LeishMANIAdb
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CLP1_P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CLP1_P domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AXV1_LEIMU
TriTrypDb:
LmxM.25.2170
Length:
445

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AXV1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 8 1
GO:0006378 mRNA polyadenylation 7 1
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 9 1
GO:0006397 mRNA processing 7 1
GO:0006399 tRNA metabolic process 7 1
GO:0008033 tRNA processing 8 1
GO:0008380 RNA splicing 7 1
GO:0016071 mRNA metabolic process 6 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043631 RNA polyadenylation 6 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0016310 phosphorylation 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0019205 nucleobase-containing compound kinase activity 5 11
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity 5 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 103 107 PF00082 0.444
CLV_PCSK_SKI1_1 160 164 PF00082 0.425
CLV_PCSK_SKI1_1 231 235 PF00082 0.383
CLV_PCSK_SKI1_1 440 444 PF00082 0.469
DEG_SPOP_SBC_1 79 83 PF00917 0.451
DOC_CYCLIN_RxL_1 228 235 PF00134 0.412
DOC_MAPK_FxFP_2 425 428 PF00069 0.573
DOC_MAPK_MEF2A_6 353 362 PF00069 0.398
DOC_PP4_FxxP_1 4 7 PF00568 0.743
DOC_PP4_FxxP_1 425 428 PF00568 0.573
DOC_USP7_MATH_1 29 33 PF00917 0.424
DOC_USP7_MATH_1 35 39 PF00917 0.425
DOC_USP7_MATH_1 354 358 PF00917 0.491
DOC_USP7_MATH_1 398 402 PF00917 0.463
DOC_USP7_MATH_1 49 53 PF00917 0.432
DOC_WW_Pin1_4 370 375 PF00397 0.505
DOC_WW_Pin1_4 399 404 PF00397 0.492
DOC_WW_Pin1_4 56 61 PF00397 0.458
LIG_14-3-3_CanoR_1 240 248 PF00244 0.385
LIG_14-3-3_CanoR_1 333 339 PF00244 0.398
LIG_14-3-3_CanoR_1 99 105 PF00244 0.356
LIG_14-3-3_CterR_2 440 445 PF00244 0.465
LIG_Actin_WH2_2 80 97 PF00022 0.458
LIG_BRCT_BRCA1_1 334 338 PF00533 0.476
LIG_BRCT_BRCA1_1 351 355 PF00533 0.200
LIG_BRCT_BRCA1_1 421 425 PF00533 0.555
LIG_Clathr_ClatBox_1 163 167 PF01394 0.332
LIG_FHA_1 100 106 PF00498 0.468
LIG_FHA_1 11 17 PF00498 0.538
LIG_FHA_1 116 122 PF00498 0.193
LIG_FHA_1 139 145 PF00498 0.372
LIG_FHA_1 171 177 PF00498 0.438
LIG_FHA_1 201 207 PF00498 0.360
LIG_FHA_1 291 297 PF00498 0.534
LIG_FHA_1 339 345 PF00498 0.532
LIG_FHA_1 431 437 PF00498 0.451
LIG_FHA_1 72 78 PF00498 0.372
LIG_FHA_1 79 85 PF00498 0.350
LIG_FHA_2 207 213 PF00498 0.468
LIG_GBD_Chelix_1 61 69 PF00786 0.458
LIG_LIR_Apic_2 186 190 PF02991 0.380
LIG_LIR_Apic_2 2 7 PF02991 0.649
LIG_LIR_Apic_2 349 354 PF02991 0.501
LIG_LIR_Apic_2 422 428 PF02991 0.536
LIG_LIR_Apic_2 66 71 PF02991 0.429
LIG_LIR_Gen_1 111 116 PF02991 0.356
LIG_LIR_Gen_1 212 222 PF02991 0.379
LIG_LIR_Gen_1 288 296 PF02991 0.425
LIG_LIR_Gen_1 307 315 PF02991 0.532
LIG_LIR_Gen_1 352 363 PF02991 0.456
LIG_LIR_Nem_3 111 115 PF02991 0.356
LIG_LIR_Nem_3 212 217 PF02991 0.346
LIG_LIR_Nem_3 288 294 PF02991 0.313
LIG_LIR_Nem_3 307 311 PF02991 0.535
LIG_LIR_Nem_3 332 337 PF02991 0.445
LIG_LIR_Nem_3 352 358 PF02991 0.463
LIG_LIR_Nem_3 64 70 PF02991 0.345
LIG_MLH1_MIPbox_1 334 338 PF16413 0.476
LIG_Pex14_1 351 355 PF04695 0.498
LIG_RPA_C_Fungi 143 155 PF08784 0.341
LIG_SH2_CRK 112 116 PF00017 0.356
LIG_SH2_CRK 406 410 PF00017 0.511
LIG_SH2_NCK_1 406 410 PF00017 0.478
LIG_SH2_PTP2 308 311 PF00017 0.527
LIG_SH2_STAP1 153 157 PF00017 0.386
LIG_SH2_STAP1 334 338 PF00017 0.476
LIG_SH2_STAT5 204 207 PF00017 0.386
LIG_SH2_STAT5 226 229 PF00017 0.336
LIG_SH2_STAT5 295 298 PF00017 0.528
LIG_SH2_STAT5 308 311 PF00017 0.495
LIG_SH2_STAT5 337 340 PF00017 0.374
LIG_SH2_STAT5 406 409 PF00017 0.300
LIG_SH2_STAT5 418 421 PF00017 0.471
LIG_SH2_STAT5 68 71 PF00017 0.427
LIG_SH3_1 300 306 PF00018 0.338
LIG_SH3_3 15 21 PF00018 0.525
LIG_SH3_3 171 177 PF00018 0.378
LIG_SH3_3 182 188 PF00018 0.314
LIG_SH3_3 300 306 PF00018 0.625
LIG_SH3_3 368 374 PF00018 0.520
LIG_SUMO_SIM_anti_2 357 362 PF11976 0.393
LIG_SUMO_SIM_anti_2 429 436 PF11976 0.418
LIG_SUMO_SIM_par_1 160 165 PF11976 0.336
LIG_SUMO_SIM_par_1 25 32 PF11976 0.427
LIG_SUMO_SIM_par_1 254 260 PF11976 0.356
LIG_SUMO_SIM_par_1 359 366 PF11976 0.387
LIG_SUMO_SIM_par_1 432 438 PF11976 0.371
LIG_TRAF2_1 376 379 PF00917 0.581
LIG_TRFH_1 67 71 PF08558 0.332
LIG_TYR_ITIM 110 115 PF00017 0.356
LIG_TYR_ITIM 65 70 PF00017 0.386
LIG_WRC_WIRS_1 211 216 PF05994 0.458
MOD_CDK_SPxxK_3 370 377 PF00069 0.549
MOD_CK1_1 101 107 PF00069 0.458
MOD_CK1_1 12 18 PF00069 0.553
MOD_CK1_1 198 204 PF00069 0.363
MOD_CK1_1 332 338 PF00069 0.522
MOD_CK1_1 349 355 PF00069 0.328
MOD_CK1_1 392 398 PF00069 0.569
MOD_CK2_1 19 25 PF00069 0.351
MOD_CK2_1 206 212 PF00069 0.466
MOD_GlcNHglycan 251 254 PF01048 0.324
MOD_GlcNHglycan 263 266 PF01048 0.313
MOD_GlcNHglycan 37 40 PF01048 0.360
MOD_GlcNHglycan 394 397 PF01048 0.522
MOD_GSK3_1 195 202 PF00069 0.332
MOD_GSK3_1 206 213 PF00069 0.309
MOD_GSK3_1 325 332 PF00069 0.367
MOD_GSK3_1 404 411 PF00069 0.457
MOD_GSK3_1 419 426 PF00069 0.387
MOD_GSK3_1 43 50 PF00069 0.391
MOD_GSK3_1 56 63 PF00069 0.218
MOD_GSK3_1 8 15 PF00069 0.587
MOD_GSK3_1 93 100 PF00069 0.411
MOD_N-GLC_1 316 321 PF02516 0.505
MOD_NEK2_1 115 120 PF00069 0.369
MOD_NEK2_1 195 200 PF00069 0.425
MOD_NEK2_1 232 237 PF00069 0.297
MOD_NEK2_1 290 295 PF00069 0.384
MOD_NEK2_1 338 343 PF00069 0.532
MOD_NEK2_1 390 395 PF00069 0.414
MOD_NEK2_1 404 409 PF00069 0.307
MOD_NEK2_1 419 424 PF00069 0.374
MOD_NEK2_1 435 440 PF00069 0.364
MOD_NEK2_1 78 83 PF00069 0.370
MOD_NEK2_1 93 98 PF00069 0.318
MOD_NEK2_2 37 42 PF00069 0.386
MOD_PIKK_1 115 121 PF00454 0.458
MOD_PIKK_1 123 129 PF00454 0.420
MOD_PIKK_1 346 352 PF00454 0.508
MOD_PK_1 14 20 PF00069 0.560
MOD_PKA_2 239 245 PF00069 0.412
MOD_PKA_2 332 338 PF00069 0.406
MOD_PKA_2 98 104 PF00069 0.315
MOD_PKB_1 238 246 PF00069 0.412
MOD_Plk_1 316 322 PF00069 0.524
MOD_Plk_1 63 69 PF00069 0.356
MOD_Plk_4 130 136 PF00069 0.412
MOD_Plk_4 195 201 PF00069 0.425
MOD_Plk_4 290 296 PF00069 0.425
MOD_Plk_4 325 331 PF00069 0.519
MOD_Plk_4 80 86 PF00069 0.429
MOD_ProDKin_1 370 376 PF00069 0.508
MOD_ProDKin_1 399 405 PF00069 0.489
MOD_ProDKin_1 56 62 PF00069 0.458
MOD_SUMO_for_1 363 366 PF00179 0.503
MOD_SUMO_for_1 376 379 PF00179 0.548
MOD_SUMO_for_1 41 44 PF00179 0.458
MOD_SUMO_rev_2 32 38 PF00179 0.436
TRG_DiLeu_BaEn_1 111 116 PF01217 0.267
TRG_DiLeu_BaEn_1 430 435 PF01217 0.404
TRG_DiLeu_BaEn_3 378 384 PF01217 0.541
TRG_ENDOCYTIC_2 112 115 PF00928 0.356
TRG_ENDOCYTIC_2 226 229 PF00928 0.342
TRG_ENDOCYTIC_2 308 311 PF00928 0.513
TRG_ENDOCYTIC_2 406 409 PF00928 0.474
TRG_ENDOCYTIC_2 67 70 PF00928 0.356
TRG_Pf-PMV_PEXEL_1 107 111 PF00026 0.386

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6Q0 Leptomonas seymouri 74% 100%
A0A0S4J450 Bodo saltans 31% 100%
A0A1X0NYA9 Trypanosomatidae 44% 100%
A0A3S5H7F2 Leishmania donovani 95% 100%
A4HEC1 Leishmania braziliensis 87% 100%
A4I1R6 Leishmania infantum 96% 100%
A7RG82 Nematostella vectensis 25% 100%
A8X9U4 Caenorhabditis briggsae 22% 100%
B0VZR4 Culex quinquefasciatus 25% 100%
C9ZKC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
Q0U2G5 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 23% 95%
Q16WA6 Aedes aegypti 24% 100%
Q2H1L0 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 25% 90%
Q4Q9M0 Leishmania major 96% 100%
Q59ST8 Candida albicans (strain SC5314 / ATCC MYA-2876) 25% 91%
Q9SR06 Arabidopsis thaliana 24% 100%
V5BCI8 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS