Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXY8_LEIMU

TriTrypDb:

LmxM.26.0050

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.728
CLV_NRD_NRD_1	120	122	PF00675	0.645
CLV_NRD_NRD_1	80	82	PF00675	0.467
CLV_PCSK_KEX2_1	250	252	PF00082	0.620
CLV_PCSK_KEX2_1	72	74	PF00082	0.679
CLV_PCSK_KEX2_1	82	84	PF00082	0.642
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.620
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.679
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.642
CLV_PCSK_SKI1_1	110	114	PF00082	0.692
CLV_PCSK_SKI1_1	115	119	PF00082	0.670
CLV_PCSK_SKI1_1	199	203	PF00082	0.636
CLV_PCSK_SKI1_1	8	12	PF00082	0.562
CLV_Separin_Metazoa	135	139	PF03568	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.547
DOC_MAPK_gen_1	81	92	PF00069	0.647
DOC_PP2B_LxvP_1	219	222	PF13499	0.514
DOC_USP7_MATH_1	148	152	PF00917	0.655
DOC_USP7_MATH_1	208	212	PF00917	0.724
DOC_USP7_MATH_1	30	34	PF00917	0.599
DOC_USP7_UBL2_3	246	250	PF12436	0.672
DOC_USP7_UBL2_3	68	72	PF12436	0.754
DOC_USP7_UBL2_3	8	12	PF12436	0.562
DOC_WW_Pin1_4	230	235	PF00397	0.809
DOC_WW_Pin1_4	241	246	PF00397	0.774
LIG_14-3-3_CanoR_1	115	124	PF00244	0.763
LIG_Actin_WH2_2	129	146	PF00022	0.606
LIG_FHA_1	124	130	PF00498	0.637
LIG_FHA_1	162	168	PF00498	0.607
LIG_FHA_1	231	237	PF00498	0.683
LIG_FHA_2	163	169	PF00498	0.628
LIG_FHA_2	233	239	PF00498	0.722
LIG_FHA_2	250	256	PF00498	0.504
LIG_LIR_Gen_1	86	93	PF02991	0.616
LIG_LIR_Nem_3	86	90	PF02991	0.640
LIG_Pex14_2	6	10	PF04695	0.548
LIG_PTAP_UEV_1	177	182	PF05743	0.555
LIG_SH2_STAT5	74	77	PF00017	0.738
LIG_SH3_2	245	250	PF14604	0.773
LIG_SH3_3	175	181	PF00018	0.703
LIG_SH3_3	188	194	PF00018	0.760
LIG_SH3_3	219	225	PF00018	0.812
LIG_SH3_3	242	248	PF00018	0.756
LIG_SUMO_SIM_par_1	163	171	PF11976	0.702
LIG_WRC_WIRS_1	7	12	PF05994	0.558
LIG_WW_3	122	126	PF00397	0.542
MOD_CDK_SPK_2	241	246	PF00069	0.518
MOD_CK1_1	176	182	PF00069	0.672
MOD_CK1_1	46	52	PF00069	0.510
MOD_CK2_1	162	168	PF00069	0.631
MOD_CK2_1	249	255	PF00069	0.616
MOD_CK2_1	44	50	PF00069	0.606
MOD_Cter_Amidation	70	73	PF01082	0.635
MOD_GlcNHglycan	175	178	PF01048	0.657
MOD_GlcNHglycan	182	185	PF01048	0.671
MOD_GlcNHglycan	32	35	PF01048	0.811
MOD_GlcNHglycan	96	99	PF01048	0.600
MOD_GSK3_1	176	183	PF00069	0.754
MOD_GSK3_1	195	202	PF00069	0.724
MOD_GSK3_1	20	27	PF00069	0.671
MOD_GSK3_1	42	49	PF00069	0.726
MOD_N-GLC_1	227	232	PF02516	0.539
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	128	133	PF00069	0.637
MOD_NEK2_1	143	148	PF00069	0.658
MOD_NEK2_1	162	167	PF00069	0.380
MOD_NEK2_1	173	178	PF00069	0.567
MOD_NEK2_1	20	25	PF00069	0.680
MOD_PIKK_1	1	7	PF00454	0.557
MOD_PIKK_1	150	156	PF00454	0.559
MOD_PKA_1	249	255	PF00069	0.616
MOD_PKA_1	72	78	PF00069	0.700
MOD_PKA_2	143	149	PF00069	0.651
MOD_PKA_2	24	30	PF00069	0.739
MOD_PKA_2	72	78	PF00069	0.714
MOD_Plk_1	1	7	PF00069	0.557
MOD_Plk_1	162	168	PF00069	0.573
MOD_Plk_1	227	233	PF00069	0.783
MOD_Plk_4	162	168	PF00069	0.551
MOD_Plk_4	182	188	PF00069	0.780
MOD_ProDKin_1	230	236	PF00069	0.810
MOD_ProDKin_1	241	247	PF00069	0.770
TRG_DiLeu_BaEn_1	168	173	PF01217	0.710
TRG_ER_diArg_1	137	140	PF00400	0.648
TRG_NLS_MonoExtC_3	248	253	PF00514	0.632
TRG_NLS_MonoExtC_3	80	85	PF00514	0.461
TRG_NLS_MonoExtN_4	246	253	PF00514	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS9	Leptomonas seymouri	44%	99%
A0A3S5H7F4	Leishmania donovani	82%	100%
A4HEL3	Leishmania braziliensis	62%	100%
A4I1U4	Leishmania infantum	82%	100%
Q4Q9I6	Leishmania major	80%	100%