Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXV9_LEIMU

TriTrypDb:

LmxM.25.2240

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AXV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.649
CLV_NRD_NRD_1	253	255	PF00675	0.575
CLV_NRD_NRD_1	464	466	PF00675	0.714
CLV_NRD_NRD_1	496	498	PF00675	0.663
CLV_NRD_NRD_1	543	545	PF00675	0.476
CLV_PCSK_KEX2_1	180	182	PF00082	0.667
CLV_PCSK_KEX2_1	253	255	PF00082	0.575
CLV_PCSK_KEX2_1	464	466	PF00082	0.665
CLV_PCSK_KEX2_1	496	498	PF00082	0.663
CLV_PCSK_KEX2_1	543	545	PF00082	0.475
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.667
CLV_PCSK_SKI1_1	180	184	PF00082	0.591
CLV_PCSK_SKI1_1	333	337	PF00082	0.642
CLV_PCSK_SKI1_1	346	350	PF00082	0.528
CLV_PCSK_SKI1_1	438	442	PF00082	0.708
CLV_PCSK_SKI1_1	52	56	PF00082	0.622
CLV_Separin_Metazoa	399	403	PF03568	0.516
DEG_COP1_1	277	287	PF00400	0.451
DOC_ANK_TNKS_1	349	356	PF00023	0.480
DOC_CDC14_PxL_1	1	9	PF14671	0.416
DOC_CDC14_PxL_1	104	112	PF14671	0.322
DOC_CYCLIN_RxL_1	178	185	PF00134	0.360
DOC_CYCLIN_RxL_1	330	339	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	233	236	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.473
DOC_MAPK_DCC_7	230	239	PF00069	0.518
DOC_MAPK_gen_1	179	186	PF00069	0.385
DOC_MAPK_gen_1	464	470	PF00069	0.503
DOC_MAPK_MEF2A_6	230	239	PF00069	0.475
DOC_MAPK_MEF2A_6	346	353	PF00069	0.341
DOC_MAPK_RevD_3	531	544	PF00069	0.289
DOC_PP1_RVXF_1	391	397	PF00149	0.518
DOC_PP2B_LxvP_1	233	236	PF13499	0.513
DOC_USP7_MATH_1	154	158	PF00917	0.421
DOC_USP7_MATH_1	283	287	PF00917	0.482
DOC_USP7_MATH_1	403	407	PF00917	0.551
DOC_USP7_MATH_1	474	478	PF00917	0.540
DOC_USP7_MATH_1	489	493	PF00917	0.417
DOC_USP7_MATH_1	98	102	PF00917	0.468
DOC_WW_Pin1_4	336	341	PF00397	0.462
DOC_WW_Pin1_4	361	366	PF00397	0.526
DOC_WW_Pin1_4	53	58	PF00397	0.419
LIG_14-3-3_CanoR_1	174	178	PF00244	0.420
LIG_14-3-3_CanoR_1	181	187	PF00244	0.424
LIG_14-3-3_CanoR_1	243	252	PF00244	0.398
LIG_14-3-3_CanoR_1	323	331	PF00244	0.446
LIG_14-3-3_CanoR_1	359	364	PF00244	0.514
LIG_14-3-3_CanoR_1	393	397	PF00244	0.517
LIG_14-3-3_CanoR_1	402	411	PF00244	0.581
LIG_14-3-3_CanoR_1	426	433	PF00244	0.458
LIG_14-3-3_CanoR_1	464	469	PF00244	0.586
LIG_14-3-3_CanoR_1	496	505	PF00244	0.478
LIG_Actin_WH2_2	387	404	PF00022	0.517
LIG_Actin_WH2_2	527	545	PF00022	0.305
LIG_BIR_III_2	41	45	PF00653	0.354
LIG_EVH1_2	108	112	PF00568	0.320
LIG_FHA_1	11	17	PF00498	0.421
LIG_FHA_1	141	147	PF00498	0.433
LIG_FHA_1	157	163	PF00498	0.282
LIG_FHA_1	194	200	PF00498	0.472
LIG_FHA_1	202	208	PF00498	0.376
LIG_FHA_1	259	265	PF00498	0.424
LIG_FHA_1	302	308	PF00498	0.430
LIG_FHA_1	330	336	PF00498	0.486
LIG_FHA_1	343	349	PF00498	0.387
LIG_FHA_1	368	374	PF00498	0.553
LIG_FHA_1	457	463	PF00498	0.504
LIG_FHA_1	54	60	PF00498	0.417
LIG_FHA_2	296	302	PF00498	0.506
LIG_LIR_Apic_2	499	505	PF02991	0.480
LIG_LIR_Apic_2	61	65	PF02991	0.467
LIG_LIR_Gen_1	526	537	PF02991	0.337
LIG_LIR_Nem_3	250	255	PF02991	0.493
LIG_LIR_Nem_3	445	451	PF02991	0.542
LIG_LIR_Nem_3	526	532	PF02991	0.337
LIG_LIR_Nem_3	53	58	PF02991	0.436
LIG_LIR_Nem_3	536	540	PF02991	0.344
LIG_LYPXL_S_1	152	156	PF13949	0.605
LIG_LYPXL_yS_3	153	156	PF13949	0.405
LIG_NRBOX	537	543	PF00104	0.304
LIG_PCNA_yPIPBox_3	160	174	PF02747	0.383
LIG_SH2_CRK	252	256	PF00017	0.486
LIG_SH2_CRK	529	533	PF00017	0.441
LIG_SH2_STAP1	193	197	PF00017	0.388
LIG_SH2_STAP1	379	383	PF00017	0.479
LIG_SH2_STAT3	479	482	PF00017	0.445
LIG_SH2_STAT5	193	196	PF00017	0.465
LIG_SH2_STAT5	326	329	PF00017	0.421
LIG_SH2_STAT5	529	532	PF00017	0.387
LIG_SH2_STAT5	81	84	PF00017	0.457
LIG_SH3_2	5	10	PF14604	0.415
LIG_SH3_3	2	8	PF00018	0.415
LIG_SH3_3	266	272	PF00018	0.434
LIG_SH3_3	394	400	PF00018	0.562
LIG_SUMO_SIM_anti_2	536	542	PF11976	0.213
LIG_SUMO_SIM_par_1	298	304	PF11976	0.340
LIG_SUMO_SIM_par_1	339	345	PF11976	0.514
LIG_SUMO_SIM_par_1	530	536	PF11976	0.213
LIG_TRAF2_1	389	392	PF00917	0.580
LIG_TYR_ITIM	151	156	PF00017	0.492
LIG_WRC_WIRS_1	448	453	PF05994	0.671
LIG_WRC_WIRS_1	534	539	PF05994	0.213
LIG_WW_1	44	47	PF00397	0.460
MOD_CK1_1	277	283	PF00069	0.621
MOD_CK1_1	364	370	PF00069	0.651
MOD_CK1_1	449	455	PF00069	0.697
MOD_CK1_1	50	56	PF00069	0.631
MOD_CK2_1	244	250	PF00069	0.452
MOD_CK2_1	295	301	PF00069	0.622
MOD_CK2_1	518	524	PF00069	0.513
MOD_GlcNHglycan	132	135	PF01048	0.433
MOD_GlcNHglycan	143	146	PF01048	0.454
MOD_GlcNHglycan	156	159	PF01048	0.355
MOD_GlcNHglycan	211	214	PF01048	0.540
MOD_GlcNHglycan	285	288	PF01048	0.517
MOD_GlcNHglycan	412	415	PF01048	0.549
MOD_GlcNHglycan	470	473	PF01048	0.683
MOD_GlcNHglycan	49	52	PF01048	0.612
MOD_GlcNHglycan	498	501	PF01048	0.539
MOD_GlcNHglycan	524	528	PF01048	0.441
MOD_GlcNHglycan	83	87	PF01048	0.508
MOD_GSK3_1	187	194	PF00069	0.483
MOD_GSK3_1	244	251	PF00069	0.513
MOD_GSK3_1	327	334	PF00069	0.450
MOD_GSK3_1	355	362	PF00069	0.662
MOD_GSK3_1	428	435	PF00069	0.620
MOD_GSK3_1	456	463	PF00069	0.623
MOD_GSK3_1	46	53	PF00069	0.601
MOD_GSK3_1	464	471	PF00069	0.576
MOD_GSK3_1	491	498	PF00069	0.709
MOD_GSK3_1	8	15	PF00069	0.514
MOD_N-GLC_1	367	372	PF02516	0.703
MOD_N-GLC_1	69	74	PF02516	0.440
MOD_NEK2_1	175	180	PF00069	0.531
MOD_NEK2_1	260	265	PF00069	0.681
MOD_NEK2_1	300	305	PF00069	0.531
MOD_NEK2_1	331	336	PF00069	0.580
MOD_NEK2_1	342	347	PF00069	0.465
MOD_NEK2_1	373	378	PF00069	0.696
MOD_NEK2_1	508	513	PF00069	0.677
MOD_NEK2_1	523	528	PF00069	0.247
MOD_NEK2_1	533	538	PF00069	0.312
MOD_NEK2_1	58	63	PF00069	0.565
MOD_NEK2_1	68	73	PF00069	0.412
MOD_NEK2_2	474	479	PF00069	0.643
MOD_NMyristoyl	1	7	PF02799	0.509
MOD_PIKK_1	122	128	PF00454	0.508
MOD_PIKK_1	244	250	PF00454	0.465
MOD_PIKK_1	373	379	PF00454	0.695
MOD_PIKK_1	432	438	PF00454	0.698
MOD_PK_1	274	280	PF00069	0.582
MOD_PKA_1	464	470	PF00069	0.636
MOD_PKA_1	496	502	PF00069	0.634
MOD_PKA_2	173	179	PF00069	0.507
MOD_PKA_2	392	398	PF00069	0.639
MOD_PKA_2	464	470	PF00069	0.762
MOD_PKA_2	495	501	PF00069	0.583
MOD_PKA_2	553	559	PF00069	0.728
MOD_Plk_1	24	30	PF00069	0.460
MOD_Plk_1	327	333	PF00069	0.594
MOD_Plk_1	342	348	PF00069	0.501
MOD_Plk_1	367	373	PF00069	0.702
MOD_Plk_1	379	385	PF00069	0.642
MOD_Plk_1	523	529	PF00069	0.426
MOD_Plk_4	108	114	PF00069	0.430
MOD_Plk_4	235	241	PF00069	0.709
MOD_Plk_4	260	266	PF00069	0.621
MOD_Plk_4	274	280	PF00069	0.458
MOD_Plk_4	295	301	PF00069	0.644
MOD_Plk_4	379	385	PF00069	0.711
MOD_Plk_4	392	398	PF00069	0.546
MOD_Plk_4	474	480	PF00069	0.669
MOD_Plk_4	498	504	PF00069	0.557
MOD_Plk_4	518	524	PF00069	0.440
MOD_Plk_4	533	539	PF00069	0.247
MOD_Plk_4	58	64	PF00069	0.571
MOD_ProDKin_1	336	342	PF00069	0.571
MOD_ProDKin_1	361	367	PF00069	0.661
MOD_ProDKin_1	53	59	PF00069	0.510
MOD_SUMO_for_1	63	66	PF00179	0.507
MOD_SUMO_rev_2	413	423	PF00179	0.481
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.700
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.592
TRG_ENDOCYTIC_2	153	156	PF00928	0.496
TRG_ENDOCYTIC_2	252	255	PF00928	0.619
TRG_ENDOCYTIC_2	293	296	PF00928	0.610
TRG_ENDOCYTIC_2	529	532	PF00928	0.414
TRG_ER_diArg_1	252	254	PF00400	0.488
TRG_ER_diArg_1	542	544	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD48	Leptomonas seymouri	37%	100%
A0A3S7WZJ8	Leishmania donovani	88%	100%
A4HEC9	Leishmania braziliensis	73%	100%
A4I1S4	Leishmania infantum	88%	100%
Q4Q9L2	Leishmania major	86%	100%