J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain/Zinc-finger double-stranded RNA-binding, putative

Species:

Leishmania mexicana

UniProt:

E9AXV3_LEIMU

TriTrypDb:

LmxM.25.2190

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.565
CLV_NRD_NRD_1	16	18	PF00675	0.318
CLV_NRD_NRD_1	182	184	PF00675	0.434
CLV_NRD_NRD_1	213	215	PF00675	0.407
CLV_NRD_NRD_1	247	249	PF00675	0.477
CLV_PCSK_FUR_1	243	247	PF00082	0.523
CLV_PCSK_KEX2_1	182	184	PF00082	0.434
CLV_PCSK_KEX2_1	213	215	PF00082	0.391
CLV_PCSK_KEX2_1	232	234	PF00082	0.409
CLV_PCSK_KEX2_1	245	247	PF00082	0.392
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.504
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.378
CLV_PCSK_PC7_1	243	249	PF00082	0.536
CLV_PCSK_SKI1_1	17	21	PF00082	0.358
CLV_PCSK_SKI1_1	329	333	PF00082	0.261
CLV_Separin_Metazoa	293	297	PF03568	0.665
DOC_PP4_FxxP_1	322	325	PF00568	0.510
DOC_USP7_UBL2_3	168	172	PF12436	0.445
DOC_USP7_UBL2_3	328	332	PF12436	0.443
DOC_USP7_UBL2_3	345	349	PF12436	0.451
LIG_14-3-3_CanoR_1	157	163	PF00244	0.457
LIG_14-3-3_CanoR_1	17	22	PF00244	0.308
LIG_14-3-3_CanoR_1	202	208	PF00244	0.457
LIG_deltaCOP1_diTrp_1	145	152	PF00928	0.494
LIG_FHA_2	18	24	PF00498	0.369
LIG_LIR_Gen_1	113	123	PF02991	0.235
LIG_LIR_Gen_1	143	153	PF02991	0.402
LIG_LIR_Gen_1	20	28	PF02991	0.387
LIG_LIR_Gen_1	305	315	PF02991	0.583
LIG_LIR_Nem_3	108	114	PF02991	0.409
LIG_LIR_Nem_3	133	139	PF02991	0.384
LIG_LIR_Nem_3	143	149	PF02991	0.412
LIG_LIR_Nem_3	160	165	PF02991	0.366
LIG_LIR_Nem_3	20	24	PF02991	0.378
LIG_LIR_Nem_3	305	311	PF02991	0.597
LIG_Pex14_1	167	171	PF04695	0.439
LIG_Pex14_2	152	156	PF04695	0.354
LIG_SH2_CRK	115	119	PF00017	0.374
LIG_SH2_CRK	58	62	PF00017	0.302
LIG_SH2_SRC	21	24	PF00017	0.422
LIG_SH2_STAP1	180	184	PF00017	0.567
LIG_SH2_STAT3	41	44	PF00017	0.366
LIG_SH2_STAT5	112	115	PF00017	0.357
LIG_SH2_STAT5	200	203	PF00017	0.411
LIG_SH2_STAT5	95	98	PF00017	0.402
LIG_SUMO_SIM_par_1	11	16	PF11976	0.359
LIG_TRAF2_1	263	266	PF00917	0.500
LIG_TYR_ITSM	111	118	PF00017	0.458
LIG_UBA3_1	280	287	PF00899	0.578
LIG_WRC_WIRS_1	162	167	PF05994	0.439
MOD_CK1_1	59	65	PF00069	0.363
MOD_CK2_1	17	23	PF00069	0.320
MOD_CK2_1	276	282	PF00069	0.601
MOD_CK2_1	69	75	PF00069	0.482
MOD_GlcNHglycan	108	111	PF01048	0.466
MOD_GSK3_1	106	113	PF00069	0.483
MOD_GSK3_1	157	164	PF00069	0.505
MOD_GSK3_1	368	375	PF00069	0.692
MOD_LATS_1	155	161	PF00433	0.392
MOD_N-GLC_1	157	162	PF02516	0.388
MOD_NEK2_1	139	144	PF00069	0.421
MOD_NEK2_1	276	281	PF00069	0.628
MOD_NEK2_2	110	115	PF00069	0.370
MOD_PKA_1	17	23	PF00069	0.302
MOD_PKA_1	29	35	PF00069	0.302
MOD_PKA_2	178	184	PF00069	0.446
MOD_PKA_2	288	294	PF00069	0.586
MOD_Plk_1	157	163	PF00069	0.395
MOD_Plk_1	358	364	PF00069	0.446
MOD_Plk_4	110	116	PF00069	0.379
MOD_Plk_4	276	282	PF00069	0.669
MOD_Plk_4	56	62	PF00069	0.369
MOD_SUMO_for_1	196	199	PF00179	0.444
MOD_SUMO_for_1	218	221	PF00179	0.514
MOD_SUMO_for_1	331	334	PF00179	0.387
MOD_SUMO_rev_2	11	20	PF00179	0.302
MOD_SUMO_rev_2	166	173	PF00179	0.426
TRG_ENDOCYTIC_2	115	118	PF00928	0.401
TRG_ENDOCYTIC_2	162	165	PF00928	0.534
TRG_ENDOCYTIC_2	21	24	PF00928	0.300
TRG_ENDOCYTIC_2	58	61	PF00928	0.348
TRG_ENDOCYTIC_2	9	12	PF00928	0.303
TRG_ENDOCYTIC_2	93	96	PF00928	0.414
TRG_ER_diArg_1	182	184	PF00400	0.463
TRG_ER_diArg_1	212	214	PF00400	0.416
TRG_ER_diArg_1	246	248	PF00400	0.473
TRG_NLS_Bipartite_1	17	33	PF00514	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE61	Leptomonas seymouri	87%	100%
A0A0S4J1C8	Bodo saltans	54%	81%
A0A1X0NZG6	Trypanosomatidae	62%	100%
A0A3Q8IDF1	Leishmania donovani	95%	100%
A0A422P4I6	Trypanosoma rangeli	59%	100%
A4HEC3	Leishmania braziliensis	92%	100%
A4I1R8	Leishmania infantum	96%	100%
C9ZKC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9Q8D0	Mus musculus	40%	71%
O14213	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	99%
Q0II91	Bos taurus	39%	71%
Q4Q9L8	Leishmania major	94%	100%
Q5F1R6	Homo sapiens	39%	71%
Q6PGY5	Danio rerio	37%	69%
V5ASJ0	Trypanosoma cruzi	58%	100%