Putative n-terminal acetyltransferase complex ard1 subunit homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-terminal acetyltransferase complex ard1 subunit homolog, putative

Species:

Leishmania mexicana

UniProt:

E9AXY0_LEIMU

TriTrypDb:

LmxM.25.0020

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031416	NatB complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AXY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXY0

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016407	acetyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0004596	peptide alpha-N-acetyltransferase activity	8	1
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1
GO:0034212	peptide N-acetyltransferase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.308
CLV_NRD_NRD_1	165	167	PF00675	0.402
CLV_NRD_NRD_1	214	216	PF00675	0.408
CLV_NRD_NRD_1	219	221	PF00675	0.449
CLV_NRD_NRD_1	58	60	PF00675	0.487
CLV_PCSK_KEX2_1	136	138	PF00082	0.308
CLV_PCSK_KEX2_1	214	216	PF00082	0.522
CLV_PCSK_KEX2_1	219	221	PF00082	0.525
CLV_PCSK_KEX2_1	58	60	PF00082	0.486
CLV_PCSK_PC7_1	210	216	PF00082	0.507
CLV_PCSK_SKI1_1	137	141	PF00082	0.420
CLV_PCSK_SKI1_1	185	189	PF00082	0.353
CLV_PCSK_SKI1_1	210	214	PF00082	0.488
CLV_PCSK_SKI1_1	229	233	PF00082	0.450
CLV_PCSK_SKI1_1	58	62	PF00082	0.396
DOC_CYCLIN_RxL_1	42	53	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.438
DOC_MAPK_gen_1	217	227	PF00069	0.435
DOC_PP2B_LxvP_1	14	17	PF13499	0.490
DOC_PP2B_LxvP_1	48	51	PF13499	0.367
DOC_USP7_MATH_1	10	14	PF00917	0.387
DOC_USP7_MATH_1	149	153	PF00917	0.420
DOC_USP7_MATH_1	199	203	PF00917	0.539
DOC_USP7_UBL2_3	217	221	PF12436	0.483
LIG_14-3-3_CanoR_1	219	225	PF00244	0.439
LIG_14-3-3_CanoR_1	58	63	PF00244	0.443
LIG_AP2alpha_1	160	164	PF02296	0.308
LIG_FHA_1	101	107	PF00498	0.409
LIG_FHA_1	141	147	PF00498	0.323
LIG_FHA_2	59	65	PF00498	0.384
LIG_Integrin_RGD_1	192	194	PF01839	0.329
LIG_LIR_Gen_1	157	165	PF02991	0.387
LIG_LIR_Gen_1	174	184	PF02991	0.342
LIG_LIR_Gen_1	65	76	PF02991	0.442
LIG_LIR_Gen_1	94	102	PF02991	0.369
LIG_LIR_Nem_3	134	138	PF02991	0.303
LIG_LIR_Nem_3	157	163	PF02991	0.289
LIG_LIR_Nem_3	174	179	PF02991	0.298
LIG_LIR_Nem_3	65	71	PF02991	0.417
LIG_LIR_Nem_3	82	88	PF02991	0.381
LIG_LIR_Nem_3	90	95	PF02991	0.358
LIG_PDZ_Class_3	234	239	PF00595	0.596
LIG_PDZ_Wminus1_1	237	239	PF00595	0.634
LIG_Pex14_1	5	9	PF04695	0.394
LIG_Pex14_2	160	164	PF04695	0.299
LIG_SH2_CRK	176	180	PF00017	0.308
LIG_SH2_CRK	184	188	PF00017	0.351
LIG_SH2_STAT5	110	113	PF00017	0.359
LIG_SH2_STAT5	159	162	PF00017	0.303
LIG_SH2_STAT5	181	184	PF00017	0.327
LIG_SH2_STAT5	88	91	PF00017	0.372
LIG_SH3_2	196	201	PF14604	0.595
LIG_SH3_3	193	199	PF00018	0.584
LIG_SH3_3	227	233	PF00018	0.421
LIG_SH3_3	4	10	PF00018	0.448
LIG_SUMO_SIM_par_1	142	147	PF11976	0.397
LIG_TYR_ITIM	182	187	PF00017	0.351
LIG_WW_3	1	5	PF00397	0.401
MOD_CK1_1	127	133	PF00069	0.308
MOD_GlcNHglycan	126	129	PF01048	0.308
MOD_GSK3_1	127	134	PF00069	0.299
MOD_GSK3_1	58	65	PF00069	0.481
MOD_GSK3_1	76	83	PF00069	0.411
MOD_N-GLC_1	80	85	PF02516	0.500
MOD_NEK2_1	108	113	PF00069	0.357
MOD_NEK2_1	140	145	PF00069	0.314
MOD_NEK2_1	62	67	PF00069	0.497
MOD_NEK2_1	76	81	PF00069	0.388
MOD_NEK2_2	80	85	PF00069	0.451
MOD_PK_1	220	226	PF00069	0.500
MOD_PKA_1	219	225	PF00069	0.493
MOD_PKA_1	58	64	PF00069	0.417
MOD_PKA_2	165	171	PF00069	0.323
MOD_PKA_2	219	225	PF00069	0.484
MOD_PKA_2	58	64	PF00069	0.472
MOD_Plk_1	80	86	PF00069	0.495
MOD_Plk_4	140	146	PF00069	0.359
MOD_Plk_4	220	226	PF00069	0.446
MOD_Plk_4	80	86	PF00069	0.428
MOD_SUMO_for_1	231	234	PF00179	0.455
TRG_ENDOCYTIC_2	176	179	PF00928	0.308
TRG_ENDOCYTIC_2	184	187	PF00928	0.334
TRG_ENDOCYTIC_2	57	60	PF00928	0.401
TRG_ENDOCYTIC_2	95	98	PF00928	0.354
TRG_ER_diArg_1	135	137	PF00400	0.308
TRG_ER_diArg_1	213	215	PF00400	0.472
TRG_ER_diArg_1	57	59	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I212	Leptomonas seymouri	91%	100%
A0A0S4JB69	Bodo saltans	28%	84%
A0A0S4KNL4	Bodo saltans	63%	100%
A0A1X0NYV1	Trypanosomatidae	77%	100%
A0A3Q8ID89	Leishmania donovani	98%	100%
A0A422N4M9	Trypanosoma rangeli	77%	100%
A4HDU9	Leishmania braziliensis	90%	100%
A4I144	Leishmania infantum	98%	100%
C9ZKU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
O61219	Caenorhabditis elegans	30%	100%
O74457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P36416	Dictyostelium discoideum	28%	100%
P61599	Homo sapiens	52%	100%
P61600	Mus musculus	52%	100%
Q05885	Leishmania donovani	97%	100%
Q06504	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q2PFM2	Macaca fascicularis	52%	100%
Q3UX61	Mus musculus	30%	100%
Q4QA94	Leishmania major	86%	100%
Q4V8K3	Rattus norvegicus	30%	97%
Q58ED9	Danio rerio	52%	100%
Q6P632	Xenopus tropicalis	51%	100%
Q7ZXR3	Xenopus laevis	52%	100%
Q8LGI8	Arabidopsis thaliana	53%	100%
Q8SSN5	Dictyostelium discoideum	52%	100%
Q9BSU3	Homo sapiens	28%	100%
Q9FKI4	Arabidopsis thaliana	33%	100%
Q9QY36	Mus musculus	29%	100%
Q9UTI3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%