Putative serine/threonine-protein kinase (Putative protein kinase)

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AGC essential kinase 1

Species:

Leishmania mexicana

UniProt:

E9AXW8_LEIMU

TriTrypDb:

LmxM.25.2340

Length:

389

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0022402	cell cycle process	2	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	296	298	PF00675	0.321
CLV_NRD_NRD_1	319	321	PF00675	0.493
CLV_NRD_NRD_1	339	341	PF00675	0.341
CLV_NRD_NRD_1	64	66	PF00675	0.287
CLV_PCSK_KEX2_1	29	31	PF00082	0.774
CLV_PCSK_KEX2_1	296	298	PF00082	0.302
CLV_PCSK_KEX2_1	64	66	PF00082	0.287
CLV_PCSK_KEX2_1	86	88	PF00082	0.381
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.759
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.381
CLV_PCSK_SKI1_1	118	122	PF00082	0.287
CLV_PCSK_SKI1_1	170	174	PF00082	0.287
CLV_PCSK_SKI1_1	256	260	PF00082	0.293
CLV_PCSK_SKI1_1	4	8	PF00082	0.639
CLV_PCSK_SKI1_1	95	99	PF00082	0.325
DEG_APCC_DBOX_1	94	102	PF00400	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.555
DEG_SCF_FBW7_1	325	332	PF00400	0.498
DEG_SCF_FBW7_1	357	364	PF00400	0.497
DEG_SCF_FBW7_2	22	27	PF00400	0.530
DOC_CKS1_1	358	363	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.346
DOC_MAPK_gen_1	170	179	PF00069	0.287
DOC_PP1_RVXF_1	106	112	PF00149	0.287
DOC_PP1_RVXF_1	116	122	PF00149	0.287
DOC_USP7_MATH_1	329	333	PF00917	0.508
DOC_USP7_MATH_1	345	349	PF00917	0.591
DOC_USP7_MATH_1	361	365	PF00917	0.500
DOC_USP7_UBL2_3	14	18	PF12436	0.592
DOC_USP7_UBL2_3	194	198	PF12436	0.381
DOC_USP7_UBL2_3	4	8	PF12436	0.573
DOC_USP7_UBL2_3	75	79	PF12436	0.287
DOC_WW_Pin1_4	20	25	PF00397	0.676
DOC_WW_Pin1_4	213	218	PF00397	0.287
DOC_WW_Pin1_4	248	253	PF00397	0.302
DOC_WW_Pin1_4	276	281	PF00397	0.414
DOC_WW_Pin1_4	325	330	PF00397	0.479
DOC_WW_Pin1_4	357	362	PF00397	0.506
LIG_14-3-3_CanoR_1	209	214	PF00244	0.287
LIG_14-3-3_CanoR_1	256	265	PF00244	0.371
LIG_14-3-3_CanoR_1	340	350	PF00244	0.422
LIG_14-3-3_CanoR_1	64	72	PF00244	0.432
LIG_BRCT_BRCA1_1	192	196	PF00533	0.287
LIG_BRCT_BRCA1_1	232	236	PF00533	0.205
LIG_BRCT_BRCA1_2	192	198	PF00533	0.381
LIG_deltaCOP1_diTrp_1	235	239	PF00928	0.287
LIG_eIF4E_1	151	157	PF01652	0.370
LIG_FHA_1	145	151	PF00498	0.314
LIG_FHA_1	229	235	PF00498	0.290
LIG_FHA_1	46	52	PF00498	0.362
LIG_FHA_2	40	46	PF00498	0.411
LIG_Integrin_isoDGR_2	254	256	PF01839	0.432
LIG_LIR_Apic_2	216	222	PF02991	0.287
LIG_LIR_Gen_1	259	270	PF02991	0.290
LIG_LIR_Gen_1	44	52	PF02991	0.287
LIG_LIR_Gen_1	56	66	PF02991	0.287
LIG_LIR_Nem_3	166	172	PF02991	0.313
LIG_LIR_Nem_3	233	239	PF02991	0.288
LIG_LIR_Nem_3	259	265	PF02991	0.290
LIG_LIR_Nem_3	44	49	PF02991	0.287
LIG_LIR_Nem_3	56	62	PF02991	0.287
LIG_Pex14_2	2	6	PF04695	0.612
LIG_PTB_Apo_2	261	268	PF02174	0.287
LIG_PTB_Phospho_1	261	267	PF10480	0.287
LIG_SH2_CRK	244	248	PF00017	0.287
LIG_SH2_GRB2like	134	137	PF00017	0.287
LIG_SH2_GRB2like	230	233	PF00017	0.298
LIG_SH2_PTP2	219	222	PF00017	0.287
LIG_SH2_PTP2	59	62	PF00017	0.302
LIG_SH2_STAP1	230	234	PF00017	0.287
LIG_SH2_STAP1	72	76	PF00017	0.287
LIG_SH2_STAT5	105	108	PF00017	0.306
LIG_SH2_STAT5	219	222	PF00017	0.287
LIG_SH2_STAT5	230	233	PF00017	0.287
LIG_SH2_STAT5	59	62	PF00017	0.302
LIG_SH3_3	211	217	PF00018	0.287
LIG_SH3_3	28	34	PF00018	0.742
LIG_SH3_3	348	354	PF00018	0.584
LIG_SH3_3	355	361	PF00018	0.511
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.302
LIG_TRAF2_1	332	335	PF00917	0.363
LIG_TYR_ITIM	167	172	PF00017	0.287
LIG_TYR_ITIM	242	247	PF00017	0.287
LIG_TYR_ITIM	265	270	PF00017	0.287
LIG_UBA3_1	1	9	PF00899	0.576
LIG_UBA3_1	285	292	PF00899	0.287
LIG_WRC_WIRS_1	110	115	PF05994	0.302
LIG_WRC_WIRS_1	236	241	PF05994	0.287
LIG_WW_3	323	327	PF00397	0.480
MOD_CDK_SPxxK_3	276	283	PF00069	0.414
MOD_CK1_1	20	26	PF00069	0.677
MOD_CK1_1	268	274	PF00069	0.394
MOD_CK2_1	254	260	PF00069	0.311
MOD_CK2_1	329	335	PF00069	0.376
MOD_GlcNHglycan	273	276	PF01048	0.457
MOD_GlcNHglycan	343	346	PF01048	0.577
MOD_GSK3_1	209	216	PF00069	0.287
MOD_GSK3_1	325	332	PF00069	0.509
MOD_GSK3_1	341	348	PF00069	0.520
MOD_GSK3_1	357	364	PF00069	0.514
MOD_N-GLC_1	341	346	PF02516	0.657
MOD_NEK2_1	109	114	PF00069	0.309
MOD_PIKK_1	362	368	PF00454	0.503
MOD_PKA_1	64	70	PF00069	0.432
MOD_PKA_2	64	70	PF00069	0.432
MOD_PKB_1	226	234	PF00069	0.432
MOD_Plk_1	163	169	PF00069	0.302
MOD_Plk_1	268	274	PF00069	0.432
MOD_Plk_2-3	45	51	PF00069	0.287
MOD_Plk_4	163	169	PF00069	0.302
MOD_Plk_4	209	215	PF00069	0.287
MOD_Plk_4	346	352	PF00069	0.444
MOD_ProDKin_1	20	26	PF00069	0.674
MOD_ProDKin_1	213	219	PF00069	0.287
MOD_ProDKin_1	248	254	PF00069	0.302
MOD_ProDKin_1	276	282	PF00069	0.414
MOD_ProDKin_1	325	331	PF00069	0.479
MOD_ProDKin_1	357	363	PF00069	0.519
MOD_SUMO_for_1	172	175	PF00179	0.287
MOD_SUMO_rev_2	10	20	PF00179	0.709
MOD_SUMO_rev_2	115	120	PF00179	0.287
MOD_SUMO_rev_2	166	174	PF00179	0.302
MOD_SUMO_rev_2	21	31	PF00179	0.571
MOD_SUMO_rev_2	279	285	PF00179	0.279
TRG_DiLeu_BaEn_1	281	286	PF01217	0.287
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.318
TRG_ENDOCYTIC_2	110	113	PF00928	0.337
TRG_ENDOCYTIC_2	169	172	PF00928	0.287
TRG_ENDOCYTIC_2	244	247	PF00928	0.287
TRG_ENDOCYTIC_2	267	270	PF00928	0.287
TRG_ENDOCYTIC_2	59	62	PF00928	0.296
TRG_ENDOCYTIC_2	71	74	PF00928	0.270
TRG_ER_diArg_1	225	228	PF00400	0.432
TRG_ER_diArg_1	296	299	PF00400	0.337
TRG_ER_diArg_1	64	66	PF00400	0.290
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	27%	70%
A0A0N0P3N5	Leptomonas seymouri	26%	91%
A0A0N0P4J7	Leptomonas seymouri	28%	88%
A0A0N0P6T0	Leptomonas seymouri	26%	71%
A0A0N0P787	Leptomonas seymouri	30%	100%
A0A0N0P8H5	Leptomonas seymouri	33%	100%
A0A0N0P953	Leptomonas seymouri	30%	81%
A0A0N1HWQ2	Leptomonas seymouri	32%	100%
A0A0N1I0C1	Leptomonas seymouri	26%	88%
A0A0N1I6T8	Leptomonas seymouri	32%	100%
A0A0N1IHM7	Leptomonas seymouri	27%	66%
A0A0N1IIF9	Leptomonas seymouri	34%	100%
A0A0N1IM47	Leptomonas seymouri	27%	100%
A0A0N1PBE9	Leptomonas seymouri	30%	77%
A0A0N1PC31	Leptomonas seymouri	89%	100%
A0A0N1PD05	Leptomonas seymouri	28%	87%
A0A0N1PDW7	Leptomonas seymouri	30%	99%
A0A0N1PE80	Leptomonas seymouri	31%	69%
A0A0S4IHW4	Bodo saltans	29%	86%
A0A0S4IMB7	Bodo saltans	27%	88%
A0A0S4IQ75	Bodo saltans	29%	77%
A0A0S4IRU8	Bodo saltans	32%	90%
A0A0S4IRZ7	Bodo saltans	27%	79%
A0A0S4IX86	Bodo saltans	26%	90%
A0A0S4IZY3	Bodo saltans	31%	100%
A0A0S4J444	Bodo saltans	30%	97%
A0A0S4J4B3	Bodo saltans	31%	87%
A0A0S4J4X4	Bodo saltans	31%	100%
A0A0S4J6L4	Bodo saltans	73%	100%
A0A0S4J7K4	Bodo saltans	33%	80%
A0A0S4J804	Bodo saltans	32%	74%
A0A0S4J842	Bodo saltans	33%	72%
A0A0S4JBR3	Bodo saltans	32%	100%
A0A0S4JCG2	Bodo saltans	31%	87%
A0A0S4JER5	Bodo saltans	39%	85%
A0A0S4JF22	Bodo saltans	25%	100%
A0A0S4JHA7	Bodo saltans	27%	84%
A0A0S4JI67	Bodo saltans	31%	85%
A0A0S4JPZ1	Bodo saltans	29%	87%
A0A0S4JTJ8	Bodo saltans	30%	85%
A0A0S4JUJ2	Bodo saltans	33%	100%
A0A0S4JWD5	Bodo saltans	31%	99%
A0A0S4KFT7	Bodo saltans	36%	100%
A0A0S4KHR9	Bodo saltans	29%	100%
A0A0S4KMV7	Bodo saltans	28%	100%
A0A0S4KN74	Bodo saltans	26%	100%
A0A1X0NFW4	Trypanosomatidae	30%	82%
A0A1X0NIA0	Trypanosomatidae	28%	90%
A0A1X0NIX2	Trypanosomatidae	28%	89%
A0A1X0NJV4	Trypanosomatidae	32%	76%
A0A1X0NQ63	Trypanosomatidae	31%	100%
A0A1X0NRF6	Trypanosomatidae	30%	71%
A0A1X0NTP1	Trypanosomatidae	32%	67%
A0A1X0NTR6	Trypanosomatidae	29%	100%
A0A1X0NUQ4	Trypanosomatidae	31%	100%
A0A1X0NW24	Trypanosomatidae	30%	100%
A0A1X0NWR7	Trypanosomatidae	25%	76%
A0A1X0NY93	Trypanosomatidae	73%	99%
A0A1X0NYK8	Trypanosomatidae	33%	100%
A0A1X0P1A2	Trypanosomatidae	32%	84%
A0A1X0P3J5	Trypanosomatidae	36%	85%
A0A1X0P4Z7	Trypanosomatidae	28%	70%
A0A1X0P549	Trypanosomatidae	32%	82%
A0A1X0P5B1	Trypanosomatidae	34%	100%
A0A1X0P5F2	Trypanosomatidae	35%	100%
A0A1X0P6V1	Trypanosomatidae	32%	100%
A0A1X0P735	Trypanosomatidae	31%	100%
A0A1X0P7V0	Trypanosomatidae	35%	100%
A0A1X0P8F7	Trypanosomatidae	36%	90%
A0A1X0P919	Trypanosomatidae	31%	100%
A0A1X0P994	Trypanosomatidae	33%	78%
A0A1X0P9C4	Trypanosomatidae	29%	78%
A0A1X0PAW2	Trypanosomatidae	29%	100%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	32%	74%
A0A3Q8IAQ1	Leishmania donovani	25%	100%
A0A3Q8IB30	Leishmania donovani	30%	100%
A0A3Q8IC87	Leishmania donovani	28%	100%
A0A3Q8IDK8	Leishmania donovani	30%	69%
A0A3Q8IEH3	Leishmania donovani	33%	100%
A0A3Q8IFK8	Leishmania donovani	29%	88%
A0A3Q8IFW0	Leishmania donovani	26%	91%
A0A3Q8II44	Leishmania donovani	25%	100%
A0A3Q8IIG1	Leishmania donovani	28%	100%
A0A3Q8IIH5	Leishmania donovani	29%	70%
A0A3Q8IJM9	Leishmania donovani	32%	82%
A0A3Q8INQ4	Leishmania donovani	97%	100%
A0A3Q8IRT6	Leishmania donovani	35%	76%
A0A3Q8ITZ9	Leishmania donovani	26%	100%
A0A3R7K109	Trypanosoma rangeli	28%	82%
A0A3R7K5P9	Trypanosoma rangeli	29%	100%
A0A3R7K681	Trypanosoma rangeli	31%	76%
A0A3R7KMF0	Trypanosoma rangeli	28%	100%
A0A3R7KRP1	Trypanosoma rangeli	26%	82%
A0A3R7KZ44	Trypanosoma rangeli	25%	66%
A0A3R7M5C7	Trypanosoma rangeli	32%	100%
A0A3R7MHW5	Trypanosoma rangeli	30%	97%
A0A3R7MJP3	Trypanosoma rangeli	30%	100%
A0A3R7MKG5	Trypanosoma rangeli	27%	88%
A0A3R7MKJ1	Trypanosoma rangeli	32%	72%
A0A3R7N4D8	Trypanosoma rangeli	70%	96%
A0A3R7N5S4	Trypanosoma rangeli	30%	100%
A0A3R7RIN5	Trypanosoma rangeli	29%	78%
A0A3R7RLL1	Trypanosoma rangeli	31%	90%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	29%	85%
A0A3S5H606	Leishmania donovani	33%	100%
A0A3S5H7M0	Leishmania donovani	26%	75%
A0A3S5IRC3	Trypanosoma rangeli	31%	100%
A0A3S7WTN9	Leishmania donovani	32%	100%
A0A3S7WUE7	Leishmania donovani	29%	70%
A0A3S7WUX5	Leishmania donovani	33%	100%
A0A3S7WWE7	Leishmania donovani	27%	100%
A0A3S7WY10	Leishmania donovani	26%	72%
A0A3S7X123	Leishmania donovani	26%	100%
A0A3S7X2F1	Leishmania donovani	26%	66%
A0A3S7X2W9	Leishmania donovani	26%	100%
A0A3S7X7Y2	Leishmania donovani	29%	100%
A0A3S7X8Z8	Leishmania donovani	29%	80%
A0A3S7X9R4	Leishmania donovani	35%	100%
A0A3S7X9S2	Leishmania donovani	34%	100%
A0A422MYB4	Trypanosoma rangeli	33%	100%
A0A422N3Y6	Trypanosoma rangeli	24%	87%
A0A422NCP0	Trypanosoma rangeli	32%	78%
A0A422NUF0	Trypanosoma rangeli	29%	97%
A0A422NWI9	Trypanosoma rangeli	28%	100%
A0A422P0J2	Trypanosoma rangeli	36%	100%
A0A422P0N6	Trypanosoma rangeli	32%	100%
A0A422P1R5	Trypanosoma rangeli	33%	100%
A0A422P270	Trypanosoma rangeli	35%	88%
A0A422P3N8	Trypanosoma rangeli	32%	66%
A0A422P4V9	Trypanosoma rangeli	37%	85%
A0A8I3S724	Canis lupus familiaris	32%	96%
A2VDV2	Bos taurus	32%	84%
A4H459	Leishmania braziliensis	24%	100%
A4H4S9	Leishmania braziliensis	29%	100%
A4H539	Leishmania braziliensis	32%	100%
A4H601	Leishmania braziliensis	26%	100%
A4H7W1	Leishmania braziliensis	27%	71%
A4H8C4	Leishmania braziliensis	32%	100%
A4H9H4	Leishmania braziliensis	33%	100%
A4H9L8	Leishmania braziliensis	33%	100%
A4HA94	Leishmania braziliensis	26%	100%
A4HAS1	Leishmania braziliensis	30%	100%
A4HBL4	Leishmania braziliensis	26%	100%
A4HCD7	Leishmania braziliensis	30%	91%
A4HED7	Leishmania braziliensis	91%	100%
A4HFA1	Leishmania braziliensis	25%	100%
A4HFF3	Leishmania braziliensis	30%	78%
A4HG26	Leishmania braziliensis	27%	100%
A4HG27	Leishmania braziliensis	29%	72%
A4HG92	Leishmania braziliensis	32%	100%
A4HH03	Leishmania braziliensis	26%	100%
A4HHE4	Leishmania braziliensis	26%	66%
A4HHQ5	Leishmania braziliensis	28%	77%
A4HHR5	Leishmania braziliensis	25%	75%
A4HHS9	Leishmania braziliensis	26%	100%
A4HI35	Leishmania braziliensis	36%	76%
A4HJT5	Leishmania braziliensis	28%	88%
A4HJW2	Leishmania braziliensis	27%	91%
A4HLJ9	Leishmania braziliensis	25%	100%
A4HLR0	Leishmania braziliensis	27%	87%
A4HN71	Leishmania braziliensis	34%	100%
A4HNI1	Leishmania braziliensis	32%	81%
A4HNT2	Leishmania braziliensis	25%	100%
A4HQG8	Leishmania braziliensis	25%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HTB4	Leishmania infantum	33%	100%
A4HW88	Leishmania infantum	29%	70%
A4HWP5	Leishmania infantum	32%	100%
A4HX71	Leishmania infantum	29%	70%
A4HXU0	Leishmania infantum	33%	100%
A4HXY2	Leishmania infantum	30%	100%
A4HYH4	Leishmania infantum	26%	100%
A4HZA2	Leishmania infantum	27%	100%
A4HZV1	Leishmania infantum	28%	100%
A4HZW8	Leishmania infantum	25%	100%
A4I1T4	Leishmania infantum	97%	100%
A4I349	Leishmania infantum	30%	69%
A4I3C6	Leishmania infantum	33%	100%
A4I435	Leishmania infantum	28%	100%
A4I4X5	Leishmania infantum	26%	75%
A4I4Y0	Leishmania infantum	26%	100%
A4I5B1	Leishmania infantum	35%	76%
A4I7A1	Leishmania infantum	29%	88%
A4I7C4	Leishmania infantum	26%	91%
A4I910	Leishmania infantum	26%	100%
A4I9Y5	Leishmania infantum	29%	100%
A4IB02	Leishmania infantum	29%	80%
A4IBT4	Leishmania infantum	34%	100%
A4IBT9	Leishmania infantum	35%	100%
A4IC37	Leishmania infantum	32%	82%
A4ICA4	Leishmania infantum	25%	100%
A4IGM9	Xenopus tropicalis	32%	100%
A5GFW1	Sus scrofa	33%	97%
A7MB74	Bos taurus	40%	90%
A8X6H4	Caenorhabditis briggsae	32%	100%
A8XJL7	Caenorhabditis briggsae	30%	82%
A8XJQ6	Caenorhabditis briggsae	32%	100%
A8XNJ6	Caenorhabditis briggsae	34%	84%
A8XW88	Caenorhabditis briggsae	31%	100%
B9FKW9	Oryza sativa subsp. japonica	35%	75%
C6K3W8	Leptomonas seymouri	36%	74%
C9ZIN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	78%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	96%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	92%
C9ZMA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	69%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
C9ZPX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	71%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	82%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	83%
D0A509	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ACW6	Leishmania major	26%	100%
E9ACW7	Leishmania major	30%	69%
E9AEB9	Leishmania major	28%	78%
E9AEC9	Leishmania major	26%	75%
E9AED4	Leishmania major	26%	100%
E9AET0	Leishmania major	29%	100%
E9AFM1	Leishmania major	34%	97%
E9AG71	Leishmania infantum	29%	85%
E9AH34	Leishmania infantum	26%	72%
E9AHC6	Leishmania infantum	26%	100%
E9AHI7	Leishmania infantum	26%	66%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	75%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	78%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	66%
E9APY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	70%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ARC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	70%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	95%
E9AS98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	80%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	71%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	76%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	88%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	91%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
J9W0G9	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	39%	68%
O00141	Homo sapiens	40%	90%
O01427	Caenorhabditis elegans	33%	100%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	83%
O14965	Homo sapiens	32%	97%
O15530	Homo sapiens	35%	70%
O22932	Arabidopsis thaliana	32%	89%
O22971	Arabidopsis thaliana	32%	77%
O43930	Homo sapiens	33%	100%
O55099	Rattus norvegicus	31%	100%
O55173	Rattus norvegicus	35%	70%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O64629	Arabidopsis thaliana	37%	100%
O64682	Arabidopsis thaliana	35%	89%
O70126	Mus musculus	31%	100%
O70291	Mus musculus	31%	68%
O70293	Mus musculus	34%	68%
O74426	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O74536	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	68%
O77708	Oryctolagus cuniculus	33%	73%
O88445	Mus musculus	32%	100%
P00517	Bos taurus	30%	100%
P05131	Bos taurus	31%	100%
P05132	Mus musculus	29%	100%
P05383	Sus scrofa	31%	100%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	98%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P08413	Rattus norvegicus	33%	72%
P08414	Mus musculus	36%	83%
P11275	Rattus norvegicus	33%	81%
P11730	Rattus norvegicus	33%	74%
P11798	Mus musculus	33%	81%
P12370	Drosophila melanogaster	30%	100%
P13234	Rattus norvegicus	36%	82%
P15791	Rattus norvegicus	33%	73%
P16911	Drosophila melanogaster	30%	100%
P16912	Drosophila melanogaster	32%	67%
P17612	Homo sapiens	30%	100%
P21137	Caenorhabditis elegans	30%	96%
P22612	Homo sapiens	31%	100%
P22694	Homo sapiens	31%	100%
P23443	Homo sapiens	36%	74%
P25321	Cricetulus griseus	30%	100%
P25323	Dictyostelium discoideum	36%	100%
P27791	Rattus norvegicus	30%	100%
P28178	Dictyostelium discoideum	34%	81%
P28327	Bos taurus	31%	69%
P28652	Mus musculus	33%	72%
P31748	AKT8 murine leukemia virus	37%	78%
P31749	Homo sapiens	38%	81%
P31750	Mus musculus	37%	81%
P31751	Homo sapiens	38%	81%
P32298	Homo sapiens	33%	67%
P36887	Sus scrofa	30%	100%
P38070	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	74%
P40376	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	76%
P42818	Arabidopsis thaliana	37%	84%
P43250	Homo sapiens	34%	68%
P47196	Rattus norvegicus	37%	81%
P47197	Rattus norvegicus	38%	81%
P49673	Ascaris suum	32%	100%
P51817	Homo sapiens	35%	100%
P54644	Dictyostelium discoideum	39%	88%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	32%	74%
P67998	Oryctolagus cuniculus	36%	74%
P67999	Rattus norvegicus	36%	74%
P68180	Cricetulus griseus	31%	100%
P68181	Mus musculus	31%	100%
P68182	Rattus norvegicus	31%	100%
P70507	Rattus norvegicus	30%	68%
P92937	Arabidopsis thaliana	32%	92%
P93759	Arabidopsis thaliana	32%	73%
P97477	Mus musculus	32%	98%
P97711	Rattus norvegicus	34%	68%
Q00168	Drosophila melanogaster	34%	73%
Q01314	Bos taurus	38%	81%
Q06226	Rattus norvegicus	39%	90%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	85%
Q09831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	69%
Q0JI49	Oryza sativa subsp. japonica	33%	77%
Q10LQ2	Oryza sativa subsp. japonica	31%	86%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	89%
Q13555	Homo sapiens	33%	70%
Q13557	Homo sapiens	33%	78%
Q14012	Homo sapiens	33%	100%
Q15208	Homo sapiens	32%	84%
Q15835	Homo sapiens	31%	69%
Q16566	Homo sapiens	36%	82%
Q17941	Caenorhabditis elegans	36%	72%
Q27687	Leishmania major	31%	98%
Q2HJF7	Bos taurus	33%	80%
Q2L6W9	Caenorhabditis elegans	32%	82%
Q2LZZ7	Drosophila pseudoobscura pseudoobscura	32%	85%
Q2PJ68	Caenorhabditis elegans	33%	84%
Q2QMI0	Oryza sativa subsp. japonica	31%	86%
Q2QY53	Oryza sativa subsp. japonica	31%	89%
Q2TA06	Bos taurus	32%	97%
Q2V452	Arabidopsis thaliana	33%	88%
Q38868	Arabidopsis thaliana	36%	72%
Q39030	Arabidopsis thaliana	36%	83%
Q3E9C0	Arabidopsis thaliana	32%	74%
Q3MHJ9	Bos taurus	33%	72%
Q4Q0B0	Leishmania major	25%	100%
Q4Q204	Leishmania major	26%	100%
Q4Q2Z2	Leishmania major	29%	100%
Q4Q449	Leishmania major	25%	100%
Q4Q5T9	Leishmania major	26%	91%
Q4Q5W2	Leishmania major	29%	88%
Q4Q7M5	Leishmania major	35%	76%
Q4Q7W2	Leishmania major	28%	100%
Q4Q9K2	Leishmania major	96%	100%
Q4QAV8	Leishmania major	26%	72%
Q4QBQ2	Leishmania major	27%	100%
Q4QBR6	Leishmania major	28%	100%
Q4QCK0	Leishmania major	27%	100%
Q4QCR2	Leishmania major	26%	100%
Q4QD66	Leishmania major	26%	100%
Q4QDX7	Leishmania major	33%	100%
Q4QEJ2	Leishmania major	29%	70%
Q4QF23	Leishmania major	32%	100%
Q4QFJ2	Leishmania major	29%	70%
Q4QIJ7	Leishmania major	33%	100%
Q4QIV8	Leishmania major	30%	100%
Q4QJJ0	Leishmania major	25%	100%
Q4R633	Macaca fascicularis	40%	90%
Q4V3C8	Arabidopsis thaliana	34%	80%
Q4V7Q6	Xenopus laevis	32%	83%
Q54C18	Dictyostelium discoideum	33%	75%
Q54CY9	Dictyostelium discoideum	33%	100%
Q54IH8	Dictyostelium discoideum	29%	72%
Q54L81	Dictyostelium discoideum	33%	84%
Q54PB4	Dictyostelium discoideum	33%	81%
Q54UZ1	Dictyostelium discoideum	32%	95%
Q54WX4	Dictyostelium discoideum	34%	100%
Q54Y26	Dictyostelium discoideum	34%	73%
Q5BKK4	Xenopus tropicalis	40%	93%
Q5JLD8	Oryza sativa subsp. japonica	31%	87%
Q5JLQ9	Oryza sativa subsp. japonica	33%	82%
Q5JLS2	Oryza sativa subsp. japonica	36%	72%
Q5Q0U5	Fundulus heteroclitus	40%	90%
Q5QNM6	Oryza sativa subsp. japonica	32%	76%
Q5R7A7	Pongo abelii	38%	78%
Q5R8M1	Pongo abelii	32%	84%
Q5RCC4	Pongo abelii	33%	81%
Q5W736	Oryza sativa subsp. japonica	33%	85%
Q5Z6X0	Oryza sativa subsp. japonica	30%	76%
Q5ZKI0	Gallus gallus	33%	81%
Q60823	Mus musculus	38%	81%
Q61XD3	Caenorhabditis briggsae	32%	100%
Q63450	Rattus norvegicus	33%	100%
Q63484	Rattus norvegicus	36%	81%
Q683C9	Arabidopsis thaliana	32%	100%
Q68Y49	Oryza sativa subsp. japonica	32%	77%
Q6A1A2	Homo sapiens	35%	98%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	94%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q6CFS5	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	66%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	100%
Q6DE08	Xenopus laevis	32%	100%
Q6DEH3	Danio rerio	34%	79%
Q6DGS3	Danio rerio	33%	70%
Q6ERS4	Oryza sativa subsp. japonica	33%	85%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	100%
Q6GLY8	Xenopus laevis	37%	90%
Q6GPL3	Xenopus laevis	32%	100%
Q6GPN6	Xenopus laevis	40%	90%
Q6IP76	Xenopus laevis	40%	80%
Q6NW76	Danio rerio	33%	100%
Q6PHZ2	Mus musculus	33%	78%
Q6TGC6	Pneumocystis carinii	31%	77%
Q6TJY3	Bos taurus	36%	74%
Q6U1I9	Gallus gallus	40%	90%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q7JP68	Caenorhabditis elegans	33%	98%
Q7TSE6	Mus musculus	33%	84%
Q7YRC6	Bos taurus	31%	100%
Q7ZTW4	Danio rerio	40%	90%
Q7ZX15	Xenopus laevis	40%	80%
Q84VQ3	Arabidopsis thaliana	32%	89%
Q852Q2	Oryza sativa subsp. japonica	32%	77%
Q869W6	Dictyostelium discoideum	33%	100%
Q86UX6	Homo sapiens	33%	80%
Q8BGW6	Mus musculus	33%	98%
Q8BSK8	Mus musculus	36%	74%
Q8BW96	Mus musculus	34%	100%
Q8IU85	Homo sapiens	34%	100%
Q8MJ44	Canis lupus familiaris	30%	100%
Q8MYF1	Dictyostelium discoideum	34%	85%
Q8QZV4	Mus musculus	32%	80%
Q8R4U9	Rattus norvegicus	38%	100%
Q8R4V0	Rattus norvegicus	38%	78%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q8W1D5	Arabidopsis thaliana	33%	80%
Q8W490	Arabidopsis thaliana	35%	83%
Q8WMV0	Bos taurus	32%	70%
Q8WP15	Sus scrofa	32%	70%
Q8WTQ7	Homo sapiens	32%	70%
Q8WU08	Homo sapiens	33%	98%
Q90XF2	Danio rerio	36%	66%
Q91819	Xenopus laevis	31%	95%
Q91820	Xenopus laevis	30%	96%
Q91VJ4	Mus musculus	32%	84%
Q91YS8	Mus musculus	33%	100%
Q922R0	Mus musculus	35%	100%
Q923T9	Mus musculus	33%	74%
Q93VK0	Arabidopsis thaliana	30%	100%
Q95266	Sus scrofa	33%	78%
Q96BR1	Homo sapiens	38%	78%
Q96GD4	Homo sapiens	32%	100%
Q98TY9	Xenopus laevis	38%	81%
Q9C562	Arabidopsis thaliana	30%	81%
Q9C6P3	Arabidopsis thaliana	35%	75%
Q9DG02	Xenopus laevis	33%	82%
Q9ERE3	Mus musculus	39%	78%
Q9FJ54	Arabidopsis thaliana	29%	89%
Q9FJ55	Arabidopsis thaliana	33%	81%
Q9FMP5	Arabidopsis thaliana	32%	74%
Q9GNR4	Leishmania major	34%	100%
Q9HBY8	Homo sapiens	39%	100%
Q9JJX8	Mus musculus	29%	94%
Q9LEU7	Arabidopsis thaliana	34%	87%
Q9LGV5	Oryza sativa subsp. japonica	32%	84%
Q9LP51	Arabidopsis thaliana	31%	75%
Q9LTW5	Arabidopsis thaliana	34%	67%
Q9LWM4	Oryza sativa subsp. japonica	32%	84%
Q9M077	Arabidopsis thaliana	31%	100%
Q9MZD9	Ovis aries	30%	100%
Q9N0X0	Sus scrofa	31%	100%
Q9N2N1	Leishmania major	33%	100%
Q9NAH6	Caenorhabditis elegans	33%	71%
Q9NBK5	Drosophila melanogaster	33%	84%
Q9NHE2	Leishmania major	25%	100%
Q9NY57	Homo sapiens	31%	94%
Q9P7J8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	68%
Q9QZS5	Mus musculus	38%	100%
Q9SEZ7	Arabidopsis thaliana	36%	83%
Q9SN43	Arabidopsis thaliana	34%	80%
Q9TXJ0	Caenorhabditis elegans	32%	100%
Q9U6V4	Leishmania donovani	26%	100%
Q9UBS0	Homo sapiens	33%	81%
Q9UQB9	Homo sapiens	32%	100%
Q9UQM7	Homo sapiens	33%	81%
Q9USX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	74%
Q9WUA6	Mus musculus	36%	81%
Q9WVC6	Mus musculus	40%	90%
Q9WVL4	Mus musculus	31%	69%
Q9XF67	Arabidopsis thaliana	35%	79%
Q9XT18	Oryctolagus cuniculus	39%	90%
Q9XTG7	Caenorhabditis elegans	38%	74%
Q9Y243	Homo sapiens	36%	81%
Q9Y2H1	Homo sapiens	33%	84%
Q9Y7J6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	71%
Q9Z1M4	Mus musculus	34%	80%
Q9Z2A0	Mus musculus	35%	70%
V5B871	Trypanosoma cruzi	28%	91%
V5B8E0	Trypanosoma cruzi	31%	100%
V5B9R6	Trypanosoma cruzi	27%	100%
V5BAZ8	Trypanosoma cruzi	30%	100%
V5BC28	Trypanosoma cruzi	27%	77%
V5BCH2	Trypanosoma cruzi	72%	99%
V5BEK5	Trypanosoma cruzi	36%	100%
V5BFK9	Trypanosoma cruzi	28%	100%
V5BG98	Trypanosoma cruzi	31%	100%
V5BH88	Trypanosoma cruzi	34%	71%
V5BI43	Trypanosoma cruzi	33%	77%
V5BKJ3	Trypanosoma cruzi	29%	100%
V5BNV8	Trypanosoma cruzi	32%	100%
V5BP88	Trypanosoma cruzi	26%	84%
V5BPJ0	Trypanosoma cruzi	33%	79%
V5BQH6	Trypanosoma cruzi	36%	90%
V5BWC2	Trypanosoma cruzi	32%	100%
V5D579	Trypanosoma cruzi	28%	90%
V5DC40	Trypanosoma cruzi	27%	71%
V5DI55	Trypanosoma cruzi	31%	93%
V5DMJ4	Trypanosoma cruzi	25%	100%
V5DPP5	Trypanosoma cruzi	31%	90%
V5DQT5	Trypanosoma cruzi	37%	85%
V5DUH0	Trypanosoma cruzi	31%	71%