DUF2431 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF2431), putative

Species:

Leishmania mexicana

UniProt:

E9AXY1_LEIMU

TriTrypDb:

LmxM.25.0030

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXY1

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	6
GO:0001510	RNA methylation	4	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0031167	rRNA methylation	5	6
GO:0032259	methylation	2	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043414	macromolecule methylation	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0070475	rRNA base methylation	6	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008168	methyltransferase activity	4	6
GO:0008170	N-methyltransferase activity	5	6
GO:0008173	RNA methyltransferase activity	4	6
GO:0008649	rRNA methyltransferase activity	5	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0016436	rRNA (uridine) methyltransferase activity	6	6
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0070042	rRNA (uridine-N3-)-methyltransferase activity	6	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140102	catalytic activity, acting on a rRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.517
CLV_C14_Caspase3-7	502	506	PF00656	0.508
CLV_NRD_NRD_1	13	15	PF00675	0.553
CLV_NRD_NRD_1	214	216	PF00675	0.402
CLV_NRD_NRD_1	377	379	PF00675	0.439
CLV_NRD_NRD_1	432	434	PF00675	0.629
CLV_NRD_NRD_1	51	53	PF00675	0.419
CLV_NRD_NRD_1	557	559	PF00675	0.527
CLV_NRD_NRD_1	64	66	PF00675	0.362
CLV_NRD_NRD_1	83	85	PF00675	0.391
CLV_PCSK_KEX2_1	12	14	PF00082	0.506
CLV_PCSK_KEX2_1	161	163	PF00082	0.223
CLV_PCSK_KEX2_1	214	216	PF00082	0.402
CLV_PCSK_KEX2_1	377	379	PF00082	0.439
CLV_PCSK_KEX2_1	42	44	PF00082	0.386
CLV_PCSK_KEX2_1	432	434	PF00082	0.629
CLV_PCSK_KEX2_1	51	53	PF00082	0.335
CLV_PCSK_KEX2_1	557	559	PF00082	0.527
CLV_PCSK_KEX2_1	63	65	PF00082	0.370
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.506
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.223
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.386
CLV_PCSK_PC7_1	373	379	PF00082	0.397
CLV_PCSK_SKI1_1	276	280	PF00082	0.528
CLV_PCSK_SKI1_1	404	408	PF00082	0.532
CLV_PCSK_SKI1_1	409	413	PF00082	0.483
CLV_PCSK_SKI1_1	51	55	PF00082	0.440
CLV_PCSK_SKI1_1	552	556	PF00082	0.515
CLV_PCSK_SKI1_1	557	561	PF00082	0.476
CLV_Separin_Metazoa	241	245	PF03568	0.302
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.384
DOC_MAPK_gen_1	12	19	PF00069	0.437
DOC_MAPK_gen_1	161	168	PF00069	0.223
DOC_MAPK_gen_1	493	503	PF00069	0.473
DOC_MAPK_gen_1	63	71	PF00069	0.386
DOC_MAPK_gen_1	84	92	PF00069	0.351
DOC_MAPK_MEF2A_6	161	168	PF00069	0.223
DOC_MAPK_MEF2A_6	63	71	PF00069	0.351
DOC_PP2B_LxvP_1	385	388	PF13499	0.561
DOC_PP2B_LxvP_1	473	476	PF13499	0.464
DOC_PP4_FxxP_1	132	135	PF00568	0.386
DOC_PP4_FxxP_1	232	235	PF00568	0.421
DOC_USP7_MATH_1	2	6	PF00917	0.658
DOC_USP7_MATH_1	202	206	PF00917	0.288
DOC_USP7_MATH_1	293	297	PF00917	0.558
DOC_USP7_MATH_1	343	347	PF00917	0.511
DOC_USP7_MATH_1	405	409	PF00917	0.446
DOC_USP7_MATH_1	80	84	PF00917	0.351
DOC_USP7_UBL2_3	409	413	PF12436	0.494
DOC_WW_Pin1_4	160	165	PF00397	0.223
DOC_WW_Pin1_4	282	287	PF00397	0.421
DOC_WW_Pin1_4	299	304	PF00397	0.462
DOC_WW_Pin1_4	379	384	PF00397	0.527
DOC_WW_Pin1_4	530	535	PF00397	0.502
LIG_14-3-3_CanoR_1	13	17	PF00244	0.528
LIG_14-3-3_CanoR_1	377	383	PF00244	0.558
LIG_14-3-3_CanoR_1	51	59	PF00244	0.392
LIG_APCC_ABBA_1	393	398	PF00400	0.547
LIG_BRCT_BRCA1_1	149	153	PF00533	0.386
LIG_BRCT_BRCA1_1	204	208	PF00533	0.386
LIG_BRCT_BRCA1_1	301	305	PF00533	0.491
LIG_eIF4E_1	143	149	PF01652	0.386
LIG_FHA_1	161	167	PF00498	0.296
LIG_FHA_1	290	296	PF00498	0.628
LIG_FHA_2	173	179	PF00498	0.328
LIG_FHA_2	249	255	PF00498	0.356
LIG_FHA_2	268	274	PF00498	0.436
LIG_FHA_2	405	411	PF00498	0.529
LIG_FHA_2	454	460	PF00498	0.480
LIG_FHA_2	52	58	PF00498	0.386
LIG_FHA_2	72	78	PF00498	0.453
LIG_LIR_Gen_1	124	135	PF02991	0.281
LIG_LIR_Gen_1	22	29	PF02991	0.451
LIG_LIR_Gen_1	268	277	PF02991	0.429
LIG_LIR_Gen_1	35	44	PF02991	0.349
LIG_LIR_Gen_1	362	371	PF02991	0.447
LIG_LIR_Gen_1	477	487	PF02991	0.585
LIG_LIR_Gen_1	508	519	PF02991	0.409
LIG_LIR_Nem_3	124	130	PF02991	0.393
LIG_LIR_Nem_3	140	146	PF02991	0.286
LIG_LIR_Nem_3	205	211	PF02991	0.309
LIG_LIR_Nem_3	22	28	PF02991	0.456
LIG_LIR_Nem_3	268	272	PF02991	0.428
LIG_LIR_Nem_3	273	277	PF02991	0.400
LIG_LIR_Nem_3	35	41	PF02991	0.349
LIG_LIR_Nem_3	353	359	PF02991	0.474
LIG_LIR_Nem_3	362	368	PF02991	0.376
LIG_LIR_Nem_3	477	482	PF02991	0.592
LIG_LIR_Nem_3	508	514	PF02991	0.428
LIG_MLH1_MIPbox_1	149	153	PF16413	0.386
LIG_MYND_1	325	329	PF01753	0.441
LIG_MYND_1	383	387	PF01753	0.581
LIG_MYND_1	391	395	PF01753	0.569
LIG_PCNA_yPIPBox_3	236	244	PF02747	0.431
LIG_Pex14_1	365	369	PF04695	0.439
LIG_Pex14_2	92	96	PF04695	0.351
LIG_REV1ctd_RIR_1	150	158	PF16727	0.386
LIG_SH2_CRK	38	42	PF00017	0.386
LIG_SH2_CRK	479	483	PF00017	0.585
LIG_SH2_GRB2like	211	214	PF00017	0.386
LIG_SH2_NCK_1	269	273	PF00017	0.441
LIG_SH2_PTP2	195	198	PF00017	0.351
LIG_SH2_SRC	359	362	PF00017	0.397
LIG_SH2_SRC	525	528	PF00017	0.490
LIG_SH2_STAP1	525	529	PF00017	0.495
LIG_SH2_STAT3	284	287	PF00017	0.586
LIG_SH2_STAT3	369	372	PF00017	0.451
LIG_SH2_STAT5	195	198	PF00017	0.526
LIG_SH2_STAT5	211	214	PF00017	0.265
LIG_SH2_STAT5	231	234	PF00017	0.220
LIG_SH2_STAT5	269	272	PF00017	0.435
LIG_SH2_STAT5	359	362	PF00017	0.432
LIG_SH2_STAT5	417	420	PF00017	0.544
LIG_SH2_STAT5	511	514	PF00017	0.397
LIG_SH2_STAT5	531	534	PF00017	0.413
LIG_SH2_STAT5	95	98	PF00017	0.521
LIG_SH3_1	389	395	PF00018	0.537
LIG_SH3_3	355	361	PF00018	0.417
LIG_SH3_3	385	391	PF00018	0.617
LIG_SH3_3	544	550	PF00018	0.481
LIG_SUMO_SIM_par_1	171	179	PF11976	0.328
LIG_SUMO_SIM_par_1	25	31	PF11976	0.436
LIG_TRAF2_1	524	527	PF00917	0.483
LIG_TYR_ITIM	228	233	PF00017	0.401
LIG_TYR_ITSM	475	482	PF00017	0.598
LIG_WW_2	391	394	PF00397	0.577
MOD_CK1_1	114	120	PF00069	0.505
MOD_CK1_1	296	302	PF00069	0.611
MOD_CK1_1	316	322	PF00069	0.403
MOD_CK1_1	346	352	PF00069	0.564
MOD_CK2_1	152	158	PF00069	0.351
MOD_CK2_1	248	254	PF00069	0.368
MOD_CK2_1	267	273	PF00069	0.426
MOD_CK2_1	404	410	PF00069	0.531
MOD_CK2_1	507	513	PF00069	0.351
MOD_CK2_1	51	57	PF00069	0.293
MOD_CK2_1	75	81	PF00069	0.355
MOD_GlcNHglycan	116	119	PF01048	0.481
MOD_GlcNHglycan	154	157	PF01048	0.386
MOD_GlcNHglycan	204	207	PF01048	0.288
MOD_GlcNHglycan	245	249	PF01048	0.377
MOD_GlcNHglycan	306	309	PF01048	0.545
MOD_GlcNHglycan	315	318	PF01048	0.505
MOD_GlcNHglycan	347	351	PF01048	0.502
MOD_GlcNHglycan	418	421	PF01048	0.468
MOD_GlcNHglycan	46	49	PF01048	0.386
MOD_GlcNHglycan	520	523	PF01048	0.390
MOD_GSK3_1	110	117	PF00069	0.519
MOD_GSK3_1	244	251	PF00069	0.349
MOD_GSK3_1	289	296	PF00069	0.562
MOD_GSK3_1	299	306	PF00069	0.552
MOD_GSK3_1	309	316	PF00069	0.496
MOD_GSK3_1	342	349	PF00069	0.539
MOD_GSK3_1	71	78	PF00069	0.523
MOD_LATS_1	160	166	PF00433	0.281
MOD_N-GLC_1	110	115	PF02516	0.386
MOD_N-GLC_1	313	318	PF02516	0.585
MOD_N-GLC_1	32	37	PF02516	0.386
MOD_N-GLC_2	446	448	PF02516	0.341
MOD_NEK2_1	152	157	PF00069	0.421
MOD_NEK2_1	34	39	PF00069	0.357
MOD_NEK2_1	44	49	PF00069	0.322
MOD_NEK2_1	543	548	PF00069	0.302
MOD_PIKK_1	350	356	PF00454	0.382
MOD_PIKK_1	434	440	PF00454	0.526
MOD_PIKK_1	51	57	PF00454	0.351
MOD_PK_1	12	18	PF00069	0.456
MOD_PKA_1	12	18	PF00069	0.456
MOD_PKA_1	42	48	PF00069	0.386
MOD_PKA_1	51	57	PF00069	0.311
MOD_PKA_2	12	18	PF00069	0.521
MOD_PKA_2	256	262	PF00069	0.556
MOD_PKA_2	42	48	PF00069	0.396
MOD_PKA_2	51	57	PF00069	0.311
MOD_PKA_2	563	569	PF00069	0.518
MOD_Plk_1	110	116	PF00069	0.386
MOD_Plk_1	248	254	PF00069	0.352
MOD_Plk_1	309	315	PF00069	0.546
MOD_Plk_1	32	38	PF00069	0.386
MOD_Plk_1	469	475	PF00069	0.459
MOD_Plk_1	507	513	PF00069	0.351
MOD_Plk_4	248	254	PF00069	0.415
MOD_Plk_4	327	333	PF00069	0.444
MOD_Plk_4	361	367	PF00069	0.447
MOD_Plk_4	396	402	PF00069	0.519
MOD_Plk_4	474	480	PF00069	0.609
MOD_ProDKin_1	160	166	PF00069	0.223
MOD_ProDKin_1	282	288	PF00069	0.431
MOD_ProDKin_1	299	305	PF00069	0.456
MOD_ProDKin_1	379	385	PF00069	0.532
MOD_ProDKin_1	530	536	PF00069	0.512
MOD_SUMO_rev_2	408	414	PF00179	0.392
TRG_DiLeu_BaEn_2	87	93	PF01217	0.351
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.453
TRG_ENDOCYTIC_2	107	110	PF00928	0.281
TRG_ENDOCYTIC_2	143	146	PF00928	0.351
TRG_ENDOCYTIC_2	195	198	PF00928	0.491
TRG_ENDOCYTIC_2	230	233	PF00928	0.496
TRG_ENDOCYTIC_2	269	272	PF00928	0.435
TRG_ENDOCYTIC_2	38	41	PF00928	0.386
TRG_ENDOCYTIC_2	479	482	PF00928	0.586
TRG_ENDOCYTIC_2	511	514	PF00928	0.397
TRG_ER_diArg_1	101	104	PF00400	0.393
TRG_ER_diArg_1	377	379	PF00400	0.380
TRG_ER_diArg_1	432	434	PF00400	0.466
TRG_ER_diArg_1	50	52	PF00400	0.427
TRG_ER_diArg_1	63	65	PF00400	0.362
TRG_NES_CRM1_1	241	256	PF08389	0.332
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID26	Leishmania donovani	82%	100%
A4HDV0	Leishmania braziliensis	67%	100%
A4I145	Leishmania infantum	82%	100%
Q4QA93	Leishmania major	86%	100%