Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXV0_LEIMU

TriTrypDb:

LmxM.25.2160

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXV0

PDB structure(s): 7ane_av

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.364
CLV_NRD_NRD_1	34	36	PF00675	0.489
CLV_PCSK_KEX2_1	34	36	PF00082	0.507
CLV_PCSK_SKI1_1	34	38	PF00082	0.512
CLV_PCSK_SKI1_1	47	51	PF00082	0.382
DEG_Nend_UBRbox_1	1	4	PF02207	0.551
DOC_MAPK_gen_1	89	98	PF00069	0.463
DOC_MAPK_MEF2A_6	2	9	PF00069	0.522
DOC_MAPK_NFAT4_5	2	10	PF00069	0.519
DOC_PP1_RVXF_1	87	93	PF00149	0.357
DOC_USP7_MATH_1	29	33	PF00917	0.597
DOC_WW_Pin1_4	129	134	PF00397	0.390
DOC_WW_Pin1_4	196	201	PF00397	0.427
DOC_WW_Pin1_4	47	52	PF00397	0.460
LIG_14-3-3_CanoR_1	2	8	PF00244	0.577
LIG_14-3-3_CanoR_1	34	43	PF00244	0.639
LIG_14-3-3_CanoR_1	91	96	PF00244	0.508
LIG_FHA_1	4	10	PF00498	0.590
LIG_FHA_2	116	122	PF00498	0.468
LIG_FHA_2	152	158	PF00498	0.410
LIG_FHA_2	176	182	PF00498	0.536
LIG_FHA_2	48	54	PF00498	0.435
LIG_LIR_Apic_2	39	45	PF02991	0.472
LIG_LIR_Gen_1	161	169	PF02991	0.459
LIG_LIR_Nem_3	161	166	PF02991	0.463
LIG_LIR_Nem_3	94	98	PF02991	0.439
LIG_MYND_1	210	214	PF01753	0.520
LIG_SH2_NCK_1	163	167	PF00017	0.463
LIG_SH2_STAP1	25	29	PF00017	0.460
LIG_SH2_STAT5	134	137	PF00017	0.375
LIG_SH3_3	74	80	PF00018	0.491
LIG_TRAF2_1	168	171	PF00917	0.463
LIG_WRC_WIRS_1	92	97	PF05994	0.435
MOD_CDC14_SPxK_1	199	202	PF00782	0.419
MOD_CDK_SPxK_1	196	202	PF00069	0.429
MOD_CK1_1	60	66	PF00069	0.453
MOD_CK2_1	115	121	PF00069	0.374
MOD_CK2_1	175	181	PF00069	0.536
MOD_CK2_1	20	26	PF00069	0.574
MOD_CK2_1	97	103	PF00069	0.368
MOD_DYRK1A_RPxSP_1	47	51	PF00069	0.425
MOD_GlcNHglycan	17	20	PF01048	0.541
MOD_GlcNHglycan	229	232	PF01048	0.461
MOD_GlcNHglycan	59	62	PF01048	0.527
MOD_GlcNHglycan	99	102	PF01048	0.436
MOD_GSK3_1	34	41	PF00069	0.490
MOD_GSK3_1	47	54	PF00069	0.424
MOD_N-GLC_1	129	134	PF02516	0.390
MOD_N-GLC_1	227	232	PF02516	0.353
MOD_NEK2_1	1	6	PF00069	0.588
MOD_NEK2_1	135	140	PF00069	0.410
MOD_NEK2_1	36	41	PF00069	0.475
MOD_NEK2_1	9	14	PF00069	0.568
MOD_NEK2_2	136	141	PF00069	0.456
MOD_PIKK_1	20	26	PF00454	0.559
MOD_PIKK_1	36	42	PF00454	0.414
MOD_PKA_1	34	40	PF00069	0.424
MOD_PKA_2	1	7	PF00069	0.583
MOD_PKA_2	34	40	PF00069	0.498
MOD_PKB_1	89	97	PF00069	0.430
MOD_Plk_1	115	121	PF00069	0.374
MOD_Plk_1	161	167	PF00069	0.396
MOD_Plk_2-3	151	157	PF00069	0.469
MOD_Plk_4	60	66	PF00069	0.431
MOD_Plk_4	91	97	PF00069	0.433
MOD_ProDKin_1	129	135	PF00069	0.383
MOD_ProDKin_1	196	202	PF00069	0.429
MOD_ProDKin_1	47	53	PF00069	0.457
MOD_SUMO_rev_2	139	149	PF00179	0.399
MOD_SUMO_rev_2	150	155	PF00179	0.380
TRG_DiLeu_BaEn_1	171	176	PF01217	0.515
TRG_ENDOCYTIC_2	163	166	PF00928	0.464
TRG_ENDOCYTIC_2	201	204	PF00928	0.443
TRG_ENDOCYTIC_2	229	232	PF00928	0.440
TRG_ER_diArg_1	34	36	PF00400	0.441
TRG_ER_diArg_1	88	91	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IST6	Bodo saltans	49%	98%
A0A1X0NY44	Trypanosomatidae	67%	100%
A0A3R7MC48	Trypanosoma rangeli	69%	100%
A0A3S7WZF0	Leishmania donovani	96%	100%
A4HEC0	Leishmania braziliensis	90%	100%
A4I1R5	Leishmania infantum	96%	100%
C9ZKC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
Q4Q9M1	Leishmania major	96%	100%