Beta galactofuranosyl transferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta galactofuranosyl transferase

Species:

Leishmania mexicana

UniProt:

E9AXX9_LEIMU

TriTrypDb:

LmxM.25.0010

Length:

434

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AXX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXX9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	37
GO:0016740	transferase activity	2	37
GO:0016757	glycosyltransferase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.471
CLV_NRD_NRD_1	365	367	PF00675	0.485
CLV_NRD_NRD_1	403	405	PF00675	0.534
CLV_PCSK_KEX2_1	10	12	PF00082	0.485
CLV_PCSK_KEX2_1	365	367	PF00082	0.509
CLV_PCSK_KEX2_1	402	404	PF00082	0.539
CLV_PCSK_PC7_1	361	367	PF00082	0.555
CLV_PCSK_SKI1_1	12	16	PF00082	0.421
CLV_PCSK_SKI1_1	120	124	PF00082	0.542
CLV_PCSK_SKI1_1	136	140	PF00082	0.469
CLV_PCSK_SKI1_1	158	162	PF00082	0.443
CLV_PCSK_SKI1_1	224	228	PF00082	0.558
CLV_PCSK_SKI1_1	337	341	PF00082	0.661
CLV_PCSK_SKI1_1	365	369	PF00082	0.530
CLV_PCSK_SKI1_1	95	99	PF00082	0.519
DEG_APCC_DBOX_1	119	127	PF00400	0.346
DEG_APCC_DBOX_1	17	25	PF00400	0.490
DEG_COP1_1	213	223	PF00400	0.261
DOC_CYCLIN_RxL_1	117	124	PF00134	0.413
DOC_CYCLIN_RxL_1	201	209	PF00134	0.207
DOC_MAPK_DCC_7	79	89	PF00069	0.339
DOC_MAPK_gen_1	10	21	PF00069	0.644
DOC_MAPK_gen_1	202	210	PF00069	0.201
DOC_MAPK_MEF2A_6	12	21	PF00069	0.505
DOC_MAPK_MEF2A_6	202	210	PF00069	0.201
DOC_MAPK_MEF2A_6	79	87	PF00069	0.378
DOC_PP1_RVXF_1	423	430	PF00149	0.244
DOC_USP7_MATH_1	118	122	PF00917	0.421
DOC_USP7_MATH_1	226	230	PF00917	0.379
DOC_USP7_MATH_1	3	7	PF00917	0.621
DOC_USP7_MATH_1	430	434	PF00917	0.265
LIG_14-3-3_CanoR_1	158	164	PF00244	0.190
LIG_14-3-3_CanoR_1	202	207	PF00244	0.315
LIG_14-3-3_CanoR_1	243	248	PF00244	0.379
LIG_14-3-3_CanoR_1	69	73	PF00244	0.401
LIG_APCC_ABBA_1	374	379	PF00400	0.270
LIG_BIR_II_1	1	5	PF00653	0.729
LIG_BRCT_BRCA1_1	348	352	PF00533	0.378
LIG_eIF4E_1	133	139	PF01652	0.350
LIG_eIF4E_1	22	28	PF01652	0.217
LIG_FHA_1	257	263	PF00498	0.375
LIG_FHA_1	271	277	PF00498	0.347
LIG_FHA_1	388	394	PF00498	0.383
LIG_FHA_2	172	178	PF00498	0.219
LIG_FHA_2	43	49	PF00498	0.427
LIG_HCF-1_HBM_1	298	301	PF13415	0.373
LIG_LIR_Gen_1	106	115	PF02991	0.225
LIG_LIR_Gen_1	60	70	PF02991	0.357
LIG_LIR_Gen_1	88	98	PF02991	0.310
LIG_LIR_Nem_3	106	110	PF02991	0.305
LIG_LIR_Nem_3	229	235	PF02991	0.226
LIG_LIR_Nem_3	258	263	PF02991	0.248
LIG_LIR_Nem_3	265	270	PF02991	0.285
LIG_LIR_Nem_3	289	295	PF02991	0.278
LIG_LIR_Nem_3	375	380	PF02991	0.423
LIG_LIR_Nem_3	418	422	PF02991	0.256
LIG_LIR_Nem_3	60	66	PF02991	0.351
LIG_LIR_Nem_3	88	94	PF02991	0.333
LIG_LYPXL_S_1	376	380	PF13949	0.456
LIG_LYPXL_yS_3	232	235	PF13949	0.212
LIG_LYPXL_yS_3	377	380	PF13949	0.269
LIG_NRBOX	20	26	PF00104	0.384
LIG_NRP_CendR_1	432	434	PF00754	0.509
LIG_Pex14_2	270	274	PF04695	0.223
LIG_PTB_Apo_2	110	117	PF02174	0.344
LIG_SH2_CRK	22	26	PF00017	0.430
LIG_SH2_GRB2like	323	326	PF00017	0.256
LIG_SH2_NCK_1	323	327	PF00017	0.299
LIG_SH2_PTP2	82	85	PF00017	0.210
LIG_SH2_SRC	323	326	PF00017	0.256
LIG_SH2_SRC	91	94	PF00017	0.407
LIG_SH2_STAP1	149	153	PF00017	0.235
LIG_SH2_STAP1	22	26	PF00017	0.206
LIG_SH2_STAT3	345	348	PF00017	0.380
LIG_SH2_STAT5	107	110	PF00017	0.339
LIG_SH2_STAT5	133	136	PF00017	0.374
LIG_SH2_STAT5	22	25	PF00017	0.364
LIG_SH2_STAT5	264	267	PF00017	0.416
LIG_SH2_STAT5	30	33	PF00017	0.331
LIG_SH2_STAT5	301	304	PF00017	0.311
LIG_SH2_STAT5	313	316	PF00017	0.289
LIG_SH2_STAT5	320	323	PF00017	0.328
LIG_SH2_STAT5	345	348	PF00017	0.394
LIG_SH2_STAT5	82	85	PF00017	0.240
LIG_SH3_3	217	223	PF00018	0.366
LIG_SH3_3	80	86	PF00018	0.381
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.202
LIG_TRAF2_1	248	251	PF00917	0.264
LIG_TRFH_1	82	86	PF08558	0.447
LIG_TYR_ITIM	80	85	PF00017	0.239
LIG_TYR_ITSM	373	380	PF00017	0.314
LIG_ULM_U2AF65_1	365	370	PF00076	0.362
LIG_WRC_WIRS_1	107	112	PF05994	0.162
LIG_WRC_WIRS_1	271	276	PF05994	0.370
LIG_WRPW_2	419	422	PF00400	0.276
MOD_CK2_1	68	74	PF00069	0.320
MOD_GlcNHglycan	40	43	PF01048	0.588
MOD_GSK3_1	189	196	PF00069	0.391
MOD_GSK3_1	270	277	PF00069	0.368
MOD_GSK3_1	38	45	PF00069	0.566
MOD_GSK3_1	99	106	PF00069	0.445
MOD_N-GLC_1	38	43	PF02516	0.385
MOD_N-GLC_1	387	392	PF02516	0.512
MOD_N-GLC_1	99	104	PF02516	0.317
MOD_NEK2_1	161	166	PF00069	0.254
MOD_NEK2_1	256	261	PF00069	0.481
MOD_NEK2_1	270	275	PF00069	0.341
MOD_NEK2_1	340	345	PF00069	0.557
MOD_NEK2_1	346	351	PF00069	0.408
MOD_NEK2_1	387	392	PF00069	0.493
MOD_NEK2_1	46	51	PF00069	0.400
MOD_NEK2_1	98	103	PF00069	0.367
MOD_NEK2_2	3	8	PF00069	0.375
MOD_PKA_2	68	74	PF00069	0.516
MOD_Plk_2-3	213	219	PF00069	0.274
MOD_Plk_2-3	68	74	PF00069	0.313
MOD_Plk_4	103	109	PF00069	0.439
MOD_Plk_4	20	26	PF00069	0.430
MOD_Plk_4	340	346	PF00069	0.291
MOD_Plk_4	372	378	PF00069	0.336
MOD_Plk_4	42	48	PF00069	0.542
MOD_SUMO_rev_2	90	97	PF00179	0.429
TRG_DiLeu_BaEn_2	400	406	PF01217	0.209
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.430
TRG_ENDOCYTIC_2	107	110	PF00928	0.449
TRG_ENDOCYTIC_2	22	25	PF00928	0.319
TRG_ENDOCYTIC_2	232	235	PF00928	0.376
TRG_ENDOCYTIC_2	260	263	PF00928	0.302
TRG_ENDOCYTIC_2	267	270	PF00928	0.338
TRG_ENDOCYTIC_2	377	380	PF00928	0.512
TRG_ENDOCYTIC_2	82	85	PF00928	0.476
TRG_ENDOCYTIC_2	91	94	PF00928	0.392
TRG_ER_diArg_1	242	245	PF00400	0.382
TRG_ER_diArg_1	364	366	PF00400	0.369
TRG_ER_diArg_1	402	404	PF00400	0.391
TRG_ER_diArg_1	431	434	PF00400	0.516
TRG_ER_diArg_1	9	12	PF00400	0.590
TRG_NES_CRM1_1	199	209	PF08389	0.231
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P269	Leptomonas seymouri	51%	100%
A0A0N1IJD9	Leptomonas seymouri	26%	76%
A0A0N1PC27	Leptomonas seymouri	31%	96%
A0A0N1PES8	Leptomonas seymouri	58%	98%
A0A1X0NWK3	Trypanosomatidae	34%	100%
A0A1X0NWM3	Trypanosomatidae	35%	100%
A0A3R7N1J7	Trypanosoma rangeli	33%	100%
A0A3S5H7D9	Leishmania donovani	83%	100%
A0A3S7WZK8	Leishmania donovani	30%	81%
A0A3S7X6F1	Leishmania donovani	30%	94%
A4HDU8	Leishmania braziliensis	70%	100%
A4HL36	Leishmania braziliensis	29%	75%
A4I143	Leishmania infantum	83%	100%
A4I1Y7	Leishmania infantum	30%	81%
A4I8P7	Leishmania infantum	30%	94%
E9AHM5	Leishmania infantum	28%	73%
E9AY34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	81%
E9B3H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	74%
E9B3L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	98%
Q05889	Leishmania donovani	83%	100%
Q4Q9D9	Leishmania major	30%	100%
Q6XFB5	Leishmania major	30%	100%
Q9NC61	Leishmania major	79%	100%
V5AJV9	Trypanosoma cruzi	33%	100%
V5AJW5	Trypanosoma cruzi	32%	100%
V5AM55	Trypanosoma cruzi	32%	100%
V5AR28	Trypanosoma cruzi	33%	100%
V5ASN8	Trypanosoma cruzi	33%	100%
V5AUJ2	Trypanosoma cruzi	32%	100%
V5B2H2	Trypanosoma cruzi	33%	100%
V5B4V1	Trypanosoma cruzi	31%	100%
V5B8H6	Trypanosoma cruzi	31%	100%
V5BB47	Trypanosoma cruzi	31%	100%
V5BRK8	Trypanosoma cruzi	33%	100%
V5BXG8	Trypanosoma cruzi	33%	100%
V5DD11	Trypanosoma cruzi	32%	100%