Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXW2_LEIMU

TriTrypDb:

LmxM.25.2280

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AXW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.540
CLV_C14_Caspase3-7	281	285	PF00656	0.676
CLV_C14_Caspase3-7	298	302	PF00656	0.595
CLV_C14_Caspase3-7	320	324	PF00656	0.723
CLV_NRD_NRD_1	142	144	PF00675	0.260
CLV_NRD_NRD_1	8	10	PF00675	0.430
CLV_PCSK_KEX2_1	142	144	PF00082	0.260
CLV_PCSK_KEX2_1	8	10	PF00082	0.398
CLV_PCSK_SKI1_1	14	18	PF00082	0.391
CLV_PCSK_SKI1_1	243	247	PF00082	0.274
CLV_PCSK_SKI1_1	28	32	PF00082	0.209
DEG_MDM2_SWIB_1	163	171	PF02201	0.356
DOC_MAPK_gen_1	283	293	PF00069	0.694
DOC_MAPK_gen_1	8	15	PF00069	0.600
DOC_MAPK_MEF2A_6	28	36	PF00069	0.127
DOC_MAPK_MEF2A_6	286	293	PF00069	0.698
DOC_MAPK_MEF2A_6	8	17	PF00069	0.605
DOC_PP2B_LxvP_1	3	6	PF13499	0.676
DOC_PP4_FxxP_1	22	25	PF00568	0.553
DOC_USP7_MATH_1	303	307	PF00917	0.716
DOC_USP7_MATH_1	311	315	PF00917	0.651
DOC_USP7_MATH_1	92	96	PF00917	0.651
DOC_WW_Pin1_4	198	203	PF00397	0.262
DOC_WW_Pin1_4	301	306	PF00397	0.717
LIG_14-3-3_CanoR_1	28	33	PF00244	0.399
LIG_14-3-3_CanoR_1	55	59	PF00244	0.263
LIG_BIR_III_2	89	93	PF00653	0.654
LIG_BRCT_BRCA1_1	222	226	PF00533	0.372
LIG_BRCT_BRCA1_1	40	44	PF00533	0.357
LIG_FHA_1	193	199	PF00498	0.333
LIG_FHA_1	204	210	PF00498	0.238
LIG_FHA_1	236	242	PF00498	0.517
LIG_FHA_1	285	291	PF00498	0.666
LIG_FHA_1	29	35	PF00498	0.342
LIG_FHA_1	46	52	PF00498	0.308
LIG_FHA_1	55	61	PF00498	0.326
LIG_FHA_2	244	250	PF00498	0.460
LIG_FHA_2	279	285	PF00498	0.669
LIG_FHA_2	315	321	PF00498	0.749
LIG_GBD_Chelix_1	165	173	PF00786	0.425
LIG_GBD_Chelix_1	66	74	PF00786	0.382
LIG_Integrin_isoDGR_2	18	20	PF01839	0.411
LIG_LIR_Gen_1	161	171	PF02991	0.371
LIG_LIR_Gen_1	41	52	PF02991	0.412
LIG_LIR_Nem_3	161	166	PF02991	0.361
LIG_LIR_Nem_3	223	229	PF02991	0.411
LIG_LIR_Nem_3	41	47	PF02991	0.343
LIG_Pex14_2	163	167	PF04695	0.320
LIG_SH2_SRC	239	242	PF00017	0.563
LIG_SH2_STAP1	120	124	PF00017	0.540
LIG_SH2_STAT3	102	105	PF00017	0.553
LIG_SH2_STAT3	108	111	PF00017	0.513
LIG_SH2_STAT3	135	138	PF00017	0.508
LIG_SH2_STAT5	102	105	PF00017	0.532
LIG_SH2_STAT5	108	111	PF00017	0.532
LIG_SH2_STAT5	135	138	PF00017	0.532
LIG_SH2_STAT5	162	165	PF00017	0.356
LIG_SH2_STAT5	239	242	PF00017	0.540
LIG_SH3_1	82	88	PF00018	0.671
LIG_SH3_3	78	84	PF00018	0.604
LIG_SH3_3	85	91	PF00018	0.623
LIG_SUMO_SIM_anti_2	216	223	PF11976	0.261
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.339
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.341
LIG_SUMO_SIM_par_1	216	223	PF11976	0.300
LIG_SUMO_SIM_par_1	33	38	PF11976	0.348
LIG_WRC_WIRS_1	181	186	PF05994	0.380
LIG_WRC_WIRS_1	221	226	PF05994	0.425
LIG_WRPW_2	125	128	PF00400	0.540
LIG_WW_3	5	9	PF00397	0.641
MOD_CK1_1	192	198	PF00069	0.329
MOD_CK1_1	203	209	PF00069	0.290
MOD_CK1_1	304	310	PF00069	0.773
MOD_CK1_1	314	320	PF00069	0.699
MOD_CK1_1	38	44	PF00069	0.420
MOD_CK2_1	193	199	PF00069	0.371
MOD_GlcNHglycan	202	205	PF01048	0.494
MOD_GlcNHglycan	246	249	PF01048	0.348
MOD_GSK3_1	189	196	PF00069	0.272
MOD_GSK3_1	203	210	PF00069	0.294
MOD_GSK3_1	235	242	PF00069	0.367
MOD_GSK3_1	301	308	PF00069	0.755
MOD_GSK3_1	310	317	PF00069	0.768
MOD_GSK3_1	54	61	PF00069	0.429
MOD_LATS_1	191	197	PF00433	0.210
MOD_N-GLC_1	243	248	PF02516	0.260
MOD_NEK2_1	172	177	PF00069	0.322
MOD_NEK2_1	209	214	PF00069	0.272
MOD_NEK2_1	229	234	PF00069	0.127
MOD_NEK2_1	30	35	PF00069	0.314
MOD_OFUCOSY	147	153	PF10250	0.260
MOD_PK_1	193	199	PF00069	0.312
MOD_PKA_2	189	195	PF00069	0.340
MOD_PKA_2	54	60	PF00069	0.263
MOD_Plk_4	167	173	PF00069	0.328
MOD_Plk_4	180	186	PF00069	0.284
MOD_Plk_4	193	199	PF00069	0.246
MOD_Plk_4	220	226	PF00069	0.402
MOD_Plk_4	235	241	PF00069	0.262
MOD_Plk_4	260	266	PF00069	0.564
MOD_Plk_4	30	36	PF00069	0.345
MOD_Plk_4	38	44	PF00069	0.314
MOD_Plk_4	92	98	PF00069	0.588
MOD_ProDKin_1	198	204	PF00069	0.262
MOD_ProDKin_1	301	307	PF00069	0.717
TRG_ENDOCYTIC_2	162	165	PF00928	0.313
TRG_ER_diArg_1	7	9	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I542	Leptomonas seymouri	64%	100%
A0A0S4IT15	Bodo saltans	26%	92%
A0A0S4J156	Bodo saltans	28%	91%
A0A0S4JRL4	Bodo saltans	27%	91%
A0A1X0NY30	Trypanosomatidae	40%	100%
A0A1X0P5Q8	Trypanosomatidae	26%	100%
A0A3R7P4J6	Trypanosoma rangeli	41%	100%
A0A3S7WSS8	Leishmania donovani	27%	100%
A0A3S7WZD9	Leishmania donovani	95%	100%
A4H7G8	Leishmania braziliensis	25%	100%
A4HCH5	Leishmania braziliensis	24%	82%
A4HVU9	Leishmania infantum	27%	100%
A4I1S8	Leishmania infantum	95%	100%
B3DN87	Arabidopsis thaliana	28%	97%
C9ZKD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
E7FH11	Danio rerio	28%	70%
E9AIR6	Leishmania braziliensis	81%	100%
E9APK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
F1QAM1	Danio rerio	29%	95%
F1QXD3	Danio rerio	25%	98%
F1R013	Danio rerio	31%	85%
O14345	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	99%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
O80685	Arabidopsis thaliana	27%	80%
P42836	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	97%
P59268	Mus musculus	32%	90%
Q06551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	91%
Q0WQK2	Arabidopsis thaliana	32%	74%
Q2TGJ1	Rattus norvegicus	28%	85%
Q2TGK3	Rattus norvegicus	23%	100%
Q4Q9K8	Leishmania major	91%	100%
Q4QFX8	Leishmania major	27%	100%
Q4R7E2	Macaca fascicularis	27%	87%
Q58CU4	Bos taurus	26%	87%
Q58DA8	Bos taurus	32%	90%
Q5PNZ1	Arabidopsis thaliana	27%	79%
Q5R5J8	Pongo abelii	32%	90%
Q5Y5T2	Mus musculus	28%	86%
Q6BHT4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	88%
Q6C890	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	80%
Q6FXC6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	99%
Q750R7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	89%
Q7ZVN4	Danio rerio	28%	84%
Q8BQQ1	Mus musculus	29%	67%
Q8IZN3	Homo sapiens	31%	67%
Q8VYS8	Arabidopsis thaliana	29%	80%
Q969W1	Homo sapiens	26%	87%
Q9ESG8	Mus musculus	26%	91%
Q9FLM3	Arabidopsis thaliana	31%	80%
Q9M1K5	Arabidopsis thaliana	30%	69%
Q9M306	Arabidopsis thaliana	30%	69%
Q9NUE0	Homo sapiens	26%	84%
Q9SB58	Arabidopsis thaliana	30%	80%
Q9Y397	Homo sapiens	32%	90%
V5BCH8	Trypanosoma cruzi	41%	100%