LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AXW1_LEIMU
TriTrypDb:
LmxM.25.2270
Length:
453

Annotations

LeishMANIAdb annotations

Unique Kinetoplastid protein of unclear topology and structure. Might not be a TM protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AXW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXW1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 116 118 PF00675 0.366
CLV_NRD_NRD_1 198 200 PF00675 0.589
CLV_NRD_NRD_1 202 204 PF00675 0.573
CLV_NRD_NRD_1 34 36 PF00675 0.390
CLV_NRD_NRD_1 401 403 PF00675 0.641
CLV_NRD_NRD_1 99 101 PF00675 0.455
CLV_PCSK_KEX2_1 116 118 PF00082 0.433
CLV_PCSK_KEX2_1 14 16 PF00082 0.451
CLV_PCSK_KEX2_1 198 200 PF00082 0.614
CLV_PCSK_KEX2_1 202 204 PF00082 0.603
CLV_PCSK_KEX2_1 34 36 PF00082 0.220
CLV_PCSK_KEX2_1 39 41 PF00082 0.389
CLV_PCSK_KEX2_1 401 403 PF00082 0.640
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.478
CLV_PCSK_PC1ET2_1 39 41 PF00082 0.418
CLV_PCSK_PC7_1 198 204 PF00082 0.633
CLV_PCSK_PC7_1 35 41 PF00082 0.339
CLV_PCSK_SKI1_1 108 112 PF00082 0.424
CLV_PCSK_SKI1_1 150 154 PF00082 0.369
CLV_PCSK_SKI1_1 210 214 PF00082 0.532
CLV_PCSK_SKI1_1 272 276 PF00082 0.578
CLV_PCSK_SKI1_1 383 387 PF00082 0.584
CLV_PCSK_SKI1_1 401 405 PF00082 0.621
CLV_PCSK_SKI1_1 69 73 PF00082 0.350
CLV_PCSK_SKI1_1 81 85 PF00082 0.367
CLV_Separin_Metazoa 151 155 PF03568 0.650
DEG_APCC_DBOX_1 382 390 PF00400 0.415
DOC_CDC14_PxL_1 57 65 PF14671 0.617
DOC_CYCLIN_RxL_1 9 22 PF00134 0.595
DOC_CYCLIN_yClb1_LxF_4 13 18 PF00134 0.607
DOC_CYCLIN_yCln2_LP_2 228 231 PF00134 0.362
DOC_CYCLIN_yCln2_LP_2 301 307 PF00134 0.542
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.417
DOC_MAPK_gen_1 164 174 PF00069 0.502
DOC_MAPK_MEF2A_6 167 176 PF00069 0.453
DOC_MAPK_MEF2A_6 310 319 PF00069 0.416
DOC_MAPK_MEF2A_6 69 76 PF00069 0.584
DOC_PP1_RVXF_1 12 19 PF00149 0.600
DOC_PP1_RVXF_1 165 171 PF00149 0.556
DOC_PP1_RVXF_1 374 380 PF00149 0.421
DOC_PP1_RVXF_1 430 436 PF00149 0.424
DOC_PP1_RVXF_1 99 106 PF00149 0.612
DOC_PP2B_LxvP_1 228 231 PF13499 0.333
DOC_PP2B_LxvP_1 404 407 PF13499 0.417
DOC_PP2B_LxvP_1 63 66 PF13499 0.573
DOC_USP7_MATH_1 122 126 PF00917 0.745
DOC_USP7_MATH_1 224 228 PF00917 0.384
DOC_USP7_MATH_1 308 312 PF00917 0.482
DOC_USP7_MATH_1 395 399 PF00917 0.436
DOC_USP7_UBL2_3 422 426 PF12436 0.430
LIG_14-3-3_CanoR_1 123 129 PF00244 0.727
LIG_14-3-3_CanoR_1 328 337 PF00244 0.505
LIG_14-3-3_CanoR_1 396 404 PF00244 0.267
LIG_14-3-3_CanoR_1 9 13 PF00244 0.594
LIG_Actin_WH2_2 347 362 PF00022 0.413
LIG_Actin_WH2_2 70 86 PF00022 0.598
LIG_AP2alpha_1 445 449 PF02296 0.435
LIG_BIR_II_1 1 5 PF00653 0.675
LIG_BIR_III_4 238 242 PF00653 0.450
LIG_BRCT_BRCA1_1 310 314 PF00533 0.469
LIG_FHA_1 184 190 PF00498 0.414
LIG_FHA_2 1 7 PF00498 0.564
LIG_FHA_2 215 221 PF00498 0.378
LIG_FHA_2 369 375 PF00498 0.460
LIG_LIR_Gen_1 160 170 PF02991 0.567
LIG_LIR_Gen_1 273 282 PF02991 0.339
LIG_LIR_Gen_1 294 303 PF02991 0.454
LIG_LIR_Nem_3 207 212 PF02991 0.353
LIG_LIR_Nem_3 273 278 PF02991 0.343
LIG_LIR_Nem_3 294 298 PF02991 0.434
LIG_LIR_Nem_3 311 317 PF02991 0.357
LIG_LIR_Nem_3 443 448 PF02991 0.352
LIG_MYND_1 335 339 PF01753 0.428
LIG_PCNA_yPIPBox_3 37 51 PF02747 0.604
LIG_Pex14_2 445 449 PF04695 0.387
LIG_PTB_Apo_2 35 42 PF02174 0.607
LIG_PTB_Phospho_1 35 41 PF10480 0.612
LIG_SH2_CRK 181 185 PF00017 0.439
LIG_SH2_CRK 225 229 PF00017 0.355
LIG_SH2_NCK_1 236 240 PF00017 0.448
LIG_SH2_STAP1 225 229 PF00017 0.421
LIG_SH2_STAP1 245 249 PF00017 0.164
LIG_SH2_STAP1 26 30 PF00017 0.589
LIG_SH2_STAT3 41 44 PF00017 0.612
LIG_SH2_STAT5 191 194 PF00017 0.321
LIG_SH2_STAT5 208 211 PF00017 0.309
LIG_SH2_STAT5 41 44 PF00017 0.565
LIG_SH2_STAT5 448 451 PF00017 0.416
LIG_SH3_3 359 365 PF00018 0.366
LIG_SH3_3 55 61 PF00018 0.565
LIG_SUMO_SIM_anti_2 211 217 PF11976 0.297
LIG_TYR_ITIM 179 184 PF00017 0.402
LIG_TYR_ITIM 189 194 PF00017 0.320
LIG_UBA3_1 76 84 PF00899 0.658
LIG_WW_1 222 225 PF00397 0.365
MOD_CK1_1 183 189 PF00069 0.500
MOD_CK2_1 214 220 PF00069 0.400
MOD_CK2_1 277 283 PF00069 0.409
MOD_CK2_1 327 333 PF00069 0.454
MOD_CK2_1 368 374 PF00069 0.383
MOD_CK2_1 447 453 PF00069 0.396
MOD_GlcNHglycan 131 134 PF01048 0.484
MOD_GlcNHglycan 238 242 PF01048 0.490
MOD_GlcNHglycan 330 333 PF01048 0.710
MOD_GlcNHglycan 367 371 PF01048 0.584
MOD_GSK3_1 210 217 PF00069 0.352
MOD_N-GLC_1 257 262 PF02516 0.562
MOD_N-GLC_1 328 333 PF02516 0.730
MOD_NEK2_1 214 219 PF00069 0.443
MOD_NEK2_1 327 332 PF00069 0.509
MOD_NEK2_1 368 373 PF00069 0.417
MOD_NEK2_1 76 81 PF00069 0.610
MOD_NEK2_2 124 129 PF00069 0.541
MOD_NEK2_2 270 275 PF00069 0.347
MOD_PIKK_1 19 25 PF00454 0.598
MOD_PKA_1 116 122 PF00069 0.613
MOD_PKA_2 116 122 PF00069 0.711
MOD_PKA_2 327 333 PF00069 0.475
MOD_PKA_2 395 401 PF00069 0.284
MOD_PKA_2 8 14 PF00069 0.597
MOD_Plk_1 139 145 PF00069 0.670
MOD_Plk_1 210 216 PF00069 0.298
MOD_Plk_1 257 263 PF00069 0.375
MOD_Plk_1 270 276 PF00069 0.354
MOD_Plk_2-3 291 297 PF00069 0.420
MOD_Plk_2-3 447 453 PF00069 0.455
MOD_Plk_4 157 163 PF00069 0.602
MOD_Plk_4 224 230 PF00069 0.417
MOD_Plk_4 257 263 PF00069 0.390
MOD_Plk_4 270 276 PF00069 0.365
MOD_Plk_4 416 422 PF00069 0.309
MOD_Plk_4 85 91 PF00069 0.566
MOD_SUMO_rev_2 104 113 PF00179 0.618
TRG_DiLeu_BaEn_3 97 103 PF01217 0.613
TRG_DiLeu_BaLyEn_6 72 77 PF01217 0.652
TRG_ENDOCYTIC_2 162 165 PF00928 0.553
TRG_ENDOCYTIC_2 181 184 PF00928 0.455
TRG_ENDOCYTIC_2 191 194 PF00928 0.298
TRG_ENDOCYTIC_2 225 228 PF00928 0.364
TRG_ENDOCYTIC_2 448 451 PF00928 0.350
TRG_ENDOCYTIC_2 54 57 PF00928 0.560
TRG_ER_diArg_1 15 18 PF00400 0.641
TRG_ER_diArg_1 197 199 PF00400 0.430
TRG_ER_diArg_1 34 36 PF00400 0.500
TRG_ER_diArg_1 401 403 PF00400 0.317
TRG_NES_CRM1_1 439 453 PF08389 0.415
TRG_NLS_MonoExtC_3 13 19 PF00514 0.618
TRG_NLS_MonoExtN_4 13 18 PF00514 0.624
TRG_Pf-PMV_PEXEL_1 100 104 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 203 207 PF00026 0.580
TRG_Pf-PMV_PEXEL_1 40 44 PF00026 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYH4 Leptomonas seymouri 66% 97%
A0A0S4J1E4 Bodo saltans 40% 100%
A0A1X0NYG5 Trypanosomatidae 49% 100%
A0A3Q8ICN7 Leishmania donovani 94% 100%
A4HED2 Leishmania braziliensis 85% 100%
C9ZKD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
Q95ZC0 Leishmania major 94% 100%
V5BH15 Trypanosoma cruzi 49% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS