Putative Lsm7p protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lsm7p protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXY3_LEIMU

TriTrypDb:

LmxM.26.0005

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005688	U6 snRNP	5	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990726	Lsm1-7-Pat1 complex	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AXY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXY3

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0110154	RNA decapping	6	1
GO:0110156	methylguanosine-cap decapping	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.241
CLV_NRD_NRD_1	9	11	PF00675	0.548
DOC_MAPK_gen_1	10	18	PF00069	0.438
DOC_MAPK_MEF2A_6	71	79	PF00069	0.465
LIG_14-3-3_CanoR_1	58	65	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_EH_1	87	91	PF12763	0.404
LIG_FHA_1	81	87	PF00498	0.446
LIG_SH2_STAT5	21	24	PF00017	0.467
LIG_SUMO_SIM_par_1	13	19	PF11976	0.384
LIG_UBA3_1	15	20	PF00899	0.426
MOD_CK1_1	80	86	PF00069	0.450
MOD_GlcNHglycan	1	4	PF01048	0.489
MOD_GlcNHglycan	79	82	PF01048	0.357
MOD_GSK3_1	57	64	PF00069	0.410
MOD_GSK3_1	77	84	PF00069	0.367
MOD_PIKK_1	26	32	PF00454	0.465
MOD_PKA_2	57	63	PF00069	0.448
MOD_Plk_1	81	87	PF00069	0.460
MOD_Plk_4	81	87	PF00069	0.552
MOD_SUMO_rev_2	17	27	PF00179	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTE3	Leptomonas seymouri	74%	100%
A0A3Q8ICP6	Leishmania donovani	92%	100%
A4HEK8	Leishmania braziliensis	89%	100%
A4I1T9	Leishmania infantum	91%	100%
C9ZPT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	99%
O74499	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	81%
Q4Q9J1	Leishmania major	93%	100%
Q9CQQ8	Mus musculus	41%	88%
Q9UK45	Homo sapiens	42%	88%