Putative glutathionylspermidine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathionylspermidine synthase, putative

Species:

Leishmania mexicana

UniProt:

E9AXX3_LEIMU

TriTrypDb:

LmxM.25.2380

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXX3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008885	glutathionylspermidine synthase activity	5	3
GO:0016874	ligase activity	2	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	3
GO:0016880	acid-ammonia (or amide) ligase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.318
CLV_C14_Caspase3-7	315	319	PF00656	0.405
CLV_C14_Caspase3-7	511	515	PF00656	0.405
CLV_C14_Caspase3-7	691	695	PF00656	0.528
CLV_NRD_NRD_1	338	340	PF00675	0.405
CLV_NRD_NRD_1	61	63	PF00675	0.618
CLV_NRD_NRD_1	84	86	PF00675	0.539
CLV_NRD_NRD_1	89	91	PF00675	0.497
CLV_PCSK_KEX2_1	260	262	PF00082	0.467
CLV_PCSK_KEX2_1	338	340	PF00082	0.405
CLV_PCSK_KEX2_1	654	656	PF00082	0.447
CLV_PCSK_KEX2_1	84	86	PF00082	0.539
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.467
CLV_PCSK_PC1ET2_1	654	656	PF00082	0.447
CLV_PCSK_SKI1_1	184	188	PF00082	0.297
CLV_PCSK_SKI1_1	227	231	PF00082	0.445
CLV_PCSK_SKI1_1	510	514	PF00082	0.230
CLV_PCSK_SKI1_1	538	542	PF00082	0.405
CLV_PCSK_SKI1_1	544	548	PF00082	0.335
CLV_PCSK_SKI1_1	654	658	PF00082	0.456
DEG_COP1_1	276	283	PF00400	0.297
DOC_ANK_TNKS_1	260	267	PF00023	0.479
DOC_MAPK_gen_1	62	68	PF00069	0.620
DOC_MAPK_gen_1	689	698	PF00069	0.504
DOC_MAPK_gen_1	701	711	PF00069	0.359
DOC_MAPK_MEF2A_6	704	711	PF00069	0.348
DOC_PP1_RVXF_1	419	426	PF00149	0.405
DOC_PP1_RVXF_1	454	461	PF00149	0.405
DOC_PP2B_LxvP_1	473	476	PF13499	0.230
DOC_PP4_FxxP_1	2	5	PF00568	0.482
DOC_PP4_FxxP_1	327	330	PF00568	0.405
DOC_PP4_MxPP_1	343	346	PF00568	0.405
DOC_USP7_MATH_1	126	130	PF00917	0.339
DOC_USP7_MATH_1	134	138	PF00917	0.272
DOC_USP7_MATH_1	298	302	PF00917	0.405
DOC_USP7_MATH_1	512	516	PF00917	0.405
DOC_USP7_MATH_1	56	60	PF00917	0.569
DOC_USP7_MATH_1	624	628	PF00917	0.628
DOC_USP7_UBL2_3	415	419	PF12436	0.405
DOC_USP7_UBL2_3	452	456	PF12436	0.405
DOC_USP7_UBL2_3	660	664	PF12436	0.482
DOC_USP7_UBL2_3	72	76	PF12436	0.405
DOC_WW_Pin1_4	106	111	PF00397	0.339
DOC_WW_Pin1_4	115	120	PF00397	0.264
DOC_WW_Pin1_4	122	127	PF00397	0.206
DOC_WW_Pin1_4	145	150	PF00397	0.339
DOC_WW_Pin1_4	26	31	PF00397	0.475
DOC_WW_Pin1_4	48	53	PF00397	0.531
LIG_14-3-3_CanoR_1	190	198	PF00244	0.505
LIG_14-3-3_CanoR_1	297	303	PF00244	0.405
LIG_14-3-3_CanoR_1	338	342	PF00244	0.405
LIG_14-3-3_CanoR_1	434	441	PF00244	0.405
LIG_14-3-3_CanoR_1	508	516	PF00244	0.405
LIG_BRCT_BRCA1_1	613	617	PF00533	0.612
LIG_Clathr_ClatBox_1	19	23	PF01394	0.516
LIG_deltaCOP1_diTrp_1	103	111	PF00928	0.339
LIG_eIF4E_1	182	188	PF01652	0.287
LIG_FHA_1	107	113	PF00498	0.339
LIG_FHA_1	15	21	PF00498	0.557
LIG_FHA_1	155	161	PF00498	0.339
LIG_FHA_1	193	199	PF00498	0.511
LIG_FHA_1	308	314	PF00498	0.405
LIG_FHA_1	511	517	PF00498	0.405
LIG_FHA_1	566	572	PF00498	0.405
LIG_FHA_1	685	691	PF00498	0.492
LIG_FHA_2	116	122	PF00498	0.339
LIG_FHA_2	518	524	PF00498	0.405
LIG_FHA_2	672	678	PF00498	0.303
LIG_FHA_2	689	695	PF00498	0.472
LIG_HCF-1_HBM_1	7	10	PF13415	0.612
LIG_Integrin_isoDGR_2	582	584	PF01839	0.405
LIG_LIR_Apic_2	245	251	PF02991	0.468
LIG_LIR_Apic_2	324	330	PF02991	0.405
LIG_LIR_Gen_1	108	119	PF02991	0.339
LIG_LIR_Gen_1	290	299	PF02991	0.230
LIG_LIR_Gen_1	340	347	PF02991	0.405
LIG_LIR_Gen_1	405	411	PF02991	0.405
LIG_LIR_Gen_1	41	52	PF02991	0.531
LIG_LIR_Gen_1	432	443	PF02991	0.405
LIG_LIR_Gen_1	496	506	PF02991	0.405
LIG_LIR_Gen_1	53	60	PF02991	0.437
LIG_LIR_Gen_1	67	75	PF02991	0.313
LIG_LIR_Nem_3	108	114	PF02991	0.339
LIG_LIR_Nem_3	147	153	PF02991	0.339
LIG_LIR_Nem_3	224	229	PF02991	0.484
LIG_LIR_Nem_3	282	287	PF02991	0.423
LIG_LIR_Nem_3	290	295	PF02991	0.340
LIG_LIR_Nem_3	324	329	PF02991	0.405
LIG_LIR_Nem_3	405	410	PF02991	0.405
LIG_LIR_Nem_3	41	47	PF02991	0.540
LIG_LIR_Nem_3	478	482	PF02991	0.248
LIG_LIR_Nem_3	496	502	PF02991	0.353
LIG_LIR_Nem_3	51	57	PF02991	0.456
LIG_LIR_Nem_3	534	540	PF02991	0.405
LIG_LIR_Nem_3	662	668	PF02991	0.460
LIG_LIR_Nem_3	67	73	PF02991	0.362
LIG_LIR_Nem_3	675	681	PF02991	0.311
LIG_LYPXL_yS_3	479	482	PF13949	0.230
LIG_MYND_1	247	251	PF01753	0.468
LIG_Pex14_2	657	661	PF04695	0.465
LIG_REV1ctd_RIR_1	654	664	PF16727	0.469
LIG_SH2_CRK	54	58	PF00017	0.578
LIG_SH2_CRK	70	74	PF00017	0.314
LIG_SH2_STAP1	182	186	PF00017	0.459
LIG_SH2_STAT3	506	509	PF00017	0.405
LIG_SH2_STAT5	258	261	PF00017	0.451
LIG_SH2_STAT5	285	288	PF00017	0.427
LIG_SH2_STAT5	321	324	PF00017	0.405
LIG_SH2_STAT5	326	329	PF00017	0.347
LIG_SH2_STAT5	435	438	PF00017	0.458
LIG_SH2_STAT5	576	579	PF00017	0.405
LIG_SH2_STAT5	665	668	PF00017	0.432
LIG_SH2_STAT5	86	89	PF00017	0.339
LIG_SH3_3	226	232	PF00018	0.502
LIG_SH3_3	233	239	PF00018	0.386
LIG_SH3_3	241	247	PF00018	0.308
LIG_SH3_3	529	535	PF00018	0.265
LIG_SH3_3	63	69	PF00018	0.558
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.413
LIG_SUMO_SIM_par_1	194	200	PF11976	0.421
LIG_SUMO_SIM_par_1	478	486	PF11976	0.344
LIG_TYR_ITIM	68	73	PF00017	0.537
LIG_WRC_WIRS_1	57	62	PF05994	0.581
MOD_CDK_SPxK_1	122	128	PF00069	0.214
MOD_CK1_1	106	112	PF00069	0.214
MOD_CK1_1	145	151	PF00069	0.339
MOD_CK1_1	192	198	PF00069	0.577
MOD_CK1_1	394	400	PF00069	0.405
MOD_CK1_1	498	504	PF00069	0.405
MOD_CK1_1	517	523	PF00069	0.184
MOD_CK1_1	610	616	PF00069	0.630
MOD_CK1_1	618	624	PF00069	0.544
MOD_CK1_1	641	647	PF00069	0.592
MOD_CK1_1	688	694	PF00069	0.522
MOD_CK2_1	115	121	PF00069	0.339
MOD_CK2_1	671	677	PF00069	0.272
MOD_CMANNOS	494	497	PF00535	0.405
MOD_GlcNHglycan	105	108	PF01048	0.414
MOD_GlcNHglycan	191	194	PF01048	0.540
MOD_GlcNHglycan	281	284	PF01048	0.432
MOD_GlcNHglycan	318	321	PF01048	0.405
MOD_GlcNHglycan	368	372	PF01048	0.405
MOD_GlcNHglycan	510	513	PF01048	0.405
MOD_GlcNHglycan	516	519	PF01048	0.335
MOD_GlcNHglycan	626	629	PF01048	0.642
MOD_GlcNHglycan	639	643	PF01048	0.430
MOD_GlcNHglycan	647	650	PF01048	0.502
MOD_GSK3_1	122	129	PF00069	0.214
MOD_GSK3_1	188	195	PF00069	0.593
MOD_GSK3_1	387	394	PF00069	0.405
MOD_GSK3_1	42	49	PF00069	0.526
MOD_GSK3_1	508	515	PF00069	0.405
MOD_GSK3_1	607	614	PF00069	0.626
MOD_GSK3_1	618	625	PF00069	0.509
MOD_GSK3_1	630	637	PF00069	0.529
MOD_GSK3_1	641	648	PF00069	0.402
MOD_GSK3_1	684	691	PF00069	0.489
MOD_N-GLC_1	126	131	PF02516	0.539
MOD_N-GLC_1	618	623	PF02516	0.462
MOD_N-GLC_1	705	710	PF02516	0.530
MOD_N-GLC_2	529	531	PF02516	0.405
MOD_N-GLC_2	638	640	PF02516	0.576
MOD_NEK2_1	188	193	PF00069	0.342
MOD_NEK2_1	259	264	PF00069	0.457
MOD_NEK2_1	307	312	PF00069	0.405
MOD_NEK2_1	42	47	PF00069	0.538
MOD_NEK2_1	609	614	PF00069	0.638
MOD_NEK2_1	622	627	PF00069	0.495
MOD_NEK2_1	645	650	PF00069	0.544
MOD_NEK2_2	206	211	PF00069	0.435
MOD_NEK2_2	298	303	PF00069	0.405
MOD_PIKK_1	376	382	PF00454	0.405
MOD_PIKK_1	387	393	PF00454	0.277
MOD_PIKK_1	611	617	PF00454	0.620
MOD_PIKK_1	628	634	PF00454	0.424
MOD_PK_1	692	698	PF00069	0.503
MOD_PKA_2	14	20	PF00069	0.559
MOD_PKA_2	189	195	PF00069	0.591
MOD_PKA_2	337	343	PF00069	0.405
MOD_PKA_2	433	439	PF00069	0.405
MOD_PKB_1	508	516	PF00069	0.230
MOD_Plk_1	618	624	PF00069	0.462
MOD_Plk_1	705	711	PF00069	0.533
MOD_Plk_4	394	400	PF00069	0.405
MOD_Plk_4	498	504	PF00069	0.405
MOD_Plk_4	641	647	PF00069	0.592
MOD_Plk_4	692	698	PF00069	0.503
MOD_ProDKin_1	106	112	PF00069	0.339
MOD_ProDKin_1	115	121	PF00069	0.264
MOD_ProDKin_1	122	128	PF00069	0.206
MOD_ProDKin_1	145	151	PF00069	0.339
MOD_ProDKin_1	26	32	PF00069	0.475
MOD_ProDKin_1	48	54	PF00069	0.538
MOD_SUMO_rev_2	59	65	PF00179	0.601
TRG_DiLeu_LyEn_5	332	337	PF01217	0.405
TRG_ENDOCYTIC_2	214	217	PF00928	0.481
TRG_ENDOCYTIC_2	326	329	PF00928	0.405
TRG_ENDOCYTIC_2	386	389	PF00928	0.405
TRG_ENDOCYTIC_2	435	438	PF00928	0.405
TRG_ENDOCYTIC_2	479	482	PF00928	0.230
TRG_ENDOCYTIC_2	54	57	PF00928	0.584
TRG_ENDOCYTIC_2	665	668	PF00928	0.467
TRG_ENDOCYTIC_2	70	73	PF00928	0.324
TRG_ER_diArg_1	337	339	PF00400	0.405
TRG_ER_diArg_1	84	86	PF00400	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y6	Leptomonas seymouri	27%	100%
A0A0N1PC88	Leptomonas seymouri	71%	100%
A0A0S4J0Y2	Bodo saltans	37%	82%
A0A0S4JSQ6	Bodo saltans	29%	100%
A0A1X0ND08	Trypanosomatidae	51%	100%
A0A1X0NR71	Trypanosomatidae	30%	100%
A0A3Q8IGF4	Leishmania donovani	28%	100%
A0A3Q8IGS6	Leishmania donovani	93%	100%
A0A3R7LYC7	Trypanosoma rangeli	30%	100%
A4HFW1	Leishmania braziliensis	26%	91%
A4I1T8	Leishmania infantum	93%	100%
A4I2Z3	Leishmania infantum	28%	100%
C9ZJE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O60993	Crithidia fasciculata	28%	100%
P0AES0	Escherichia coli (strain K12)	27%	100%
P0AES1	Shigella flexneri	27%	100%
P90518	Crithidia fasciculata	72%	100%
Q711P7	Leishmania major	27%	89%
Q9GT49	Trypanosoma cruzi (strain CL Brener)	29%	100%
V5ASH7	Trypanosoma cruzi	48%	100%
V5AYP7	Trypanosoma cruzi	29%	100%