LeishMANIAdb
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Parkin coregulated gene protein homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Parkin coregulated gene protein homolog
Gene product:
parkin co-regulated protein, putative
Species:
Leishmania mexicana
UniProt:
E9AXV4_LEIMU
TriTrypDb:
LmxM.25.2200
Length:
310

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 19
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 2
GO:0110165 cellular anatomical entity 1 2
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

E9AXV4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV4

Function

Biological processes
Term Name Level Count
GO:0010941 regulation of cell death 4 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0060548 negative regulation of cell death 5 2
GO:0065007 biological regulation 1 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0030544 Hsp70 protein binding 4 2
GO:0031072 heat shock protein binding 3 2
GO:0051087 protein-folding chaperone binding 3 2
GO:0051879 Hsp90 protein binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 91 95 PF00656 0.524
CLV_NRD_NRD_1 124 126 PF00675 0.297
CLV_NRD_NRD_1 19 21 PF00675 0.628
CLV_NRD_NRD_1 256 258 PF00675 0.335
CLV_NRD_NRD_1 84 86 PF00675 0.651
CLV_PCSK_KEX2_1 115 117 PF00082 0.401
CLV_PCSK_KEX2_1 124 126 PF00082 0.250
CLV_PCSK_KEX2_1 14 16 PF00082 0.516
CLV_PCSK_KEX2_1 255 257 PF00082 0.344
CLV_PCSK_KEX2_1 74 76 PF00082 0.672
CLV_PCSK_PC1ET2_1 115 117 PF00082 0.428
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.523
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.337
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.672
CLV_PCSK_SKI1_1 204 208 PF00082 0.262
CLV_PCSK_SKI1_1 241 245 PF00082 0.278
DEG_APCC_DBOX_1 240 248 PF00400 0.341
DOC_CDC14_PxL_1 193 201 PF14671 0.262
DOC_CYCLIN_yCln2_LP_2 117 120 PF00134 0.534
DOC_MAPK_DCC_7 191 201 PF00069 0.262
DOC_MAPK_DCC_7 241 249 PF00069 0.341
DOC_MAPK_MEF2A_6 129 136 PF00069 0.262
DOC_MAPK_MEF2A_6 241 249 PF00069 0.341
DOC_PP2B_LxvP_1 117 120 PF13499 0.534
DOC_PP2B_LxvP_1 199 202 PF13499 0.262
DOC_USP7_MATH_1 45 49 PF00917 0.713
DOC_USP7_MATH_1 80 84 PF00917 0.524
DOC_USP7_UBL2_3 100 104 PF12436 0.589
DOC_USP7_UBL2_3 251 255 PF12436 0.306
LIG_14-3-3_CanoR_1 256 265 PF00244 0.449
LIG_14-3-3_CanoR_1 39 45 PF00244 0.429
LIG_APCC_ABBA_1 159 164 PF00400 0.262
LIG_BIR_II_1 1 5 PF00653 0.480
LIG_EVH1_2 119 123 PF00568 0.260
LIG_FHA_1 216 222 PF00498 0.221
LIG_FHA_1 278 284 PF00498 0.257
LIG_FHA_2 11 17 PF00498 0.530
LIG_Integrin_RGD_1 129 131 PF01839 0.209
LIG_LIR_Gen_1 170 177 PF02991 0.306
LIG_LIR_Gen_1 290 301 PF02991 0.272
LIG_LIR_Nem_3 154 158 PF02991 0.274
LIG_LIR_Nem_3 170 176 PF02991 0.267
LIG_LIR_Nem_3 290 296 PF02991 0.272
LIG_PTB_Apo_2 292 299 PF02174 0.262
LIG_PTB_Phospho_1 292 298 PF10480 0.262
LIG_SH2_CRK 173 177 PF00017 0.235
LIG_SH2_CRK 240 244 PF00017 0.271
LIG_SH2_CRK 298 302 PF00017 0.271
LIG_SH2_GRB2like 293 296 PF00017 0.281
LIG_SH2_NCK_1 22 26 PF00017 0.527
LIG_SH2_PTP2 293 296 PF00017 0.281
LIG_SH2_SRC 158 161 PF00017 0.281
LIG_SH2_SRC 293 296 PF00017 0.281
LIG_SH2_STAP1 303 307 PF00017 0.281
LIG_SH2_STAT3 239 242 PF00017 0.269
LIG_SH2_STAT3 4 7 PF00017 0.529
LIG_SH2_STAT5 158 161 PF00017 0.271
LIG_SH2_STAT5 293 296 PF00017 0.281
LIG_SH2_STAT5 70 73 PF00017 0.622
LIG_SH3_1 191 197 PF00018 0.262
LIG_SH3_3 191 197 PF00018 0.262
LIG_SH3_3 63 69 PF00018 0.504
LIG_UBA3_1 199 204 PF00899 0.262
LIG_UBA3_1 243 251 PF00899 0.228
MOD_CK1_1 140 146 PF00069 0.273
MOD_CK1_1 302 308 PF00069 0.373
MOD_CK1_1 37 43 PF00069 0.633
MOD_GlcNHglycan 104 107 PF01048 0.552
MOD_GlcNHglycan 42 45 PF01048 0.650
MOD_GlcNHglycan 47 50 PF01048 0.672
MOD_GSK3_1 202 209 PF00069 0.281
MOD_N-GLC_1 277 282 PF02516 0.333
MOD_NEK2_2 80 85 PF00069 0.524
MOD_PKA_2 140 146 PF00069 0.244
MOD_PKA_2 166 172 PF00069 0.321
MOD_Plk_1 277 283 PF00069 0.268
MOD_SUMO_rev_2 140 148 PF00179 0.262
TRG_DiLeu_BaEn_1 279 284 PF01217 0.235
TRG_DiLeu_BaEn_3 170 176 PF01217 0.271
TRG_DiLeu_BaLyEn_6 113 118 PF01217 0.538
TRG_ENDOCYTIC_2 158 161 PF00928 0.296
TRG_ENDOCYTIC_2 173 176 PF00928 0.236
TRG_ENDOCYTIC_2 240 243 PF00928 0.271
TRG_ENDOCYTIC_2 293 296 PF00928 0.281
TRG_ER_diArg_1 123 125 PF00400 0.274
TRG_ER_diArg_1 256 259 PF00400 0.240
TRG_NLS_Bipartite_1 74 89 PF00514 0.460
TRG_NLS_MonoExtC_3 254 259 PF00514 0.240
TRG_NLS_MonoExtC_3 84 89 PF00514 0.647
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.262

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5N4 Leptomonas seymouri 84% 100%
A0A0N0P9H6 Leptomonas seymouri 57% 97%
A0A0S4IYX0 Bodo saltans 62% 100%
A0A0S4J0U8 Bodo saltans 63% 100%
A0A1X0NY39 Trypanosomatidae 73% 100%
A0A1X0P4X2 Trypanosomatidae 59% 100%
A0A3S7WZF1 Leishmania donovani 98% 100%
A0A3S7XA05 Leishmania donovani 59% 99%
A0A422P182 Trypanosoma rangeli 58% 98%
A0A422P4M1 Trypanosoma rangeli 71% 100%
A4HEC4 Leishmania braziliensis 90% 100%
A4HND5 Leishmania braziliensis 57% 100%
A4I1R9 Leishmania infantum 98% 100%
A4IC08 Leishmania infantum 59% 99%
A5PK71 Bos taurus 57% 100%
C9ZKC7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
E9AFU6 Leishmania major 55% 100%
E9B6Z8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 99%
Q4Q9L7 Leishmania major 97% 100%
Q96M98 Homo sapiens 46% 100%
Q9D3X5 Mus musculus 29% 100%
Q9DAK2 Mus musculus 56% 100%
V5B824 Trypanosoma cruzi 73% 100%
V5BXN2 Trypanosoma cruzi 57% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS