Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXW9_LEIMU

TriTrypDb:

LmxM.25.2350

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.625
CLV_C14_Caspase3-7	280	284	PF00656	0.599
CLV_NRD_NRD_1	256	258	PF00675	0.435
CLV_NRD_NRD_1	32	34	PF00675	0.586
CLV_NRD_NRD_1	344	346	PF00675	0.458
CLV_NRD_NRD_1	49	51	PF00675	0.629
CLV_PCSK_FUR_1	254	258	PF00082	0.439
CLV_PCSK_KEX2_1	171	173	PF00082	0.646
CLV_PCSK_KEX2_1	256	258	PF00082	0.493
CLV_PCSK_KEX2_1	272	274	PF00082	0.581
CLV_PCSK_KEX2_1	32	34	PF00082	0.586
CLV_PCSK_KEX2_1	49	51	PF00082	0.605
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.646
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.613
CLV_PCSK_SKI1_1	171	175	PF00082	0.590
CLV_PCSK_SKI1_1	220	224	PF00082	0.592
CLV_PCSK_SKI1_1	345	349	PF00082	0.548
DEG_SIAH_1	16	24	PF03145	0.581
DEG_SPOP_SBC_1	179	183	PF00917	0.496
DOC_CDC14_PxL_1	78	86	PF14671	0.777
DOC_PP1_RVXF_1	185	192	PF00149	0.485
DOC_PP2B_LxvP_1	84	87	PF13499	0.760
DOC_PP4_FxxP_1	263	266	PF00568	0.532
DOC_USP7_MATH_1	101	105	PF00917	0.694
DOC_USP7_MATH_1	133	137	PF00917	0.596
DOC_USP7_MATH_1	175	179	PF00917	0.708
DOC_USP7_UBL2_3	342	346	PF12436	0.579
DOC_WW_Pin1_4	128	133	PF00397	0.608
DOC_WW_Pin1_4	180	185	PF00397	0.803
DOC_WW_Pin1_4	60	65	PF00397	0.746
LIG_14-3-3_CanoR_1	220	229	PF00244	0.597
LIG_14-3-3_CanoR_1	240	246	PF00244	0.652
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BIR_III_2	80	84	PF00653	0.485
LIG_BRCT_BRCA1_1	25	29	PF00533	0.585
LIG_FHA_1	194	200	PF00498	0.634
LIG_FHA_1	260	266	PF00498	0.712
LIG_FHA_2	158	164	PF00498	0.596
LIG_FHA_2	181	187	PF00498	0.630
LIG_FHA_2	202	208	PF00498	0.633
LIG_FHA_2	253	259	PF00498	0.737
LIG_FHA_2	68	74	PF00498	0.694
LIG_GBD_Chelix_1	111	119	PF00786	0.502
LIG_LIR_Apic_2	261	266	PF02991	0.535
LIG_LIR_Nem_3	214	218	PF02991	0.555
LIG_NRBOX	302	308	PF00104	0.558
LIG_Rb_pABgroove_1	23	31	PF01858	0.586
LIG_SH2_CRK	14	18	PF00017	0.609
LIG_SH2_PTP2	296	299	PF00017	0.541
LIG_SH2_STAP1	218	222	PF00017	0.521
LIG_SH2_STAP1	245	249	PF00017	0.676
LIG_SH2_STAP1	275	279	PF00017	0.517
LIG_SH2_STAP1	95	99	PF00017	0.685
LIG_SH2_STAT5	296	299	PF00017	0.541
LIG_SH3_3	129	135	PF00018	0.506
LIG_SH3_3	17	23	PF00018	0.501
LIG_SH3_3	62	68	PF00018	0.780
LIG_SH3_3	76	82	PF00018	0.673
LIG_SUMO_SIM_anti_2	300	309	PF11976	0.531
LIG_SUMO_SIM_par_1	138	145	PF11976	0.450
LIG_SUMO_SIM_par_1	276	283	PF11976	0.606
LIG_TRAF2_1	211	214	PF00917	0.613
LIG_TYR_ITIM	294	299	PF00017	0.297
LIG_WRC_WIRS_1	24	29	PF05994	0.587
LIG_WW_2	82	85	PF00397	0.480
MOD_CDK_SPxxK_3	180	187	PF00069	0.494
MOD_CK1_1	124	130	PF00069	0.627
MOD_CK1_1	178	184	PF00069	0.791
MOD_CK1_1	60	66	PF00069	0.745
MOD_CK2_1	180	186	PF00069	0.505
MOD_CK2_1	222	228	PF00069	0.554
MOD_CK2_1	37	43	PF00069	0.576
MOD_CK2_1	67	73	PF00069	0.571
MOD_GlcNHglycan	176	180	PF01048	0.593
MOD_GlcNHglycan	204	207	PF01048	0.434
MOD_GlcNHglycan	224	227	PF01048	0.426
MOD_GlcNHglycan	267	270	PF01048	0.596
MOD_GlcNHglycan	60	63	PF01048	0.775
MOD_GSK3_1	117	124	PF00069	0.673
MOD_GSK3_1	138	145	PF00069	0.476
MOD_GSK3_1	157	164	PF00069	0.634
MOD_GSK3_1	175	182	PF00069	0.489
MOD_N-GLC_1	101	106	PF02516	0.645
MOD_NEK2_1	126	131	PF00069	0.556
MOD_NEK2_1	161	166	PF00069	0.602
MOD_NEK2_1	199	204	PF00069	0.597
MOD_NEK2_1	221	226	PF00069	0.578
MOD_NEK2_1	229	234	PF00069	0.653
MOD_NEK2_1	241	246	PF00069	0.650
MOD_PIKK_1	121	127	PF00454	0.598
MOD_PIKK_1	133	139	PF00454	0.577
MOD_PK_1	107	113	PF00069	0.510
MOD_Plk_1	107	113	PF00069	0.706
MOD_Plk_1	161	167	PF00069	0.648
MOD_Plk_1	185	191	PF00069	0.706
MOD_Plk_2-3	157	163	PF00069	0.606
MOD_Plk_2-3	277	283	PF00069	0.602
MOD_Plk_2-3	309	315	PF00069	0.520
MOD_Plk_4	117	123	PF00069	0.632
MOD_Plk_4	138	144	PF00069	0.593
MOD_Plk_4	23	29	PF00069	0.537
MOD_Plk_4	259	265	PF00069	0.707
MOD_ProDKin_1	128	134	PF00069	0.597
MOD_ProDKin_1	180	186	PF00069	0.801
MOD_ProDKin_1	60	66	PF00069	0.748
MOD_SUMO_rev_2	181	189	PF00179	0.491
MOD_SUMO_rev_2	224	232	PF00179	0.560
MOD_SUMO_rev_2	253	262	PF00179	0.665
TRG_DiLeu_BaEn_4	276	282	PF01217	0.601
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.499
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.554
TRG_ENDOCYTIC_2	218	221	PF00928	0.594
TRG_ENDOCYTIC_2	275	278	PF00928	0.484
TRG_ENDOCYTIC_2	296	299	PF00928	0.541
TRG_ER_diArg_1	254	257	PF00400	0.441
TRG_ER_diArg_1	31	33	PF00400	0.584
TRG_ER_diArg_1	337	340	PF00400	0.451
TRG_NES_CRM1_1	301	317	PF08389	0.301
TRG_NLS_MonoExtC_3	170	175	PF00514	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE1	Leptomonas seymouri	42%	100%
A0A1X0NZJ6	Trypanosomatidae	29%	100%
A0A3R7KZA5	Trypanosoma rangeli	29%	91%
A0A3S5H7F3	Leishmania donovani	83%	100%
A4HED8	Leishmania braziliensis	70%	100%
A4I1T5	Leishmania infantum	83%	100%
C9ZKE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
Q4Q9K1	Leishmania major	84%	100%