EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania mexicana

UniProt:

E9AXW4_LEIMU

TriTrypDb:

LmxM.25.2300

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AXW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.579
CLV_C14_Caspase3-7	171	175	PF00656	0.560
CLV_C14_Caspase3-7	27	31	PF00656	0.395
CLV_C14_Caspase3-7	275	279	PF00656	0.463
CLV_C14_Caspase3-7	311	315	PF00656	0.490
CLV_C14_Caspase3-7	336	340	PF00656	0.607
CLV_NRD_NRD_1	213	215	PF00675	0.480
CLV_NRD_NRD_1	259	261	PF00675	0.481
CLV_NRD_NRD_1	306	308	PF00675	0.768
CLV_NRD_NRD_1	357	359	PF00675	0.790
CLV_NRD_NRD_1	440	442	PF00675	0.519
CLV_NRD_NRD_1	479	481	PF00675	0.392
CLV_NRD_NRD_1	592	594	PF00675	0.507
CLV_PCSK_KEX2_1	213	215	PF00082	0.425
CLV_PCSK_KEX2_1	259	261	PF00082	0.508
CLV_PCSK_KEX2_1	273	275	PF00082	0.597
CLV_PCSK_KEX2_1	306	308	PF00082	0.776
CLV_PCSK_KEX2_1	357	359	PF00082	0.749
CLV_PCSK_KEX2_1	440	442	PF00082	0.519
CLV_PCSK_KEX2_1	486	488	PF00082	0.433
CLV_PCSK_KEX2_1	592	594	PF00082	0.507
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.559
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.433
CLV_PCSK_SKI1_1	213	217	PF00082	0.396
CLV_PCSK_SKI1_1	226	230	PF00082	0.410
CLV_PCSK_SKI1_1	259	263	PF00082	0.512
CLV_PCSK_SKI1_1	380	384	PF00082	0.380
CLV_PCSK_SKI1_1	476	480	PF00082	0.468
CLV_PCSK_SKI1_1	481	485	PF00082	0.484
CLV_PCSK_SKI1_1	570	574	PF00082	0.336
CLV_Separin_Metazoa	477	481	PF03568	0.357
DOC_CDC14_PxL_1	110	118	PF14671	0.525
DOC_CDC14_PxL_1	85	93	PF14671	0.455
DOC_CYCLIN_RxL_1	210	218	PF00134	0.442
DOC_CYCLIN_RxL_1	566	574	PF00134	0.351
DOC_MAPK_gen_1	38	47	PF00069	0.427
DOC_MAPK_gen_1	546	554	PF00069	0.555
DOC_MAPK_HePTP_8	563	575	PF00069	0.429
DOC_MAPK_MEF2A_6	566	575	PF00069	0.458
DOC_MAPK_MEF2A_6	618	627	PF00069	0.285
DOC_MAPK_MEF2A_6	90	98	PF00069	0.512
DOC_PP2B_LxvP_1	98	101	PF13499	0.632
DOC_USP7_MATH_1	149	153	PF00917	0.595
DOC_USP7_MATH_1	157	161	PF00917	0.566
DOC_USP7_MATH_1	168	172	PF00917	0.462
DOC_USP7_MATH_1	356	360	PF00917	0.629
DOC_USP7_MATH_1	368	372	PF00917	0.582
DOC_USP7_MATH_1	522	526	PF00917	0.382
DOC_USP7_MATH_1	558	562	PF00917	0.483
DOC_USP7_MATH_1	616	620	PF00917	0.539
DOC_USP7_MATH_1	632	636	PF00917	0.532
DOC_USP7_UBL2_3	395	399	PF12436	0.409
DOC_WW_Pin1_4	324	329	PF00397	0.662
DOC_WW_Pin1_4	343	348	PF00397	0.509
DOC_WW_Pin1_4	552	557	PF00397	0.731
LIG_14-3-3_CanoR_1	238	244	PF00244	0.430
LIG_14-3-3_CanoR_1	321	325	PF00244	0.677
LIG_14-3-3_CanoR_1	370	374	PF00244	0.646
LIG_14-3-3_CanoR_1	472	476	PF00244	0.488
LIG_14-3-3_CanoR_1	90	95	PF00244	0.511
LIG_Actin_WH2_2	369	385	PF00022	0.334
LIG_Actin_WH2_2	411	427	PF00022	0.391
LIG_Actin_WH2_2	637	655	PF00022	0.380
LIG_BIR_II_1	1	5	PF00653	0.411
LIG_BRCT_BRCA1_1	603	607	PF00533	0.242
LIG_BRCT_BRCA1_1	642	646	PF00533	0.402
LIG_CtBP_PxDLS_1	56	60	PF00389	0.445
LIG_EH1_1	3	11	PF00400	0.314
LIG_FHA_1	120	126	PF00498	0.460
LIG_FHA_1	372	378	PF00498	0.505
LIG_FHA_1	389	395	PF00498	0.253
LIG_FHA_1	431	437	PF00498	0.370
LIG_FHA_1	527	533	PF00498	0.481
LIG_FHA_2	194	200	PF00498	0.328
LIG_FHA_2	25	31	PF00498	0.480
LIG_FHA_2	334	340	PF00498	0.650
LIG_FHA_2	472	478	PF00498	0.340
LIG_FHA_2	504	510	PF00498	0.399
LIG_FHA_2	61	67	PF00498	0.392
LIG_FHA_2	637	643	PF00498	0.417
LIG_LIR_Apic_2	151	157	PF02991	0.651
LIG_LIR_Gen_1	164	175	PF02991	0.474
LIG_LIR_Gen_1	180	189	PF02991	0.239
LIG_LIR_Gen_1	371	379	PF02991	0.503
LIG_LIR_Gen_1	567	575	PF02991	0.370
LIG_LIR_Gen_1	585	591	PF02991	0.285
LIG_LIR_Gen_1	604	614	PF02991	0.236
LIG_LIR_Nem_3	164	170	PF02991	0.463
LIG_LIR_Nem_3	178	184	PF02991	0.292
LIG_LIR_Nem_3	2	6	PF02991	0.438
LIG_LIR_Nem_3	218	224	PF02991	0.463
LIG_LIR_Nem_3	255	261	PF02991	0.501
LIG_LIR_Nem_3	371	376	PF02991	0.619
LIG_LIR_Nem_3	461	467	PF02991	0.342
LIG_LIR_Nem_3	509	515	PF02991	0.346
LIG_LIR_Nem_3	567	571	PF02991	0.367
LIG_LIR_Nem_3	585	590	PF02991	0.249
LIG_LIR_Nem_3	604	610	PF02991	0.230
LIG_NRBOX	239	245	PF00104	0.530
LIG_PTB_Apo_2	514	521	PF02174	0.414
LIG_PTB_Phospho_1	514	520	PF10480	0.412
LIG_REV1ctd_RIR_1	1	9	PF16727	0.277
LIG_SH2_GRB2like	184	187	PF00017	0.437
LIG_SH2_PTP2	587	590	PF00017	0.472
LIG_SH2_STAP1	217	221	PF00017	0.377
LIG_SH2_STAP1	246	250	PF00017	0.454
LIG_SH2_STAP1	254	258	PF00017	0.407
LIG_SH2_STAP1	390	394	PF00017	0.419
LIG_SH2_STAT5	390	393	PF00017	0.481
LIG_SH2_STAT5	415	418	PF00017	0.357
LIG_SH2_STAT5	535	538	PF00017	0.467
LIG_SH2_STAT5	587	590	PF00017	0.437
LIG_SH3_3	346	352	PF00018	0.720
LIG_SH3_3	93	99	PF00018	0.413
LIG_SUMO_SIM_par_1	490	496	PF11976	0.406
LIG_TRAF2_1	127	130	PF00917	0.583
LIG_TRAF2_1	177	180	PF00917	0.495
LIG_TRAF2_1	619	622	PF00917	0.377
LIG_UBA3_1	385	393	PF00899	0.480
LIG_WRC_WIRS_1	602	607	PF05994	0.236
LIG_WRC_WIRS_1	637	642	PF05994	0.420
MOD_CDK_SPK_2	552	557	PF00069	0.446
MOD_CK1_1	363	369	PF00069	0.556
MOD_CK1_1	371	377	PF00069	0.531
MOD_CK1_1	60	66	PF00069	0.510
MOD_CK2_1	193	199	PF00069	0.327
MOD_CK2_1	282	288	PF00069	0.570
MOD_CK2_1	302	308	PF00069	0.564
MOD_CK2_1	45	51	PF00069	0.460
MOD_CK2_1	471	477	PF00069	0.337
MOD_CK2_1	503	509	PF00069	0.418
MOD_CK2_1	60	66	PF00069	0.426
MOD_CK2_1	614	620	PF00069	0.479
MOD_CK2_1	636	642	PF00069	0.335
MOD_GlcNHglycan	133	136	PF01048	0.596
MOD_GlcNHglycan	151	154	PF01048	0.603
MOD_GlcNHglycan	159	162	PF01048	0.530
MOD_GlcNHglycan	174	178	PF01048	0.350
MOD_GlcNHglycan	21	24	PF01048	0.487
MOD_GlcNHglycan	226	229	PF01048	0.390
MOD_GlcNHglycan	247	250	PF01048	0.542
MOD_GlcNHglycan	292	295	PF01048	0.621
MOD_GlcNHglycan	489	492	PF01048	0.473
MOD_GlcNHglycan	523	527	PF01048	0.373
MOD_GlcNHglycan	658	661	PF01048	0.452
MOD_GSK3_1	320	327	PF00069	0.637
MOD_GSK3_1	329	336	PF00069	0.625
MOD_GSK3_1	356	363	PF00069	0.686
MOD_GSK3_1	371	378	PF00069	0.399
MOD_GSK3_1	522	529	PF00069	0.547
MOD_GSK3_1	632	639	PF00069	0.390
MOD_GSK3_1	652	659	PF00069	0.336
MOD_GSK3_1	90	97	PF00069	0.505
MOD_N-GLC_1	119	124	PF02516	0.425
MOD_N-GLC_1	168	173	PF02516	0.360
MOD_N-GLC_1	45	50	PF02516	0.418
MOD_NEK2_1	119	124	PF00069	0.432
MOD_NEK2_1	131	136	PF00069	0.539
MOD_NEK2_1	19	24	PF00069	0.455
MOD_NEK2_1	329	334	PF00069	0.669
MOD_NEK2_1	338	343	PF00069	0.680
MOD_NEK2_1	369	374	PF00069	0.554
MOD_NEK2_1	45	50	PF00069	0.440
MOD_NEK2_1	503	508	PF00069	0.505
MOD_NEK2_1	57	62	PF00069	0.392
MOD_NEK2_1	640	645	PF00069	0.447
MOD_NEK2_1	652	657	PF00069	0.487
MOD_NEK2_1	68	73	PF00069	0.311
MOD_NEK2_2	162	167	PF00069	0.397
MOD_PIKK_1	175	181	PF00454	0.498
MOD_PIKK_1	356	362	PF00454	0.747
MOD_PIKK_1	400	406	PF00454	0.390
MOD_PIKK_1	558	564	PF00454	0.555
MOD_PIKK_1	632	638	PF00454	0.544
MOD_PK_1	5	11	PF00069	0.281
MOD_PK_1	90	96	PF00069	0.342
MOD_PKA_2	264	270	PF00069	0.573
MOD_PKA_2	320	326	PF00069	0.715
MOD_PKA_2	356	362	PF00069	0.755
MOD_PKA_2	369	375	PF00069	0.594
MOD_PKA_2	406	412	PF00069	0.393
MOD_PKA_2	471	477	PF00069	0.355
MOD_PKA_2	503	509	PF00069	0.538
MOD_PKA_2	89	95	PF00069	0.441
MOD_Plk_1	17	23	PF00069	0.496
MOD_Plk_1	338	344	PF00069	0.635
MOD_Plk_1	522	528	PF00069	0.560
MOD_Plk_1	57	63	PF00069	0.422
MOD_Plk_2-3	282	288	PF00069	0.575
MOD_Plk_4	162	168	PF00069	0.544
MOD_Plk_4	239	245	PF00069	0.477
MOD_Plk_4	5	11	PF00069	0.281
MOD_Plk_4	606	612	PF00069	0.404
MOD_ProDKin_1	324	330	PF00069	0.661
MOD_ProDKin_1	343	349	PF00069	0.508
MOD_ProDKin_1	552	558	PF00069	0.727
MOD_SUMO_for_1	4	7	PF00179	0.433
MOD_SUMO_rev_2	359	369	PF00179	0.727
TRG_DiLeu_BaEn_1	621	626	PF01217	0.374
TRG_DiLeu_BaEn_2	461	467	PF01217	0.349
TRG_DiLeu_BaEn_2	641	647	PF01217	0.335
TRG_DiLeu_BaEn_3	621	627	PF01217	0.344
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.484
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.314
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.449
TRG_ENDOCYTIC_2	415	418	PF00928	0.357
TRG_ENDOCYTIC_2	587	590	PF00928	0.472
TRG_ER_diArg_1	213	215	PF00400	0.468
TRG_ER_diArg_1	258	260	PF00400	0.476
TRG_ER_diArg_1	40	43	PF00400	0.500
TRG_ER_diArg_1	439	441	PF00400	0.512
TRG_ER_diArg_1	591	593	PF00400	0.496
TRG_NES_CRM1_1	562	574	PF08389	0.374
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P4	Leptomonas seymouri	61%	99%
A0A0S4IQL8	Bodo saltans	25%	100%
A0A0S4J4H6	Bodo saltans	39%	97%
A0A1X0NY28	Trypanosomatidae	41%	97%
A0A3R7KSG2	Trypanosoma rangeli	40%	97%
A0A3S7WZE2	Leishmania donovani	91%	100%
A4I1T0	Leishmania infantum	91%	100%
E9AIR7	Leishmania braziliensis	78%	100%
Q95ZB7	Leishmania major	92%	100%
V5ASI1	Trypanosoma cruzi	41%	90%