	82	PF00675	0.659
CLV_PCSK_FUR_1	78	82	PF00082	0.560
CLV_PCSK_KEX2_1	113	115	PF00082	0.633
CLV_PCSK_KEX2_1	187	189	PF00082	0.703
CLV_PCSK_KEX2_1	242	244	PF00082	0.818
CLV_PCSK_KEX2_1	42	44	PF00082	0.674
CLV_PCSK_KEX2_1	80	82	PF00082	0.672
CLV_PCSK_SKI1_1	114	118	PF00082	0.695
CLV_PCSK_SKI1_1	22	26	PF00082	0.509
CLV_PCSK_SKI1_1	283	287	PF00082	0.812
DEG_APCC_DBOX_1	113	121	PF00400	0.693
DEG_APCC_DBOX_1	21	29	PF00400	0.588
DEG_COP1_1	250	260	PF00400	0.746
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DOC_MAPK_gen_1	78	86	PF00069	0.453
DOC_USP7_MATH_1	157	161	PF00917	0.818
DOC_USP7_MATH_1	17	21	PF00917	0.717
DOC_USP7_MATH_1	225	229	PF00917	0.722
DOC_WW_Pin1_4	101	106	PF00397	0.480
DOC_WW_Pin1_4	161	166	PF00397	0.681
DOC_WW_Pin1_4	219	224	PF00397	0.643
DOC_WW_Pin1_4	245	250	PF00397	0.758
DOC_WW_Pin1_4	290	295	PF00397	0.828
DOC_WW_Pin1_4	46	51	PF00397	0.630
LIG_14-3-3_CanoR_1	132	137	PF00244	0.419
LIG_14-3-3_CanoR_1	78	84	PF00244	0.441
LIG_BRCT_BRCA1_1	185	189	PF00533	0.698
LIG_FHA_1	147	153	PF00498	0.713
LIG_FHA_1	264	270	PF00498	0.628
LIG_FHA_1	35	41	PF00498	0.393
LIG_FHA_2	47	53	PF00498	0.574
LIG_FHA_2	94	100	PF00498	0.643
LIG_Integrin_RGD_1	243	245	PF01839	0.725
LIG_LIR_Apic_2	207	213	PF02991	0.627
LIG_LIR_Gen_1	196	205	PF02991	0.688
LIG_LIR_Nem_3	196	202	PF02991	0.710
LIG_Pex14_1	210	214	PF04695	0.686
LIG_Pex14_2	214	218	PF04695	0.510
LIG_PTAP_UEV_1	264	269	PF05743	0.507
LIG_RPA_C_Fungi	57	69	PF08784	0.500
LIG_SH2_CRK	199	203	PF00017	0.474
LIG_SH2_CRK	89	93	PF00017	0.655
LIG_SH2_STAP1	89	93	PF00017	0.553
LIG_SH3_3	113	119	PF00018	0.696
LIG_SH3_3	199	205	PF00018	0.763
LIG_SH3_3	221	227	PF00018	0.651
LIG_SH3_3	262	268	PF00018	0.511
LIG_TRAF2_1	100	103	PF00917	0.765
LIG_TRAF2_1	250	253	PF00917	0.783
LIG_TYR_ITIM	197	202	PF00017	0.551
LIG_WRC_WIRS_1	226	231	PF05994	0.641
MOD_CK1_1	277	283	PF00069	0.731
MOD_CK1_1	82	88	PF00069	0.369
MOD_CK2_1	105	111	PF00069	0.706
MOD_CK2_1	17	23	PF00069	0.704
MOD_CK2_1	247	253	PF00069	0.756
MOD_CK2_1	48	54	PF00069	0.577
MOD_GlcNHglycan	138	141	PF01048	0.579
MOD_GlcNHglycan	158	162	PF01048	0.705
MOD_GlcNHglycan	191	194	PF01048	0.562
MOD_GlcNHglycan	249	252	PF01048	0.805
MOD_GlcNHglycan	280	283	PF01048	0.626
MOD_GSK3_1	101	108	PF00069	0.725
MOD_GSK3_1	132	139	PF00069	0.537
MOD_GSK3_1	146	153	PF00069	0.793
MOD_GSK3_1	157	164	PF00069	0.631
MOD_GSK3_1	270	277	PF00069	0.678
MOD_GSK3_1	32	39	PF00069	0.545
MOD_N-GLC_1	169	174	PF02516	0.746
MOD_N-GLC_1	270	275	PF02516	0.791
MOD_NEK2_1	136	141	PF00069	0.499
MOD_NEK2_1	189	194	PF00069	0.610
MOD_NEK2_1	276	281	PF00069	0.759
MOD_NEK2_1	34	39	PF00069	0.521
MOD_PIKK_1	151	157	PF00454	0.514
MOD_PKA_2	150	156	PF00069	0.607
MOD_PKA_2	79	85	PF00069	0.373
MOD_PKB_1	130	138	PF00069	0.490
MOD_PKB_1	68	76	PF00069	0.511
MOD_Plk_1	157	163	PF00069	0.746
MOD_Plk_1	169	175	PF00069	0.647
MOD_Plk_1	70	76	PF00069	0.402
MOD_Plk_4	132	138	PF00069	0.586
MOD_Plk_4	170	176	PF00069	0.589
MOD_Plk_4	225	231	PF00069	0.672
MOD_Plk_4	256	262	PF00069	0.776
MOD_Plk_4	88	94	PF00069	0.486
MOD_ProDKin_1	101	107	PF00069	0.474
MOD_ProDKin_1	161	167	PF00069	0.678
MOD_ProDKin_1	219	225	PF00069	0.644
MOD_ProDKin_1	245	251	PF00069	0.756
MOD_ProDKin_1	290	296	PF00069	0.828
MOD_ProDKin_1	46	52	PF00069	0.624
TRG_ENDOCYTIC_2	199	202	PF00928	0.668
TRG_ENDOCYTIC_2	89	92	PF00928	0.660
TRG_ER_diArg_1	113	115	PF00400	0.626
TRG_ER_diArg_1	130	133	PF00400	0.465
TRG_ER_diArg_1	187	189	PF00400	0.703
TRG_ER_diArg_1	205	208	PF00400	0.504
TRG_ER_diArg_1	241	243	PF00400	0.813
TRG_ER_diArg_1	42	44	PF00400	0.642
TRG_ER_diArg_1	78	81	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M0	Leptomonas seymouri	41%	87%
A0A3Q8IDN0	Leishmania donovani	84%	100%
A4HEL4	Leishmania braziliensis	62%	100%
A4I1U5	Leishmania infantum	84%	100%
Q4Q9I5	Leishmania major	82%	100%