RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pex2 / Pex12 amino terminal region/Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXW3_LEIMU

TriTrypDb:

LmxM.25.2290

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	9
GO:0042579	microbody	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AXW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0016558	protein import into peroxisome matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.232
CLV_C14_Caspase3-7	286	290	PF00656	0.620
CLV_MEL_PAP_1	135	141	PF00089	0.419
CLV_NRD_NRD_1	110	112	PF00675	0.324
CLV_NRD_NRD_1	198	200	PF00675	0.297
CLV_NRD_NRD_1	228	230	PF00675	0.258
CLV_PCSK_KEX2_1	110	112	PF00082	0.225
CLV_PCSK_KEX2_1	198	200	PF00082	0.407
CLV_PCSK_KEX2_1	228	230	PF00082	0.166
CLV_PCSK_SKI1_1	110	114	PF00082	0.327
CLV_PCSK_SKI1_1	127	131	PF00082	0.281
CLV_PCSK_SKI1_1	220	224	PF00082	0.275
CLV_PCSK_SKI1_1	26	30	PF00082	0.307
CLV_PCSK_SKI1_1	90	94	PF00082	0.246
CLV_Separin_Metazoa	280	284	PF03568	0.680
DEG_APCC_DBOX_1	89	97	PF00400	0.487
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DEG_SPOP_SBC_1	205	209	PF00917	0.688
DOC_CYCLIN_RxL_1	107	117	PF00134	0.532
DOC_CYCLIN_RxL_1	144	157	PF00134	0.307
DOC_MAPK_gen_1	145	154	PF00069	0.329
DOC_MAPK_gen_1	217	225	PF00069	0.549
DOC_MAPK_RevD_3	95	111	PF00069	0.449
DOC_PP1_RVXF_1	146	152	PF00149	0.333
DOC_USP7_MATH_1	114	118	PF00917	0.466
DOC_USP7_MATH_1	197	201	PF00917	0.658
DOC_WW_Pin1_4	290	295	PF00397	0.640
LIG_14-3-3_CanoR_1	150	155	PF00244	0.265
LIG_14-3-3_CanoR_1	198	205	PF00244	0.650
LIG_14-3-3_CanoR_1	26	33	PF00244	0.550
LIG_14-3-3_CanoR_1	262	272	PF00244	0.516
LIG_14-3-3_CanoR_1	63	68	PF00244	0.471
LIG_Actin_WH2_2	139	157	PF00022	0.443
LIG_Clathr_ClatBox_1	133	137	PF01394	0.314
LIG_EH1_1	169	177	PF00400	0.311
LIG_eIF4E_1	170	176	PF01652	0.389
LIG_FHA_1	116	122	PF00498	0.511
LIG_FHA_1	265	271	PF00498	0.584
LIG_FHA_1	27	33	PF00498	0.412
LIG_FHA_2	157	163	PF00498	0.232
LIG_FHA_2	191	197	PF00498	0.549
LIG_FHA_2	205	211	PF00498	0.711
LIG_FHA_2	284	290	PF00498	0.728
LIG_LIR_Gen_1	54	64	PF02991	0.516
LIG_LIR_Gen_1	70	78	PF02991	0.459
LIG_LIR_LC3C_4	180	183	PF02991	0.419
LIG_LIR_Nem_3	137	142	PF02991	0.299
LIG_LIR_Nem_3	169	173	PF02991	0.257
LIG_LIR_Nem_3	54	59	PF02991	0.514
LIG_LIR_Nem_3	70	74	PF02991	0.459
LIG_PTB_Apo_2	224	231	PF02174	0.349
LIG_SH2_STAP1	44	48	PF00017	0.457
LIG_SH2_STAT5	170	173	PF00017	0.381
LIG_SH2_STAT5	18	21	PF00017	0.495
LIG_SH2_STAT5	274	277	PF00017	0.558
LIG_SH2_STAT5	56	59	PF00017	0.441
LIG_SH3_1	79	85	PF00018	0.532
LIG_SH3_2	85	90	PF14604	0.532
LIG_SH3_3	79	85	PF00018	0.532
LIG_SUMO_SIM_par_1	174	180	PF11976	0.299
LIG_UBA3_1	9	15	PF00899	0.525
LIG_WW_3	280	284	PF00397	0.697
MOD_CK1_1	54	60	PF00069	0.533
MOD_CK2_1	190	196	PF00069	0.499
MOD_CK2_1	205	211	PF00069	0.662
MOD_GlcNHglycan	217	220	PF01048	0.401
MOD_GSK3_1	150	157	PF00069	0.257
MOD_GSK3_1	186	193	PF00069	0.512
MOD_GSK3_1	206	213	PF00069	0.636
MOD_GSK3_1	59	66	PF00069	0.515
MOD_N-GLC_1	205	210	PF02516	0.442
MOD_NEK2_1	223	228	PF00069	0.480
MOD_NEK2_1	32	37	PF00069	0.561
MOD_NEK2_1	59	64	PF00069	0.533
MOD_PIKK_1	264	270	PF00454	0.568
MOD_PKA_1	198	204	PF00069	0.669
MOD_PKA_2	186	192	PF00069	0.532
MOD_PKA_2	197	203	PF00069	0.664
MOD_PKB_1	148	156	PF00069	0.307
MOD_Plk_2-3	210	216	PF00069	0.619
MOD_Plk_4	166	172	PF00069	0.311
MOD_Plk_4	266	272	PF00069	0.565
MOD_Plk_4	51	57	PF00069	0.491
MOD_ProDKin_1	290	296	PF00069	0.644
TRG_DiLeu_BaEn_1	70	75	PF01217	0.457
TRG_ENDOCYTIC_2	170	173	PF00928	0.337
TRG_ENDOCYTIC_2	274	277	PF00928	0.564
TRG_ENDOCYTIC_2	56	59	PF00928	0.454
TRG_ER_diArg_1	110	112	PF00400	0.436
TRG_ER_diArg_1	147	150	PF00400	0.307
TRG_ER_diArg_1	228	230	PF00400	0.349
TRG_NES_CRM1_1	123	137	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N1	Leptomonas seymouri	77%	97%
A0A0S4J0W7	Bodo saltans	39%	100%
A0A1X0NY02	Trypanosomatidae	50%	96%
A0A3R7LE72	Trypanosoma rangeli	47%	100%
A0A3S7WZG1	Leishmania donovani	94%	100%
A4I1S9	Leishmania infantum	95%	100%
B1AUE5	Mus musculus	27%	91%
C0HKD7	Caenorhabditis elegans	24%	94%
C9ZKD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
O60683	Homo sapiens	26%	91%
Q00940	Pichia angusta	27%	100%
Q05568	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	88%
Q54S31	Dictyostelium discoideum	28%	79%
Q95ZB8	Leishmania major	95%	100%
V5D8I1	Trypanosoma cruzi	52%	99%