Vacuolar protein sorting-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-like protein

Species:

Leishmania mexicana

UniProt:

E9AXV2_LEIMU

TriTrypDb:

LmxM.25.2180

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	1
GO:0032991	protein-containing complex	1	1
GO:0033263	CORVET complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099023	vesicle tethering complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.244
CLV_NRD_NRD_1	370	372	PF00675	0.250
CLV_NRD_NRD_1	398	400	PF00675	0.389
CLV_NRD_NRD_1	467	469	PF00675	0.238
CLV_PCSK_KEX2_1	324	326	PF00082	0.244
CLV_PCSK_KEX2_1	372	374	PF00082	0.266
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.338
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.286
CLV_PCSK_SKI1_1	156	160	PF00082	0.396
CLV_PCSK_SKI1_1	167	171	PF00082	0.247
CLV_PCSK_SKI1_1	183	187	PF00082	0.178
CLV_PCSK_SKI1_1	286	290	PF00082	0.309
CLV_PCSK_SKI1_1	302	306	PF00082	0.219
CLV_PCSK_SKI1_1	332	336	PF00082	0.256
CLV_PCSK_SKI1_1	372	376	PF00082	0.360
CLV_PCSK_SKI1_1	423	427	PF00082	0.410
CLV_PCSK_SKI1_1	588	592	PF00082	0.530
DEG_APCC_KENBOX_2	428	432	PF00400	0.303
DEG_SCF_FBW7_1	245	250	PF00400	0.248
DOC_CKS1_1	244	249	PF01111	0.244
DOC_CYCLIN_RxL_1	180	190	PF00134	0.298
DOC_CYCLIN_RxL_1	370	377	PF00134	0.220
DOC_CYCLIN_RxL_1	402	414	PF00134	0.312
DOC_CYCLIN_RxL_1	585	594	PF00134	0.408
DOC_MAPK_gen_1	399	409	PF00069	0.359
DOC_MAPK_gen_1	421	428	PF00069	0.309
DOC_MAPK_gen_1	585	593	PF00069	0.452
DOC_MAPK_gen_1	60	67	PF00069	0.421
DOC_MAPK_HePTP_8	397	409	PF00069	0.322
DOC_MAPK_JIP1_4	111	117	PF00069	0.389
DOC_MAPK_MEF2A_6	156	164	PF00069	0.389
DOC_MAPK_MEF2A_6	400	409	PF00069	0.264
DOC_PP1_RVXF_1	238	245	PF00149	0.243
DOC_PP1_RVXF_1	370	377	PF00149	0.265
DOC_PP2B_LxvP_1	115	118	PF13499	0.338
DOC_PP4_FxxP_1	244	247	PF00568	0.309
DOC_USP7_MATH_1	288	292	PF00917	0.145
DOC_USP7_UBL2_3	335	339	PF12436	0.244
DOC_WW_Pin1_4	243	248	PF00397	0.311
LIG_14-3-3_CanoR_1	142	147	PF00244	0.265
LIG_14-3-3_CanoR_1	585	591	PF00244	0.389
LIG_Actin_WH2_2	377	393	PF00022	0.451
LIG_Actin_WH2_2	542	560	PF00022	0.338
LIG_BIR_II_1	1	5	PF00653	0.466
LIG_BIR_III_1	1	5	PF00653	0.393
LIG_BIR_III_3	1	5	PF00653	0.393
LIG_BRCT_BRCA1_1	134	138	PF00533	0.389
LIG_BRCT_BRCA1_1	240	244	PF00533	0.309
LIG_BRCT_BRCA1_1	366	370	PF00533	0.273
LIG_BRCT_BRCA1_2	366	372	PF00533	0.365
LIG_Clathr_ClatBox_1	235	239	PF01394	0.287
LIG_Clathr_ClatBox_1	590	594	PF01394	0.520
LIG_eIF4E_2	493	499	PF01652	0.309
LIG_FHA_1	157	163	PF00498	0.469
LIG_FHA_1	232	238	PF00498	0.309
LIG_FHA_1	33	39	PF00498	0.429
LIG_FHA_1	442	448	PF00498	0.396
LIG_FHA_1	538	544	PF00498	0.244
LIG_FHA_1	575	581	PF00498	0.309
LIG_FHA_2	548	554	PF00498	0.244
LIG_GBD_Chelix_1	405	413	PF00786	0.371
LIG_LIR_Apic_2	241	247	PF02991	0.389
LIG_LIR_Gen_1	147	158	PF02991	0.291
LIG_LIR_Gen_1	293	304	PF02991	0.301
LIG_LIR_Gen_1	401	411	PF02991	0.281
LIG_LIR_Nem_3	135	141	PF02991	0.298
LIG_LIR_Nem_3	147	153	PF02991	0.281
LIG_LIR_Nem_3	165	169	PF02991	0.280
LIG_LIR_Nem_3	190	196	PF02991	0.259
LIG_LIR_Nem_3	253	257	PF02991	0.244
LIG_LIR_Nem_3	293	299	PF02991	0.274
LIG_LIR_Nem_3	301	307	PF02991	0.312
LIG_LIR_Nem_3	401	406	PF02991	0.281
LIG_LIR_Nem_3	414	420	PF02991	0.198
LIG_LIR_Nem_3	443	448	PF02991	0.409
LIG_LIR_Nem_3	462	467	PF02991	0.315
LIG_LIR_Nem_3	61	67	PF02991	0.318
LIG_LYPXL_yS_3	464	467	PF13949	0.211
LIG_MYND_1	518	522	PF01753	0.265
LIG_NRBOX	408	414	PF00104	0.389
LIG_PCNA_yPIPBox_3	584	597	PF02747	0.437
LIG_Pex14_2	166	170	PF04695	0.389
LIG_Pex14_2	64	68	PF04695	0.215
LIG_SH2_CRK	417	421	PF00017	0.164
LIG_SH2_CRK	436	440	PF00017	0.251
LIG_SH2_CRK	493	497	PF00017	0.298
LIG_SH2_PTP2	150	153	PF00017	0.389
LIG_SH2_SRC	488	491	PF00017	0.254
LIG_SH2_SRC	493	496	PF00017	0.266
LIG_SH2_STAP1	103	107	PF00017	0.309
LIG_SH2_STAT3	116	119	PF00017	0.389
LIG_SH2_STAT5	103	106	PF00017	0.149
LIG_SH2_STAT5	116	119	PF00017	0.338
LIG_SH2_STAT5	150	153	PF00017	0.408
LIG_SH2_STAT5	219	222	PF00017	0.451
LIG_SH2_STAT5	392	395	PF00017	0.271
LIG_SH2_STAT5	76	79	PF00017	0.309
LIG_SH2_STAT5	84	87	PF00017	0.454
LIG_SH3_2	592	597	PF14604	0.522
LIG_SH3_3	1	7	PF00018	0.373
LIG_SH3_3	266	272	PF00018	0.278
LIG_SH3_3	589	595	PF00018	0.523
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.287
LIG_SUMO_SIM_par_1	233	239	PF11976	0.311
LIG_SUMO_SIM_par_1	408	414	PF11976	0.303
LIG_TRAF2_1	18	21	PF00917	0.385
LIG_TRFH_1	84	88	PF08558	0.338
LIG_TYR_ITIM	148	153	PF00017	0.379
LIG_TYR_ITIM	252	257	PF00017	0.259
LIG_TYR_ITIM	415	420	PF00017	0.145
LIG_UBA3_1	295	302	PF00899	0.308
LIG_UBA3_1	425	429	PF00899	0.309
LIG_WRC_WIRS_1	442	447	PF05994	0.308
MOD_CK1_1	165	171	PF00069	0.389
MOD_CK1_1	176	182	PF00069	0.389
MOD_CK1_1	24	30	PF00069	0.396
MOD_CK1_1	362	368	PF00069	0.389
MOD_CK1_1	46	52	PF00069	0.477
MOD_CK1_1	476	482	PF00069	0.355
MOD_CK1_1	552	558	PF00069	0.444
MOD_CK1_1	92	98	PF00069	0.429
MOD_CK2_1	227	233	PF00069	0.308
MOD_CK2_1	271	277	PF00069	0.351
MOD_CK2_1	474	480	PF00069	0.315
MOD_CK2_1	547	553	PF00069	0.244
MOD_GlcNHglycan	23	26	PF01048	0.350
MOD_GlcNHglycan	277	281	PF01048	0.347
MOD_GlcNHglycan	45	48	PF01048	0.420
MOD_GlcNHglycan	457	460	PF01048	0.377
MOD_GlcNHglycan	553	557	PF01048	0.292
MOD_GlcNHglycan	565	568	PF01048	0.377
MOD_GlcNHglycan	581	584	PF01048	0.200
MOD_GlcNHglycan	77	80	PF01048	0.334
MOD_GSK3_1	227	234	PF00069	0.311
MOD_GSK3_1	243	250	PF00069	0.128
MOD_GSK3_1	271	278	PF00069	0.323
MOD_GSK3_1	302	309	PF00069	0.284
MOD_GSK3_1	352	359	PF00069	0.259
MOD_GSK3_1	361	368	PF00069	0.247
MOD_GSK3_1	455	462	PF00069	0.321
MOD_GSK3_1	575	582	PF00069	0.239
MOD_GSK3_1	88	95	PF00069	0.380
MOD_N-GLC_1	176	181	PF02516	0.309
MOD_N-GLC_1	289	294	PF02516	0.318
MOD_N-GLC_1	474	479	PF02516	0.359
MOD_NEK2_1	101	106	PF00069	0.284
MOD_NEK2_1	132	137	PF00069	0.340
MOD_NEK2_1	275	280	PF00069	0.366
MOD_NEK2_1	500	505	PF00069	0.371
MOD_NEK2_1	586	591	PF00069	0.321
MOD_PIKK_1	101	107	PF00454	0.338
MOD_PIKK_1	247	253	PF00454	0.244
MOD_PIKK_1	362	368	PF00454	0.248
MOD_Plk_1	176	182	PF00069	0.317
MOD_Plk_1	238	244	PF00069	0.242
MOD_Plk_1	300	306	PF00069	0.348
MOD_Plk_1	474	480	PF00069	0.359
MOD_Plk_1	552	558	PF00069	0.244
MOD_Plk_1	88	94	PF00069	0.265
MOD_Plk_2-3	227	233	PF00069	0.389
MOD_Plk_4	110	116	PF00069	0.347
MOD_Plk_4	118	124	PF00069	0.288
MOD_Plk_4	165	171	PF00069	0.345
MOD_Plk_4	176	182	PF00069	0.337
MOD_Plk_4	231	237	PF00069	0.269
MOD_Plk_4	306	312	PF00069	0.254
MOD_Plk_4	411	417	PF00069	0.262
MOD_Plk_4	441	447	PF00069	0.334
MOD_Plk_4	5	11	PF00069	0.542
MOD_Plk_4	500	506	PF00069	0.358
MOD_Plk_4	516	522	PF00069	0.389
MOD_ProDKin_1	243	249	PF00069	0.311
MOD_SUMO_for_1	18	21	PF00179	0.380
MOD_SUMO_for_1	524	527	PF00179	0.280
MOD_SUMO_rev_2	125	135	PF00179	0.350
MOD_SUMO_rev_2	149	158	PF00179	0.389
MOD_SUMO_rev_2	327	337	PF00179	0.244
TRG_DiLeu_BaEn_1	231	236	PF01217	0.338
TRG_DiLeu_BaEn_1	346	351	PF01217	0.244
TRG_DiLeu_BaEn_1	449	454	PF01217	0.191
TRG_DiLeu_BaEn_2	332	338	PF01217	0.244
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.389
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.259
TRG_DiLeu_LyEn_5	346	351	PF01217	0.244
TRG_ENDOCYTIC_2	150	153	PF00928	0.379
TRG_ENDOCYTIC_2	254	257	PF00928	0.244
TRG_ENDOCYTIC_2	417	420	PF00928	0.154
TRG_ENDOCYTIC_2	464	467	PF00928	0.330
TRG_ER_diArg_1	370	373	PF00400	0.244
TRG_NES_CRM1_1	227	239	PF08389	0.290
TRG_NES_CRM1_1	42	57	PF08389	0.302
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.238
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV5	Leptomonas seymouri	77%	100%
A0A0S4IXS0	Bodo saltans	46%	99%
A0A0S4JI94	Bodo saltans	24%	91%
A0A1X0NZL8	Trypanosomatidae	50%	99%
A0A3Q8IDK4	Leishmania donovani	92%	100%
A0A3R7P4L0	Trypanosoma rangeli	47%	100%
A4HEC2	Leishmania braziliensis	87%	100%
A4I1R7	Leishmania infantum	92%	100%
C9ZKC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
P20795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	86%
P34260	Caenorhabditis elegans	24%	99%
P59016	Mus musculus	25%	97%
Q18891	Caenorhabditis elegans	22%	97%
Q2HJ18	Bos taurus	25%	97%
Q4Q9L9	Leishmania major	91%	100%
Q58EN8	Danio rerio	26%	97%
Q63615	Rattus norvegicus	34%	100%
Q63616	Rattus norvegicus	26%	97%
Q94KJ7	Arabidopsis thaliana	31%	100%
Q96AX1	Homo sapiens	33%	100%
Q9D2N9	Mus musculus	34%	100%
Q9H267	Homo sapiens	26%	97%
Q9P7V6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9Y1I2	Drosophila melanogaster	27%	97%
V5D8I9	Trypanosoma cruzi	49%	100%