VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXW7_LEIMU

TriTrypDb:

LmxM.25.2330

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.423
CLV_C14_Caspase3-7	313	317	PF00656	0.460
CLV_NRD_NRD_1	320	322	PF00675	0.508
CLV_NRD_NRD_1	365	367	PF00675	0.337
CLV_NRD_NRD_1	409	411	PF00675	0.469
CLV_NRD_NRD_1	662	664	PF00675	0.461
CLV_NRD_NRD_1	793	795	PF00675	0.353
CLV_PCSK_KEX2_1	320	322	PF00082	0.508
CLV_PCSK_KEX2_1	365	367	PF00082	0.337
CLV_PCSK_KEX2_1	409	411	PF00082	0.449
CLV_PCSK_KEX2_1	662	664	PF00082	0.437
CLV_PCSK_KEX2_1	793	795	PF00082	0.355
CLV_PCSK_SKI1_1	355	359	PF00082	0.366
CLV_PCSK_SKI1_1	432	436	PF00082	0.483
CLV_PCSK_SKI1_1	663	667	PF00082	0.475
CLV_PCSK_SKI1_1	767	771	PF00082	0.435
CLV_Separin_Metazoa	136	140	PF03568	0.239
DEG_APCC_DBOX_1	431	439	PF00400	0.429
DEG_SCF_FBW7_1	76	82	PF00400	0.460
DEG_SPOP_SBC_1	13	17	PF00917	0.460
DEG_SPOP_SBC_1	569	573	PF00917	0.287
DEG_SPOP_SBC_1	8	12	PF00917	0.487
DOC_CKS1_1	76	81	PF01111	0.459
DOC_CYCLIN_RxL_1	764	774	PF00134	0.453
DOC_CYCLIN_RxL_1	819	828	PF00134	0.469
DOC_MAPK_FxFP_2	192	195	PF00069	0.383
DOC_MAPK_gen_1	355	363	PF00069	0.488
DOC_MAPK_gen_1	492	499	PF00069	0.393
DOC_MAPK_gen_1	662	670	PF00069	0.447
DOC_MAPK_MEF2A_6	640	649	PF00069	0.528
DOC_MAPK_MEF2A_6	662	670	PF00069	0.490
DOC_PP1_RVXF_1	703	710	PF00149	0.475
DOC_PP2B_LxvP_1	284	287	PF13499	0.627
DOC_PP2B_LxvP_1	701	704	PF13499	0.472
DOC_PP2B_LxvP_1	738	741	PF13499	0.469
DOC_PP4_FxxP_1	192	195	PF00568	0.427
DOC_USP7_MATH_1	13	17	PF00917	0.637
DOC_USP7_MATH_1	171	175	PF00917	0.411
DOC_USP7_MATH_1	507	511	PF00917	0.572
DOC_USP7_MATH_1	568	572	PF00917	0.408
DOC_USP7_MATH_1	811	815	PF00917	0.530
DOC_USP7_MATH_1	818	822	PF00917	0.433
DOC_WW_Pin1_4	1	6	PF00397	0.673
DOC_WW_Pin1_4	275	280	PF00397	0.567
DOC_WW_Pin1_4	287	292	PF00397	0.641
DOC_WW_Pin1_4	75	80	PF00397	0.459
LIG_14-3-3_CanoR_1	125	135	PF00244	0.425
LIG_14-3-3_CanoR_1	204	211	PF00244	0.537
LIG_14-3-3_CanoR_1	409	418	PF00244	0.475
LIG_14-3-3_CanoR_1	428	432	PF00244	0.229
LIG_14-3-3_CanoR_1	508	516	PF00244	0.485
LIG_14-3-3_CanoR_1	663	669	PF00244	0.285
LIG_14-3-3_CanoR_1	778	785	PF00244	0.379
LIG_14-3-3_CanoR_1	822	827	PF00244	0.482
LIG_APCC_ABBA_1	517	522	PF00400	0.372
LIG_CSL_BTD_1	701	704	PF09270	0.342
LIG_deltaCOP1_diTrp_1	301	308	PF00928	0.541
LIG_EH1_1	595	603	PF00400	0.360
LIG_eIF4E_1	449	455	PF01652	0.354
LIG_eIF4E_1	466	472	PF01652	0.223
LIG_eIF4E_1	596	602	PF01652	0.266
LIG_FHA_1	186	192	PF00498	0.357
LIG_FHA_1	338	344	PF00498	0.529
LIG_FHA_1	372	378	PF00498	0.599
LIG_FHA_1	519	525	PF00498	0.368
LIG_FHA_1	536	542	PF00498	0.292
LIG_FHA_1	597	603	PF00498	0.340
LIG_FHA_1	622	628	PF00498	0.271
LIG_FHA_1	665	671	PF00498	0.321
LIG_FHA_1	685	691	PF00498	0.552
LIG_FHA_1	78	84	PF00498	0.417
LIG_FHA_1	829	835	PF00498	0.568
LIG_FHA_2	313	319	PF00498	0.408
LIG_FHA_2	496	502	PF00498	0.418
LIG_FHA_2	613	619	PF00498	0.290
LIG_FHA_2	727	733	PF00498	0.570
LIG_FHA_2	96	102	PF00498	0.404
LIG_LIR_Apic_2	190	195	PF02991	0.416
LIG_LIR_Apic_2	734	740	PF02991	0.435
LIG_LIR_Gen_1	199	208	PF02991	0.459
LIG_LIR_Gen_1	305	312	PF02991	0.468
LIG_LIR_Gen_1	696	706	PF02991	0.353
LIG_LIR_Nem_3	106	111	PF02991	0.348
LIG_LIR_Nem_3	163	168	PF02991	0.281
LIG_LIR_Nem_3	199	205	PF02991	0.338
LIG_LIR_Nem_3	305	311	PF02991	0.471
LIG_LIR_Nem_3	514	520	PF02991	0.428
LIG_LIR_Nem_3	696	701	PF02991	0.497
LIG_LIR_Nem_3	71	76	PF02991	0.379
LIG_LYPXL_yS_3	468	471	PF13949	0.468
LIG_MYND_1	287	291	PF01753	0.649
LIG_NRBOX	536	542	PF00104	0.411
LIG_NRBOX	829	835	PF00104	0.507
LIG_PCNA_PIPBox_1	823	832	PF02747	0.320
LIG_PCNA_yPIPBox_3	626	640	PF02747	0.411
LIG_Pex14_1	302	306	PF04695	0.402
LIG_Pex14_1	69	73	PF04695	0.484
LIG_Pex14_2	364	368	PF04695	0.316
LIG_Pex14_2	65	69	PF04695	0.500
LIG_PTB_Apo_2	722	729	PF02174	0.592
LIG_Rb_LxCxE_1	774	790	PF01857	0.300
LIG_SH2_CRK	466	470	PF00017	0.408
LIG_SH2_CRK	475	479	PF00017	0.429
LIG_SH2_CRK	73	77	PF00017	0.374
LIG_SH2_NCK_1	475	479	PF00017	0.389
LIG_SH2_PTP2	698	701	PF00017	0.400
LIG_SH2_STAP1	475	479	PF00017	0.389
LIG_SH2_STAP1	520	524	PF00017	0.259
LIG_SH2_STAP1	756	760	PF00017	0.380
LIG_SH2_STAT5	108	111	PF00017	0.370
LIG_SH2_STAT5	153	156	PF00017	0.266
LIG_SH2_STAT5	168	171	PF00017	0.266
LIG_SH2_STAT5	176	179	PF00017	0.313
LIG_SH2_STAT5	342	345	PF00017	0.569
LIG_SH2_STAT5	369	372	PF00017	0.376
LIG_SH2_STAT5	466	469	PF00017	0.248
LIG_SH2_STAT5	520	523	PF00017	0.418
LIG_SH2_STAT5	585	588	PF00017	0.299
LIG_SH2_STAT5	698	701	PF00017	0.369
LIG_SH2_STAT5	737	740	PF00017	0.500
LIG_SH3_2	817	822	PF14604	0.503
LIG_SH3_3	258	264	PF00018	0.313
LIG_SH3_3	40	46	PF00018	0.432
LIG_SH3_3	814	820	PF00018	0.523
LIG_SUMO_SIM_anti_2	729	737	PF11976	0.487
LIG_SUMO_SIM_par_1	821	828	PF11976	0.491
LIG_TRAF2_1	615	618	PF00917	0.360
LIG_TRAF2_1	729	732	PF00917	0.570
MOD_CDK_SPK_2	1	6	PF00069	0.619
MOD_CDK_SPxxK_3	287	294	PF00069	0.648
MOD_CK1_1	121	127	PF00069	0.447
MOD_CK1_1	16	22	PF00069	0.577
MOD_CK1_1	310	316	PF00069	0.517
MOD_CK1_1	327	333	PF00069	0.311
MOD_CK1_1	337	343	PF00069	0.487
MOD_CK1_1	675	681	PF00069	0.556
MOD_CK1_1	825	831	PF00069	0.389
MOD_CK1_1	95	101	PF00069	0.499
MOD_CK2_1	312	318	PF00069	0.388
MOD_CK2_1	612	618	PF00069	0.307
MOD_CK2_1	726	732	PF00069	0.524
MOD_CK2_1	777	783	PF00069	0.586
MOD_CMANNOS	84	87	PF00535	0.328
MOD_Cter_Amidation	407	410	PF01082	0.563
MOD_GlcNHglycan	120	123	PF01048	0.618
MOD_GlcNHglycan	128	131	PF01048	0.529
MOD_GlcNHglycan	148	151	PF01048	0.292
MOD_GlcNHglycan	16	19	PF01048	0.510
MOD_GlcNHglycan	171	174	PF01048	0.320
MOD_GlcNHglycan	264	267	PF01048	0.386
MOD_GlcNHglycan	269	272	PF01048	0.468
MOD_GlcNHglycan	380	384	PF01048	0.434
MOD_GlcNHglycan	411	414	PF01048	0.602
MOD_GlcNHglycan	53	56	PF01048	0.416
MOD_GlcNHglycan	572	575	PF01048	0.272
MOD_GlcNHglycan	674	677	PF01048	0.544
MOD_GlcNHglycan	757	760	PF01048	0.383
MOD_GSK3_1	19	26	PF00069	0.470
MOD_GSK3_1	200	207	PF00069	0.537
MOD_GSK3_1	422	429	PF00069	0.325
MOD_GSK3_1	551	558	PF00069	0.431
MOD_GSK3_1	568	575	PF00069	0.287
MOD_GSK3_1	596	603	PF00069	0.411
MOD_GSK3_1	672	679	PF00069	0.546
MOD_GSK3_1	680	687	PF00069	0.587
MOD_GSK3_1	75	82	PF00069	0.448
MOD_GSK3_1	8	15	PF00069	0.599
MOD_GSK3_1	818	825	PF00069	0.547
MOD_N-GLC_1	337	342	PF02516	0.583
MOD_NEK2_1	145	150	PF00069	0.513
MOD_NEK2_1	185	190	PF00069	0.428
MOD_NEK2_1	371	376	PF00069	0.381
MOD_NEK2_1	426	431	PF00069	0.330
MOD_NEK2_1	486	491	PF00069	0.452
MOD_NEK2_1	587	592	PF00069	0.439
MOD_NEK2_1	611	616	PF00069	0.282
MOD_NEK2_1	620	625	PF00069	0.246
MOD_NEK2_1	749	754	PF00069	0.414
MOD_NEK2_1	755	760	PF00069	0.441
MOD_NEK2_1	94	99	PF00069	0.467
MOD_NEK2_2	391	396	PF00069	0.552
MOD_NEK2_2	427	432	PF00069	0.292
MOD_OFUCOSY	206	213	PF10250	0.460
MOD_OFUCOSY	370	375	PF10250	0.420
MOD_PIKK_1	473	479	PF00454	0.508
MOD_PIKK_1	509	515	PF00454	0.668
MOD_PIKK_1	535	541	PF00454	0.428
MOD_PIKK_1	555	561	PF00454	0.403
MOD_PIKK_1	585	591	PF00454	0.411
MOD_PIKK_1	613	619	PF00454	0.360
MOD_PKA_1	409	415	PF00069	0.503
MOD_PKA_2	267	273	PF00069	0.439
MOD_PKA_2	302	308	PF00069	0.545
MOD_PKA_2	409	415	PF00069	0.525
MOD_PKA_2	427	433	PF00069	0.222
MOD_PKA_2	507	513	PF00069	0.551
MOD_PKA_2	555	561	PF00069	0.346
MOD_PKA_2	569	575	PF00069	0.408
MOD_PKA_2	777	783	PF00069	0.488
MOD_Plk_1	481	487	PF00069	0.409
MOD_Plk_1	731	737	PF00069	0.574
MOD_Plk_2-3	495	501	PF00069	0.391
MOD_Plk_4	187	193	PF00069	0.352
MOD_Plk_4	307	313	PF00069	0.441
MOD_Plk_4	628	634	PF00069	0.305
MOD_Plk_4	664	670	PF00069	0.276
MOD_Plk_4	731	737	PF00069	0.610
MOD_ProDKin_1	1	7	PF00069	0.673
MOD_ProDKin_1	275	281	PF00069	0.573
MOD_ProDKin_1	287	293	PF00069	0.634
MOD_ProDKin_1	75	81	PF00069	0.454
MOD_SUMO_rev_2	212	221	PF00179	0.545
TRG_DiLeu_BaEn_1	731	736	PF01217	0.533
TRG_DiLeu_BaEn_4	731	737	PF01217	0.522
TRG_DiLeu_BaLyEn_6	764	769	PF01217	0.426
TRG_ENDOCYTIC_2	108	111	PF00928	0.365
TRG_ENDOCYTIC_2	468	471	PF00928	0.392
TRG_ENDOCYTIC_2	475	478	PF00928	0.369
TRG_ENDOCYTIC_2	698	701	PF00928	0.480
TRG_ENDOCYTIC_2	73	76	PF00928	0.366
TRG_ER_diArg_1	138	141	PF00400	0.456
TRG_ER_diArg_1	320	322	PF00400	0.619
TRG_ER_diArg_1	364	366	PF00400	0.330
TRG_ER_diArg_1	409	411	PF00400	0.422
TRG_ER_diArg_1	792	794	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	822	827	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV2	Leptomonas seymouri	61%	99%
A0A0S4IXM9	Bodo saltans	33%	78%
A0A1X0NY26	Trypanosomatidae	38%	92%
A0A3S7WZE1	Leishmania donovani	93%	100%
A0A422P4H0	Trypanosoma rangeli	39%	90%
A4HED6	Leishmania braziliensis	86%	100%
A4I1T3	Leishmania infantum	94%	100%
C9ZKD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
Q4Q9K3	Leishmania major	92%	100%
V5BH11	Trypanosoma cruzi	41%	95%