Transcription initiation factor TFIID subunit 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXW5_LEIMU

TriTrypDb:

LmxM.25.2310

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.435
CLV_C14_Caspase3-7	368	372	PF00656	0.550
CLV_C14_Caspase3-7	66	70	PF00656	0.433
CLV_NRD_NRD_1	148	150	PF00675	0.521
CLV_NRD_NRD_1	45	47	PF00675	0.710
CLV_NRD_NRD_1	505	507	PF00675	0.530
CLV_NRD_NRD_1	98	100	PF00675	0.520
CLV_PCSK_KEX2_1	148	150	PF00082	0.521
CLV_PCSK_KEX2_1	45	47	PF00082	0.710
CLV_PCSK_KEX2_1	505	507	PF00082	0.556
CLV_PCSK_KEX2_1	574	576	PF00082	0.493
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.493
CLV_PCSK_SKI1_1	115	119	PF00082	0.453
CLV_PCSK_SKI1_1	148	152	PF00082	0.473
CLV_PCSK_SKI1_1	29	33	PF00082	0.587
CLV_PCSK_SKI1_1	309	313	PF00082	0.471
CLV_PCSK_SKI1_1	468	472	PF00082	0.483
CLV_PCSK_SKI1_1	571	575	PF00082	0.502
DEG_APCC_DBOX_1	147	155	PF00400	0.546
DEG_APCC_DBOX_1	467	475	PF00400	0.483
DOC_CKS1_1	22	27	PF01111	0.531
DOC_MAPK_gen_1	280	289	PF00069	0.495
DOC_MAPK_MEF2A_6	230	238	PF00069	0.577
DOC_MAPK_MEF2A_6	282	291	PF00069	0.513
DOC_MAPK_MEF2A_6	425	432	PF00069	0.493
DOC_PP1_RVXF_1	113	119	PF00149	0.501
DOC_PP1_SILK_1	260	265	PF00149	0.450
DOC_PP2B_LxvP_1	23	26	PF13499	0.677
DOC_USP7_MATH_1	12	16	PF00917	0.571
DOC_USP7_MATH_1	127	131	PF00917	0.574
DOC_USP7_MATH_1	158	162	PF00917	0.562
DOC_USP7_MATH_1	384	388	PF00917	0.488
DOC_USP7_MATH_1	44	48	PF00917	0.554
DOC_USP7_MATH_1	70	74	PF00917	0.552
DOC_USP7_UBL2_3	155	159	PF12436	0.549
DOC_USP7_UBL2_3	59	63	PF12436	0.489
DOC_WW_Pin1_4	21	26	PF00397	0.540
DOC_WW_Pin1_4	270	275	PF00397	0.457
DOC_WW_Pin1_4	291	296	PF00397	0.410
DOC_WW_Pin1_4	317	322	PF00397	0.479
DOC_WW_Pin1_4	423	428	PF00397	0.496
LIG_14-3-3_CanoR_1	29	37	PF00244	0.623
LIG_14-3-3_CanoR_1	45	53	PF00244	0.346
LIG_Actin_WH2_2	140	157	PF00022	0.589
LIG_Actin_WH2_2	453	470	PF00022	0.423
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BRCT_BRCA1_1	194	198	PF00533	0.510
LIG_BRCT_BRCA1_1	3	7	PF00533	0.363
LIG_BRCT_BRCA1_1	448	452	PF00533	0.555
LIG_EH_1	76	80	PF12763	0.491
LIG_eIF4E_1	466	472	PF01652	0.519
LIG_FHA_1	120	126	PF00498	0.477
LIG_FHA_1	183	189	PF00498	0.481
LIG_FHA_1	197	203	PF00498	0.427
LIG_FHA_1	266	272	PF00498	0.373
LIG_FHA_1	32	38	PF00498	0.535
LIG_FHA_1	343	349	PF00498	0.555
LIG_FHA_1	357	363	PF00498	0.563
LIG_FHA_1	557	563	PF00498	0.397
LIG_FHA_2	134	140	PF00498	0.630
LIG_FHA_2	205	211	PF00498	0.424
LIG_FHA_2	288	294	PF00498	0.482
LIG_FHA_2	31	37	PF00498	0.518
LIG_FHA_2	334	340	PF00498	0.525
LIG_LIR_Apic_2	298	302	PF02991	0.462
LIG_LIR_Apic_2	378	384	PF02991	0.540
LIG_LIR_Gen_1	250	259	PF02991	0.398
LIG_LIR_Gen_1	268	274	PF02991	0.305
LIG_LIR_Gen_1	363	372	PF02991	0.479
LIG_LIR_Gen_1	4	14	PF02991	0.574
LIG_LIR_Gen_1	498	504	PF02991	0.379
LIG_LIR_Nem_3	250	254	PF02991	0.389
LIG_LIR_Nem_3	268	272	PF02991	0.381
LIG_LIR_Nem_3	363	369	PF02991	0.466
LIG_LIR_Nem_3	4	10	PF02991	0.570
LIG_LIR_Nem_3	498	502	PF02991	0.368
LIG_MLH1_MIPbox_1	448	452	PF16413	0.555
LIG_PCNA_yPIPBox_3	206	217	PF02747	0.393
LIG_Pex14_1	564	568	PF04695	0.355
LIG_Pex14_2	447	451	PF04695	0.542
LIG_SH2_CRK	299	303	PF00017	0.383
LIG_SH2_CRK	318	322	PF00017	0.495
LIG_SH2_CRK	381	385	PF00017	0.563
LIG_SH2_CRK	83	87	PF00017	0.372
LIG_SH2_NCK_1	318	322	PF00017	0.495
LIG_SH2_SRC	381	384	PF00017	0.538
LIG_SH2_SRC	393	396	PF00017	0.381
LIG_SH2_STAP1	251	255	PF00017	0.437
LIG_SH2_STAP1	572	576	PF00017	0.477
LIG_SH2_STAT3	85	88	PF00017	0.553
LIG_SH2_STAT5	156	159	PF00017	0.552
LIG_SH2_STAT5	265	268	PF00017	0.370
LIG_SH2_STAT5	318	321	PF00017	0.486
LIG_SH2_STAT5	466	469	PF00017	0.413
LIG_SH3_3	159	165	PF00018	0.504
LIG_SH3_3	19	25	PF00018	0.510
LIG_SH3_3	268	274	PF00018	0.454
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.568
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.331
LIG_SUMO_SIM_par_1	12	18	PF11976	0.511
LIG_SUMO_SIM_par_1	252	258	PF11976	0.401
LIG_SUMO_SIM_par_1	287	294	PF11976	0.547
LIG_SUMO_SIM_par_1	492	498	PF11976	0.481
LIG_UBA3_1	304	309	PF00899	0.409
LIG_WRC_WIRS_1	266	271	PF05994	0.382
LIG_WW_1	508	511	PF00397	0.615
MOD_CDK_SPK_2	270	275	PF00069	0.483
MOD_CK1_1	15	21	PF00069	0.527
MOD_CK1_1	48	54	PF00069	0.607
MOD_CK1_1	528	534	PF00069	0.733
MOD_CK1_1	538	544	PF00069	0.652
MOD_CK1_1	546	552	PF00069	0.350
MOD_CK2_1	287	293	PF00069	0.516
MOD_CK2_1	30	36	PF00069	0.526
MOD_CK2_1	333	339	PF00069	0.537
MOD_GlcNHglycan	105	108	PF01048	0.467
MOD_GlcNHglycan	26	29	PF01048	0.598
MOD_GlcNHglycan	298	302	PF01048	0.478
MOD_GlcNHglycan	386	389	PF01048	0.472
MOD_GlcNHglycan	414	417	PF01048	0.525
MOD_GlcNHglycan	42	45	PF01048	0.486
MOD_GlcNHglycan	527	530	PF01048	0.713
MOD_GlcNHglycan	535	538	PF01048	0.731
MOD_GSK3_1	1	8	PF00069	0.408
MOD_GSK3_1	160	167	PF00069	0.456
MOD_GSK3_1	182	189	PF00069	0.421
MOD_GSK3_1	192	199	PF00069	0.414
MOD_GSK3_1	287	294	PF00069	0.436
MOD_GSK3_1	342	349	PF00069	0.516
MOD_GSK3_1	356	363	PF00069	0.361
MOD_GSK3_1	40	47	PF00069	0.535
MOD_GSK3_1	400	407	PF00069	0.606
MOD_GSK3_1	513	520	PF00069	0.727
MOD_GSK3_1	528	535	PF00069	0.737
MOD_N-GLC_1	103	108	PF02516	0.440
MOD_N-GLC_1	192	197	PF02516	0.526
MOD_N-GLC_1	356	361	PF02516	0.281
MOD_NEK2_1	160	165	PF00069	0.509
MOD_NEK2_1	169	174	PF00069	0.542
MOD_NEK2_1	184	189	PF00069	0.508
MOD_NEK2_1	255	260	PF00069	0.516
MOD_NEK2_1	342	347	PF00069	0.570
MOD_NEK2_1	356	361	PF00069	0.485
MOD_NEK2_1	400	405	PF00069	0.623
MOD_NEK2_1	447	452	PF00069	0.504
MOD_NEK2_1	495	500	PF00069	0.394
MOD_NEK2_1	71	76	PF00069	0.576
MOD_PIKK_1	202	208	PF00454	0.535
MOD_PIKK_1	48	54	PF00454	0.616
MOD_PIKK_1	71	77	PF00454	0.569
MOD_PK_1	230	236	PF00069	0.532
MOD_PK_1	45	51	PF00069	0.641
MOD_PKA_1	45	51	PF00069	0.673
MOD_PKA_2	346	352	PF00069	0.576
MOD_PKA_2	44	50	PF00069	0.539
MOD_Plk_1	447	453	PF00069	0.479
MOD_Plk_1	5	11	PF00069	0.496
MOD_Plk_4	204	210	PF00069	0.421
MOD_Plk_4	287	293	PF00069	0.518
MOD_Plk_4	361	367	PF00069	0.513
MOD_Plk_4	447	453	PF00069	0.477
MOD_ProDKin_1	21	27	PF00069	0.542
MOD_ProDKin_1	270	276	PF00069	0.462
MOD_ProDKin_1	291	297	PF00069	0.411
MOD_ProDKin_1	317	323	PF00069	0.476
MOD_ProDKin_1	423	429	PF00069	0.486
MOD_SUMO_for_1	221	224	PF00179	0.613
MOD_SUMO_rev_2	210	219	PF00179	0.568
MOD_SUMO_rev_2	368	375	PF00179	0.599
MOD_SUMO_rev_2	56	61	PF00179	0.546
TRG_ENDOCYTIC_2	251	254	PF00928	0.425
TRG_ENDOCYTIC_2	81	84	PF00928	0.460
TRG_ER_diArg_1	147	149	PF00400	0.506
TRG_ER_diArg_1	504	506	PF00400	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P620	Leptomonas seymouri	72%	100%
A0A0S4J1E1	Bodo saltans	33%	97%
A0A1X0NY27	Trypanosomatidae	39%	100%
A0A3R7RTJ3	Trypanosoma rangeli	38%	100%
A0A3S7WZE8	Leishmania donovani	95%	100%
A4HED4	Leishmania braziliensis	87%	100%
A4I1T1	Leishmania infantum	95%	100%
Q95ZB6	Leishmania major	94%	100%
V5B817	Trypanosoma cruzi	40%	100%