PUM-HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pumilio homology domain family member 8

Species:

Leishmania mexicana

UniProt:

E9AXX0_LEIMU

TriTrypDb:

LmxM.25.2360

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXX0

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.469
CLV_NRD_NRD_1	313	315	PF00675	0.424
CLV_NRD_NRD_1	385	387	PF00675	0.398
CLV_NRD_NRD_1	541	543	PF00675	0.753
CLV_NRD_NRD_1	560	562	PF00675	0.775
CLV_PCSK_FUR_1	523	527	PF00082	0.805
CLV_PCSK_KEX2_1	217	219	PF00082	0.429
CLV_PCSK_KEX2_1	237	239	PF00082	0.404
CLV_PCSK_KEX2_1	313	315	PF00082	0.443
CLV_PCSK_KEX2_1	503	505	PF00082	0.658
CLV_PCSK_KEX2_1	522	524	PF00082	0.493
CLV_PCSK_KEX2_1	525	527	PF00082	0.737
CLV_PCSK_KEX2_1	541	543	PF00082	0.696
CLV_PCSK_KEX2_1	560	562	PF00082	0.789
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.399
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.443
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.661
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.493
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.762
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.703
CLV_PCSK_SKI1_1	129	133	PF00082	0.489
CLV_PCSK_SKI1_1	136	140	PF00082	0.500
CLV_PCSK_SKI1_1	201	205	PF00082	0.347
CLV_PCSK_SKI1_1	237	241	PF00082	0.386
CLV_PCSK_SKI1_1	24	28	PF00082	0.450
CLV_PCSK_SKI1_1	315	319	PF00082	0.416
CLV_PCSK_SKI1_1	389	393	PF00082	0.425
CLV_PCSK_SKI1_1	44	48	PF00082	0.587
CLV_PCSK_SKI1_1	443	447	PF00082	0.427
CLV_PCSK_SKI1_1	468	472	PF00082	0.415
CLV_PCSK_SKI1_1	543	547	PF00082	0.693
CLV_PCSK_SKI1_1	560	564	PF00082	0.775
CLV_PCSK_SKI1_1	568	572	PF00082	0.525
CLV_Separin_Metazoa	55	59	PF03568	0.422
DEG_APCC_DBOX_1	236	244	PF00400	0.533
DEG_APCC_DBOX_1	467	475	PF00400	0.486
DEG_SCF_FBW7_1	105	112	PF00400	0.411
DEG_SCF_FBW7_2	379	385	PF00400	0.394
DOC_CDC14_PxL_1	171	179	PF14671	0.390
DOC_CDC14_PxL_1	435	443	PF14671	0.439
DOC_CKS1_1	106	111	PF01111	0.421
DOC_CKS1_1	379	384	PF01111	0.367
DOC_CKS1_1	413	418	PF01111	0.490
DOC_CYCLIN_RxL_1	234	241	PF00134	0.457
DOC_MAPK_MEF2A_6	201	208	PF00069	0.367
DOC_MAPK_NFAT4_5	201	209	PF00069	0.367
DOC_MAPK_RevD_3	545	561	PF00069	0.490
DOC_PP1_RVXF_1	127	134	PF00149	0.444
DOC_PP4_FxxP_1	390	393	PF00568	0.438
DOC_USP7_MATH_1	109	113	PF00917	0.396
DOC_USP7_MATH_1	199	203	PF00917	0.457
DOC_USP7_MATH_1	300	304	PF00917	0.413
DOC_USP7_MATH_1	430	434	PF00917	0.470
DOC_USP7_MATH_1	535	539	PF00917	0.687
DOC_USP7_MATH_1	545	549	PF00917	0.706
DOC_USP7_MATH_1	566	570	PF00917	0.558
DOC_USP7_MATH_1	75	79	PF00917	0.681
DOC_USP7_MATH_2	159	165	PF00917	0.552
DOC_USP7_UBL2_3	132	136	PF12436	0.514
DOC_USP7_UBL2_3	44	48	PF12436	0.486
DOC_USP7_UBL2_3	563	567	PF12436	0.732
DOC_USP7_UBL2_3	568	572	PF12436	0.598
DOC_WW_Pin1_4	105	110	PF00397	0.410
DOC_WW_Pin1_4	194	199	PF00397	0.525
DOC_WW_Pin1_4	366	371	PF00397	0.372
DOC_WW_Pin1_4	378	383	PF00397	0.358
DOC_WW_Pin1_4	412	417	PF00397	0.495
DOC_WW_Pin1_4	516	521	PF00397	0.582
LIG_14-3-3_CanoR_1	113	119	PF00244	0.384
LIG_14-3-3_CanoR_1	286	294	PF00244	0.365
LIG_APCC_ABBA_1	206	211	PF00400	0.421
LIG_APCC_ABBA_1	380	385	PF00400	0.439
LIG_BRCT_BRCA1_1	134	138	PF00533	0.429
LIG_BRCT_BRCA1_1	240	244	PF00533	0.445
LIG_BRCT_BRCA1_1	302	306	PF00533	0.409
LIG_Clathr_ClatBox_1	400	404	PF01394	0.453
LIG_deltaCOP1_diTrp_1	384	395	PF00928	0.372
LIG_deltaCOP1_diTrp_1	407	413	PF00928	0.466
LIG_EH1_1	148	156	PF00400	0.354
LIG_eIF4E_1	371	377	PF01652	0.445
LIG_FHA_1	106	112	PF00498	0.447
LIG_FHA_1	420	426	PF00498	0.445
LIG_FHA_1	430	436	PF00498	0.405
LIG_FHA_2	272	278	PF00498	0.409
LIG_FHA_2	379	385	PF00498	0.406
LIG_FHA_2	535	541	PF00498	0.800
LIG_FHA_2	63	69	PF00498	0.557
LIG_LIR_Apic_2	192	198	PF02991	0.518
LIG_LIR_Apic_2	330	336	PF02991	0.388
LIG_LIR_Apic_2	412	416	PF02991	0.487
LIG_LIR_Gen_1	143	154	PF02991	0.438
LIG_LIR_Gen_1	161	171	PF02991	0.330
LIG_LIR_Gen_1	99	109	PF02991	0.535
LIG_LIR_Nem_3	135	141	PF02991	0.402
LIG_LIR_Nem_3	143	149	PF02991	0.340
LIG_LIR_Nem_3	161	166	PF02991	0.397
LIG_LIR_Nem_3	385	391	PF02991	0.544
LIG_LIR_Nem_3	99	105	PF02991	0.466
LIG_LYPXL_yS_3	222	225	PF13949	0.408
LIG_LYPXL_yS_3	259	262	PF13949	0.439
LIG_LYPXL_yS_3	88	91	PF13949	0.419
LIG_NRBOX	340	346	PF00104	0.474
LIG_NRBOX	375	381	PF00104	0.387
LIG_PCNA_yPIPBox_3	263	275	PF02747	0.392
LIG_PTB_Apo_2	365	372	PF02174	0.375
LIG_PTB_Phospho_1	365	371	PF10480	0.464
LIG_Rb_pABgroove_1	238	246	PF01858	0.469
LIG_Rb_pABgroove_1	336	344	PF01858	0.340
LIG_RPA_C_Fungi	455	467	PF08784	0.553
LIG_SH2_CRK	163	167	PF00017	0.452
LIG_SH2_CRK	333	337	PF00017	0.346
LIG_SH2_CRK	373	377	PF00017	0.445
LIG_SH2_STAP1	141	145	PF00017	0.424
LIG_SH2_STAP1	146	150	PF00017	0.413
LIG_SH2_STAP1	163	167	PF00017	0.507
LIG_SH2_STAP1	191	195	PF00017	0.394
LIG_SH2_STAP1	346	350	PF00017	0.400
LIG_SH2_STAP1	84	88	PF00017	0.491
LIG_SH2_STAT3	346	349	PF00017	0.419
LIG_SH2_STAT3	371	374	PF00017	0.483
LIG_SH2_STAT5	269	272	PF00017	0.393
LIG_SH2_STAT5	354	357	PF00017	0.362
LIG_SH2_STAT5	448	451	PF00017	0.528
LIG_SH3_1	217	223	PF00018	0.558
LIG_SH3_3	103	109	PF00018	0.446
LIG_SH3_3	169	175	PF00018	0.367
LIG_SH3_3	217	223	PF00018	0.552
LIG_SH3_3	254	260	PF00018	0.265
LIG_SH3_3	364	370	PF00018	0.524
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.391
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.351
LIG_SUMO_SIM_par_1	421	427	PF11976	0.472
LIG_TRAF2_1	11	14	PF00917	0.696
LIG_TRAF2_1	382	385	PF00917	0.484
LIG_TRAF2_1	488	491	PF00917	0.570
LIG_TRAF2_1	509	512	PF00917	0.750
LIG_TRAF2_1	65	68	PF00917	0.639
LIG_TYR_ITIM	257	262	PF00017	0.432
LIG_UBA3_1	203	210	PF00899	0.354
LIG_UBA3_1	243	249	PF00899	0.395
LIG_UBA3_1	400	406	PF00899	0.493
LIG_UBA3_1	56	62	PF00899	0.480
LIG_UBA3_1	94	101	PF00899	0.422
LIG_WRC_WIRS_1	318	323	PF05994	0.535
MOD_CDK_SPxK_1	516	522	PF00069	0.728
MOD_CDK_SPxxK_3	194	201	PF00069	0.516
MOD_CDK_SPxxK_3	516	523	PF00069	0.536
MOD_CK1_1	189	195	PF00069	0.451
MOD_CK1_1	548	554	PF00069	0.783
MOD_CK1_1	79	85	PF00069	0.621
MOD_CK2_1	249	255	PF00069	0.486
MOD_CK2_1	271	277	PF00069	0.412
MOD_CK2_1	304	310	PF00069	0.420
MOD_CK2_1	378	384	PF00069	0.422
MOD_CK2_1	484	490	PF00069	0.528
MOD_CK2_1	62	68	PF00069	0.602
MOD_Cter_Amidation	501	504	PF01082	0.728
MOD_Cter_Amidation	558	561	PF01082	0.762
MOD_GlcNHglycan	122	125	PF01048	0.524
MOD_GlcNHglycan	454	457	PF01048	0.511
MOD_GlcNHglycan	486	489	PF01048	0.565
MOD_GlcNHglycan	537	540	PF01048	0.587
MOD_GlcNHglycan	551	554	PF01048	0.727
MOD_GSK3_1	105	112	PF00069	0.403
MOD_GSK3_1	132	139	PF00069	0.507
MOD_GSK3_1	186	193	PF00069	0.390
MOD_GSK3_1	300	307	PF00069	0.436
MOD_GSK3_1	545	552	PF00069	0.673
MOD_GSK3_1	75	82	PF00069	0.740
MOD_N-GLC_1	527	532	PF02516	0.766
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	209	214	PF00069	0.398
MOD_NEK2_1	281	286	PF00069	0.276
MOD_NEK2_1	304	309	PF00069	0.416
MOD_NEK2_1	328	333	PF00069	0.435
MOD_NEK2_1	47	52	PF00069	0.441
MOD_NEK2_2	566	571	PF00069	0.627
MOD_PIKK_1	249	255	PF00454	0.432
MOD_PIKK_1	527	533	PF00454	0.821
MOD_PK_1	107	113	PF00069	0.548
MOD_PK_1	48	54	PF00069	0.307
MOD_PKA_2	14	20	PF00069	0.617
MOD_Plk_1	136	142	PF00069	0.497
MOD_Plk_1	199	205	PF00069	0.487
MOD_Plk_4	114	120	PF00069	0.413
MOD_Plk_4	186	192	PF00069	0.523
MOD_Plk_4	409	415	PF00069	0.418
MOD_ProDKin_1	105	111	PF00069	0.403
MOD_ProDKin_1	194	200	PF00069	0.520
MOD_ProDKin_1	366	372	PF00069	0.368
MOD_ProDKin_1	378	384	PF00069	0.365
MOD_ProDKin_1	412	418	PF00069	0.493
MOD_ProDKin_1	516	522	PF00069	0.584
MOD_SUMO_for_1	524	527	PF00179	0.746
MOD_SUMO_rev_2	40	46	PF00179	0.344
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.476
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.406
TRG_ENDOCYTIC_2	146	149	PF00928	0.377
TRG_ENDOCYTIC_2	163	166	PF00928	0.335
TRG_ENDOCYTIC_2	222	225	PF00928	0.397
TRG_ENDOCYTIC_2	259	262	PF00928	0.421
TRG_ENDOCYTIC_2	373	376	PF00928	0.446
TRG_ENDOCYTIC_2	88	91	PF00928	0.419
TRG_ER_diArg_1	237	239	PF00400	0.465
TRG_ER_diArg_1	560	562	PF00400	0.789
TRG_NLS_Bipartite_1	525	547	PF00514	0.771
TRG_NLS_MonoExtC_3	541	546	PF00514	0.758
TRG_NLS_MonoExtN_4	541	547	PF00514	0.755
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWV1	Leptomonas seymouri	81%	100%
A0A0S4IXV1	Bodo saltans	48%	82%
A0A1X0NZF1	Trypanosomatidae	59%	93%
A0A3Q8IDL8	Leishmania donovani	94%	100%
A0A3R7MC19	Trypanosoma rangeli	55%	98%
A4HED9	Leishmania braziliensis	83%	100%
A4I1T6	Leishmania infantum	94%	100%
C9ZKE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
Q4Q9K0	Leishmania major	92%	100%
V5D8H4	Trypanosoma cruzi	56%	98%