Methylmalonyl-coa epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylmalonyl-coa epimerase-like protein

Species:

Leishmania mexicana

UniProt:

E9AXY5_LEIMU

TriTrypDb:

LmxM.26.0020

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXY5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035383	thioester metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046491	L-methylmalonyl-CoA metabolic process	5	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004493	methylmalonyl-CoA epimerase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016854	racemase and epimerase activity	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.582
CLV_PCSK_KEX2_1	3	5	PF00082	0.582
CLV_PCSK_SKI1_1	6	10	PF00082	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DOC_MAPK_MEF2A_6	17	25	PF00069	0.345
DOC_PP2B_LxvP_1	98	101	PF13499	0.379
DOC_PP4_FxxP_1	133	136	PF00568	0.405
DOC_PP4_FxxP_1	9	12	PF00568	0.354
DOC_USP7_MATH_1	27	31	PF00917	0.447
DOC_USP7_MATH_1	44	48	PF00917	0.189
DOC_WW_Pin1_4	76	81	PF00397	0.345
LIG_APCC_ABBA_1	58	63	PF00400	0.456
LIG_APCC_ABBA_1	72	77	PF00400	0.301
LIG_FHA_1	57	63	PF00498	0.345
LIG_FHA_2	142	148	PF00498	0.438
LIG_FHA_2	65	71	PF00498	0.379
LIG_LIR_Gen_1	36	46	PF02991	0.393
LIG_LIR_Gen_1	59	69	PF02991	0.347
LIG_LIR_Nem_3	36	41	PF02991	0.470
LIG_LIR_Nem_3	59	64	PF02991	0.324
LIG_SH2_CRK	38	42	PF00017	0.345
LIG_SH2_STAP1	38	42	PF00017	0.393
LIG_SH3_3	43	49	PF00018	0.354
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.345
MOD_CK2_1	141	147	PF00069	0.445
MOD_CK2_1	27	33	PF00069	0.470
MOD_CK2_1	64	70	PF00069	0.345
MOD_N-GLC_1	27	32	PF02516	0.235
MOD_NEK2_1	64	69	PF00069	0.393
MOD_NEK2_2	56	61	PF00069	0.345
MOD_Plk_1	27	33	PF00069	0.179
MOD_ProDKin_1	76	82	PF00069	0.345
MOD_SUMO_for_1	50	53	PF00179	0.379
MOD_SUMO_rev_2	145	151	PF00179	0.495
TRG_ENDOCYTIC_2	38	41	PF00928	0.345
TRG_ER_diArg_1	2	4	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K5	Leptomonas seymouri	77%	99%
A0A0S4INE6	Bodo saltans	63%	100%
A0A3S7WZI1	Leishmania donovani	89%	100%
A4HEL0	Leishmania braziliensis	79%	100%
A4I1U1	Leishmania infantum	88%	100%
O58010	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
P54540	Bacillus subtilis (strain 168)	31%	100%
Q2KIZ3	Bos taurus	59%	86%
Q3IZP4	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	57%	100%
Q4Q9I9	Leishmania major	88%	100%
Q553V2	Dictyostelium discoideum	60%	91%
Q96PE7	Homo sapiens	61%	86%
Q9D1I5	Mus musculus	55%	85%