PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXV8_LEIMU

TriTrypDb:

LmxM.25.2235

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.507
CLV_MEL_PAP_1	28	34	PF00089	0.490
CLV_NRD_NRD_1	314	316	PF00675	0.436
CLV_PCSK_KEX2_1	314	316	PF00082	0.436
CLV_PCSK_SKI1_1	315	319	PF00082	0.464
DEG_APCC_DBOX_1	244	252	PF00400	0.517
DEG_COP1_1	82	90	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SPOP_SBC_1	219	223	PF00917	0.489
DEG_SPOP_SBC_1	59	63	PF00917	0.468
DOC_ANK_TNKS_1	73	80	PF00023	0.489
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.509
DOC_MAPK_MEF2A_6	149	156	PF00069	0.584
DOC_PP2B_LxvP_1	99	102	PF13499	0.740
DOC_PP2B_PxIxI_1	104	110	PF00149	0.523
DOC_USP7_MATH_1	114	118	PF00917	0.516
DOC_WW_Pin1_4	101	106	PF00397	0.437
DOC_WW_Pin1_4	155	160	PF00397	0.574
DOC_WW_Pin1_4	35	40	PF00397	0.568
DOC_WW_Pin1_4	86	91	PF00397	0.575
DOC_WW_Pin1_4	92	97	PF00397	0.524
LIG_14-3-3_CanoR_1	180	186	PF00244	0.649
LIG_14-3-3_CanoR_1	291	297	PF00244	0.427
LIG_BRCT_BRCA1_1	44	48	PF00533	0.543
LIG_BRCT_BRCA1_1	94	98	PF00533	0.543
LIG_FHA_1	222	228	PF00498	0.494
LIG_FHA_1	234	240	PF00498	0.399
LIG_FHA_1	284	290	PF00498	0.420
LIG_FHA_1	78	84	PF00498	0.762
LIG_FHA_2	257	263	PF00498	0.518
LIG_LIR_Apic_2	298	304	PF02991	0.399
LIG_LIR_Gen_1	45	56	PF02991	0.518
LIG_LIR_Gen_1	95	105	PF02991	0.521
LIG_LIR_Nem_3	45	51	PF02991	0.560
LIG_LIR_Nem_3	53	59	PF02991	0.464
LIG_LIR_Nem_3	69	75	PF02991	0.568
LIG_LIR_Nem_3	95	101	PF02991	0.527
LIG_LYPXL_S_1	71	75	PF13949	0.569
LIG_LYPXL_yS_3	72	75	PF13949	0.569
LIG_MYND_1	246	250	PF01753	0.516
LIG_MYND_1	92	96	PF01753	0.665
LIG_NRP_CendR_1	318	319	PF00754	0.485
LIG_SH2_PTP2	293	296	PF00017	0.400
LIG_SH2_STAP1	56	60	PF00017	0.549
LIG_SH2_STAT5	129	132	PF00017	0.461
LIG_SH2_STAT5	233	236	PF00017	0.653
LIG_SH2_STAT5	293	296	PF00017	0.408
LIG_SH2_STAT5	302	305	PF00017	0.346
LIG_SH2_STAT5	316	319	PF00017	0.392
LIG_SH2_STAT5	56	59	PF00017	0.467
LIG_SH3_3	153	159	PF00018	0.579
LIG_SH3_3	84	90	PF00018	0.564
LIG_SH3_3	99	105	PF00018	0.446
LIG_SUMO_SIM_par_1	79	85	PF11976	0.573
LIG_TRAF2_1	174	177	PF00917	0.551
LIG_UBA3_1	248	255	PF00899	0.496
LIG_WRC_WIRS_1	251	256	PF05994	0.484
MOD_CK1_1	135	141	PF00069	0.685
MOD_CK1_1	221	227	PF00069	0.495
MOD_CK1_1	297	303	PF00069	0.408
MOD_CK1_1	61	67	PF00069	0.480
MOD_CK1_1	82	88	PF00069	0.573
MOD_CK2_1	256	262	PF00069	0.510
MOD_GlcNHglycan	138	141	PF01048	0.498
MOD_GlcNHglycan	187	190	PF01048	0.686
MOD_GlcNHglycan	193	196	PF01048	0.649
MOD_GlcNHglycan	200	203	PF01048	0.672
MOD_GlcNHglycan	207	210	PF01048	0.597
MOD_GSK3_1	114	121	PF00069	0.551
MOD_GSK3_1	132	139	PF00069	0.621
MOD_GSK3_1	176	183	PF00069	0.560
MOD_GSK3_1	292	299	PF00069	0.429
MOD_GSK3_1	50	57	PF00069	0.501
MOD_GSK3_1	82	89	PF00069	0.699
MOD_LATS_1	118	124	PF00433	0.471
MOD_N-GLC_1	190	195	PF02516	0.600
MOD_NEK2_1	132	137	PF00069	0.595
MOD_NEK2_1	296	301	PF00069	0.426
MOD_NEK2_2	250	255	PF00069	0.491
MOD_OFUCOSY	52	58	PF10250	0.458
MOD_PIKK_1	210	216	PF00454	0.472
MOD_PIKK_1	61	67	PF00454	0.467
MOD_PK_1	180	186	PF00069	0.562
MOD_PKA_2	179	185	PF00069	0.573
MOD_PKA_2	191	197	PF00069	0.534
MOD_Plk_4	285	291	PF00069	0.415
MOD_Plk_4	297	303	PF00069	0.341
MOD_Plk_4	44	50	PF00069	0.567
MOD_Plk_4	82	88	PF00069	0.678
MOD_ProDKin_1	101	107	PF00069	0.439
MOD_ProDKin_1	155	161	PF00069	0.574
MOD_ProDKin_1	35	41	PF00069	0.562
MOD_ProDKin_1	86	92	PF00069	0.571
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.581
TRG_ENDOCYTIC_2	129	132	PF00928	0.668
TRG_ENDOCYTIC_2	293	296	PF00928	0.416
TRG_ENDOCYTIC_2	56	59	PF00928	0.547
TRG_ENDOCYTIC_2	72	75	PF00928	0.569
TRG_ER_diArg_1	245	248	PF00400	0.521
TRG_ER_diArg_1	313	315	PF00400	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGR6	Leishmania donovani	83%	99%
A4I1S3	Leishmania infantum	82%	96%
Q4Q9L3	Leishmania major	75%	99%