COP9 signalosome complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXV5_LEIMU

TriTrypDb:

LmxM.25.2210

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0008180	COP9 signalosome	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000502	proteasome complex	3	3
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3
GO:1905369	endopeptidase complex	4	3

Expansion

Sequence features

E9AXV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV5

Function

Biological processes
Term	Name	Level	Count
GO:0000338	protein deneddylation	6	1
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.478
CLV_NRD_NRD_1	125	127	PF00675	0.299
CLV_NRD_NRD_1	152	154	PF00675	0.379
CLV_NRD_NRD_1	203	205	PF00675	0.474
CLV_NRD_NRD_1	213	215	PF00675	0.514
CLV_NRD_NRD_1	402	404	PF00675	0.342
CLV_PCSK_KEX2_1	124	126	PF00082	0.293
CLV_PCSK_KEX2_1	152	154	PF00082	0.379
CLV_PCSK_KEX2_1	213	215	PF00082	0.454
CLV_PCSK_SKI1_1	107	111	PF00082	0.425
CLV_PCSK_SKI1_1	125	129	PF00082	0.413
CLV_PCSK_SKI1_1	133	137	PF00082	0.297
CLV_PCSK_SKI1_1	152	156	PF00082	0.355
CLV_PCSK_SKI1_1	403	407	PF00082	0.330
CLV_PCSK_SKI1_1	67	71	PF00082	0.363
CLV_PCSK_SKI1_1	77	81	PF00082	0.471
DEG_COP1_1	140	150	PF00400	0.428
DEG_Nend_UBRbox_2	1	3	PF02207	0.601
DOC_CYCLIN_RxL_1	193	201	PF00134	0.495
DOC_CYCLIN_RxL_1	398	412	PF00134	0.533
DOC_MAPK_DCC_7	221	231	PF00069	0.568
DOC_MAPK_gen_1	124	132	PF00069	0.444
DOC_MAPK_gen_1	152	158	PF00069	0.408
DOC_MAPK_MEF2A_6	124	132	PF00069	0.463
DOC_PP1_RVXF_1	402	409	PF00149	0.571
DOC_PP2B_LxvP_1	325	328	PF13499	0.548
DOC_PP4_FxxP_1	95	98	PF00568	0.546
DOC_USP7_MATH_1	225	229	PF00917	0.573
DOC_USP7_MATH_1	235	239	PF00917	0.317
DOC_USP7_MATH_1	255	259	PF00917	0.171
DOC_USP7_MATH_1	414	418	PF00917	0.462
DOC_USP7_UBL2_3	107	111	PF12436	0.408
LIG_14-3-3_CanoR_1	133	142	PF00244	0.535
LIG_14-3-3_CanoR_1	152	157	PF00244	0.454
LIG_14-3-3_CanoR_1	63	67	PF00244	0.420
LIG_Actin_WH2_2	19	34	PF00022	0.651
LIG_Actin_WH2_2	215	232	PF00022	0.515
LIG_APCC_ABBAyCdc20_2	153	159	PF00400	0.476
LIG_BRCT_BRCA1_1	359	363	PF00533	0.561
LIG_deltaCOP1_diTrp_1	246	256	PF00928	0.385
LIG_FHA_1	129	135	PF00498	0.407
LIG_FHA_1	153	159	PF00498	0.391
LIG_FHA_1	18	24	PF00498	0.629
LIG_FHA_1	195	201	PF00498	0.465
LIG_FHA_1	351	357	PF00498	0.560
LIG_FHA_1	363	369	PF00498	0.506
LIG_FHA_1	385	391	PF00498	0.542
LIG_FHA_1	427	433	PF00498	0.566
LIG_FHA_1	88	94	PF00498	0.522
LIG_FHA_2	94	100	PF00498	0.503
LIG_LIR_Apic_2	342	346	PF02991	0.352
LIG_LIR_Gen_1	311	321	PF02991	0.499
LIG_LIR_Gen_1	87	95	PF02991	0.436
LIG_LIR_Nem_3	140	145	PF02991	0.446
LIG_LIR_Nem_3	201	206	PF02991	0.456
LIG_LIR_Nem_3	311	316	PF02991	0.499
LIG_LIR_Nem_3	319	324	PF02991	0.495
LIG_LIR_Nem_3	337	343	PF02991	0.484
LIG_LIR_Nem_3	360	366	PF02991	0.498
LIG_LIR_Nem_3	65	69	PF02991	0.370
LIG_LIR_Nem_3	87	92	PF02991	0.413
LIG_LIR_Nem_3	9	15	PF02991	0.613
LIG_Rb_pABgroove_1	76	84	PF01858	0.454
LIG_RPA_C_Fungi	249	261	PF08784	0.510
LIG_SH2_CRK	203	207	PF00017	0.413
LIG_SH2_CRK	272	276	PF00017	0.450
LIG_SH2_CRK	89	93	PF00017	0.401
LIG_SH2_GRB2like	16	19	PF00017	0.685
LIG_SH2_PTP2	277	280	PF00017	0.420
LIG_SH2_PTP2	343	346	PF00017	0.454
LIG_SH2_SRC	16	19	PF00017	0.725
LIG_SH2_SRC	163	166	PF00017	0.399
LIG_SH2_SRC	33	36	PF00017	0.287
LIG_SH2_SRC	343	346	PF00017	0.421
LIG_SH2_SRC	355	358	PF00017	0.365
LIG_SH2_SRC	7	10	PF00017	0.495
LIG_SH2_STAP1	163	167	PF00017	0.440
LIG_SH2_STAP1	359	363	PF00017	0.399
LIG_SH2_STAP1	82	86	PF00017	0.361
LIG_SH2_STAP1	89	93	PF00017	0.370
LIG_SH2_STAT3	88	91	PF00017	0.441
LIG_SH2_STAT5	277	280	PF00017	0.326
LIG_SH2_STAT5	33	36	PF00017	0.462
LIG_SH2_STAT5	343	346	PF00017	0.376
LIG_SH2_STAT5	355	358	PF00017	0.283
LIG_SH2_STAT5	89	92	PF00017	0.517
LIG_SH3_3	142	148	PF00018	0.513
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.403
LIG_SUMO_SIM_anti_2	417	424	PF11976	0.624
LIG_SUMO_SIM_par_1	126	131	PF11976	0.487
LIG_SUMO_SIM_par_1	364	370	PF11976	0.390
LIG_TYR_ITIM	275	280	PF00017	0.346
LIG_WRC_WIRS_1	318	323	PF05994	0.421
MOD_CK1_1	180	186	PF00069	0.660
MOD_CK1_1	362	368	PF00069	0.428
MOD_CK1_1	426	432	PF00069	0.559
MOD_CK2_1	231	237	PF00069	0.438
MOD_CK2_1	339	345	PF00069	0.371
MOD_CK2_1	364	370	PF00069	0.448
MOD_CK2_1	39	45	PF00069	0.419
MOD_GlcNHglycan	233	236	PF01048	0.451
MOD_GlcNHglycan	237	240	PF01048	0.392
MOD_GlcNHglycan	257	260	PF01048	0.184
MOD_GlcNHglycan	265	268	PF01048	0.483
MOD_GlcNHglycan	329	332	PF01048	0.260
MOD_GlcNHglycan	387	390	PF01048	0.400
MOD_GSK3_1	194	201	PF00069	0.441
MOD_GSK3_1	231	238	PF00069	0.474
MOD_GSK3_1	355	362	PF00069	0.422
MOD_GSK3_1	423	430	PF00069	0.510
MOD_N-GLC_1	17	22	PF02516	0.634
MOD_NEK2_1	128	133	PF00069	0.290
MOD_NEK2_1	198	203	PF00069	0.456
MOD_NEK2_1	231	236	PF00069	0.499
MOD_NEK2_1	316	321	PF00069	0.411
MOD_NEK2_1	385	390	PF00069	0.413
MOD_NEK2_1	39	44	PF00069	0.483
MOD_NEK2_2	62	67	PF00069	0.377
MOD_PIKK_1	113	119	PF00454	0.509
MOD_PIKK_1	87	93	PF00454	0.457
MOD_PKA_1	152	158	PF00069	0.380
MOD_PKA_2	152	158	PF00069	0.474
MOD_PKA_2	409	415	PF00069	0.602
MOD_PKA_2	62	68	PF00069	0.412
MOD_Plk_1	128	134	PF00069	0.308
MOD_Plk_1	177	183	PF00069	0.582
MOD_Plk_1	316	322	PF00069	0.423
MOD_Plk_1	44	50	PF00069	0.519
MOD_Plk_2-3	17	23	PF00069	0.655
MOD_Plk_2-3	339	345	PF00069	0.163
MOD_Plk_2-3	53	59	PF00069	0.277
MOD_Plk_4	146	152	PF00069	0.432
MOD_Plk_4	188	194	PF00069	0.497
MOD_Plk_4	279	285	PF00069	0.408
MOD_Plk_4	317	323	PF00069	0.439
MOD_Plk_4	339	345	PF00069	0.287
MOD_Plk_4	364	370	PF00069	0.370
MOD_SUMO_for_1	161	164	PF00179	0.410
MOD_SUMO_rev_2	25	34	PF00179	0.533
TRG_ENDOCYTIC_2	142	145	PF00928	0.456
TRG_ENDOCYTIC_2	203	206	PF00928	0.403
TRG_ENDOCYTIC_2	209	212	PF00928	0.400
TRG_ENDOCYTIC_2	216	219	PF00928	0.417
TRG_ENDOCYTIC_2	272	275	PF00928	0.368
TRG_ENDOCYTIC_2	277	280	PF00928	0.305
TRG_ENDOCYTIC_2	82	85	PF00928	0.370
TRG_ENDOCYTIC_2	89	92	PF00928	0.370
TRG_ER_diArg_1	123	126	PF00400	0.480
TRG_ER_diArg_1	151	153	PF00400	0.385
TRG_ER_diArg_1	212	214	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE5	Leptomonas seymouri	63%	98%
A0A0S4J4F8	Bodo saltans	26%	96%
A0A1X0NY12	Trypanosomatidae	31%	98%
A0A3S7WZD2	Leishmania donovani	93%	100%
A0A422P4P2	Trypanosoma rangeli	32%	98%
A4HEC5	Leishmania braziliensis	84%	100%
A4I1S0	Leishmania infantum	93%	100%
C9ZKC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
O01422	Caenorhabditis elegans	20%	88%
P61201	Homo sapiens	21%	98%
P61202	Mus musculus	21%	98%
P61203	Rattus norvegicus	21%	98%
Q4Q9L6	Leishmania major	92%	100%
Q54HL6	Dictyostelium discoideum	23%	97%
Q5B3U7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	21%	86%
Q6IQT4	Danio rerio	21%	98%
Q6IR75	Xenopus laevis	22%	99%
Q7SI58	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	21%	89%
Q8W207	Arabidopsis thaliana	23%	99%
Q94899	Drosophila melanogaster	21%	98%
Q9HFR0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
V5BH20	Trypanosoma cruzi	32%	98%